Effectiveness of internet-based cognitive behavioural treatment for adolescents with chronic fatigue syndrome (FITNET): a randomised controlled trial

Nijhof, Sanne L; Bleijenberg, Gijs; Uiterwaal, Cuno SPM; Kimpen, Jan LL; van de Putte, Elise M

doi:10.1016/s0140-6736(12)60025-7

Cited by 208Fibromyalgia and Chronic Fatigue Syndrome ResearchDigital Mental Health InterventionsSleep and related disorders

Effectiveness of internet-based cognitive behavioural treatment for adolescents with chronic fatigue syndrome (FITNET): a randomised controlled trial

Nijhof, Sanne L, Bleijenberg, Gijs, Uiterwaal, Cuno SPM, Kimpen, Jan LL, van de Putte, Elise M·2012·The Lancet

DOI 10.1016/s0140-6736(12)60025-7

Open this paper in CoChat — free account

Abstract

Background Chronic fatigue syndrome is characterised by persistent fatigue and severe disability. Cognitive behavioural therapy seems to be a promising treatment, but its availability is restricted. We developed Fatigue In Teenagers on the interNET (FITNET), the first dedicated internet-based therapeutic program for adolescents with this disorder, and compared its effectiveness with that of usual care.Methods Adolescents aged 12-18 years with chronic fatigue syndrome were assigned to FITNET or usual care in a 1:1 ratio at one tertiary treatment centre in the Netherlands by use of a computer-generated blocked randomisation allocation schedule. The study was open label. Primary outcomes were school attendance, fatigue severity, and physical functioning, and were assessed at 6 months with computerised questionnaires. Analysis was by intention to treat. Thereafter, all patients were offered FITNET if needed. This trial is registered, number ISRCTN59878666.Findings 68 of 135 adolescents were assigned to FITNET and 67 to usual care, and 67 and 64, respectively, were analysed. FITNET was significantly more effective than was usual care for all dichotomised primary outcomes at 6 months-full school attendance (50 [75%] vs 10 [16%], relative risk 4·8, 95% CI 2·7-8·9; p<0·0001), absence of severe fatigue (57 [85%] vs 17 [27%], 3·2, 2·1-4·9; p<0·0001), and normal physical functioning (52 [78%] vs 13 [20%], 3·8, 2·3-6·3; p<0·0001). No serious adverse events were reported.Interpretation FITNET offers a readily accessible and highly effective treatment for adolescents with chronic fatigue syndrome. The results of this study justify implementation on a broader scale.Funding Netherlands Organisation for Health Research and Development.

Integrity signals

Registry

Crossref · 10.1016/s0140-6736(12)60025-7

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Family-based CBT and internet-delivered CBT have proven effective in young patients with specific FSS.
“Family-based CBT and internet-delivered CBT have proven effective in young patients with specific FSS.31–36”
From Comparing group-based acceptance and commitment therapy (ACT) with enhanced usual care for adolescents with functional somatic syndromes: A study protocol for a randomised trial (2016) · cites this paper as [34]

