Polo on the Rise—from Mitotic Entry to Cytokinesis with Plk1

Polo-like kinases and the orchestration of cell division

Barr, F. A., Silljé, H. H. W., & Nigg, E. A. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1401 · Cited by 1,087

The BRCT Domain Is a Phospho-Protein Binding Domain

Yu, X., Chini, C. C. S., He, M., Mer, G., & Chen, J. (2003) · Science · doi:10.1126/science.1088753 · Cited by 862

Targeting polo-like kinase 1 for cancer therapy

Strebhardt, K., & Ullrich, A. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1841 · Cited by 841

BI 2536, a Potent and Selective Inhibitor of Polo-like Kinase 1, Inhibits Tumor Growth In Vivo

Steegmaier, M., Hoffmann, M., Baum, A., Lénárt, P., Petronczki, M., Krššák, M., Gürtler, U., Garin-Chesa, P., Lieb, S., Quant, J., et al. (2007) · Current Biology · doi:10.1016/j.cub.2006.12.037 · Cited by 834

The Molecular Basis for Phosphodependent Substrate Targeting and Regulation of Plks by the Polo-Box Domain

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GENETIC CONTROL OF THE CELL DIVISION CYCLE IN YEAST: V. GENETIC ANALYSIS OF cdc MUTANTS

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The Molecular Requirements for Cytokinesis

Glotzer, M. (2005) · Science · doi:10.1126/science.1096896 · Cited by 708

Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes.

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Proteomic Screen Finds pSer/pThr-Binding Domain Localizing Plk1 to Mitotic Substrates

Elia, A. E. H., Cantley, L. C., & Yaffe, M. B. (2003) · Science · doi:10.1126/science.1079079 · Cited by 684

Tetraploidy, aneuploidy and cancer

Ganem, N. J., Storchova, Z., & Pellman, D. (2007) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2007.02.011 · Cited by 668

The Small-Molecule Inhibitor BI 2536 Reveals Novel Insights into Mitotic Roles of Polo-like Kinase 1

Lénárt, P., Petronczki, M., Steegmaier, M., Di Fiore, B., Lipp, J. J., Hoffmann, M., Rettig, W. J., Kraut, N., & Peters, J.-M. (2007) · Current Biology · doi:10.1016/j.cub.2006.12.046 · Cited by 653

BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

Manke, I. A., Lowery, D. M., Nguyen, A., & Yaffe, M. B. (2003) · Science · doi:10.1126/science.1088877 · Cited by 651

THE STRUCTURE AND FUNCTION OF SMC AND KLEISIN COMPLEXES

Nasmyth, K., & Haering, C. H. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133219 · Cited by 613

Active cyclin B1–Cdk1 first appears on centrosomes in prophase

Jackman, M., Lindon, C., Nigg, E. A., & Pines, J. (2003) · Nature Cell Biology · doi:10.1038/ncb918 · Cited by 612

Shugoshin collaborates with protein phosphatase 2A to protect cohesin

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Polo, a mitotic mutant of Drosophila displaying abnormal spindle poles

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Purification and Molecular Cloning of Plx1, a Cdc25-Regulatory Kinase from Xenopus Egg Extracts

Kumagai, A., & Dunphy, W. G. (1996) · Science · doi:10.1126/science.273.5280.1377 · Cited by 507

Central Spindle Assembly and Cytokinesis Require a Kinesin-like Protein/RhoGAP Complex with Microtubule Bundling Activity

Mishima, M., Kaitna, S., & Glotzer, M. (2002) · Developmental Cell · doi:10.1016/s1534-5807(01)00110-1 · Cited by 502

Cytokinesis: Placing and Making the Final Cut

Barr, F. A., & Gruneberg, U. (2007) · Cell · doi:10.1016/j.cell.2007.11.011 · Cited by 485

An ECT2–centralspindlin complex regulates the localization and function of RhoA

Yüce, O., Piekny, A., & Glotzer, M. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200501097 · Cited by 480

Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function.

