Therapeutic Potential of Fecal Microbiota Transplantation
Open accessAbstract
There has been growing interest in the use of fecal microbiota for the treatment of patients with chronic gastrointestinal infections and inflammatory bowel diseases. Lately, there has also been interest in its therapeutic potential for cardiometabolic, autoimmune, and other extraintestinal conditions that were not previously considered to be associated with the intestinal microbiota. Although it is not clear if changes in the microbiota cause these conditions, we review the most current and best methods for performing fecal microbiota transplantation and summarize clinical observations that have implicated the intestinal microbiota in various diseases. We also discuss case reports of fecal microbiota transplantations for different disorders, including Clostridium difficile infection, irritable bowel syndrome, inflammatory bowel diseases, insulin resistance, multiple sclerosis, and idiopathic thrombocytopenic purpura. There has been increasing focus on the interaction between the intestinal microbiome, obesity, and cardiometabolic diseases, and we explore these relationships and the potential roles of different microbial strains. We might someday be able to mine for intestinal bacterial strains that can be used in the diagnosis or treatment of these diseases.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The text we found for this paper looks like another document, so the self-check wasn’t run.
Cites
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624 · see citing works
Enterotypes of the human gut microbiome
MetaHIT Consortium (additional members), Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D. R., Fernandes, G. R., Tap, J., Bruls, T., et al. (2011) · Nature · doi:10.1038/nature09944 · Cited by 7,548 · see citing works
Self-citationMetabolic Endotoxemia Initiates Obesity and Insulin Resistance
Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638 · see citing works
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176 · see citing works
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
Wang, Z., Klipfell, E., Bennett, B. J., Koeth, R., Levison, B. S., DuGar, B., Feldstein, A. E., Britt, E. B., Fu, X., Chung, Y.-M., et al. (2011) · Nature · doi:10.1038/nature09922 · Cited by 5,597 · see citing works
Everard, A., Belzer, C., Geurts, L., Ouwerkerk, J. P., Druart, C., Bindels, L. B., Guiot, Y., Derrien, M., Muccioli, G. G., Delzenne, N. M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219451110 · Cited by 4,511 · see citing works
Self-citationFunctional interactions between the gut microbiota and host metabolism
Tremaroli, V., & Bäckhed, F. (2012) · Nature · doi:10.1038/nature11552 · Cited by 4,387 · see citing works
Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis
Koeth, R. A., Wang, Z., Levison, B. S., Buffa, J. A., Org, E., Sheehy, B. T., Britt, E. B., Fu, X., Wu, Y., Li, L., et al. (2013) · Nature Medicine · doi:10.1038/nm.3145 · Cited by 4,386 · see citing works
Duodenal Infusion of Donor Feces for Recurrent <i>Clostridium difficile</i>
van Nood, E., Vrieze, A., Nieuwdorp, M., Fuentes, S., Zoetendal, E. G., de Vos, W. M., Visser, C. E., Kuijper, E. J., Bartelsman, J. F. W. M., Tijssen, J. G. P., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1205037 · Cited by 3,708 · see citing works
Self-citationIntestinal microbial metabolism of phosphatidylcholine and cardiovascular risk
Tang, W. H. W., Wang, Z., Levison, B. S., Koeth, R. A., Britt, E. B., Fu, X., Wu, Y., & Hazen, S. L. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1109400 · Cited by 3,402 · see citing works
Vrieze, A., Van Nood, E., Holleman, F., Salojärvi, J., Kootte, R. S., Bartelsman, J. F. W. M., Dallinga–Thie, G. M., Ackermans, M. T., Serlie, M. J., Oozeer, R., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.06.031 · Cited by 2,913 · see citing works
Self-citationInflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
Henao-Mejia, J., Elinav, E., Jin, C., Hao, L., Mehal, W. Z., Strowig, T., Thaiss, C. A., Kau, A. L., Eisenbarth, S. C., Jurczak, M. J., et al. (2012) · Nature · doi:10.1038/nature10809 · Cited by 2,435 · see citing works
Risk of Cardiovascular Disease in Patients with Nonalcoholic Fatty Liver Disease
Targher, G., Day, C. P., & Bonora, E. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0912063 · Cited by 1,907 · see citing works
An ecological and evolutionary perspective on human–microbe mutualism and disease
Dethlefsen, L., McFall-Ngai, M., & Relman, D. A. (2007) · Nature · doi:10.1038/nature06245 · Cited by 1,660 · see citing works
Guidelines for diagnosis, treatment, and prevention of Clostridium difficile infections
Surawicz, C. M., Brandt, L. J., Binion, D. G., Ananthakrishnan, A. N., Curry, S. R., Gilligan, P. H., McFarland, L. V., Mellow, M., & Zuckerbraun, B. S. (2013) · American Journal of Gastroenterology · doi:10.1038/ajg.2013.4 · Cited by 1,645 · see citing works
Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease
Miele, L., Valenza, V., La Torre, G., Montalto, M., Cammarota, G., Ricci, R., Mascianà, R., Forgione, A., Gabrieli, M. L., Perotti, G., et al. (2009) · Hepatology · doi:10.1002/hep.22848 · Cited by 1,434 · see citing works
Symptomatic atherosclerosis is associated with an altered gut metagenome
Karlsson, F. H., Fåk, F., Nookaew, I., Tremaroli, V., Fagerberg, B., Petranovic, D., Bäckhed, F., & Nielsen, J. (2012) · Nature Communications · doi:10.1038/ncomms2266 · Cited by 1,371 · see citing works
