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MITOPLD Is a Mitochondrial Protein Essential for Nuage Formation and piRNA Biogenesis in the Mouse Germline
Open accessAbstract
SUMMARY MitoPLD is a member of the phospholipase D superfamily proteins conserved among diverse species. Zucchini, the Drosophila homolog of MitoPLD, has been implicated in primary biogenesis of Piwi-interacting RNAs (piRNAs). By contrast, MitoPLD has been shown to hydrolyze cardiolipin in the outer membrane of mitochondria to generate phosphatidic acid, which is a signaling molecule. To assess whether the mammalian MitoPLD is involved in piRNA biogenesis, we generated MitoPLD mutant mice. The mice display meiotic arrest during spermatogenesis, demethylation and derepression of retrotransposons, and defects in primary piRNA biogenesis. Furthermore, in mutant germ cells, mitochondria and the components of the nuage, a perinuclear structure involved in piRNA biogenesis/function, are mislocalized to regions around the centrosome, suggesting that MitoPLD may be involved in microtubule-dependent localization of mitochondria and these proteins. Our results indicate a conserved role for MitoPLD/Zuc in the piRNA pathway and link mitochondrial membrane metabolism/signaling to small RNA biogenesis.
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Citations
Cites
Biogenesis of small RNAs in animals
Kim, V. N., Han, J., & Siomi, M. C. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2632 · Cited by 2,814
Discrete Small RNA-Generating Loci as Master Regulators of Transposon Activity in Drosophila
Brennecke, J., Aravin, A. A., Stark, A., Dus, M., Kellis, M., Sachidanandam, R., & Hannon, G. J. (2007) · Cell · doi:10.1016/j.cell.2007.01.043 · Cited by 2,524
Stability and flexibility of epigenetic gene regulation in mammalian development
Reik, W. (2007) · Nature · doi:10.1038/nature05918 · Cited by 1,963 · cited 1×
“5, when MILI and MIWI2 are expressed (Girard and Hannon, 2008; Reik, 2007; Sasaki and Matsui, 2008; Schaefer et al., 2007).”
BackgroundA germline-specific class of small RNAs binds mammalian Piwi proteins
Girard, A., Sachidanandam, R., Hannon, G. J., & Carmell, M. A. (2006) · Nature · doi:10.1038/nature04917 · Cited by 1,762
A novel class of small RNAs bind to MILI protein in mouse testes
Aravin, A., Gaidatzis, D., Pfeffer, S., Lagos-Quintana, M., Landgraf, P., Iovino, N., Morris, P., Brownstein, M. J., Kuramochi-Miyagawa, S., Nakano, T., et al. (2006) · Nature · doi:10.1038/nature04916 · Cited by 1,516
Self-citationSpermatogenic cells of the prepuberal mouse: isolation and morphological characterization
Bellve, A., Cavicchia, J., Millette, C., O'Brien, D., Bhatnagar, Y., & Dym, M. (1977) · The Journal of Cell Biology · doi:10.1083/jcb.74.1.68 · Cited by 1,385
A Distinct Small RNA Pathway Silences Selfish Genetic Elements in the Germline
Vagin, V. V., Sigova, A., Li, C., Seitz, H., Gvozdev, V., & Zamore, P. D. (2006) · Science · doi:10.1126/science.1129333 · Cited by 1,342
P bodies and the control of mRNA translation and degradation
Parker, R., & Sheth, U. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.02.011 · Cited by 1,335
A piRNA Pathway Primed by Individual Transposons Is Linked to De Novo DNA Methylation in Mice
Aravin, A. A., Sachidanandam, R., Bourc'his, D., Schaefer, C., Pezic, D., Toth, K. F., Bestor, T., & Hannon, G. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.09.003 · Cited by 1,173
A Slicer-Mediated Mechanism for Repeat-Associated siRNA 5' End Formation in Drosophila
Gunawardane, L. S., Saito, K., Nishida, K. M., Miyoshi, K., Kawamura, Y., Nagami, T., Siomi, H., & Siomi, M. C. (2007) · Science · doi:10.1126/science.1140494 · Cited by 1,171
MIWI2 Is Essential for Spermatogenesis and Repression of Transposons in the Mouse Male Germline