Golsteyn, R. M., Mundt, K. E., Fry, A. M., & Nigg, E. A. (1995) · The Journal of cell biology · doi:10.1083/jcb.129.6.1617 · Cited by 473

Timing and Checkpoints in the Regulation of Mitotic Progression

Meraldi, P., Draviam, V. M., & Sorger, P. K. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.06.006 · Cited by 469

The Dissociation of Cohesin from Chromosomes in Prophase Is Regulated by Polo-like Kinase

Sumara, I., Vorlaufer, E., Stukenberg, P. T., Kelm, O., Redemann, N., Nigg, E. A., & Peters, J.-M. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00473-2 · Cited by 453

Animal Cytokinesis: From Parts List to Mechanisms

Eggert, U. S., Mitchison, T. J., & Field, C. M. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133425 · Cited by 441

Dissociation of Cohesin from Chromosome Arms and Loss of Arm Cohesion during Early Mitosis Depends on Phosphorylation of SA2

Hauf, S., Roitinger, E., Koch, B., Dittrich, C. M., Mechtler, K., & Peters, J.-M. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030069 · Cited by 440

Chromosomes Can Congress to the Metaphase Plate Before Biorientation

Kapoor, T. M., Lampson, M. A., Hergert, P., Cameron, L., Cimini, D., Salmon, E. D., McEwen, B. F., & Khodjakov, A. (2006) · Science · doi:10.1126/science.1122142 · Cited by 439

CDC5 and CKII Control Adaptation to the Yeast DNA Damage Checkpoint

Toczyski, D. P., Galgoczy, D. J., & Hartwell, L. H. (1997) · Cell · doi:10.1016/s0092-8674(00)80375-x · Cited by 436

Separase, Polo Kinase, the Kinetochore Protein Slk19, and Spo12 Function in a Network that Controls Cdc14 Localization during Early Anaphase

Stegmeier, F., Visintin, R., & Amon, A. (2002) · Cell · doi:10.1016/s0092-8674(02)00618-9 · Cited by 432

Human Ect2 Is an Exchange Factor for Rho Gtpases, Phosphorylated in G2/M Phases, and Involved in Cytokinesis

Tatsumoto, T., Xie, X., Blumenthal, R., Okamoto, I., & Miki, T. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.5.921 · Cited by 431

Mitotic regulation of the human anaphase-promoting complex by phosphorylation

Kraft, C. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg627 · Cited by 425

polo encodes a protein kinase homolog required for mitosis in Drosophila.

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Polo-like Kinase-1 Controls Recovery from a G2 DNA Damage-Induced Arrest in Mammalian Cells

van Vugt, M. A. T. M., Brás, A., & Medema, R. H. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.07.015 · Cited by 385

The conserved Schizosaccharomyces pombe kinase plo1, required to form a bipolar spindle, the actin ring, and septum, can drive septum formation in G1 and G2 cells.

Ohkura, H., Hagan, I. M., & Glover, D. M. (1995) · Genes & Development · doi:10.1101/gad.9.9.1059 · Cited by 371

Genome-wide genetic analysis of polyploidy in yeast

Storchová, Z., Breneman, A., Cande, J., Dunn, J., Burbank, K., O'Toole, E., & Pellman, D. (2006) · Nature · doi:10.1038/nature05178 · Cited by 366

Cytokinesis: Welcome to the Rho zone

Piekny, A., Werner, M., & Glotzer, M. (2005) · Trends in Cell Biology · doi:10.1016/j.tcb.2005.10.006 · Cited by 365

Polo-like kinases and oncogenesis

Eckerdt, F., Yuan, J., & Strebhardt, K. (2005) · Oncogene · doi:10.1038/sj.onc.1208273 · Cited by 365

Shugoshin Prevents Dissociation of Cohesin from Centromeres During Mitosis in Vertebrate Cells

McGuinness, B. E., Hirota, T., Kudo, N. R., Peters, J.-M., & Nasmyth, K. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030086 · Cited by 364

Polo-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase

Toyoshima-Morimoto, F., Taniguchi, E., Shinya, N., Iwamatsu, A., & Nishida, E. (2001) · Nature · doi:10.1038/35065617 · Cited by 364

Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells

Lindon, C., & Pines, J. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200309035 · Cited by 356

Comparative Analysis of Cytokinesis in Budding Yeast, Fission Yeast and Animal Cells

Balasubramanian, M. K., Bi, E., & Glotzer, M. (2004) · Current Biology · doi:10.1016/j.cub.2004.09.022 · Cited by 354

PICH, a Centromere-Associated SNF2 Family ATPase, Is Regulated by Plk1 and Required for the Spindle Checkpoint

Baumann, C., Körner, R., Hofmann, K., & Nigg, E. A. (2007) · Cell · doi:10.1016/j.cell.2006.11.041 · Cited by 354

Roles of Polo-like Kinase 1 in the Assembly of Functional Mitotic Spindles

Sumara, I., Giménez-Abián, J. F., Gerlich, D., Hirota, T., Kraft, C., de la Torre, C., Ellenberg, J., & Peters, J.-M. (2004) · Current Biology · doi:10.1016/j.cub.2004.09.049 · Cited by 345

A RhoGEF and Rho Family GTPase-Activating Protein Complex Links the Contractile Ring to Cortical Microtubules at the Onset of Cytokinesis

Somers, W. G., & Saint, R. (2003) · Developmental Cell · doi:10.1016/s1534-5807(02)00402-1 · Cited by 339

A microtubule-dependent zone of active RhoA during cleavage plane specification

Bement, W. M., Benink, H. A., & von Dassow, G. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200501131 · Cited by 339

Cdk1/Erk2- and Plk1-Dependent Phosphorylation of a Centrosome Protein, Cep55, Is Required for Its Recruitment to Midbody and Cytokinesis

Fabbro, M., Zhou, B.-B., Takahashi, M., Sarcevic, B., Lal, P., Graham, M. E., Gabrielli, B. G., Robinson, P. J., Nigg, E. A., Ono, Y., et al. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.09.003 · Cited by 333

Cohesin release is required for sister chromatid resolution, but not for condensin-mediated compaction, at the onset of mitosis

Losada, A., Hirano, M., & Hirano, T. (2002) · Genes & Development · doi:10.1101/gad.249202 · Cited by 333

PP2A Is Required for Centromeric Localization of Sgo1 and Proper Chromosome Segregation

Tang, Z., Shu, H., Qi, W., Mahmood, N. A., Mumby, M. C., & Yu, H. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.03.010 · Cited by 327

Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis

Neef, R., Preisinger, C., Sutcliffe, J., Kopajtich, R., Nigg, E. A., Mayer, T. U., & Barr, F. A. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200306009 · Cited by 319

Tension-sensitive Plk1 phosphorylation on BubR1 regulates the stability of kinetochore–microtubule interactions

Elowe, S., Hümmer, S., Uldschmid, A., Li, X., & Nigg, E. A. (2007) · Genes & Development · doi:10.1101/gad.436007 · Cited by 312

The human mitotic checkpoint protein BubR1 regulates chromosome–spindle attachments

Lampson, M. A., & Kapoor, T. M. (2005) · Nature Cell Biology · doi:10.1038/ncb1208 · Cited by 311

Normal Cells, but Not Cancer Cells, Survive Severe Plk1 Depletion

Liu, X., Lei, M., & Erikson, R. L. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.6.2093-2108.2006 · Cited by 303

Polo-like Kinase 1 Triggers the Initiation of Cytokinesis in Human Cells by Promoting Recruitment of the RhoGEF Ect2 to the Central Spindle

Petronczki, M., Glotzer, M., Kraut, N., & Peters, J.-M. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.03.013 · Cited by 301

Polo-Like Kinases: A Team in Control of the Division

Weerdt, B. C. M. V. D., & Medema, R. H. (2006) · Cell Cycle · doi:10.4161/cc.5.8.2692 · Cited by 300

Structure and function of Polo-like kinases

Lowery, D. M., Lim, D., & Yaffe, M. B. (2005) · Oncogene · doi:10.1038/sj.onc.1208280 · Cited by 293

Induction and down-regulation of PLK, a humanserine/threonine kinase expressed in proliferating cells andtumors.

