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Emerging treatment mechanisms for depression: focus on glutamate and synaptic plasticity
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“Glutamate antagonists have been shown to improve symptoms of anxiety and depression in preclinical models (Gerhard et al, 2016)”
From Lisdexamfetamine Effects on Executive Activation and Neurochemistry in Menopausal Women with Executive Function Difficulties (2017) · cites this paper as Gerhard et al, 2016
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“Reduced volume of PFC and hippocampus could contribute to impairments in executive function and memory often observed in MDD patients [8, 24] (Figure 1).”
BackgroundNMDA receptor blockade at rest triggers rapid behavioural antidepressant responses
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BackgroundSelf-citationBipolar and major depressive disorder: Neuroimaging the developmental-degenerative divide
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Metadata
- Authors
- Gerhard, D. M., Wohleb, E. S., & Duman, R. S.
- Venue
- Drug Discovery Today
- Publisher
- Elsevier BV
- Published
- 2016-03
- Volume
- 21
- Issue
- 3
- Pages
- 454-464
- ISSN
- 1359-6446
- PMC
- PMC4803609
- Cited by
- 261
- References
- 22
- Language
- en
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