Carmell, M. A., Girard, A., van de Kant, H. J. G., Bourc'his, D., Bestor, T. H., de Rooij, D. G., & Hannon, G. J. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.03.001 · Cited by 1,147
Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes
Watanabe, T., Totoki, Y., Toyoda, A., Kaneda, M., Kuramochi-Miyagawa, S., Obata, Y., Chiba, H., Kohara, Y., Kono, T., Nakano, T., et al. (2008) · Nature · doi:10.1038/nature06908 · Cited by 1,116
Self-citationA Role for Piwi and piRNAs in Germ Cell Maintenance and Transposon Silencing in Zebrafish
Houwing, S., Kamminga, L. M., Berezikov, E., Cronembold, D., Girard, A., van den Elst, H., Filippov, D. V., Blaser, H., Raz, E., Moens, C. B., et al. (2007) · Cell · doi:10.1016/j.cell.2007.03.026 · Cited by 1,113
The Piwi-piRNA Pathway Provides an Adaptive Defense in the Transposon Arms Race
Aravin, A. A., Hannon, G. J., & Brennecke, J. (2007) · Science · doi:10.1126/science.1146484 · Cited by 1,096
Developmentally Regulated piRNA Clusters Implicate MILI in Transposon Control
Aravin, A. A., Sachidanandam, R., Girard, A., Fejes-Toth, K., & Hannon, G. J. (2007) · Science · doi:10.1126/science.1142612 · Cited by 1,033
Characterization of the piRNA Complex from Rat Testes
Lau, N. C., Seto, A. G., Kim, J., Kuramochi-Miyagawa, S., Nakano, T., Bartel, D. P., & Kingston, R. E. (2006) · Science · doi:10.1126/science.1130164 · Cited by 931
Self-citationKuramochi-Miyagawa, S., Watanabe, T., Gotoh, K., Totoki, Y., Toyoda, A., Ikawa, M., Asada, N., Kojima, K., Yamaguchi, Y., Ijiri, T. W., et al. (2008) · Genes & Development · doi:10.1101/gad.1640708 · Cited by 925
Self-citationEpigenetic events in mammalian germ-cell development: reprogramming and beyond
Sasaki, H., & Matsui, Y. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2295 · Cited by 871
Self-citationmiwi, a Murine Homolog of piwi, Encodes a Cytoplasmic Protein Essential for Spermatogenesis
Deng, W., & Lin, H. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00165-x · Cited by 865
Self-citationSpecialized piRNA Pathways Act in Germline and Somatic Tissues of the Drosophila Ovary
Malone, C. D., Brennecke, J., Dus, M., Stark, A., McCombie, W. R., Sachidanandam, R., & Hannon, G. J. (2009) · Cell · doi:10.1016/j.cell.2009.03.040 · Cited by 863
A novel class of small RNAs in mouse spermatogenic cells
Grivna, S. T., Beyret, E., Wang, Z., & Lin, H. (2006) · Genes & Development · doi:10.1101/gad.1434406 · Cited by 855
Self-citationMili, a mammalian member of piwi family gene, is essential for spermatogenesis
Kuramochi-Miyagawa, S., Kimura, T., Ijiri, T. W., Isobe, T., Asada, N., Fujita, Y., Ikawa, M., Iwai, N., Okabe, M., Deng, W., et al. (2004) · Development · doi:10.1242/dev.00973 · Cited by 761
Self-citationCharacterization of the piRNA Complex from Rat Testes
Iseni, F., Barge, A., Baudin, F., Blondel, D., Ruigrok, R. W. H., Schoehn, G., & Mavrakis, M. (2006) · Cited by 714
Saito, K., Nishida, K. M., Mori, T., Kawamura, Y., Miyoshi, K., Nagami, T., Siomi, H., & Siomi, M. C. (2006) · Genes & Development · doi:10.1101/gad.1454806 · Cited by 648
Watanabe, T., Takeda, A., Tsukiyama, T., Mise, K., Okuno, T., Sasaki, H., Minami, N., & Imai, H. (2006) · Genes & Development · doi:10.1101/gad.1425706 · Cited by 578
Self-citationCollapse of Germline piRNAs in the Absence of Argonaute3 Reveals Somatic piRNAs in Flies
Li, C., Vagin, V. V., Lee, S., Xu, J., Ma, S., Xi, H., Seitz, H., Horwich, M. D., Syrzycka, M., Honda, B. M., et al. (2009) · Cell · doi:10.1016/j.cell.2009.04.027 · Cited by 542
de Rooij, D. G., & Grootegoed, J. A. (1998) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(98)80109-9 · Cited by 537
Moving messages: the intracellular localization of mRNAs
St Johnston, D. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1643 · Cited by 536
Schüpbach, T., & Wieschaus, E. (1991) · Genetics · doi:10.1093/genetics/129.4.1119 · Cited by 510