Holtrich, U., Wolf, G., Bräuninger, A., Karn, T., Böhme, B., Rübsamen-Waigmann, H., & Strebhardt, K. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.5.1736 · Cited by 275

Getting in and out of mitosis with Polo-like kinase-1

van Vugt, M. A. T. M., & Medema, R. H. (2005) · Oncogene · doi:10.1038/sj.onc.1208617 · Cited by 271

Centralspindlin regulates ECT2 and RhoA accumulation at the equatorial cortex during cytokinesis

Nishimura, Y., & Yonemura, S. (2006) · Journal of Cell Science · doi:10.1242/jcs.02737 · Cited by 268

Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1

Neef, R., Gruneberg, U., Kopajtich, R., Li, X., Nigg, E. A., Sillje, H., & Barr, F. A. (2007) · Nature Cell Biology · doi:10.1038/ncb1557 · Cited by 257

Proteomic screen defines the Polo‐box domain interactome and identifies Rock2 as a Plk1 substrate

Lowery, D. M., Clauser, K. R., Hjerrild, M., Lim, D., Alexander, J., Kishi, K., Ong, S., Gammeltoft, S., Carr, S. A., & Yaffe, M. B. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601683 · Cited by 257

Self-Regulated Plk1 Recruitment to Kinetochores by the Plk1-PBIP1 Interaction Is Critical for Proper Chromosome Segregation

Kang, Y. H., Park, J.-E., Yu, L.-R., Soung, N.-K., Yun, S.-M., Bang, J. K., Seong, Y.-S., Yu, H., Garfield, S., Veenstra, T. D., et al. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.10.016 · Cited by 254

Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells

Burkard, M. E., Randall, C. L., Larochelle, S., Zhang, C., Shokat, K. M., Fisher, R. P., & Jallepalli, P. V. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701140104 · Cited by 251

Polo-like Kinase 1 Regulates Nlp, a Centrosome Protein Involved in Microtubule Nucleation

Casenghi, M., Meraldi, P., Weinhart, U., Duncan, P. I., Körner, R., & Nigg, E. A. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00193-x · Cited by 248

Mutation of the polo-box disrupts localization and mitotic functions of the mammalian polo kinase Plk

Lee, K. S., Grenfell, T. Z., Yarm, F. R., & Erikson, R. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9301 · Cited by 245

Downregulation of PP2ACdc55 Phosphatase by Separase Initiates Mitotic Exit in Budding Yeast

Queralt, E., Lehane, C., Novak, B., & Uhlmann, F. (2006) · Cell · doi:10.1016/j.cell.2006.03.038 · Cited by 240

Activated Polo-Like Kinase Plx1 Is Required at Multiple Points during Mitosis in Xenopus laevis

Qian, Y.-W., Erikson, E., Li, C., & Maller, J. L. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.7.4262 · Cited by 239

Dissecting the Role of Rho-mediated Signaling in Contractile Ring Formation

Kamijo, K., Ohara, N., Abe, M., Uchimura, T., Hosoya, H., Lee, J.-S., & Miki, T. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-06-0569 · Cited by 231

Regulation of Sister Chromatid Cohesion between Chromosome Arms

Giménez-Abián, J. F., Sumara, I., Hirota, T., Hauf, S., Gerlich, D., de la Torre, C., Ellenberg, J., & Peters, J.-M. (2004) · Current Biology · doi:10.1016/j.cub.2004.06.052 · Cited by 229

A cytokinesis furrow is positioned by two consecutive signals

Bringmann, H., & Hyman, A. A. (2005) · Nature · doi:10.1038/nature03823 · Cited by 223

The polo-like kinase Plx1 is required for M phase exit and destruction of mitotic regulators in Xenopus egg extracts

Descombes, P. (1998) · The EMBO Journal · doi:10.1093/emboj/17.5.1328 · Cited by 211

Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome

Moshe, Y., Boulaire, J., Pagano, M., & Hershko, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402442101 · Cited by 211

A Spindle Checkpoint Arrest and a Cytokinesis Failure by the Dominant-negative Polo-box Domain of Plk1 in U-2 OS Cells

Seong, Y.-S., Kamijo, K., Lee, J.-S., Fernandez, E., Kuriyama, R., Miki, T., & Lee, K. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202602200 · Cited by 210

Drosophila Polo Kinase Is Required for Cytokinesis

Carmena, M., Riparbelli, M. G., Minestrini, G., Tavares, Á. M., Adams, R., Callaini, G., & Glover, D. M. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.3.659 · Cited by 209

MgcRacGAP controls the assembly of the contractile ring and the initiation of cytokinesis

Zhao, W.-M., & Fang, G. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504145102 · Cited by 208

Plk1 Regulates Activation of the Anaphase Promoting Complex by Phosphorylating and Triggering SCF βTrCP -dependent Destruction of the APC Inhibitor Emi1

Hansen, D. V., Loktev, A. V., Ban, K. H., & Jackson, P. K. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-07-0598 · Cited by 208

Use of the Novel Plk1 Inhibitor ZK-Thiazolidinone to Elucidate Functions of Plk1 in Early and Late Stages of Mitosis

Santamaria, A., Neef, R., Eberspächer, U., Eis, K., Husemann, M., Mumberg, D., Prechtl, S., Schulze, V., Siemeister, G., Wortmann, L., et al. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-05-0517 · Cited by 199

Polo-like Kinase-1 Is Required for Bipolar Spindle Formation but Is Dispensable for Anaphase Promoting Complex/Cdc20 Activation and Initiation of Cytokinesis

van Vugt, M. A. T. M., van de Weerdt, B. C. M., Vader, G., Janssen, H., Calafat, J., Klompmaker, R., Wolthuis, R. M. F., & Medema, R. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313681200 · Cited by 198

Functional studies on the role of the C-terminal domain of mammalian polo-like kinase

Jang, Y.-J., Lin, C.-Y., Ma, S., & Erikson, R. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.042689299 · Cited by 195

Cleavage furrow formation and ingression during animal cytokinesis: a microtubule legacy

D'Avino, P. P., Savoian, M. S., & Glover, D. M. (2005) · Journal of Cell Science · doi:10.1242/jcs.02335 · Cited by 190

Complex formation of Plk1 and INCENP required for metaphase–anaphase transition

Goto, H., Kiyono, T., Tomono, Y., Kawajiri, A., Urano, T., Furukawa, K., Nigg, E. A., & Inagaki, M. (2006) · Nature Cell Biology · doi:10.1038/ncb1350 · Cited by 184

A Cell Proliferation and Chromosomal Instability Signature in Anaplastic Thyroid Carcinoma

Salvatore, G., Nappi, T. C., Salerno, P., Jiang, Y., Garbi, C., Ugolini, C., Miccoli, P., Basolo, F., Castellone, M. D., Cirafici, A. M., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1887 · Cited by 182

Plk Is a Functional Homolog of Saccharomyces cerevisiae Cdc5, and Elevated Plk Activity Induces Multiple Septation Structures

Lee, K. S., & Erikson, R. L. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.6.3408 · Cited by 180

The Cyclin-Ubiquitin Ligase Activity of Cyclosome/APC Is Jointly Activated by Protein Kinases Cdk1-Cyclin B and Plk

Golan, A., Yudkovsky, Y., & Hershko, A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111476200 · Cited by 172

Myosin Phosphatase-Targeting Subunit 1 Regulates Mitosis by Antagonizing Polo-like Kinase 1

Yamashiro, S., Yamakita, Y., Totsukawa, G., Goto, H., Kaibuchi, K., Ito, M., Hartshorne, D. J., & Matsumura, F. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.02.013 · Cited by 167

Polo-Like Kinase Cdc5 Controls the Local Activation of Rho1 to Promote Cytokinesis

Yoshida, S., Kono, K., Lowery, D. M., Bartolini, S., Yaffe, M. B., Ohya, Y., & Pellman, D. (2006) · Science · doi:10.1126/science.1126747 · Cited by 159

Phosphorylation- and Polo-Box–dependent Binding of Plk1 to Bub1 Is Required for the Kinetochore Localization of Plk1

Qi, W., Tang, Z., & Yu, H. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-03-0240 · Cited by 157

Polo-like Kinase 1 Creates the Tension-Sensing 3F3/2 Phosphoepitope and Modulates the Association of Spindle-Checkpoint Proteins at Kinetochores

Ahonen, L. J., Kallio, M. J., Daum, J. R., Bolton, M. A., Manke, I. A., Yaffe, M. B., Stukenberg, P. T., & Gorbsky, G. J. (2005) · Current Biology · doi:10.1016/j.cub.2005.05.026 · Cited by 156

Astral Signals Spatially Bias Cortical Myosin Recruitment to Break Symmetry and Promote Cytokinesis

Werner, M. E., Munro, E., & Glotzer, M. (2007) · Current Biology · doi:10.1016/j.cub.2007.06.070 · Cited by 156

The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarity

Oshimori, N., Ohsugi, M., & Yamamoto, T. S. (2006) · Nature Cell Biology · doi:10.1038/ncb1474 · Cited by 156

Centromeric Aurora-B Activation Requires TD-60, Microtubules, and Substrate Priming Phosphorylation

Rosasco, S. E., Lan, W., Khorasanizadeh, S., & Stukenberg, P. T. (2008) · Science · doi:10.1126/science.1148980 · Cited by 155

Downregulation of human polo-like kinase activity by antisense oligonucleotides induces growth inhibition in cancer cells

Spänkuch, B., Wolf, G., Solbach, C., Loibl, S., Knecht, R., Stegmüller, M., von Minckwitz, G., Kaufmann, M., & Strebhardt, K. (2002) · Oncogene · doi:10.1038/sj.onc.1205412 · Cited by 149

Different Plk1 Functions Show Distinct Dependencies on Polo-Box Domain-mediated Targeting

Hanisch, A., Wehner, A., Nigg, E. A., & Silljé, H. H. W. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-08-0801 · Cited by 148

Plo1 Kinase Recruitment to the Spindle Pole Body and Its Role in Cell Division in Schizosaccharomyces pombe

Mulvihill, D. P., Petersen, J., Ohkura, H., Glover, D. M., & Hagan, I. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.8.2771 · Cited by 147

GFP tagging reveals human Polo-like kinase 1 at the kinetochore/centromere region of mitotic chromosomes

Arnaud, L., Pines, J., & Nigg, E. A. (1998) · Chromosoma · doi:10.1007/s004120050326 · Cited by 142

In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1

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The Tandem BRCT Domains of Ect2 Are Required for Both Negative and Positive Regulation of Ect2 in Cytokinesis

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Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance

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NudC Is Required for Plk1 Targeting to the Kinetochore and Chromosome Congression

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The Polo-Box Domain: A Molecular Integrator of Mitotic Kinase Cascades and Polo-like Kinase Function

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Mitotic Phosphorylation of the Peripheral Golgi Protein Nir2 by Cdk1 Provides a Docking Mechanism for Plk1 and Affects Cytokinesis Completion

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RacGAP50C is sufficient to signal cleavage furrow formation during cytokinesis

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Plx1 is the 3F3/2 kinase responsible for targeting spindle checkpoint proteins to kinetochores

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Recruitment of Polo Kinase to the Spindle Midzone during Cytokinesis Requires the Feo/Klp3A Complex

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Polo Kinase and Cytokinesis Initiation in Mammalian Cells: Harnessing the Awesome Power of Chemical Genetics

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A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene

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Present and Future Perspective on PLK1 Inhibition in Cancer Treatment

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Alternative functions of core cell cycle regulators in neuronal migration, neuronal maturation, and synaptic plasticity

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The STARD9/Kif16a Kinesin Associates with Mitotic Microtubules and Regulates Spindle Pole Assembly

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