The Chronic Fatigue Syndrome: A Comprehensive Approach to Its Definition and Study
Fukuda, K., Straus, S. E., Hickie, I., Sharpe, M. C., Dobbins, J. G., Komaroff, A., & and International Chronic Fatigue Syndrome Study Group. (1994) · Annals of Internal Medicine · doi:10.7326/0003-4819-121-12-199412150-00009 · Cited by 4,969 · see citing works
The Children's Depression, Inventory (CDI).
Kovacs, M. (1985) · Psychopharmacology bulletin · doi:10.1007/978-0-387-79061-9_4285 · Cited by 4,292 · see citing works
Dimensional assessment of chronic fatigue syndrome
Vercoulen, J. H. M. M., Swanink, C. M. A., Fennis, J. F. M., Galama, J. M. D., van der Meer, J. W. M., & Bleijenberg, G. (1994) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(94)90099-x · Cited by 1,306 · see citing works
Self-citation
A Behavior Change Model for Internet Interventions
Ritterband, L. M., Thorndike, F. P., Cox, D. J., Kovatchev, B. P., & Gonder-Frederick, L. A. (2009) · Annals of Behavioral Medicine · doi:10.1007/s12160-009-9133-4 · Cited by 591 · see citing works
Internet-administered cognitive behavior therapy for health problems: a systematic review
Cuijpers, P., van Straten, A., & Andersson, G. (2008) · Journal of Behavioral Medicine · doi:10.1007/s10865-007-9144-1 · Cited by 555 · see citing works
Cognitive behaviour therapy for chronic fatigue syndrome: a multicentre randomised controlled trial
Prins, J. B., Bleijenberg, G., Bazelmans, E., Elving, L. D., de Boo, T. M., Severens, J. L., van der Wilt, G. J., Spinhoven, P., & van der Meer, J. W. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04198-2 · Cited by 531 · see citing works
Self-citation
Cognitive behaviour therapy for adolescents with chronic fatigue syndrome: randomised controlled trial
Stulemeijer, M., de Jong, L. W. A. M., Fiselier, T. J. W., Hoogveld, S. W. B., & Bleijenberg, G. (2004) · BMJ · doi:10.1136/bmj.38301.587106.63 · Cited by 271 · see citing works
Self-citation
The feasibility and outcome of clinic plus Internet delivery of cognitive-behavior therapy for childhood anxiety.
Spence, S. H., Holmes, J. M., March, S., & Lipp, O. V. (2006) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.74.3.614 · Cited by 261 · see citing works
Cost Effectiveness of Internet Interventions: Review and Recommendations
Tate, D. F., Finkelstein, E. A., Khavjou, O., & Gustafson, A. (2009) · Annals of Behavioral Medicine · doi:10.1007/s12160-009-9131-6 · Cited by 261 · see citing works
The persistence of fatigue in chronic fatigue syndrome and multiple sclerosis
Vercoulen, J. H. M. M., Swanink, C. M. A., Galama, J. M. D., Fennis, J. F. M., Jongen, P. J., Hommes, O. R., van der Meer, J. W. M., & Bleijenberg, G. (1998) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(98)00023-3 · Cited by 248 · see citing works
Self-citation
Incidence, prognosis, and risk factors for fatigue and chronic fatigue syndrome in adolescents: A prospective community study
Rimes, K. A., Goodman, R., Hotopf, M., Wessely, S., Meltzer, H., & Chalder, T. (2007) · PEDIATRICS · doi:10.1542/peds.2006-2231 · Cited by 200 · see citing works
Technological innovations in clinical assessment and psychotherapy
Emmelkamp, P. M. G. (2005) · Psychotherapy and Psychosomatics · doi:10.1159/000087780 · Cited by 200 · see citing works
Effects of a Cognitive‐Behavioural Internet Program on Depression, Vulnerability to Depression and Stigma in Adolescent Males: A School‐Based Controlled Trial
O'Kearney, R., Gibson, M., Christensen, H., & Griffiths, K. M. (2006) · Cognitive Behaviour Therapy · doi:10.1080/16506070500303456 · Cited by 183 · see citing works
Adolescent Chronic Fatigue Syndrome: Prevalence, Incidence, and Morbidity
Nijhof, S. L., Maijer, K., Bleijenberg, G., Uiterwaal, C. S. P. M., Kimpen, J. L. L., & van de Putte, E. M. (2011) · Pediatrics · doi:10.1542/peds.2010-1147 · Cited by 162 · see citing works
Self-citation
A randomized controlled trial of Internet-based self-help training for recurrent headache in childhood and adolescence
Trautmann, E., & Kröner-Herwig, B. (2010) · Behaviour Research and Therapy · doi:10.1016/j.brat.2009.09.004 · Cited by 159 · see citing works
Reliability and validity of the child health questionnaire-child form (CHQ-CF87) in a Dutch adolescent population
Raat, H., Landgraf, J. M., Bonsel, G. J., Gemke, R. J. B. J., & Essink‐Bot, M. (2002) · Quality of Life Research · doi:10.1023/a:1016393311799 · Cited by 155 · see citing works
Epidemiology of chronic fatigue syndrome and self reported myalgic encephalomyelitis in 5-15 year olds: cross sectional study
Chalder, T., Goodman, R., Wessely, S. C., Hotopf, M. H., & Meltzer, H. (2003) · BMJ · doi:10.1136/bmj.327.7416.654 · Cited by 135 · see citing works
Prevalence of chronic disabling fatigue in children and adolescents
FARMER, A. E., Fowler, T., Scourfield, J., & Thapar, A. (2004) · The British Journal of Psychiatry · doi:10.1192/bjp.184.6.477 · Cited by 127 · see citing works
The course of severe chronic fatigue syndrome in childhood
Rangel, L., Garralda, M. E., Levin, M., & Roberts, H. (2000) · Journal of the Royal Society of Medicine · doi:10.1177/014107680009300306 · Cited by 123 · see citing works
Thirteen-Year Follow-Up of Children and Adolescents With Chronic Fatigue Syndrome
Bell, D. S., Jordan, K. M., & Robinson, M. L. (2001) · PEDIATRICS · doi:10.1542/peds.107.5.994 · Cited by 119 · see citing works
Randomized clinical trial of an Internet-based versus brief office intervention for adolescent smoking cessation
Patten, C. A., Croghan, I. T., Meis, T. M., Decker, P. A., Pingree, S., Colligan, R. C., Dornelas, E. A., Offord, K. P., Boberg, E. W., Baumberger, R. K., et al. (2006) · Patient Education and Counseling · doi:10.1016/j.pec.2006.03.001 · Cited by 114 · see citing works
Association between school absence and physical function in paediatric chronic fatigue syndrome/myalgic encephalopathy
Crawley, E. M., & Sterne, J. A. C. (2008) · Archives of Disease in Childhood · doi:10.1136/adc.2008.143537 · Cited by 109 · see citing works
Family-focused cognitive behaviour therapy versus psycho-education for chronic fatigue syndrome in 11- to 18-year-olds: a randomized controlled treatment trial
Chalder, T., Deary, V., Husain, K., & Walwyn, R. E. A. (2009) · Psychological Medicine · doi:10.1017/s003329170999153x · Cited by 107 · see citing works
Chronic fatigue syndrome and other fatiguing illnesses in adolescents: a population-based study
Jones, J. F., Nisenbaum, R. A., Solomon, L., Reyes, M., & Reeves, W. C. (2004) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2003.09.007 · Cited by 104 · see citing works
Assessment of anxiety and achievement in kindergarten and first-and second-grade children
Papay, J. P., & Spielberger, C. D. (1986) · Research on Child and Adolescent Psychopathology · doi:10.1007/bf00915446 · Cited by 94 · see citing works
Family cognitive behaviour therapy for chronic fatigue syndrome: an uncontrolled study
Chalder, T. (2002) · Archives of Disease in Childhood · doi:10.1136/adc.86.2.95 · Cited by 82 · see citing works
Long-Term Sickness Absence Due to ME/CFS in UK Schools
Dowsett, E. G., & Colby, J. (1997) · Journal of Chronic Fatigue Syndrome · doi:10.1300/j092v03n02_04 · Cited by 79 · see citing works
Handbook of Chronic Fatigue Syndrome
Jason, L. A., Fennell, P. A., & Taylor, R. R. (2003) · Cited by 75 · see citing works
Handbook of chronic fatigue syndrome
Couper, J. W. (2004) · Australian & New Zealand Journal of Psychiatry · doi:10.1111/j.1440-1614.2004.01390.x · Cited by 72 · see citing works
Chronic fatigue syndrome and other fatiguing illnesses in adolescents: a population-based study
Jones, J. F., Nisenbaum, R., Solomon, L., et al. (2004) · Journal of Adolescent Health · doi:10.1016/s1054-139x(03)00372-0 · Cited by 69 · see citing works
A randomized, placebo-controlled, double-blind study of fluoxetine in Chronic Fatigue Syndrome
Vercoulen, J. H. M. M., Swanink, C. M. A., Zitman, F. G., Vreden, S., Hoofs, M. P. E., Fennis, J. F. M., Galama, J. M. D., van der Meer, J. W. M., & Bleijenberg, G. (1996) · Radboud Repository (Radboud University) · doi:10.1016/s0140-6736(96)91345-8 · Cited by 59 · see citing works
Self-citation
Effectiveness of stepped care for chronic fatigue syndrome: A randomized noninferiority trial.
Tummers, M., Knoop, H., & Bleijenberg, G. (2010) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0020052 · Cited by 57 · see citing works
Self-citation
Personality and chronic fatigue syndrome: methodological and conceptual issues
van Geelen, S. M., Sinnema, G., Hermans, H. J. M., & Kuis, W. (2007) · Clinical Psychology Review · doi:10.1016/j.cpr.2007.01.010 · Cited by 52 · see citing works
Cognitive Behavioral Therapies
Stephen Hupp, E. R., & Jewell, J. (2016) · The SAGE Encyclopedia of Theory in Psychology · doi:10.4135/9781483346274.n49 · Cited by 47 · see citing works
Report of a workshop on the epidemiology, natural history, and pathogenesis of chronic fatigue syndrome in adolescents
Marshall, G. S. (1999) · The Journal of Pediatrics · doi:10.1016/s0022-3476(99)70195-2 · Cited by 46 · see citing works
Adolescent Chronic Fatigue Syndrome
van Geelen, S. M., Bakker, R. J., Kuis, W., & van de Putte, E. M. (2010) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpediatrics.2010.145 · Cited by 35 · see citing works
Fatigue In Teenagers on the interNET - The FITNET Trial. A randomized clinical trial of web-based cognitive behavioural therapy for adolescents with chronic fatigue syndrome: study protocol. [ISRCTN59878666]
Nijhof, S. L., Bleijenberg, G., Uiterwaal, C. S. P. M., Kimpen, J. L. L., & van de Putte, E. M. (2011) · BMC Neurology · doi:10.1186/1471-2377-11-23 · Cited by 25 · see citing works
Self-citation