Hirasawa, R., Chiba, H., Kaneda, M., Tajima, S., Li, E., Jaenisch, R., & Sasaki, H. (2008) · Genes & Development · doi:10.1101/gad.1667008 · Cited by 489
Self-citationA common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis
Choi, S.-Y., Huang, P., Jenkins, G. M., Chan, D. C., Schiller, J., & Frohman, M. A. (2006) · Nature Cell Biology · doi:10.1038/ncb1487 · Cited by 479
SeqMap: mapping massive amount of oligonucleotides to the genome
Jiang, H., & Wong, W. H. (2008) · Bioinformatics · doi:10.1093/bioinformatics/btn429 · Cited by 471
A regulatory circuit for piwi by the large Maf gene traffic jam in Drosophila
Saito, K., Inagaki, S., Mituyama, T., Kawamura, Y., Ono, Y., Sakota, E., Kotani, H., Asai, K., Siomi, H., & Siomi, M. C. (2009) · Nature · doi:10.1038/nature08501 · Cited by 439
Phosphatidic acid- and phosphatidylserine-binding proteins
STACE, C., & KTISTAKIS, N. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.03.006 · Cited by 384
Synaptonemal complex proteins: occurrence, epitope mapping and chromosome disjunction
Dobson, M. J., Pearlman, R. E., Karaiskakis, A., Spyropoulos, B., & Moens, P. B. (1994) · Journal of Cell Science · doi:10.1242/jcs.107.10.2749 · Cited by 384
Soper, S. F. C., van der Heijden, G. W., Hardiman, T. C., Goodheart, M., Martin, S. L., de Boer, P., & Bortvin, A. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.05.015 · Cited by 341
Shoji, M., Tanaka, T., Hosokawa, M., Reuter, M., Stark, A., Kato, Y., Kondoh, G., Okawa, K., Chujo, T., Suzuki, T., et al. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.10.012 · Cited by 336
Self-citationKlopfenstein, D. R., Tomishige, M., Stuurman, N., & Vale, R. D. (2002) · Cell · doi:10.1016/s0092-8674(02)00708-0 · Cited by 327
Huang, H., Gao, Q., Peng, X., Choi, S.-Y., Sarma, K., Ren, H., Morris, A. J., & Frohman, M. A. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.01.004 · Cited by 322
Vagin, V. V., Wohlschlegel, J., Qu, J., Jonsson, Z., Huang, X., Chuma, S., Girard, A., Sachidanandam, R., Hannon, G. J., & Aravin, A. A. (2009) · Genes & Development · doi:10.1101/gad.1814809 · Cited by 313
Self-citationPane, A., Wehr, K., & Schüpbach, T. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.03.022 · Cited by 308
Roles for the Yb body components Armitage and Yb in primary piRNA biogenesis in Drosophila
Saito, K., Ishizu, H., Komai, M., Kotani, H., Kawamura, Y., Nishida, K. M., Siomi, H., & Siomi, M. C. (2010) · Genes & Development · doi:10.1101/gad.1989510 · Cited by 301
Cytoplasmic Compartmentalization of the Fetal piRNA Pathway in Mice
Aravin, A. A., van der Heijden, G. W., Castañeda, J., Vagin, V. V., Hannon, G. J., & Bortvin, A. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000764 · Cited by 282
Two mouse piwi-related genes: miwi and mili
Kuramochi-Miyagawa, S., Kimura, T., Yomogida, K., Kuroiwa, A., Tadokoro, Y., Fujita, Y., Sato, M., Matsuda, Y., & Nakano, T. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00499-3 · Cited by 269
Self-citationOlivieri, D., Sykora, M. M., Sachidanandam, R., Mechtler, K., & Brennecke, J. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.212 · Cited by 268
Reuter, M., Chuma, S., Tanaka, T., Franz, T., Stark, A., & Pillai, R. S. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1615 · Cited by 256
Self-citationA Novel Active L1 Retrotransposon Subfamily in the Mouse
Goodier, J. L., Ostertag, E. M., Du, K., & Kazazian, H. H. (2001) · Genome Research · doi:10.1101/gr.198301 · Cited by 244
Chuma, S., Hosokawa, M., Kitamura, K., Kasai, S., Fujioka, M., Hiyoshi, M., Takamune, K., Noce, T., & Nakatsuji, N. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601878103 · Cited by 241
Self-citationMVH in piRNA processing and gene silencing of retrotransposons
