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Cited by 964

The DOI matches its Crossref record; 121 of the 121 references it cites were found in a registry or an index.

Preparing for the First Breath: Genetic and Cellular Mechanisms in Lung Development

Open access
Morrisey, Edward E., Hogan, Brigid L.M.·2010·Developmental Cell

Abstract

The mammalian respiratory system—the trachea and the lungs—arises from the anterior foregut through a sequence of morphogenetic events involving reciprocal endodermal-mesodermal interactions. The lung itself consists of two highly branched, tree-like systems—the airways and the vasculature—that develop in a coordinated way from the primary bud stage to the generation of millions of alveolar gas exchange units. We are beginning to understand some of the molecular and cellular mechanisms that underlie critical processes such as branching morphogenesis, vascular development, and the differentiation of multipotent progenitor populations. Nevertheless, many gaps remain in our knowledge, the filling of which is essential for understanding respiratory disorders, congenital defects in human neonates, and how the disruption of morphogenetic programs early in lung development can lead to deficiencies that persist throughout life.

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Crossref · 10.1016/j.devcel.2009.12.010

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Metadata

Authors
Morrisey, E. E., & Hogan, B. L. M.
Venue
Developmental Cell
Publisher
Elsevier BV
Published
2010-01
Volume
18
Issue
1
Pages
8-23
ISSN
1534-5807 (ISSN-L)
OpenAlex
W2052350776
Cited by
964
References
121
FWCI
50.67
Type
journal article
Language
en
Open access
bronze

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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