Flagged first, then by citations

Sorted by citations

Internet- and Mobile-Based Psychological Interventions: Applications, Efficacy, and Potential for Improving Mental Health: A Report of the EFPA E-Health Taskforce
Ebert, D. D., Van Daele, T., Nordgreen, T., Karekla, M., Compare, A., Zarbo, C., Brugnera, A., Øverland, S., Trebbi, G., Jensen, K. L., et al. (2018) · European Psychologist · doi:10.1027/1016-9040/a000318 · Cited by 437 · see citing works
Patient-Centered Approaches to Health Care
McMillan, S. S., Kendall, E. A., Sav, A., King, M. A., Whitty, J. A., Kelly, F., & Wheeler, A. (2013) · Medical Care Research and Review · doi:10.1177/1077558713496318 · Cited by 341 · see citing works
Internet-delivered cognitive behavior therapy for children and adolescents: A systematic review and meta-analysis
Vigerland, S., Lenhard, F., Bonnert, M., Lalouni, M., Hedman, E., Ahlen, J., Olén, O., Serlachius, E., & Ljótsson, B. (2016) · Clinical Psychology Review · doi:10.1016/j.cpr.2016.09.005 · Cited by 292 · see citing works
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Diagnosis and Management in Young People: A Primer
Rowe, P. C., Underhill, R. A., Friedman, K. J., Gurwitt, A., Medow, M. S., Schwartz, M. S., Speight, N., Stewart, J. M., Vallings, R., & Rowe, K. S. (2017) · Frontiers in Pediatrics · doi:10.3389/fped.2017.00121 · Cited by 212 · see citing works
Advancing psychotherapy and evidence‐based psychological interventions
Emmelkamp, P. M. G., David, D., Beckers, T., Muris, P., Cuijpers, P. J., Lutz, W., Andersson, G., Araya, R., Rivera, R. M. B., Barkham, M., et al. (2013) · International Journal of Methods in Psychiatric Research · doi:10.1002/mpr.1411 · Cited by 167 · see citing works
Treatment and management of chronic fatigue syndrome/myalgic encephalomyelitis: all roads lead to Rome
Castro‐Marrero, J., Sáez‐Francàs, N., Santillo, D., & Alegre, J. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13702 · Cited by 142 · see citing works
Internet-based guided self-help versus group cognitive behavioral therapy for chronic tinnitus: A randomized controlled trial
Jasper, K., Weise, C., Conrad, I., Andersson, G., Hiller, W., & Kleinstäuber, M. (2014) · Psychotherapy and Psychosomatics · doi:10.1159/000360705 · Cited by 128 · see citing works
Recovery from chronic fatigue syndrome after treatments given in the PACE trial
White, P. D., Goldsmith, K., Johnson, A. L., Chalder, T., & Sharpe, M. (2013) · Psychological Medicine · doi:10.1017/s0033291713000020 · Cited by 124 · see citing works
Chronic fatigue syndrome: diagnosis and treatment.
Yancey, J. R., & Thomas, S. M. (2012) · PubMed · Cited by 117 · see citing works
Neurobiological studies of fatigue
Harrington, M. E. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.07.004 · Cited by 112 · see citing works
“Cognitive behavioral therapy delivered via the internet was recently shown to be more effective than usual care for adolescents with chronic fatigue syndrome (Nijhof et al., 2012).”
The role of hypocortisolism in chronic fatigue syndrome
Nijhof, S. L., Rutten, J. M. T. M., Uiterwaal, C. S. P. M., Bleijenberg, G., Kimpen, J. L. L., & van de Putte, E. M. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.01.017 · Cited by 93 · see citing works
Self-citation
Psychological Interventions for Children with Functional Somatic Symptoms: A Systematic Review and Meta-Analysis
Bonvanie, I. J., Kallesøe, K. H., Janssens, K. A. M., Schröder, A., Rosmalen, J. G. M., & Rask, C. U. (2017) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2017.03.017 · Cited by 84 · see citing works
Adolescent Fatigue, POTS, and Recovery: A Guide for Clinicians
Kizilbash, S. J., Ahrens, S. P., Bruce, B. K., Chelimsky, G., Driscoll, S. W., Harbeck-Weber, C., Lloyd, R. M., Mack, K. J., Nelson, D. E., Ninis, N., et al. (2014) · Current Problems in Pediatric and Adolescent Health Care · doi:10.1016/j.cppeds.2013.12.014 · Cited by 120 · see citing works
Systematic review of randomized controlled trials for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)
Kim, D.-Y., Lee, J., Park, S.-Y., Kim, S., & Son, C. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-019-02196-9 · Cited by 83 · see citing works
Prevalence of Severe Fatigue Among Adolescents With Pediatric Rheumatic Diseases
Nijhof, L. N., van de Putte, E. M., Wulffraat, N. M., & Nijhof, S. L. (2015) · Arthritis Care & Research · doi:10.1002/acr.22710 · Cited by 77 · see citing works
Self-citation
Digital Interventions for Mental Disorders: Key Features, Efficacy, and Potential for Artificial Intelligence Applications
Ebert, D. D., Harrer, M., Apolinário-Hagen, J., & Baumeister, H. (2019) · Advances in Experimental Medicine and Biology · doi:10.1007/978-981-32-9721-0_29 · Cited by 76 · see citing works
Somatoform and related disorders
Garralda, M. E., & Rask, C. U. (2015) · Rutter's Child and Adolescent Psychiatry · doi:10.1002/9781118381953.ch72 · Cited by 81 · see citing works
Disease Mechanisms and Clonidine Treatment in Adolescent Chronic Fatigue Syndrome
Sulheim, D., Fagermoen, E., Winger, A., Andersen, A. M., Godang, K., Müller, F., Rowe, P. C., Saul, J. P., Skovlund, E., Øie, M. G., et al. (2014) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2013.4647 · Cited by 74 · see citing works
eHealth and mHealth psychosocial interventions for youths with chronic illnesses: systematic review
Lau, N., Waldbaum, S., Parigoris, R., O'Daffer, A., Walsh, C., Colt, S. F., Yi-Frazier, J. P., Palermo, T. M., McCauley, E., & Rosenberg, A. R. (2020) · JMIR Pediatrics and Parenting · doi:10.2196/22329 · Cited by 68 · see citing works
“Ten were eHealth interventions [44-48,51-59,61] and 2 mHealth interventions [49,60].”
BackgroundInfluential
Efficacy of web-based cognitive–behavioural therapy for chronic fatigue syndrome: randomised controlled trial
Janse, A., Worm-Smeitink, M., Bleijenberg, G., Donders, R., & Knoop, H. (2018) · The British Journal of Psychiatry · doi:10.1192/bjp.2017.22 · Cited by 72 · see citing works
Self-citation
Fatigue in Child Chronic Health Conditions: A Systematic Review of Assessment Instruments
Crichton, A. J., Knight, S., Oakley, E. A., Babl, F. E., & Anderson, V. A. (2015) · PEDIATRICS · doi:10.1542/peds.2014-2440 · Cited by 74 · see citing works
A review of the predisposing, precipitating and perpetuating factors in Chronic Fatigue Syndrome in children and adolescents.
Lievesley, K., Rimes, K., & Chalder, T. (2014) · Clinical Psychology Review · doi:10.1016/j.cpr.2014.02.002 · Cited by 73 · see citing works
Functional somatic symptoms in childhood and adolescence
Kozlowska, K. (2013) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e3283642ca0 · Cited by 64 · see citing works
Chronic Fatigue Syndrome
Chalder, T. (2013) · doi:10.1002/9781118528563.wbcbt23 · Cited by 63 · see citing works
Fatigue in childhood chronic disease
der Vlist, M. M. N.-V., Dalmeijer, G. W., Grootenhuis, M. A., van der Ent, C. K., van den Heuvel‐Eibrink, M. M., Wulffraat, N. M., Swart, J. F., van Litsenburg, R. R. L., van de Putte, E. M., & Nijhof, S. L. (2019) · Archives of Disease in Childhood · doi:10.1136/archdischild-2019-316782 · Cited by 61 · see citing works
Self-citation
Understanding fatigue in paediatric multiple sclerosis: a systematic review of clinical and psychosocial factors
Carroll, S., Chalder, T., Hemingway, C. A., Heyman, I., & Moss-Morris, R. E. (2015) · Developmental Medicine & Child Neurology · doi:10.1111/dmcn.12964 · Cited by 60 · see citing works
The epidemiology of chronic fatigue syndrome/myalgic encephalitis in children