Kuramochi-Miyagawa, S., Watanabe, T., Gotoh, K., Takamatsu, K., Chuma, S., Kojima-Kita, K., Shiromoto, Y., Asada, N., Toyoda, A., Fujiyama, A., et al. (2010) · Genes & Development · doi:10.1101/gad.1902110 · Cited by 238
Self-citationUnhavaithaya, Y., Hao, Y., Beyret, E., Yin, H., Kuramochi-Miyagawa, S., Nakano, T., & Lin, H. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m809104200 · Cited by 222
Self-citationZheng, K., Xiol, J., Reuter, M., Eckardt, S., Leu, N. A., McLaughlin, K. J., Stark, A., Sachidanandam, R., Pillai, R. S., & Wang, P. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003953107 · Cited by 214
Frost, R. J. A., Hamra, F. K., Richardson, J. A., Qi, X., Bassel-Duby, R., & Olson, E. N. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1007158107 · Cited by 199
Epigenetic Decisions in Mammalian Germ Cells
Schaefer, C. B., Ooi, S. K. T., Bestor, T. H., & Bourc'his, D. (2007) · Science · doi:10.1126/science.1137544 · Cited by 196
Chuma, S., & Nakatsuji, N. (2001) · Developmental Biology · doi:10.1006/dbio.2000.9989 · Cited by 190
Self-citationConserved themes in small-RNA-mediated transposon control
Girard, A., & Hannon, G. J. (2008) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.01.004 · Cited by 183
Mili Interacts with Tudor Domain-Containing Protein 1 in Regulating Spermatogenesis
Wang, J., Saxe, J. P., Tanaka, T., Chuma, S., & Lin, H. (2009) · Current Biology · doi:10.1016/j.cub.2009.02.061 · Cited by 160
Self-citationMa, L., Buchold, G. M., Greenbaum, M. P., Roy, A., Burns, K. H., Zhu, H., Han, D. Y., Harris, R. A., Coarfa, C., Gunaratne, P. H., et al. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000635 · Cited by 160
Probing the initiation and effector phases of the somatic piRNA pathway inDrosophilaPreprint
Haase, A. D., Fenoglio, S., Muerdter, F., Guzzardo, P. M., Czech, B., Pappin, D., Chen, C., Gordon, A., & Hannon, G. J. (2010) · Genes & Development · doi:10.1101/gad.1968110 · Cited by 156
Chuma, S., Hosokawa, M., Tanaka, T. S. T., & Nakatsuji, N. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.11.009 · Cited by 143
Self-citationManifava, M., Thuring, J. W. J. F., Lim, Z., Packman, L. C., Holmes, A. B., & Ktistakis, N. T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010308200 · Cited by 134
Chuma, S., Hiyoshi, M., Yamamoto, A., Hosokawa, M., Takamune, K., & Nakatsuji, N. (2003) · Mechanisms of Development · doi:10.1016/s0925-4773(03)00181-3 · Cited by 117
Self-citationExpression of the homophilic adhesion molecule, Ep-CAM, in the mammalian germ line
Anderson, R., Schaible, K., Heasman, J., & Wylie, C. C. (1999) · Reproduction · doi:10.1530/jrf.0.1160379 · Cited by 102
Lipid signaling on the mitochondrial surface
Huang, H., & Frohman, M. A. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.05.012 · Cited by 68
Kojima, K., Kuramochi‐Miyagawa, S., Chuma, S., Tanaka, T. S. T., Nakatsuji, N., Kimura, T., & Nakano, T. (2009) · Genes to Cells · doi:10.1111/j.1365-2443.2009.01342.x · Cited by 64
Self-citationGoodier, J. L., Ostertag, E. M., Du, K. L., & Kazazian, J. (2001) · Genome Research · Cited by 33
Analysis of Small RNA Profiles During Development
Watanabe, T., Totoki, Y., Sasaki, H., Minami, N., & Imai, H. (2007) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(07)27009-0 · Cited by 18
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Metadata
- Authors
- Watanabe, T., Chuma, S., Yamamoto, Y., Kuramochi-Miyagawa, S., Totoki, Y., Toyoda, A., Hoki, Y., Fujiyama, A., Shibata, T., Sado, T., Noce, T., Nakano, T., Nakatsuji, N., Lin, H., & Sasaki, H.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 20
- Issue
- 3
- Pages
- 364-375
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2081028399
- Cited by
- 305
- References
- 66
- FWCI
- 35.60
- Type
- journal article
- Language
- en
- Open access
- bronze
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