Developing functional network connectivity of the dorsal anterior cingulate cortex mediates externalizing psychopathology in adolescents with child neglect
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Abstract
Childhood adversity has been associated with elevated risk for psychopathology. We investigated whether development of functional brain networks important for executive function (EF) could serve as potential mediators of this association. We analyzed data of 475 adolescents, a subsample of the multisite longitudinal NCANDA (National Consortium on Alcohol and Neurodevelopment in Adolescence) cohort with completed measures of childhood trauma, resting-state functional brain connectivity data, and symptoms of internalizing and externalizing psychopathology at baseline and follow-up years 1-4. Using parallel process latent growth models, we found that childhood adversity was associated with increased risk for externalizing/internalizing behaviors. We specifically investigated whether functional connectivity of the dorsal anterior cingulate cortex (dACC) to brain regions within the cingulo-opercular (CO) network, a well-known EF network that underlies control of attention and self-regulation, mediates the association between adversity and symptoms of psychopathology. We found that childhood adversity, specifically child neglect was negatively associated with functional connectivity of the dACC within the CO network, and that this connectivity mediated the association between neglect and externalizing behaviors. Our study advances a mechanistic understanding of how childhood adversity may impact the development of psychopathology, highlighting the relevance of dACC functional networks particularly for externalizing psychopathology.
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Molecular mechanisms and behavioral relevance underlying neural correlates of childhood neglect
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Self-citationEnvironmental determinates of psychopathology and brain structure/function
Jeong, H. J., & Kaczkurkin, A. N. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-820480-1.00164-9
Functional reorganization of brain networks from childhood to adolescence: A multi-level approach
Tapia‐Medina, M. G., Cosío‐Guirado, R., Peró, M., Cañete‐Massé, C., Villuendas‐González, E. R., & Guàrdia‐Olmos, J. (2026) · International Journal of Clinical and Health Psychology · doi:10.1016/j.ijchp.2026.100700
- Authors
- Silveira, S., Boney, S., Tapert, S. F., & Mishra, J.
- Affiliations
- University of California San Diego (US)
- East Carolina University (US)
- Corresponding author
- Mishra, Jyoti
- Venue
- Developmental Cognitive Neuroscience
- Publisher
- Elsevier BV
- Published
- 2021-06
- Volume
- 49
- Pages
- 100962
- ISSN
- 1878-9293 (ISSN-L)
- PMC
- PMC8142040
- OpenAlex
- W3163398204
- Cited by
- 20
- References
- 81
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 5 · 2021: 3
- FWCI
- 2.90
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Developmental Cognitive Neuroscience (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- University of California, San Diego
- Deutsche Akademie der Naturforscher Leopoldina - Nationale Akademie der Wissenschaften
- National Institutes of Health (AA021681, AA021690, AA021691, AA021692, AA021695, AA021696, AA021697)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- child neglect, childhood adversity, externalizing psychopathology, internalizing psychopathology, dorsal anterior cingulate cortex, cingulo-opercular network, resting-state functional connectivity, executive function, adolescent development, mediation
- MeSH terms
- Adolescent, Mental Disorders, Child Abuse, Female, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Psychopathology, Young Adult
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