Crawley, E. M. (2013) · Archives of Disease in Childhood · doi:10.1136/archdischild-2012-302156 · Cited by 56 · see citing works
Internet-Based Therapy for Adolescents With Chronic Fatigue Syndrome: Long-term Follow-up
Nijhof, S. L., Priesterbach-Ackley, L. P., Uiterwaal, C. S. P. M., Bleijenberg, G., Kimpen, J. L. L., & van de Putte, E. M. (2013) · PEDIATRICS · doi:10.1542/peds.2012-2007 · Cited by 56 · see citing works
Self-citation
Long Term Follow up of Young People With Chronic Fatigue Syndrome Attending a Pediatric Outpatient Service
Rowe, K. S. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00021 · Cited by 56 · see citing works
Family-focused cognitive behaviour therapy versus psycho-education for adolescents with chronic fatigue syndrome: Long-term follow-up of an RCT
Lloyd, S., Chalder, T., & Rimes, K. A. (2012) · Behaviour Research and Therapy · doi:10.1016/j.brat.2012.08.005 · Cited by 50 · see citing works
Psychosocial perspectives in the treatment of pediatric chronic pain
Carter, B. D., & Threlkeld, B. M. (2012) · Pediatric Rheumatology · doi:10.1186/1546-0096-10-15 · Cited by 51 · see citing works
Chronic fatigue syndrome (CFS) or myalgic encephalomyelitis (ME) is different in children compared to in adults: a study of UK and Dutch clinical cohorts
Collin, S. M., Nuevo, R., van de Putte, E. M., Nijhof, S. L., & Crawley, E. M. (2015) · BMJ Open · doi:10.1136/bmjopen-2015-008830 · Cited by 48 · see citing works
Self-citation
Efficacy of digital health interventions in youth with chronic medical conditions: A meta-analysis
Domhardt, M., Schröder, A., Geirhos, A., Steubl, L., & Baumeister, H. (2021) · Internet Interventions · doi:10.1016/j.invent.2021.100373 · Cited by 45 · see citing works
Severe fatigue after kidney transplantation: a highly prevalent, disabling and multifactorial symptom
Goedendorp, M. M., Hoitsma, A. J., Bloot, L., Bleijenberg, G., & Knoop, H. (2013) · Transplant International · doi:10.1111/tri.12166 · Cited by 45 · see citing works
Self-citation
Prevalence and predictors of recovery from chronic fatigue syndrome in a routine clinical practice
Flo, E., & Chalder, T. (2014) · Behaviour Research and Therapy · doi:10.1016/j.brat.2014.08.013 · Cited by 44 · see citing works
Social Media and New Technology: A Primer
Hogan, M. J., & Strasburger, V. C. (2018) · Clinical Pediatrics · doi:10.1177/0009922818769424 · Cited by 44 · see citing works
Clinical and cost-effectiveness of the Lightning Process in addition to specialist medical care for paediatric chronic fatigue syndrome: randomised controlled trial
Crawley, E. M., Gaunt, D., Garfield, K., Hollingworth, W., Sterne, J. A. C., Beasant, L., Collin, S. M., Mills, N., & Montgomery, A. A. (2017) · Archives of Disease in Childhood · doi:10.1136/archdischild-2017-313375 · Cited by 43 · see citing works
The Updated NICE Guidance Exposed the Serious Flaws in CBT and Graded Exercise Therapy Trials for ME/CFS
Vink, M., & Vink-Niese, A. (2022) · Healthcare · doi:10.3390/healthcare10050898 · Cited by 38 · see citing works
Clinical Practice: Chronic fatigue syndrome
Werker, C. L., Nijhof, S. L., & van de Putte, E. M. (2013) · European Journal of Pediatrics · doi:10.1007/s00431-013-2058-8 · Cited by 39 · see citing works
Self-citation
Illness perceptions in adolescents with chronic fatigue syndrome and other physical health conditions: Application of the common sense model
Haines, C., Loades, M., & Davis, C. (2019) · Clinical Child Psychology and Psychiatry · doi:10.1177/1359104519829796 · Cited by 39 · see citing works
New NICE guideline on chronic fatigue syndrome: more ideology than science?
Flottorp, S. A., Brurberg, K. G., Fink, P., Knoop, H., & Wyller, V. B. B. (2022) · The Lancet · doi:10.1016/s0140-6736(22)00183-0 · Cited by 37 · see citing works
‘Sometimes it feels as if the world goes on without me’: adolescents' experiences of living with chronic fatigue syndrome
Winger, A., Ekstedt, M., Wyller, V. B., & Helseth, S. (2013) · Journal of Clinical Nursing · doi:10.1111/jocn.12522 · Cited by 37 · see citing works
Interventions in Pediatric Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Systematic Review
Knight, S., Scheinberg, A. M., & Harvey, A. R. (2013) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2013.03.009 · Cited by 35 · see citing works
Fibromyalgia: can online cognitive behavioral therapy help?
(2014) · PubMed Central · Cited by 35 · see citing works
Internet and smartphone-based ecological momentary assessment and personalized advice (PROfeel) in adolescents with chronic conditions: a feasibility study
Nap-van der Vlist, M. M., Houtveen, J., Dalmeijer, G. W., Grootenhuis, M. A., van der Ent, C. K., van Grotel, M., Swart, J. F., van Montfrans, J. M., van de Putte, E. M., & Nijhof, S. L. (2021) · Internet Interventions · doi:10.1016/j.invent.2021.100395 · Cited by 31 · see citing works
Self-citation
Assessing severity of illness and outcomes of treatment in children with C hronic F atigue S yndrome/ M yalgic E ncephalomyelitis ( CFS / ME ): a systematic review of patient‐reported outcome measures ( PROMs )
Haywood, K. L., Collin, S. M., & Crawley, E. M. (2014) · Child Care Health and Development · doi:10.1111/cch.12135 · Cited by 30 · see citing works
Reducing fatigue in pediatric rheumatic conditions: a systematic review
Kant‐Smits, K., van Brussel, M., Nijhof, S. L., & van der Net, J. J. (2021) · Pediatric Rheumatology · doi:10.1186/s12969-021-00580-8 · Cited by 27 · see citing works
Self-citation
Does the effect of cognitive behavior therapy for chronic fatigue syndrome (ME/CFS) vary by patient characteristics? A systematic review and individual patient data meta-analysis
Kuut, T. A., Buffart, L. M., Braamse, A. M. J., Csorba, I., Bleijenberg, G., Nieuwkerk, P., Moss-Morris, R., Müller, F., & Knoop, H. (2024) · Psychological Medicine · doi:10.1017/s0033291723003148 · Cited by 27 · see citing works
Self-citation
Does neuropsychological test performance predict outcome of cognitive behavior therapy for Chronic Fatigue Syndrome and what is the role of underperformance?
Goedendorp, M. M., van der Werf, S. P., Bleijenberg, G., Tummers, M., & Knoop, H. (2013) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2013.07.011 · Cited by 26 · see citing works
Self-citation
A Systematic Review of Behavioral Intervention Technologies for Youth With Chronic Health Conditions and Physical and Intellectual Disabilities: Implications for Adolescents and Young Adults With Spina Bifida
Stiles‐Shields, C., Crowe, A. N., Driscoll, C., Ohanian, D. M., Stern, A., Wartman, E. C., Winning, A. M., Wafford, Q. E., Lattie, E. G., & Holmbeck, G. N. (2018) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsy097 · Cited by 25 · see citing works
The impact of chronic fatigue syndrome on cognitive functioning in adolescents
Nijhof, L. N., Nijhof, S. L., Bleijenberg, G., Stellato, R. K., Kimpen, J. L. L., Pol, H. E. H., & van de Putte, E. M. (2015) · European Journal of Pediatrics · doi:10.1007/s00431-015-2626-1 · Cited by 25 · see citing works
Self-citation
‘It’s personal to me’: A qualitative study of depression in young people with CFS/ME
Taylor, A. K., Loades, M. E., Brigden, A., Collin, S. M., & Crawley, E. M. (2016) · Clinical Child Psychology and Psychiatry · doi:10.1177/1359104516672507 · Cited by 25 · see citing works
Can linguistic analysis be used to identify whether adolescents with a chronic illness are depressed?
Jones, L. S., Anderson, E. C., Loades, M. E., Barnes, R., & Crawley, E. M. (2019) · Clinical Psychology & Psychotherapy · doi:10.1002/cpp.2417 · Cited by 25 · see citing works
