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Biology and Mechanisms of Action of the Vitamin D Hormone

Pike, J. Wesley, Christakos, Sylvia·2017·Endocrinology and Metabolism Clinics of North America
DOI 10.1016/j.ecl.2017.07.001
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  1. Mellanby, 1919, An experimental investigation on rickets, Lancet, 1, 407
  2. McCollum, 1922, An experimental demonstration of the existence of a vitamin which promotes calcium deposition, J Biol Chem, 1922, 293, 10.1016/S0021-9258(18)85783-0 · DOI · Paper page
  3. Steenbock, 1924, Fat soluble vitamins. XVII. The induction of growth promoting and calcifying properties in a ration by exposure to ultraviolet light, J Biol Chem, 61, 405, 10.1016/S0021-9258(18)85139-0 · DOI · Paper page
  4. Windaus, 1936, Uber das antirachitisch wirksame bestrahlungs-produkt aus 7-dehydrocholesterin, Hoppe-Seyler's Z Physiol Chem, 241, 100, 10.1515/bchm2.1936.241.1-3.100 · DOI
  5. DeLuca, 2004, Overview of general physiologic features and functions of vitamin D, Am J Clin Nutr, 80, 1689S, 10.1093/ajcn/80.6.1689S · DOI · Paper page
  6. Brumbaugh, 1974, 1 Alpha,25-dihydroxycholecalciferol receptors in intestine. I. Association of 1 alpha,25-dihydroxycholecalciferol with intestinal mucosa chromatin, J Biol Chem, 249, 1251, 10.1016/S0021-9258(19)42968-2 · DOI · Paper page
  7. Brumbaugh, 1974, 1a,25-dihydroxycholecalciferol receptors in intestine. II. Temperature-dependent transfer of the hormone to chromatin via a specific cytosol receptor, J Biol Chem, 249, 1258, 10.1016/S0021-9258(19)42969-4 · DOI · Paper page
  8. Pike, 1979, Purification of chicken intestinal receptor for 1,25-dihydroxyvitamin D, Proc Natl Acad Sci U S A, 76, 5485, 10.1073/pnas.76.11.5485 · DOI
  9. Pike, 2016, Genomic determinants of vitamin D-regulated gene expression, Vitam Horm, 100, 21, 10.1016/bs.vh.2015.10.011 · DOI
  10. McDonnell, 1987, Molecular cloning of complementary DNA encoding the avian receptor for vitamin D, Science, 235, 1214, 10.1126/science.3029866 · DOI · Paper page
  11. Baker, 1988, Cloning and expression of full-length cDNA encoding human vitamin D receptor, Proc Natl Acad Sci U S A, 85, 3294, 10.1073/pnas.85.10.3294 · DOI · Paper page
  12. Evans, 1988, The steroid and thyroid hormone receptor superfamily, Science, 240, 889, 10.1126/science.3283939 · DOI · Paper page
  13. Plum, 2010, Vitamin D, disease and therapeutic opportunities, Nat Rev Drug Discov, 9, 941, 10.1038/nrd3318 · DOI · Paper page
  14. Feldman, 2014, The role of vitamin D in reducing cancer risk and progression, Nat Rev Cancer, 14, 342, 10.1038/nrc3691 · DOI · Paper page
  15. DeLuca, 1988, The vitamin D story: a collaborative effort of basic science and clinical medicine, FASEB J, 2, 224, 10.1096/fasebj.2.3.3280376 · DOI · Paper page
  16. Cheng, 2003, De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase, J Biol Chem, 278, 38084, 10.1074/jbc.M307028200 · DOI · Paper page
  17. Cheng, 2004, Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase, Proc Natl Acad Sci U S A, 101, 7711, 10.1073/pnas.0402490101 · DOI · Paper page
  18. Al Mutair, 2012, Mutation of the CYP2R1 vitamin D 25-hydroxylase in a Saudi Arabian family with severe vitamin D deficiency, J Clin Endocrinol Metab, 97, E2022, 10.1210/jc.2012-1340 · DOI