Ott, S. J., Musfeldt, M., Wenderoth, D. F., Hampe, J., Brant, O., Fölsch, U. R., Timmis, K. N., & Schreiber, S. (2004) · Gut · doi:10.1136/gut.2003.025403 · Cited by 1,311 · see citing works
Human colonic microbiota associated with diet, obesity and weight loss
Duncan, S. H., Lobley, G. E., Holtrop, G., Ince, J., Johnstone, A. M., Louis, P., & Flint, H. J. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.155 · Cited by 1,222 · see citing works
Human oral, gut, and plaque microbiota in patients with atherosclerosis
Koren, O., Spor, A., Felin, J., Fåk, F., Stombaugh, J., Tremaroli, V., Behre, C. J., Knight, R., Fagerberg, B., Ley, R. E., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011383107 · Cited by 1,196 · see citing works
Rajilić–Stojanović, M., Biagi, E., Heilig, H. G. H. J., Kajander, K., Kekkonen, R. A., Tims, S., & de Vos, W. M. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.07.043 · Cited by 1,041 · see citing works
Self-citationTreating Clostridium difficile infection with fecal microbiota transplantation
Bakken, J. S., Borody, T., Brandt, L. J., Brill, J. V., Demarco, D. C., Franzos, M. A., Kelly, C., Khoruts, A., Louie, T., Martinelli, L. P., et al. (2011) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2011.08.014 · Cited by 1,003 · see citing works
Self-citationGough, E., Shaikh, H., & Manges, A. R. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/cir632 · Cited by 1,003 · see citing works
(1958) · PubMed · Cited by 978 · see citing works
Kassam, Z., Lee, C. H., Yuan, Y., & Hunt, R. H. (2013) · American Journal of Gastroenterology · doi:10.1038/ajg.2013.59 · Cited by 904 · see citing works
An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota
Jeffery, I. B., O'Toole, P. W., Öhman, L., Claesson, M. J., Deane, J., Quigley, E. M. M., & Simrén, M. (2012) · Gut · doi:10.1136/gutjnl-2011-301501 · Cited by 835 · see citing works
Intestinal microbiota in patients with nonalcoholic fatty liver disease
Mouzaki, M., Comelli, E. M., Arendt, B. M., Bonengel, J., Fung, S. K., Fischer, S. E., McGilvray, I. D., & Allard, J. P. (2013) · Hepatology · doi:10.1002/hep.26319 · Cited by 749 · see citing works
Hamilton, M. J., Weingarden, A. R., Sadowsky, M. J., & Khoruts, A. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2011.482 · Cited by 738 · see citing works
Fecal microbiota transplantation and emerging applications
Borody, T. J., & Khoruts, A. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2011.244 · Cited by 677 · see citing works
Self-citationRaman, M., Ahmed, I., Gillevet, P. M., Probert, C. S., Ratcliffe, N. M., Smith, S., Greenwood, R., Sikaroodi, M., Lam, V., Crotty, P., et al. (2013) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2013.02.015 · Cited by 672 · see citing works
Brandt, L. J., Aroniadis, O. C., Mellow, M., Kanatzar, A., Kelly, C., Park, T., Stollman, N., Rohlke, F., & Surawicz, C. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2012.60 · Cited by 672 · see citing works
Khoruts, A., Dicksved, J., Jansson, J. K., & Sadowsky, M. J. (2010) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3181c87e02 · Cited by 649 · see citing works
Should we standardize the 1,700-year-old fecal microbiota transplantation?
Zhang, F., Luo, W., Shi, Y., Fan, Z., & Ji, G. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2012.251 · Cited by 619 · see citing works
BACTERIOTHERAPY FOR CHRONIC RELAPSING CLOSTRIDIUM DIFFICILE DIARRHOEA IN SIX PATIENTS
Tvede, M., & Rask-Madsen, J. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92749-9 · Cited by 595 · see citing works
Frank, D. N., Robertson, C. E., Hamm, C. M., Kpadeh, Z. Z., Zhang, T., Chen, H., Zhu, W., Sartor, R. B., Boedeker, E. C., Harpaz, N., et al. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21339 · Cited by 594 · see citing works
Energy intake is associated with endotoxemia in apparently healthy men
Amar, J., Burcelin, R., Ruidavets, J. B., Cani, P. D., Fauvel, J., Alessi, M., Chamontin, B., & Ferrières, J. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.5.1219 · Cited by 594 · see citing works
Association of endotoxemia with carotid atherosclerosis and cardiovascular disease
Wiedermann, C. J., Kiechl, S., Dunzendorfer, S., Schratzberger, P., Egger, G., Oberhollenzer, F., & Willeit, J. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00448-9 · Cited by 505 · see citing works
TLR-dependent T cell activation in autoimmunity
Mills, K. H. G. (2011) · Nature reviews. Immunology · doi:10.1038/nri3095 · Cited by 439 · see citing works
Treatment of Ulcerative Colitis Using Fecal Bacteriotherapy
Borody, T. J., Warren, E. F., Leis, S., Surace, R., & Ashman, O. (2003) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200307000-00012 · Cited by 388 · see citing works
Self-citationThe therapeutic potential of manipulating gut microbiota in obesity and type 2 diabetes mellitus
Kootte, R. S., Vrieze, A., Holleman, F., Dallinga‐Thie, G. M., Zoetendal, E. G., de Vos, W. M., Groen, A. K., Hoekstra, J. B. L., Stroes, E. S. G., & Nieuwdorp, M. (2011) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2011.01483.x · Cited by 348 · see citing works
Self-citationSystematic review: faecal microbiota transplantation in the management of inflammatory bowel disease
Anderson, J. E., Edney, R. J., & Whelan, K. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2012.05220.x · Cited by 313 · see citing works
Bacteriotherapy for chronic relapsing Clostridium difficile in six patients
Tvede, M. (1989) · The Lancet · Cited by 290 · see citing works
Bacteriotherapy Using Fecal Flora: Toying With Human Motions