Systematic Review of Primary Outcome Measurements for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) in Randomized Controlled Trials
Kim, D.-Y., Lee, J.-S., & Son, C.-G. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9113463 · Cited by 24 · see citing works
Cost-effectiveness of Interventions for Chronic Fatigue Syndrome or Myalgic Encephalomyelitis: A Systematic Review of Economic Evaluations
Cochrane, M., Mitchell, E., Hollingworth, W., Crawley, E. M., & Trépel, D. (2021) · Applied Health Economics and Health Policy · doi:10.1007/s40258-021-00635-7 · Cited by 24 · see citing works
Relationship between autonomic cardiovascular control, case definition, clinical symptoms, and functional disability in adolescent chronic fatigue syndrome: an exploratory study
Wyller, V. B., & Helland, I. B. (2013) · BioPsychoSocial Medicine · doi:10.1186/1751-0759-7-5 · Cited by 24 · see citing works
Cross-Cultural Validation of the Korean Version of the Chalder Fatigue Scale
Ha, H., Jeong, D., Hahm, B., & Shim, E. (2017) · International Journal of Behavioral Medicine · doi:10.1007/s12529-017-9701-0 · Cited by 25 · see citing works
Comparing group-based acceptance and commitment therapy (ACT) with enhanced usual care for adolescents with functional somatic syndromes: A study protocol for a randomised trial
Kallesøe, K. H., Schröder, A., Wicksell, R. K., Fink, P., Ørnbøl, E., & Rask, C. U. (2016) · BMJ Open · doi:10.1136/bmjopen-2016-012743 · Cited by 23 · see citing works
Cognitive Behavior Therapy for Persistent Severe Fatigue in Childhood Cancer Survivors: A Pilot Study
Boonstra, A., Gielissen, M. F. M., Broeder, E. V. D., Blijlevens, N., Knoop, H., & Loonen, J. J. (2018) · Journal of Pediatric Hematology/Oncology · doi:10.1097/mph.0000000000001345 · Cited by 23 · see citing works
Practical management of chronic fatigue syndrome or myalgic encephalomyelitis in childhood
Brigden, A., Loades, M. E., Abbott, A., Bond-Kendall, J., & Crawley, E. M. (2017) · Archives of Disease in Childhood · doi:10.1136/archdischild-2016-310622 · Cited by 22 · see citing works
Investigating the effectiveness and cost-effectiveness of FITNET-NHS (Fatigue In Teenagers on the interNET in the NHS) compared to Activity Management to treat paediatric chronic fatigue syndrome (CFS)/myalgic encephalomyelitis (ME): protocol for a randomised controlled trial
Baos, S., Brigden, A., Anderson, E. C., Hollingworth, W., Price, S., Mills, N., Beasant, L., Gaunt, D., Garfield, K., Metcalfe, C. D., et al. (2018) · Trials · doi:10.1186/s13063-018-2500-3 · Cited by 22 · see citing works
Self-citation
Cognitive and behavioural responses to symptoms in adolescents with chronic fatigue syndrome: A case-control study nested within a cohort
Loades, M. E., Rimes, K. A., Lievesley, K., Ali, S., & Chalder, T. (2019) · Clinical Child Psychology and Psychiatry · doi:10.1177/1359104519835583 · Cited by 22 · see citing works
The feasibility and acceptability of conducting a trial of specialist medical care and the Lightning Process in children with chronic fatigue syndrome: feasibility randomized controlled trial (SMILE study)
Crawley, E. M., Mills, N., Beasant, L., Johnson, D., Collin, S. M., Deans, Z., White, K., & Montgomery, A. A. (2013) · Trials · doi:10.1186/1745-6215-14-415 · Cited by 21 · see citing works
Nonpharmacological interventions for treating fatigue in adolescents: A systematic review and narrative synthesis of randomised controlled trials
Higson‐Sweeney, N., Mikkola, A., Smith, L., Shafique, J., Draper, L., Cooper, K., Dunn, B. D., & Loades, M. E. (2022) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2022.111070 · Cited by 20 · see citing works
Cognitive remediation training improves performance in patients with chronic fatigue syndrome
McBride, R., Horsfield, S., Sandler, C. X., Cassar, J., Casson, S. M., Cvejic, E., Vollmer-Conna, U. S., & Lloyd, A. R. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.08.035 · Cited by 20 · see citing works
Altered right anterior insular connectivity and loss of associated functions in adolescent chronic fatigue syndrome
Wortinger, L. A., Øie, M. G., Endestad, T., & Wyller, V. B. (2017) · PLoS ONE · doi:10.1371/journal.pone.0184325 · Cited by 21 · see citing works
No evidence found for an increased risk of long-term fatigue following human papillomavirus vaccination of adolescent girls
Klooster, T. M. S.-V., Kemmeren, J. M., van der Maas, N., van de Putte, E. M., ter Wolbeek, M., Nijhof, S. L., Vanrolleghem, A. M., van Vliet, J. A., Sturkenboom, M., & de Melker, H. E. (2018) · Vaccine · doi:10.1016/j.vaccine.2018.09.019 · Cited by 20 · see citing works
Self-citation
Using the internet to cope with chronic fatigue syndrome/myalgic encephalomyelitis in adolescence: a qualitative study
Brigden, A., Barnett, J. C., Parslow, R. M., Beasant, L., & Crawley, E. M. (2018) · BMJ Paediatrics Open · doi:10.1136/bmjpo-2018-000299 · Cited by 19 · see citing works
Acupuncture for Chronic Fatigue Syndrome: An Overview of Systematic Reviews
Yin, Z., Wang, L., Cheng, Y., Chen, J., Hong, X., Zhao, L., & Liang, F. (2020) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-020-3195-3 · Cited by 19 · see citing works
Kronisk utmattelsessyndrom/myalgisk encefalopati – sykdomsmekanismer, diagnostikk og behandling
Wyller, V. B., Reme, S. E., & Mollnes, T. E. (2015) · Tidsskrift for Den norske legeforening · doi:10.4045/tidsskr.15.1180 · Cited by 18 · see citing works
Cortisol output in adolescents with chronic fatigue syndrome: Pilot study on the comparison with healthy adolescents and change after cognitive behavioural guided self-help treatment
Rimes, K. A., Papadopoulos, A. S., Cleare, A. J., & Chalder, T. (2014) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2014.08.018 · Cited by 18 · see citing works
Adolescent and parent factors related to fatigue in paediatric multiple sclerosis and chronic fatigue syndrome: A comparative study
Carroll, S., Chalder, T., Hemingway, C. A., Heyman, I., Bear, H. A., Sweeney, L., & Moss-Morris, R. E. (2018) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2018.10.006 · Cited by 18 · see citing works
Fatigue in Epstein-Barr virus infected adolescents and healthy controls: A prospective multifactorial association study
Pedersen, M., Asprusten, T. T., Godang, K., Leegaard, T. M., Osnes, L., Skovlund, E., Tjade, T., Øie, M. G., & Wyller, V. B. (2019) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2019.04.008 · Cited by 18 · see citing works
Children's experiences following a CBT intervention to reduce dental anxiety: One year on
Rodd, H., Kirby, J., Duffy, E., Porritt, J., Morgan, A., Prasad, S., Baker, S., & Marshman, Z. (2018) · British Dental Journal · doi:10.1038/sj.bdj.2018.540 · Cited by 17 · see citing works
Physical activity patterns among children and adolescents with mild-to-moderate chronic fatigue syndrome/myalgic encephalomyelitis
Solomon-Moore, E., Jago, R., Beasant, L., Brigden, A., & Crawley, E. M. (2019) · BMJ Paediatrics Open · doi:10.1136/bmjpo-2018-000425 · Cited by 17 · see citing works
Recruiting Adolescents With Chronic Fatigue Syndrome/Myalgic Encephalomyelitis to Internet-Delivered Therapy: Internal Pilot Within a Randomized Controlled Trial
Anderson, E. C., Parslow, R. M., Hollingworth, W., Mills, N., Beasant, L., Gaunt, D., Metcalfe, C. D., Kessler, D. S., Macleod, J., Pywell, S., et al. (2020) · Journal of Medical Internet Research · doi:10.2196/17768 · Cited by 17 · see citing works
Self-citation
Risk and Protective Factors and Course of Functional Somatic Symptoms in Young People
Rask, C. U., Bonvanie, I. J., & Garralda, M. E. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-815310-9.00004-6 · Cited by 19 · see citing works
