Distinct linear and non-linear trajectories of reward and punishment reversal learning during development: Relevance for dopamine's role in adolescent decision making
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Abnormalities in value-based decision making during adolescence have often been attributed to non-linear, inverted-U shaped development of reward-related processes. This hypothesis is strengthened by functional imaging work revealing an inverted-U shaped relationship between age and reward-related activity in the striatum. However, behavioural studies have mostly reported linear rather than non-linear increases in reward-related performance. In the present study, we investigated the mechanisms underlying the development of reward- and punishment-related processing across four age groups using a reversal learning task previously shown to depend on striatal dopamine. We demonstrate both linear and non-linear age effects on distinct components of reversal learning. Specifically, results revealed a linear shift with age in terms of valence-dependent reversal learning, with children exhibiting better punishment than reward reversal learning, adults exhibiting better reward than punishment reversal learning and adolescents exhibiting an intermediate performance pattern. In addition, we also observed a non-linear, inverted-U shaped relationship between age and valence-independent reversal learning, which was due to aberrant ability of adolescents to update behaviour in response to negative performance feedback. These findings indicate that the (linear or nonlinear) nature of the relationship between age and reward learning depends on the type of reward learning under study.
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DA systems affect not only reward processing, but also punishment, decision-making, cognition, reward prediction, and reward valuation.
“Furthermore, it is clear that these DA systems affect not only reward processing, but a number of related functions, including punishment [24], decision-making [25,26], cognition [27], reward prediction [28,29], and reward valuation [30-32].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [26]
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- Authors
- van der Schaaf, M. E., Warmerdam, E., Crone, E. A., & Cools, R.
- Affiliations
- Leiden University (NL)
- Radboud University Nijmegen (NL)
- Venue
- Developmental Cognitive Neuroscience
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 1
- Issue
- 4
- Pages
- 578-590
- ISSN
- 1878-9293 (ISSN-L)
- PMC
- PMC6987536
- OpenAlex
- W2046991951
- Cited by
- 70
- References
- 58
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 4 · 2023: 5 · 2022: 7 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 7 · 2017: 2 · 2016: 7 · 2015: 5 · 2014: 4 · 2013: 2 · 2012: 4
- FWCI
- 1.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Developmental Cognitive Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion, other-oa)
- Funders
- Innovational Research Incentives Scheme of the Netherlands Organization for Scientific Research
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Decision Sciences › General Decision Sciences › Decision-Making and Behavioral Economics
- Keywords
- adolescent development, dopamine, striatum, value-based decision making, age differences in learning
- MeSH terms
- Adolescent, Adolescent Behavior, Child, Decision Making, Dopamine, Female, Humans, Male, Photic Stimulation, Reversal Learning, Reward, Linear Models, Nonlinear Dynamics, Young Adult
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