Borody, T. J., Warren, E. F., Leis, S. M., Surace, R., Ashman, O., & Siarakas, S. (2004) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000128988.13808.dc · Cited by 283 · see citing works
Self-citationGuerra-Ruiz, A. R., Casafont, F., Crespo, J., Cayón, A., Mayorga, M. M., Estébanez, Á., Fernández-Escalante, J. C., & Pons‐Romero, F. (2007) · Obesity Surgery · doi:10.1007/s11695-007-9243-7 · Cited by 268 · see citing works
Durable Alteration of the Colonic Microbiota by the Administration of Donor Fecal Flora
Grehan, M., Borody, T. J., Leis, S., Campbell, J., Mitchell, H. M., & Wettstein, A. R. (2010) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3181e5d06b · Cited by 253 · see citing works
Self-citationPotential mechanisms for the emerging link between obesity and increased intestinal permeability
Teixeira, T. F. S., Collado, M. C., Ferreira, C. L. D. L. F., Bressan, J., & Pelúzio, M. D. C. G. (2012) · Nutrition Research · doi:10.1016/j.nutres.2012.07.003 · Cited by 242 · see citing works
Borody, T. J., George, L., Andrews, P., Brandl, S., Noonan, S., Cole, P., Hyland, L., Morgan, A., Maysey, J., & Moore‐Jones, D. (1989) · Medical Journal of Australia · doi:10.5694/j.1326-5377.1989.tb136704.x · Cited by 221 · see citing works
Self-citationFrémont, M., Coomans, D. H., Massart, S., & Meirleir, K. D. (2013) · Anaerobe · doi:10.1016/j.anaerobe.2013.06.002 · Cited by 208 · see citing works
Persky, S. E., & Brandt, L. J. (2000) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.03302.x · Cited by 178 · see citing works
Yoon, S. S., & Brandt, L. J. (2010) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3181dac035 · Cited by 178 · see citing works
Brandt, L. J. (2013) · The American Journal of Gastroenterology · doi:10.1038/ajg.2012.450 · Cited by 171 · see citing works
Fecal Flora Reconstitution for Recurrent Clostridium difficile Infection: Results and Methodology
Rohlke, F., Surawicz, C. M., & Stollman, N. (2010) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3181dadb10 · Cited by 165 · see citing works
Increased d-lactic Acid intestinal bacteria in patients with chronic fatigue syndrome.
Sheedy, J. R., Wettenhall, R. E. H., Scanlon, D. B., Gooley, P. R., Lewis, D. P., McGregor, N., Stapleton, D., Butt, H. L., & Meirleir, K. L. D. (2009) · PubMed · Cited by 161 · see citing works
Pathogenesis in immune thrombocytopenia: new insights
Johnsen, J. M. (2012) · Hematology · doi:10.1182/asheducation.v2012.1.306.3798320 · Cited by 154 · see citing works
Fecal Microbiota Transplantation (FMT) in Multiple Sclerosis (MS): 942
Borody, T., Leis, S., Campbell, J., Torres, M., & Nowak, A. (2011) · American Journal of Gastroenterology · doi:10.14309/00000434-201110002-00942 · Cited by 149 · see citing works
Self-citationGut inflammation in chronic fatigue syndrome
Lakhan, S. E., & Kirchgessner, A. (2010) · Nutrition & Metabolism · doi:10.1186/1743-7075-7-79 · Cited by 143 · see citing works
Postigo, R., & Kim, J. H. (2012) · Infection · doi:10.1007/s15010-012-0307-9 · Cited by 119 · see citing works
Neemann, K., Eichele, D. D., Smith, P. W., Bociek, R., Akhtari, M., & Freifeld, A. (2012) · Transplant Infectious Disease · doi:10.1111/tid.12017 · Cited by 107 · see citing works
Reversal of Idiopathic Thrombocytopenic Purpura [ITP] with Fecal Microbiota Transplantation [FMT]
Borody, T. J., Campbell, J., Torres, M., Nowak, A. K., & Leis, S. (2011) · The American Journal of Gastroenterology · doi:10.14309/00000434-201110002-00941 · Cited by 74 · see citing works
Self-citationTrubiano, J. A., Gardiner, B., Kwong, J. C., Ward, P., Testro, A. G., & Charles, P. G. P. (2013) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e32835b2da9 · Cited by 64 · see citing works
de Vos, W. M., & Nieuwdorp, M. (2013) · Nature · doi:10.1038/nature12251 · Cited by 63 · see citing works
Self-citationVermeire, S., Joossens, M., Verbeke, K., Hildebrand, F., Machiels, K., Van den Broeck, K., Van Assche, G., Rutgeerts, P. J., & Raes, J. (2012) · Gastroenterology · doi:10.1016/s0016-5085(12)61356-0 · Cited by 63 · see citing works
Fecal microbiota transplantation: current status and future directions
Borody, T. J., & Campbell, J. (2011) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/egh.11.71 · Cited by 62 · see citing works
Self-citationClostridium difficile Infection and Inflammatory Bowel Disease
Reddy, S. S., & Brandt, L. J. (2013) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e31828b288a · Cited by 52 · see citing works
Bacteriotherapy for chronic constipation - a long term follow-up
(1995) · Gastroenterology · doi:10.1016/0016-5085(95)26563-5 · Cited by 42 · see citing works
Self-citationMerde: Excursions in scientific, cultural and socio-historical coprology
LaMont, J. T. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)70334-9 · Cited by 34 · see citing works
Gallegos-Orozco, J. F., Paskvan-Gawryletz, C., Gurudu, & Orenstein, R. (2012) · PubMed · Cited by 27 · see citing works
Bacteriotherapy in Chronic Fatigue Syndrome (CFS): A Retrospective Review
Borody, T. J., Nowak, A., Torres, M., Campbell, J., Finlayson, S., & Leis, S. (2012) · The American Journal of Gastroenterology · doi:10.14309/00000434-201210001-01481 · Cited by 26 · see citing works
Self-citationKnaapen, M., Kootte, R. S., Zoetendal, E. G., de Vos, W. M., Dallinga‐Thie, G. M., Levi, M. M., Stroes, E. S. G., & Nieuwdorp, M. (2013) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12170 · Cited by 23 · see citing works
Self-citationFecal Microbiota Transplantation: Are We Opening a Can of Worms?