Fatigue, sleep disturbance, and pain interference in children and adolescents with chronic pain: a longitudinal study
Roman‐Juan, J., Ceniza-Bordallo, G., Sánchez‐Rodríguez, E., Jensen, M. P., & Miró, J. (2024) · Pain · doi:10.1097/j.pain.0000000000003432 · Cited by 16 · see citing works
Physical frailty deteriorates after a 5‐day dexamethasone course in children with acute lymphoblastic leukemia, results of a national prospective study
Verwaaijen, E. J., van Hulst, A. M., Hartman, A., Pieters, R., Fiocco, M. F., Pluijm, S. M. F., van Litsenburg, R. R. L., Grootenhuis, M. A., van den Akker, E. L. T., & van den Heuvel‐Eibrink, M. M. (2023) · Cancer Medicine · doi:10.1002/cam4.6779 · Cited by 15 · see citing works
Managed Activity Graded Exercise iN Teenagers and pre-Adolescents (MAGENTA) feasibility randomised controlled trial: study protocol
Brigden, A., Beasant, L., Hollingworth, W., Metcalfe, C. D., Gaunt, D., Mills, N., Jago, R., & Crawley, E. M. (2016) · BMJ Open · doi:10.1136/bmjopen-2016-011255 · Cited by 16 · see citing works
Recovery from chronic fatigue syndrome: a systematic review—heterogeneity of definition limits study comparison
Moore, Y., Serafimova, T., Anderson, N., King, H., Richards, A., Brigden, A., Sinai, P., Higgins, J. P. T., Ascough, C., Clery, P., et al. (2021) · Archives of Disease in Childhood · doi:10.1136/archdischild-2020-320196 · Cited by 16 · see citing works
Psychological and demographic factors associated with fatigue and social adjustment in young people with severe chronic fatigue syndrome/myalgic encephalomyelitis: a preliminary mixed-methods study
Ali, S., Adamczyk, L., Burgess, M., & Chalder, T. (2019) · Journal of Behavioral Medicine · doi:10.1007/s10865-019-00010-x · Cited by 15 · see citing works
Patients’ experiences and effects of non-pharmacological treatment for myalgic encephalomyelitis/chronic fatigue syndrome – a scoping mixed methods review
Mengshoel, A. M., Helland, I. B., Meeus, M., Castro‐Marrero, J., Pheby, D., & Strand, E. B. (2020) · International Journal of Qualitative Studies on Health and Well-Being · doi:10.1080/17482631.2020.1764830 · Cited by 15 · see citing works
Patient‐Centred Care in Dentistry: Definitions and Models ‐ Commentary
Alrawiai, S., Asimakopoulou, K. G., & Scambler, S. (2020) · European Journal Of Dental Education · doi:10.1111/eje.12629 · Cited by 14 · see citing works
Study findings challenge the content validity of the Canadian Consensus Criteria for adolescent chronic fatigue syndrome
Asprusten, T. T., Fagermoen, E., Sulheim, D., Skovlund, E., Sørensen, Ø., Mollnes, T. E., & Wyller, V. B. (2015) · Acta Paediatrica · doi:10.1111/apa.12950 · Cited by 14 · see citing works
Health-related quality of life in Norwegian adolescents living with chronic fatigue syndrome
Similä, W. A., Halsteinli, V., Helland, I. B., Suvatne, C., Elmi, H., & Rø, T. B. (2020) · Health and Quality of Life Outcomes · doi:10.1186/s12955-020-01430-z · Cited by 14 · see citing works
What treatments work for anxiety in children with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)? Systematic review
Stoll, S. V. E., Crawley, E. M., Richards, V., Lal, N., Brigden, A., & Loades, M. E. (2017) · BMJ Open · doi:10.1136/bmjopen-2016-015481 · Cited by 13 · see citing works
Measuring School Functioning in Students With Chronic Fatigue Syndrome: A Systematic Review
Tollit, M. A., Politis, J., & Knight, S. (2017) · Journal of School Health · doi:10.1111/josh.12580 · Cited by 13 · see citing works
Psychometric properties of the Cognitive and Behavioural Responses Questionnaire (CBRQ) in adolescents with chronic fatigue syndrome
Loades, M. E., Vitoratou, S., Rimes, K. A., Ali, S., & Chalder, T. (2019) · Behavioural and Cognitive Psychotherapy · doi:10.1017/s1352465819000390 · Cited by 13 · see citing works
Chronic Fatigue Syndrome
Sapra, A., & Bhandari, P. (2021) · StatPearls · Cited by 13 · see citing works
Paediatric chronic fatigue syndrome: 25 year perspective
Loades, M. E., Crawley, E. M., Chalder, T., & Flannery, H. (2020) · Clinical Child Psychology and Psychiatry · doi:10.1177/1359104520978461 · Cited by 13 · see citing works
Humoral and cellular immune responses after influenza vaccination in patients with chronic fatigue syndrome
Prinsen, H., de Vries, I. J. M., Torensma, R., Pots, J. M., Mulder, S. F., van Herpen, C. M. L., Elving, L. D., Bleijenberg, G., Stelma, F. F., & van Laarhoven, H. W. M. (2012) · BMC Immunology · doi:10.1186/1471-2172-13-71 · Cited by 12 · see citing works
Self-citation
Comparing specialist medical care with specialist medical care plus the Lightning Process® for chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME): study protocol for a randomised controlled trial (SMILE Trial)
Crawley, E. M., Mills, N., Hollingworth, W., Deans, Z., Sterne, J. A. C., Donovan, J., Beasant, L., & Montgomery, A. A. (2013) · Trials · doi:10.1186/1745-6215-14-444 · Cited by 12 · see citing works
Depressive symptoms in adolescents with chronic fatigue syndrome (CFS): Are rates higher than in controls and do depressive symptoms affect outcome?
Loades, M. E., Rimes, K. A., Ali, S., & Chalder, T. (2019) · Clinical Child Psychology and Psychiatry · doi:10.1177/1359104519838584 · Cited by 12 · see citing works
The Permutation Distancing Test for dependent single-case observational AB-phase design data: A Monte Carlo simulation study
Vroegindeweij, A., Nijhof, L. N., Onghena, P., van de Putte, E. M., Nijhof, S. L., & Houtveen, J. H. (2023) · Behavior Research Methods · doi:10.3758/s13428-023-02167-5 · Cited by 11 · see citing works
Self-citation
Graded exercise therapy compared to activity management for paediatric chronic fatigue syndrome/myalgic encephalomyelitis: pragmatic randomized controlled trial
Gaunt, D., Brigden, A., Harris, S. R. S., Hollingworth, W., Jago, R., Solomon-Moore, E., Beasant, L., Mills, N., Sinai, P., Crawley, E. M., et al. (2024) · European Journal of Pediatrics · doi:10.1007/s00431-024-05458-x · Cited by 11 · see citing works
Effectiveness of Internet-Based Cognitive Behavior Therapy (Fatigue in Teenagers on the Internet) for Adolescents With Chronic Fatigue Syndrome in Routine Clinical Care: Observational Study
Albers, E., Nijhof, L. N., van der Sprenkel, E. E. B., van de Putte, E. M., Nijhof, S. L., & Knoop, H. (2021) · Journal of Medical Internet Research · doi:10.2196/24839 · Cited by 11 · see citing works
Self-citation
Dynamic modeling of experience sampling methodology data reveals large heterogeneity in biopsychosocial factors associated with persistent fatigue in young people living with a chronic condition
Vroegindeweij, A., Levelt, L., Houtveen, J. H., van de Putte, E. M., Wulffraat, N. M., Swart, J. F., & Nijhof, S. L. (2023) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2023.111195 · Cited by 11 · see citing works
Self-citation
Testing the efficacy of web-based cognitive behavioural therapy for adult patients with chronic fatigue syndrome (CBIT): study protocol for a randomized controlled trial
Janse, A., Worm-Smeitink, M., Bussel-Lagarde, J., Bleijenberg, G., Nikolaus, S., & Knoop, H. (2015) · BMC Neurology · doi:10.1186/s12883-015-0392-3 · Cited by 11 · see citing works
Self-citation
Do adolescents with chronic fatigue syndrome (CFS/ME) and co-morbid anxiety and/or depressive symptoms think differently to those who do not have co-morbid psychopathology?
Loades, M. E., Stallard, P. N., Morris, R. W., Kessler, D. S., & Crawley, E. M. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.05.113 · Cited by 11 · see citing works

