Cited by 717Gut microbiota and healthClostridium difficile and Clostridium perfringens researchGastrointestinal motility and disorders

Therapeutic Potential of Fecal Microbiota Transplantation

Open access
Smits, Loek P., Bouter, Kristien E.C., de Vos, Willem M., Borody, Thomas J., Nieuwdorp, Max·2013·Gastroenterology

Abstract

There has been growing interest in the use of fecal microbiota for the treatment of patients with chronic gastrointestinal infections and inflammatory bowel diseases. Lately, there has also been interest in its therapeutic potential for cardiometabolic, autoimmune, and other extraintestinal conditions that were not previously considered to be associated with the intestinal microbiota. Although it is not clear if changes in the microbiota cause these conditions, we review the most current and best methods for performing fecal microbiota transplantation and summarize clinical observations that have implicated the intestinal microbiota in various diseases. We also discuss case reports of fecal microbiota transplantations for different disorders, including Clostridium difficile infection, irritable bowel syndrome, inflammatory bowel diseases, insulin resistance, multiple sclerosis, and idiopathic thrombocytopenic purpura. There has been increasing focus on the interaction between the intestinal microbiome, obesity, and cardiometabolic diseases, and we explore these relationships and the potential roles of different microbial strains. We might someday be able to mine for intestinal bacterial strains that can be used in the diagnosis or treatment of these diseases.

Integrity signals

Registry

Crossref · 10.1053/j.gastro.2013.08.058

Cites

75 of 75 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

The text we found for this paper looks like another document, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The text we found for this paper looks like another document, so the self-check wasn’t run.

Cites

Flagged first, then by citations

6 of the 81 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. Andrews, 1992, Chronic constipation reversed by restoration of bowel flora: a case and a hypothesis, Eur J Gastroenterol Hepatol, 4, 245

Cited by

Sorted by citations

Authors
Smits, L. P., Bouter, K. E. C., de Vos, W. M., Borody, T. J., & Nieuwdorp, M.
Affiliations
  • Amsterdam UMC Location University of Amsterdam (NL)
  • Centre For Digestive Diseases (AU)
Corresponding author
Nieuwdorp, Max
Venue
Gastroenterology
Publisher
Elsevier BV
Published
2013-11
Volume
145
Issue
5
Pages
946-953
ISSN
0016-5085 (ISSN-L)
OpenAlex
W2135717147
Cited by
717
References
81
Citations by year
2026: 28 · 2025: 47 · 2024: 66 · 2023: 57 · 2022: 74 · 2021: 63 · 2020: 67 · 2019: 52 · 2018: 42 · 2017: 45 · 2016: 54 · 2015: 54 · 2014: 59 · 2013: 7 · 2012: 2
FWCI
5.46
Type
journal article
Language
en
Open access
Locations
  • Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
  • Socio-Environmental Systems Modeling (acceptedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Pure Amsterdam UMC (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
fecal microbiota transplantation, gut microbiota, Clostridium difficile infection, irritable bowel syndrome, inflammatory bowel disease, insulin resistance, multiple sclerosis, idiopathic thrombocytopenic purpura, cardiometabolic disease, obesity, autoimmune disease, extraintestinal diseases
MeSH terms
Enterocolitis, Pseudomembranous, Feces, Gastrointestinal Diseases, Humans, Transplantation, Homologous, Inflammatory Bowel Diseases, Clostridioides difficile, Treatment Outcome, Transplants, Microbiota

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Classified by jev-1.13-20260917 (gold-guideline-v0.2) on 2026-10-07.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review