El‐Matary, W., Simpson, R., & Ricketts–Burns, N. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.04.055 · Cited by 22 · see citing works
Borody, T. J., Wettstein, A. R., Leis, S., Hills, L. A., Campbell, J., & Torres, M. (2008) · Gastroenterology · doi:10.1016/s0016-5085(08)61684-4 · Cited by 19 · see citing works
Self-citationAroniadis, O. C., Brandt, L. J., Greenberg, A., et al. (2013) · Gastroenterology · doi:10.1016/s0016-5085(13)60656-3 · Cited by 16 · see citing works
Self-citationMerde: Excursions in Scientific, Cultural, and Socio-Historical Coprology
Lewin, R. A. (1999) · Cited by 16 · see citing works
Fecal feedings as a therapy in Staphylococcus enterocolitis.
Cutolo, L., Kleppel, N. H., Freund, H. R., et al. (1959) · PubMed · Cited by 14 · see citing works
Flagged first, then by citations
6 of the 81 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Andrews, 1992, Chronic constipation reversed by restoration of bowel flora: a case and a hypothesis, Eur J Gastroenterol Hepatol, 4, 245
Cited by
Sorted by citations
Hill (2014) · doi:10.1038/nrgastro.2014.66 · Cited by 9,592 · see citing works
The Microbiome in Inflammatory Bowel Disease: Current Status and the Future Ahead
Kostic, A. D., Xavier, R. J., & Gevers, D. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.02.009 · Cited by 1,789 · see citing works
Minireview: Gut microbiota: The neglected endocrine organ
Clarke, G., Stilling, R. M., Kennedy, P. J., Stanton, C., Cryan, J. F., & Dinan, T. G. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1108 · Cited by 1,192 · see citing works
Kootte, R. S., Levin, E., Salojärvi, J., Smits, L. P., Hartstra, A. V., Udayappan, S. D., Hermes, G., Bouter, K. E., Koopen, A. M., Holst, J. J., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.09.008 · Cited by 1,039 · see citing works
Self-citationThe Gut Microbiota and Alzheimer’s Disease
Jiang, C., Li, G., Huang, P., Liu, Z., & Zhao, B. (2017) · Journal of Alzheimer's Disease · doi:10.3233/jad-161141 · Cited by 852 · see citing works
Short-chain fatty acids in diseases
Zhang, D., Jian, Y., Zhang, Y., Li, Y., Gu, L.-T., Sun, H.-H., Liu, M., Zhou, H., Wang, Y., & Xu, Z. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01219-9 · Cited by 763 · see citing works
Ott, S. J., Waetzig, G. H., Rehman, A., Moltzau-Anderson, J., Bharti, R., Grasis, J. A., Cassidy, L., Tholey, A., Fickenscher, H., Seegert, D., et al. (2017) · Gastroenterology · doi:10.1053/j.gastro.2016.11.010 · Cited by 695 · see citing works
Gut microbiome and aging: physiological and mechanistic insights
Nagpal, R., Mainali, R., Ahmadi, S., Wang, S., Singh, R., Kavanagh, K., Kitzman, D. W., Kushugulova, A., Marotta, F., & Yadav, H. (2018) · Nutrition and Healthy Aging · doi:10.3233/nha-170030 · Cited by 670 · see citing works
Insights into the role of the microbiome in obesity and type 2 diabetes
Hartstra, A. V., Bouter, K. E. C., Bäckhed, F., & Nieuwdorp, M. (2015) · Diabetes Care · doi:10.2337/dc14-0769 · Cited by 641 · see citing works
Self-citationShen, Z.-H., Zhu, C.-X., Quan, Y.-S., Yang, Z.-Y., Wu, S., Luo, W.-W., Tan, B., & Wang, X.-Y. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i1.5 · Cited by 646 · see citing works
Microbial genes, brain & behaviour – epigenetic regulation of the gut–brain axis
Stilling, R. M., Dinan, T. G., & Cryan, J. F. (2014) · Genes, Brain and Behavior · doi:10.1111/gbb.12109 · Cited by 637 · see citing works
Gut microbiota modulation: a novel strategy for prevention and treatment of colorectal cancer
Fong, W., Li, Q., & Yu, J. Q. (2020) · Oncogene · doi:10.1038/s41388-020-1341-1 · Cited by 625 · see citing works
The Intestinal Microbiota and Colorectal Cancer
Cheng, Y., Ling, Z., & Li, L. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.615056 · Cited by 587 · see citing works
Fecal microbiota transplantation: Review and update
Wang, J.-W., Kuo, C.-H., Kuo, F.-C., Wang, Y.-K., Hsu, W.-H., Yu, F.-J., Hu, H.-M., Hsu, P.-I., Wang, J.-Y., & Wu, D.-C. (2019) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2018.08.011 · Cited by 576 · see citing works
Durable coexistence of donor and recipient strains after fecal microbiota transplantation
Li, S. S., Zhu, A., Beneš, V., Costea, P. I., Hercog, R., Hildebrand, F., Huerta‐Cepas, J., Nieuwdorp, M., Salojärvi, J., Voigt, A. Y., et al. (2016) · Science · doi:10.1126/science.aad8852 · Cited by 544 · see citing works
Self-citationUnderstanding the mechanisms of faecal microbiota transplantation
Khoruts, A., & Sadowsky, M. J. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.98 · Cited by 563 · see citing works
Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis
Tojo, R. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i41.15163 · Cited by 533 · see citing works