Internet-based cognitive behavioural therapy (FITNET) is an effective treatment for adolescents with chronic fatigue syndrome
BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health (2012) · Archives of Disease in Childhood Education & Practice · doi:10.1136/archdischild-2012-302484 · Cited by 2 · see citing works
Fatigue In Teenagers on the interNET - The FITNET Trial. A randomized clinical trial of web-based cognitive behavioural therapy for adolescents with chronic fatigue syndrome: study protocol. [ISRCTN59878666]
Nijhof, S. L., Bleijenberg, G., Uiterwaal, C. S. P. M., Kimpen, J. L. L., & van de Putte, E. M. (2011) · BMC Neurology · doi:10.1186/1471-2377-11-23 · Cited by 25 · see citing works
Self-citation
Effectiveness of Internet-Based Cognitive Behavior Therapy (Fatigue in Teenagers on the Internet) for Adolescents With Chronic Fatigue Syndrome in Routine Clinical Care: Observational Study
Albers, E., Nijhof, L. N., van der Sprenkel, E. E. B., van de Putte, E. M., Nijhof, S. L., & Knoop, H. (2021) · Journal of Medical Internet Research · doi:10.2196/24839 · Cited by 11 · see citing works
Self-citation
Internet-Based Therapy for Adolescents With Chronic Fatigue Syndrome: Long-term Follow-up
Nijhof, S. L., Priesterbach-Ackley, L. P., Uiterwaal, C. S. P. M., Bleijenberg, G., Kimpen, J. L. L., & van de Putte, E. M. (2013) · PEDIATRICS · doi:10.1542/peds.2012-2007 · Cited by 56 · see citing works
Self-citation
The effectiveness of an online cognitive behavioral therapy (FitNet), for\nchronic fatigue syndrome in adolescents, in routine clinical practice
de Morée, A. F. (2019) · Utrecht University Repository (Utrecht University)

