Cited by 20Child Abuse and TraumaFunctional Brain Connectivity StudiesChild and Adolescent Psychosocial and Emotional Development

Developing functional network connectivity of the dorsal anterior cingulate cortex mediates externalizing psychopathology in adolescents with child neglect

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Silveira, Sarita, Boney, Simone, Tapert, Susan F., Mishra, Jyoti·2021·Developmental Cognitive Neuroscience

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Abstract

Childhood adversity has been associated with elevated risk for psychopathology. We investigated whether development of functional brain networks important for executive function (EF) could serve as potential mediators of this association. We analyzed data of 475 adolescents, a subsample of the multisite longitudinal NCANDA (National Consortium on Alcohol and Neurodevelopment in Adolescence) cohort with completed measures of childhood trauma, resting-state functional brain connectivity data, and symptoms of internalizing and externalizing psychopathology at baseline and follow-up years 1-4. Using parallel process latent growth models, we found that childhood adversity was associated with increased risk for externalizing/internalizing behaviors. We specifically investigated whether functional connectivity of the dorsal anterior cingulate cortex (dACC) to brain regions within the cingulo-opercular (CO) network, a well-known EF network that underlies control of attention and self-regulation, mediates the association between adversity and symptoms of psychopathology. We found that childhood adversity, specifically child neglect was negatively associated with functional connectivity of the dACC within the CO network, and that this connectivity mediated the association between neglect and externalizing behaviors. Our study advances a mechanistic understanding of how childhood adversity may impact the development of psychopathology, highlighting the relevance of dACC functional networks particularly for externalizing psychopathology.

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Authors
Silveira, S., Boney, S., Tapert, S. F., & Mishra, J.
Affiliations
  • University of California San Diego (US)
  • East Carolina University (US)
Corresponding author
Mishra, Jyoti
Venue
Developmental Cognitive Neuroscience
Publisher
Elsevier BV
Published
2021-06
Volume
49
Pages
100962
ISSN
1878-9293 (ISSN-L)
OpenAlex
W3163398204
Cited by
20
References
81
Citations by year
2026: 1 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 5 · 2021: 3
FWCI
2.90
Type
journal article
Language
en
Open access
Locations
  • Developmental Cognitive Neuroscience (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • eScholarship (California Digital Library) (submittedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • University of California, San Diego
  • Deutsche Akademie der Naturforscher Leopoldina - Nationale Akademie der Wissenschaften
  • National Institutes of Health (AA021681, AA021690, AA021691, AA021692, AA021695, AA021696, AA021697)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Keywords
child neglect, childhood adversity, externalizing psychopathology, internalizing psychopathology, dorsal anterior cingulate cortex, cingulo-opercular network, resting-state functional connectivity, executive function, adolescent development, mediation
MeSH terms
Adolescent, Mental Disorders, Child Abuse, Female, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Psychopathology, Young Adult

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