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Preparing for the First Breath: Genetic and Cellular Mechanisms in Lung Development
Open accessAbstract
The mammalian respiratory system—the trachea and the lungs—arises from the anterior foregut through a sequence of morphogenetic events involving reciprocal endodermal-mesodermal interactions. The lung itself consists of two highly branched, tree-like systems—the airways and the vasculature—that develop in a coordinated way from the primary bud stage to the generation of millions of alveolar gas exchange units. We are beginning to understand some of the molecular and cellular mechanisms that underlie critical processes such as branching morphogenesis, vascular development, and the differentiation of multipotent progenitor populations. Nevertheless, many gaps remain in our knowledge, the filling of which is essential for understanding respiratory disorders, congenital defects in human neonates, and how the disruption of morphogenetic programs early in lung development can lead to deficiencies that persist throughout life.
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Self-citationZhang, Y., Rath, N., Hannenhalli, S. S., Wang, Z., Cappola, T. P., Kimura, S., Atochina‐Vasserman, E. N., Lu, M. M., Beers, M. F., & Morrisey, E. E. (2006) · Development · doi:10.1242/dev.02720 · Cited by 80
Self-citationFoxf1haploinsufficiency reduces Notch-2 signaling during mouse lung development
Kalinichenko, V. V., Gusarova, G. A., Kim, I., Shin, B., Yoder, H. M., Clark, J. C., Sapozhnikov, A. M., Whitsett, J. A., & Costa, R. H. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00212.2003 · Cited by 66
Gata4 Is Necessary for Normal Pulmonary Lobar Development
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Retinoic acid stimulates immature lung fibroblast growth via a PDGF-mediated autocrine mechanism
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Alveolarization in Retinoic Acid Receptor-β–Deficient Mice
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Cited by
Hogan, B. L. M., Barkauskas, C. E., Chapman, H. A., Epstein, J. A., Jain, R., Hsia, C. C. W., Niklason, L., Calle, E., Le, A., Randell, S. H., et al. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.07.012 · Cited by 876
Self-citationLung development: orchestrating the generation and regeneration of a complex organ
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Self-citationThe hope and the hype of organoid research
Huch, M., Knoblich, J. A., Lutolf, M. P., & Martinez-Arias, A. (2017) · Development · doi:10.1242/dev.150201 · Cited by 409
The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future
Basil, M. C., Katzen, J., Engler, A. E., Guo, M., Herriges, M. J., Kathiriya, J. J., Windmueller, R., Ysasi, A. B., Zacharias, W. J., Chapman, H. A., et al. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.03.009 · Cited by 414
Self-citationEarly lung development: lifelong effect on respiratory health and disease
Stocks, J., Hislop, A., & Sonnappa, S. (2013) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(13)70118-8 · Cited by 390
Metadata
- Authors
- Morrisey, E. E., & Hogan, B. L. M.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 18
- Issue
- 1
- Pages
- 8-23
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2052350776
- Cited by
- 964
- References
- 121
- FWCI
- 50.67
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.