Cuevas-Sierra, A., Ramos-Lopez, O., Riezu-Boj, J. I., Milagro, F. I., & Martinez, J. A. (2019) · Advances in Nutrition · doi:10.1093/advances/nmy078 · Cited by 523 · see citing works
The links between the gut microbiome and non-alcoholic fatty liver disease (NAFLD)
Safari, Z., & Gérard, P. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03011-w · Cited by 512 · see citing works
Fecal microbiota transplantation: in perspective
Gupta, S., Allen‐Vercoe, E., & Petrof, E. O. (2015) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x15607414 · Cited by 484 · see citing works
Gut microbiota-derived short-chain fatty acids and their role in human health and disease
Mukhopadhya, I., & Louis, P. (2025) · Nature Reviews Microbiology · doi:10.1038/s41579-025-01183-w · Cited by 581 · see citing works
Zhou, D., Pan, Q., Shen, F., Cao, H.-X., Ding, W.-J., Chen, Y.-W., & Fan, J.-G. (2017) · Scientific Reports · doi:10.1038/s41598-017-01751-y · Cited by 421 · see citing works
Hu, J., Ma, L., Nie, Y., Chen, J., Zheng, W., Wang, X., Xie, C., Zheng, Z., Wang, Z., Yang, T., et al. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.11.006 · Cited by 334 · see citing works
Interaction between Lipopolysaccharide and Gut Microbiota in Inflammatory Bowel Diseases
Candelli, M., Franza, L., Pignataro, G., Ojetti, V., Covino, M., Piccioni, A., Gasbarrini, A., & Franceschi, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126242 · Cited by 402 · see citing works
Korpela, K., Helve, O., Kolho, K.-L., Saisto, T., Skogberg, K., Dikareva, E., Stefanović, V., Salonen, A., Andersson, S., & de Vos, W. M. (2020) · Cell · doi:10.1016/j.cell.2020.08.047 · Cited by 358 · see citing works
Self-citationToll-like Receptors and Inflammatory Bowel Disease
Lu, Y., Li, X., Liu, S., Zhang, Y., & Zhang, D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00072 · Cited by 342 · see citing works
Inflammatory Bowel Disease as a Model for Translating the Microbiome
Huttenhower, C., Kostic, A. D., & Xavier, R. J. (2014) · Immunity · doi:10.1016/j.immuni.2014.05.013 · Cited by 332 · see citing works
The gut-brain axis: the missing link in depression
Evrensel, A., & Ceylan, M. E. (2015) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2015.13.3.239 · Cited by 338 · see citing works
Irritable bowel syndrome: A microbiome-gut-brain axis disorder?
Kennedy, P. J. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i39.14105 · Cited by 335 · see citing works
Metabolic syndrome and nonalcoholic fatty liver disease: Is insulin resistance the link?
Asrih, M., & Jornayvaz, F. R. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.02.018 · Cited by 331 · see citing works
Fecal Microbiota Transplantation: Current Applications, Effectiveness, and Future Perspectives
Choi, H. H., & Cho, Y.-S. (2016) · Clinical Endoscopy · doi:10.5946/ce.2015.117 · Cited by 318 · see citing works
Fecal microbiota transplantation in metabolic syndrome: History, present and future
de Groot, P. F., Frissen, M. N., de Clercq, N. C., & Nieuwdorp, M. (2017) · Gut Microbes · doi:10.1080/19490976.2017.1293224 · Cited by 322 · see citing works
Self-citationModulation of immune development and function by intestinal microbiota
Kabat, A. M., Srinivasan, N., & Maloy, K. J. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.07.010 · Cited by 312 · see citing works
Cui, B., Feng, Q., Wang, H., Wang, M., Peng, Z., Li, P., Huang, G., Liu, Z., Wu, P., Fan, Z., et al. (2015) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.12727 · Cited by 298 · see citing works
Microbiota regulation of the mammalian gut-brain axis
Burokas, A., Moloney, R. D., Dinan, T. G., & Cryan, J. F. (2015) · Advances in applied microbiology · doi:10.1016/bs.aambs.2015.02.001 · Cited by 300 · see citing works
West, C. E., Renz, H. E., Jenmalm, M. C., Kozyrskyj, A. L., Allen, K. J., Vuillermin, P., Prescott, S. L., Mackay, C. R., Salminen, S., Wong, G., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.11.012 · Cited by 281 · see citing works
Manipulating the gut microbiota to maintain health and treat disease
Scott, K. P., Antoine, J., Midtvedt, T., & van Hemert, S. (2015) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v26.25877 · Cited by 284 · see citing works
Facchin, S., Bertin, L., Bonazzi, E., Lorenzon, G., Barba, C. D., Barberio, B., Zingone, F., Maniero, D., Scarpa, M., Ruffolo, C., et al. (2024) · Life · doi:10.3390/life14050559 · Cited by 422 · see citing works
The microbiota-gut-brain axis in sleep disorders
Wang, Z., Wang, Z., Lu, T., Chen, W., Yan, W., Yuan, K., Shi, L., Liu, X., Zhou, X., Shi, J., et al. (2022) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2022.101691 · Cited by 296 · see citing works
Shetty, S. A., Hugenholtz, F., Lahti, L., Smidt, H., & de Vos, W. M. (2016) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuw045 · Cited by 248 · see citing works
Self-citationZuo, T., Wong, S. H., Cheung, C. P., Lam, K., Lui, R. N.-S., Cheung, K., Zhang, F., Tang, W., Ching, J. Y. L., Wu, J. C. Y., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06103-6 · Cited by 256 · see citing works
Lin, S., Mukherjee, S., Li, J., Hou, W., Pan, C., & Liu, J. (2021) · Science Advances · doi:10.1126/sciadv.abf0677 · Cited by 254 · see citing works
The Microbiome in Psychology and Cognitive Neuroscience
Sarkar, A., Harty, S., Lehto, S. M., Moeller, A. H., Dinan, T. G., Dunbar, R., Cryan, J. F., & Burnet, P. W. J. (2018) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2018.04.006 · Cited by 233 · see citing works
Treatment of IBD: Where We Are and Where We Are Going
Bernstein, C. N. (2014) · The American Journal of Gastroenterology · doi:10.1038/ajg.2014.357 · Cited by 236 · see citing works
Kim, H. S., Whon, T. W., Sung, H., Jeong, Y., Jung, E. S., Shin, N., Hyun, D., Kim, P. S., Lee, J., Lee, C. H., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20389-5 · Cited by 200 · see citing works
Cian, R., Drago, S., De Medina, F., & Martínez-Augustin, O. (2015) · Marine Drugs · doi:10.3390/md13085358 · Cited by 238 · see citing works
Nutrition Facts in Multiple Sclerosis
Riccio, P., & Rossano, R. (2015) · ASN NEURO · doi:10.1177/1759091414568185 · Cited by 232 · see citing works
Role of the enteric microbiota in intestinal homeostasis and inflammation
Koboziev, I., Webb, C. R., Furr, K. L., & Grisham, M. B. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.11.008 · Cited by 229 · see citing works
Update of probiotics in human world: A nonstop source of benefactions till the end of time
Zommiti, M., Feuilloley, M. G. J., & Connil, N. (2020) · Microorganisms · doi:10.3390/microorganisms8121907 · Cited by 225 · see citing works
Futuristic Non-antibiotic Therapies to Combat Antibiotic Resistance: A Review
Kumar, M., Sarma, D. K., Shubham, S., Kumawat, M., Verma, V., Nina, P. B., Devraj, J. P., Kumar, S., Singh, B., & Tiwari, R. R. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.609459 · Cited by 223 · see citing works
Gut-liver axis and probiotics: Their role in non-alcoholic fatty liver disease
Paolella, G. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i42.15518 · Cited by 213 · see citing works
Lithocholic acid, a bacterial metabolite reduces breast cancer cell proliferation and aggressiveness
Mikó, E., Vida, A., Kovàcs, T., Ujlaki, G., Trencsényi, G., Márton, J., Sári, Z., Kovács, P., Boratkó, A., Hujber, Z., et al. (2018) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2018.04.002 · Cited by 207 · see citing works
Characterization of the 17 strains of regulatory T cell-inducing human-derived Clostridia
Narushima, S., Sugiura, Y., Oshima, K., Atarashi, K., Hattori, M., Suematsu, M., & Honda, K. (2014) · Gut Microbes · doi:10.4161/gmic.28572 · Cited by 210 · see citing works
Chang, C.-W., Lee, H., Li, L.-H., Chiau, J. C., Wang, T.-E., Chuang, W.-H., Chen, M., Wang, H.-Y., Shih, S., Liu, C.-Y., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21020386 · Cited by 205 · see citing works
Berberine-induced bioactive metabolites of the gut microbiota improve energy metabolism
Wang, Y., Shou, J., Li, X., Zhao, Z., Fu, J., He, C., Feng, R., Ma, C., Wen, B., Guo, F., et al. (2017) · Metabolism · doi:10.1016/j.metabol.2017.02.003 · Cited by 206 · see citing works
He, Z., Ma, Y.-L., Yang, S., Zhang, S., Liu, S., Xiao, J.-X., Wang, Y., Wang, W., Yang, H.-J., Li, S.-L., et al. (2022) · Microbiome · doi:10.1186/s40168-022-01269-0 · Cited by 162 · see citing works
Procedures for Fecal Microbiota Transplantation in Murine Microbiome Studies
Bokoliya, S. C., Dorsett, Y., Panier, H. A., & Zhou, Y. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.711055 · Cited by 186 · see citing works
From Stool Transplants to Next-Generation Microbiota Therapeutics
Petrof, E. O., & Khoruts, A. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.01.004 · Cited by 184 · see citing works
Rodríguez‐Nogales, A., Algieri, F., Garrido‐Mesa, J., Vezza, T., Utrilla, M. P., Chueca, N., García, F., Olivares, M. M., Rodríguez‐Cabezas, M. E., & Gálvez, J. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700144 · Cited by 189 · see citing works
Gut microbiota and diabetes: From correlation to causality and mechanism
Li, W., Stirling, K., Yang, J., & Zhang, L. (2020) · World Journal of Diabetes · doi:10.4239/wjd.v11.i7.293 · Cited by 187 · see citing works
Targeting the gut‐skin axis—Probiotics as new tools for skin disorder management?
Szántó, M., Dózsa, A., Antal, D., Szabó, K., Kemény, L., & Bai, P. (2019) · Experimental Dermatology · doi:10.1111/exd.14016 · Cited by 189 · see citing works
On‐Demand Bacterial Reactivation by Restraining within a Triggerable Nanocoating
Feng, P., Cao, Z., Wang, X., Li, J., & Liu, J. (2020) · Advanced Materials · doi:10.1002/adma.202002406 · Cited by 190 · see citing works
Gut microbiota: a key player in health and disease. A review focused on obesity
Villanueva-Millán, M. J., Pérez‐Matute, P., & Oteo, J. A. (2015) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-015-0390-3 · Cited by 185 · see citing works
The intestinal barrier in multiple sclerosis: implications for pathophysiology and therapeutics
Camara-Lemarroy, C. R., Metz, L. M., Meddings, J. B., Sharkey, K. A., & Yong, V. W. (2018) · Brain · doi:10.1093/brain/awy131 · Cited by 188 · see citing works
The Gut-Brain Axis, the Human Gut Microbiota and Their Integration in the Development of Obesity
Bliss, E., & Whiteside, E. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00900 · Cited by 188 · see citing works
Rapidly expanding knowledge on the role of the gut microbiome in health and disease
Cénit, M. C., Matzaraki, V., Tigchelaar, E. F., & Zhernakova, A. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.05.023 · Cited by 185 · see citing works
A psychology of the human brain-gut-microbiome axis
Allen, A. P., Dinan, T. G., Clarke, G., & Cryan, J. F. (2017) · Social and Personality Psychology Compass · doi:10.1111/spc3.12309 · Cited by 174 · see citing works
Nitzan, O. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i43.7577 · Cited by 174 · see citing works
Critical role of the gut microbiota in immune responses and cancer immunotherapy
Li, Z., Xiong, W., Zhu, L. W., Wang, J., Zeng, Z., Kołat, D., Li, X., Zhou, D., Xu, X., & Zhao, L.-Y. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01541-w · Cited by 188 · see citing works
Walker, W. A. (2017) · Pediatric Research · doi:10.1038/pr.2017.111 · Cited by 169 · see citing works
Colorectal cancer occurrence and treatment based on changes in intestinal flora
Si, H., Yang, Q. F., Hu, H., Ding, C., Wang, H., & Lin, X. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.05.004 · Cited by 162 · see citing works
Antibiotics in Food Chain: The Consequences for Antibiotic Resistance
Kumar, S. B., Arnipalli, S. R., & Ziouzenkova, O. (2020) · Antibiotics · doi:10.3390/antibiotics9100688 · Cited by 166 · see citing works
Satokari, R., Mattila, E., Kainulainen, V., & Arkkila, P. (2015) · Alimentary Pharmacology and Therapeutics · doi:10.1111/apt.13009 · Cited by 150 · see citing works
Fecal microbiota transplantation beyond Clostridioides difficile infections
Wortelboer, K., Nieuwdorp, M., & Herrema, H. (2019) · eBioMedicine · doi:10.1016/j.ebiom.2019.05.066 · Cited by 163 · see citing works
Self-citationWang, L. L., Janes, M. E., Kumbhojkar, N., Kapate, N., Clegg, J. R., Prakash, S., Heavey, M. K., Zhao, Z., Anselmo, A. C., & Mitragotri, S. (2021) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10214 · Cited by 162 · see citing works
Gut Microbiota in Colorectal Cancer: Biological Role and Therapeutic Opportunities
Pandey, H., Tang, D. W. T., Wong, S. H., & Lal, D. (2023) · Cancers · doi:10.3390/cancers15030866 · Cited by 165 · see citing works
Schizophrenia and the gut–brain axis
Nemani, K., Hosseini Ghomi, R., McCormick, B., & Fan, X. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.08.018 · Cited by 151 · see citing works
Dutta, S., Verma, S., Jain, V., Surapaneni, B. K., Vinayek, R., Phillips, L. E., & Nair, P. P. (2019) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm19044 · Cited by 149 · see citing works
Donor Recruitment for Fecal Microbiota Transplantation
Paramsothy, S., Borody, T. J., Lin, E., Finlayson, S., Walsh, A. J., Samuel, D., van den Bogaerde, J., Leong, R. W. L., Connor, S. J., Ng, W., et al. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000405 · Cited by 149 · see citing works
Self-citationFecal Microbiota Transplantation and Its Usage in Neuropsychiatric Disorders
Evrensel, A., & Ceylan, M. E. (2016) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2016.14.3.231 · Cited by 150 · see citing works
Involvement of Reduced Microbial Diversity in Inflammatory Bowel Disease
Gong, D., Gong, X., Wang, L., Yu, X., & Dong, Q. (2016) · Gastroenterology Research and Practice · doi:10.1155/2016/6951091 · Cited by 142 · see citing works
Castro‐Marrero, J., Sáez‐Francàs, N., Santillo, D., & Alegre, J. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13702 · Cited by 142 · see citing works
Intestinal dysbiosis in children with short bowel syndrome is associated with impaired outcome
Engstrand Lilja, H., Wefer, H., Nyström, N., Finkel, Y., & Engstrand, L. (2015) · Microbiome · doi:10.1186/s40168-015-0084-7 · Cited by 145 · see citing works
Microbiota y diabetes mellitus tipo 2
Muñoz‐Garach, A., Díaz-Perdigones, C. M., & Tinahones, F. J. (2016) · Endocrinología y Nutrición · doi:10.1016/j.endonu.2016.07.008 · Cited by 146 · see citing works
Fecal Microbiota Transplantation: a Future Therapeutic Option for Obesity/Diabetes?
Aron‐Wisnewsky, J., Clément, K., & Nieuwdorp, M. (2019) · Current Diabetes Reports · doi:10.1007/s11892-019-1180-z · Cited by 144 · see citing works
Self-citationCarcinogenesis and therapeutics: the microbiota perspective
Tsilimigras, M. C. B., Fodor, A., & Jobin, C. (2017) · Nature Microbiology · doi:10.1038/nmicrobiol.2017.8 · Cited by 144 · see citing works
Policy: how to regulate faecal transplants
Smith, M. B., Kelly, C., & Alm, E. J. (2014) · Nature · doi:10.1038/506290a · Cited by 140 · see citing works
The Role of Gut–Liver Axis in Gut Microbiome Dysbiosis Associated NAFLD and NAFLD-HCC
Song, Q., & Zhang, X. (2022) · Biomedicines · doi:10.3390/biomedicines10030524 · Cited by 147 · see citing works
Gut Microbiota in Obesity and Undernutrition
de Clercq, N. C., Groen, A. K., Romijn, J. A., & Nieuwdorp, M. (2016) · Advances in Nutrition · doi:10.3945/an.116.012914 · Cited by 140 · see citing works
Self-citationHe, C., Yu, T., Shi, Y., Ma, C., Yang, W., Fang, L., Sun, M., Wu, W. H., Xiao, F., Guo, F., et al. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.01.049 · Cited by 139 · see citing works
Zhang, J., Zhao, X., Jiang, Y., Zhao, W., Guo, T., Cao, Y., Teng, J., Hao, X., Zhao, J., & Yang, Z. (2017) · Journal of Dairy Science · doi:10.3168/jds.2016-12480 · Cited by 141 · see citing works
Ishikawa, D., Sasaki, T., Osada, T., Kuwahara‐Arai, K., Haga, K., Shibuya, T., Hiramatsu, K., & Watanabe, S. (2016) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000975 · Cited by 135 · see citing works
Impact of Gut Microbiota Composition on Onset and Progression of Chronic Non-Communicable Diseases
Noce, A., Marrone, G., Daniele, F. D., Ottaviani, E., Jones, G. W., Bernini, R., Romani, A., & Rovella, V. (2019) · Nutrients · doi:10.3390/nu11051073 · Cited by 158 · see citing works
Gut microbiota modulation: probiotics, antibiotics or fecal microbiota transplantation?
Cammarota, G., Ianiro, G., Bibbò, S., & Gasbarrini, A. (2014) · Internal and Emergency Medicine · doi:10.1007/s11739-014-1069-4 · Cited by 136 · see citing works
Hu, X.-F., Zhang, W., Wen, Q., Chen, W., Wang, Z., Chen, J., Zhu, F., Liu, K., Cheng, L., Yang, J., et al. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.11.042 · Cited by 131 · see citing works
Akkermansia muciniphila : is it the Holy Grail for ameliorating metabolic diseases?
Yan, J., Sheng, L., & Li, H. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1984104 · Cited by 142 · see citing works
Brugman, S., Ikeda‐Ohtsubo, W., Braber, S., Folkerts, G., Pieterse, C. M. J., & Bakker, P. A. H. M. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00080 · Cited by 127 · see citing works
Gut Microbiome and Multiple Sclerosis
Bhargava, P., & Mowry, E. M. (2014) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-014-0492-2 · Cited by 129 · see citing works
Gut microbiome and anticancer immune response: really hot Sh*t!
Viaud, S., Daillère, R., Boneca, I. G., Lepage, P., Langella, P., Chamaillard, M., Pittet, M. J., Ghiringhelli, F., Trinchieri, G., Goldszmid, R., et al. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2014.56 · Cited by 123 · see citing works
Lai, C. Y., Sung, J. C. Y., Cheng, F., Tang, W., Wong, S. H., Chan, P. K. S., Kamm, M. A., Sung, J. J. �., Kaplan, G. G., Chan, F. K. L., et al. (2019) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15116 · Cited by 119 · see citing works
- Authors
- Smits, L. P., Bouter, K. E. C., de Vos, W. M., Borody, T. J., & Nieuwdorp, M.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- Centre For Digestive Diseases (AU)
- Corresponding author
- Nieuwdorp, Max
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 145
- Issue
- 5
- Pages
- 946-953
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2135717147
- Cited by
- 717
- References
- 81
- Citations by year
- 2026: 28 · 2025: 47 · 2024: 66 · 2023: 57 · 2022: 74 · 2021: 63 · 2020: 67 · 2019: 52 · 2018: 42 · 2017: 45 · 2016: 54 · 2015: 54 · 2014: 59 · 2013: 7 · 2012: 2
- FWCI
- 5.46
- Type
- journal article
- Language
- en
- Open access
- green
- research.wur.nl
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- fecal microbiota transplantation, gut microbiota, Clostridium difficile infection, irritable bowel syndrome, inflammatory bowel disease, insulin resistance, multiple sclerosis, idiopathic thrombocytopenic purpura, cardiometabolic disease, obesity, autoimmune disease, extraintestinal diseases
- MeSH terms
- Enterocolitis, Pseudomembranous, Feces, Gastrointestinal Diseases, Humans, Transplantation, Homologous, Inflammatory Bowel Diseases, Clostridioides difficile, Treatment Outcome, Transplants, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Classified by jev-1.13-20260917 (gold-guideline-v0.2) on 2026-10-07.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review