Authors: Nijhof, S. L., Bleijenberg, G., Uiterwaal, C. S., Kimpen, J. L., & van de Putte, E. M.
Affiliations: University Medical Center Utrecht (NL)
Radboud University Medical Center (NL)
Corresponding author: Nijhof, Sanne L
ORCID: Nijhof, Sanne L
Bleijenberg, Gijs
Uiterwaal, Cuno SPM
Venue: The Lancet
Publisher: Elsevier BV
Published: 2012-04
Volume: 379
Issue: 9824
Pages: 1412-1418
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(12)60025-7
OpenAlex: W2116645073
Cited by: 208
References: 36
Citations by year: 2026: 4 · 2025: 10 · 2024: 8 · 2023: 11 · 2022: 12 · 2021: 13 · 2020: 16 · 2019: 22 · 2018: 16 · 2017: 18 · 2016: 8 · 2015: 18 · 2014: 11 · 2013: 25 · 2012: 16
FWCI: 15.94
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Radboud Repository (Radboud University) (submittedVersion)
Funders: Radboud Universiteit
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords: chronic fatigue syndrome, internet-based cognitive behavioral therapy, adolescents, FITNET, school attendance, fatigue severity, physical function, usual care comparison, web-based treatment
MeSH terms: Adolescent, Adolescent Behavior, Child, Female, Follow-Up Studies, Humans, Male, Netherlands, Patient Compliance, Reference Values, Severity of Illness Index, Therapy, Computer-Assisted, Fatigue Syndrome, Chronic, Cognitive Behavioral Therapy, Treatment Outcome, Internet

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Effectiveness of internet-based cognitive behavioural treatment for adolescents with chronic fatigue syndrome (FITNET): a randomised controlled trial

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks