Resistance to PD1/PDL1 checkpoint inhibition

The blockade of immune checkpoints in cancer immunotherapy

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Safety, activity, and immune correlates of anti–PD-1 antibody in cancer

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Signatures of mutational processes in human cancer

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Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma

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Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer

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PD-1 blockade induces responses by inhibiting adaptive immune resistance

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Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome

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Pembrolizumab versus Ipilimumab in Advanced Melanoma

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Nivolumab in Previously Untreated Melanoma without BRAF Mutation

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PD-1 and Its Ligands in Tolerance and Immunity

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The immune contexture in human tumours: impact on clinical outcome

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The future of immune checkpoint therapy

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Neoantigens in cancer immunotherapy

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Molecular and cellular insights into T cell exhaustion

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Final Version of 2009 AJCC Melanoma Staging and Classification

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Nivolumab plus Ipilimumab in Advanced Melanoma

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T cell exhaustion

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Commensal Bifidobacterium promotes antitumor immunity and facilitates anti–PD-L1 efficacy

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Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

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Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

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The Consensus Coding Sequences of Human Breast and Colorectal Cancers

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The Three Es of Cancer Immunoediting

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Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance

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Genomic correlates of response to CTLA-4 blockade in metastatic melanoma

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Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

Spranger, S., Bao, R., & Gajewski, T. F. (2015) · Nature · doi:10.1038/nature14404 · Cited by 2,830

Nivolumab and ipilimumab versus ipilimumab in untreated melanoma

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Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma

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Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

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The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting

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T Cell Activation

Smith-Garvin, J. E., Koretzky, G. A., & Jordan, M. S. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132706 · Cited by 2,144

Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

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Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function

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PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors

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Up-Regulation of PD-L1, IDO, and T regs in the Melanoma Tumor Microenvironment Is Driven by CD8 + T Cells

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VEGF-targeted therapy: mechanisms of anti-tumour activity

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Prognostic and Predictive Value of Tumor-Infiltrating Lymphocytes in a Phase III Randomized Adjuvant Breast Cancer Trial in Node-Positive Breast Cancer Comparing the Addition of Docetaxel to Doxorubicin With Doxorubicin-Based Chemotherapy: BIG 02-98

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Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints

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New insights into cancer immunoediting and its three component phases--elimination, equilibrium and escape

Mittal, D., Gubin, M. M., Schreiber, R. D., & Smyth, M. J. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.01.004 · Cited by 1,471

Anti–PD-1/PD-L1 therapy of human cancer: past, present, and future

Chen, L., & Han, X. (2015) · Journal of Clinical Investigation · doi:10.1172/jci80011 · Cited by 1,437

Management of Immune-Related Adverse Events and Kinetics of Response With Ipilimumab

Weber, J. S., Kähler, K. C., & Hauschild, A. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2012.41.6750 · Cited by 1,415

Classifying Cancers Based on T-cell Infiltration and PD-L1

Teng, M. W. L., Ngiow, S. F., Ribas, A., & Smyth, M. J. (2015) · Cancer Research · doi:10.1158/0008-5472.can-15-0255 · Cited by 1,411

PD-L1 Expression in Triple-Negative Breast Cancer

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Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma

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Mutant MHC class II epitopes drive therapeutic immune responses to cancer

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Overcoming T cell exhaustion in infection and cancer

Pauken, K. E., & Wherry, E. J. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.02.008 · Cited by 1,171

Tissue-resident memory T cells: local specialists in immune defence

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Combination cancer immunotherapies tailored to the tumour microenvironment

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Human memory T cells: generation, compartmentalization and homeostasis

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Anti-PD-1 Blockade and Stereotactic Radiation Produce Long-Term Survival in Mice With Intracranial Gliomas

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Memory T Cell Subsets, Migration Patterns, and Tissue Residence

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TIGIT and PD-1 impair tumor antigen–specific CD8+ T cells in melanoma patients

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Disruption of CXCR2-Mediated MDSC Tumor Trafficking Enhances Anti-PD1 Efficacy

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Dual Blockade of PD-1 and CTLA-4 Combined with Tumor Vaccine Effectively Restores T-Cell Rejection Function in Tumors

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Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)

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CD8+ T Cell Effector Mechanisms in Resistance to Infection

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Stereotactic Radiation Therapy Augments Antigen-Specific PD-1–Mediated Antitumor Immune Responses via Cross-Presentation of Tumor Antigen

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Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4

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Adaptive Immune Resistance: How Cancer Protects from Immune Attack

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In Vitro Characterization of the Anti-PD-1 Antibody Nivolumab, BMS-936558, and In Vivo Toxicology in Non-Human Primates

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Selective expansion of a subset of exhausted CD8 T cells by αPD-L1 blockade

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Shaping and reshaping CD8+ T-cell memory

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Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8(+) T cells directly within the tumor microenvironment

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Antagonist Antibodies to PD-1 and B7-H1 (PD-L1) in the Treatment of Advanced Human Cancer—Response

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Antagonist Antibodies to PD-1 and B7-H1 (PD-L1) in the Treatment of Advanced Human Cancer

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Cancer Immunotherapy with Immunomodulatory Anti-CD137 and Anti–PD-1 Monoclonal Antibodies Requires BATF3-Dependent Dendritic Cells

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Acquired resistance to immunotherapy and future challenges

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Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function.

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Targeting CD73 Enhances the Antitumor Activity of Anti-PD-1 and Anti-CTLA-4 mAbs

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Migration, maintenance and recall of memory T cells in peripheral tissues

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PD-1 Blockade Expands Intratumoral Memory T Cells

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Progression of Lung Cancer Is Associated with Increased Dysfunction of T Cells Defined by Coexpression of Multiple Inhibitory Receptors

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CD8 T cell dysfunction during chronic viral infection

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Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging

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Targeting Cancer-Derived Adenosine:New Therapeutic Approaches

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Strength of PD-1 signaling differentially affects T-cell effector functions

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Molecular Pathways: Mechanism of Action for Talimogene Laherparepvec, a New Oncolytic Virus Immunotherapy

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OX40 engagement depletes intratumoral Tregs via activating FcγRs, leading to antitumor efficacy

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Immune Cell–Poor Melanomas Benefit from PD-1 Blockade after Targeted Type I IFN Activation

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The Mechanism of Anti-CTLA-4 Activity and the Negative Regulation of T-Cell Activation

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A Threshold Level of Intratumor CD8+ T-cell PD1 Expression Dictates Therapeutic Response to Anti-PD1

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PD-1 Blockade and OX40 Triggering Synergistically Protects against Tumor Growth in a Murine Model of Ovarian Cancer

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Current state of anti-PD-L1 and anti-PD-1 agents in cancer therapy

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The Roles of CD73 in Cancer

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Paucity of PD-L1 expression in prostate cancer: innate and adaptive immune resistance

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Viral Infection of Tumors Overcomes Resistance to PD-1-immunotherapy by Broadening Neoantigenome-directed T-cell Responses

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