  19. Zhu, 2013, CYP2R1 is a major, but not exclusive, contributor to 25-hydroxyvitamin D production in vivo, Proc Natl Acad Sci U S A, 110, 15650, 10.1073/pnas.1315006110 · DOI · Paper page
  20. Holick, 1971, Identification of 1,25-dihydroxycholecalciferol, a form of vitamin D3 metabolically active in the intestine, Proc Natl Acad Sci U S A, 68, 803, 10.1073/pnas.68.4.803 · DOI · Paper page
  21. Fu, 1997, Cloning of human 25-hydroxyvitamin D-1 alpha-hydroxylase and mutations causing vitamin D-dependent rickets type 1, Mol Endocrinol, 11, 1961
  22. Fraser, 1973, Pathogenesis of hereditary vitamin-D-dependent rickets. An inborn error of vitamin D metabolism involving defective conversion of 25-hydroxyvitamin D to 1 alpha,25-dihydroxyvitamin D, N Engl J Med, 289, 817, 10.1056/NEJM197310182891601 · DOI · Paper page
  23. Dardenne, 2001, Targeted inactivation of the 25-hydroxyvitamin D(3)-1(alpha)-hydroxylase gene (CYP27B1) creates an animal model of pseudovitamin D-deficiency rickets, Endocrinology, 142, 3135, 10.1210/endo.142.7.8281 · DOI · Paper page
  24. Garabedian, 1972, Control of 25-hydroxycholecalciferol metabolism by parathyroid glands, Proc Natl Acad Sci U S A, 69, 1673, 10.1073/pnas.69.7.1673 · DOI · Paper page
  25. Quarles, 2012, Skeletal secretion of FGF-23 regulates phosphate and vitamin D metabolism, Nat Rev Endocrinol, 8, 276, 10.1038/nrendo.2011.218 · DOI · Paper page
  26. Hu, 2013, Fibroblast growth factor 23 and Klotho: physiology and pathophysiology of an endocrine network of mineral metabolism, Annu Rev Physiol, 75, 503, 10.1146/annurev-physiol-030212-183727 · DOI · Paper page
  27. Jones, 2014, Cytochrome P450-mediated metabolism of vitamin D, J Lipid Res, 55, 13, 10.1194/jlr.R031534 · DOI · Paper page
  28. Shimada, 2004, FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis, J Bone Miner Res, 19, 429, 10.1359/JBMR.0301264 · DOI · Paper page
  29. Clinkenbeard, 2016, Systemic control of bone homeostasis by FGF23 signaling, Curr Mol Biol Rep, 2, 62, 10.1007/s40610-016-0035-5 · DOI
  30. Ajibade, 2010, Evidence for a role of prolactin in calcium homeostasis: regulation of intestinal transient receptor potential vanilloid type 6, intestinal calcium absorption, and the 25-hydroxyvitamin D(3) 1alpha hydroxylase gene by prolactin, Endocrinology, 151, 2974, 10.1210/en.2010-0033 · DOI
  31. Hewison, 2007, Extra-renal 25-hydroxyvitamin D3-1alpha-hydroxylase in human health and disease, J Steroid Biochem Mol Biol, 103, 316, 10.1016/j.jsbmb.2006.12.078 · DOI · Paper page
  32. Bikle, 1993, Vitamin D, calcium, and epidermal differentiation, Endocr Rev, 14, 3
  33. Bikle, 2010, Vitamin D and the skin, J Bone Miner Metab, 28, 117, 10.1007/s00774-009-0153-8 · DOI
  34. Omdahl, 2002, Hydroxylase enzymes of the vitamin D pathway: expression, function, and regulation, Annu Rev Nutr, 22, 139, 10.1146/annurev.nutr.22.120501.150216 · DOI · Paper page
  35. Veldurthy, 2016, 25-hydroxyvitamin D₃ 24-hydroxylase: a key regulator of 1,25(OH)₂D₃ catabolism and calcium homeostasis, Vitam Horm, 100, 137, 10.1016/bs.vh.2015.10.005 · DOI
  36. Christakos, 2016, Vitamin D: Metabolism, molecular mechanism of action, and pleiotropic effects, Physiol Rev, 96, 365, 10.1152/physrev.00014.2015 · DOI · Paper page
  37. St-Arnaud, 1999, Targeted inactivation of vitamin D hydroxylases in mice, Bone, 25, 127, 10.1016/S8756-3282(99)00118-0 · DOI
  38. St-Arnaud, 1998, 24,25-Dihydroxyvitamin D–active metabolite or inactive catabolite?, Endocrinology, 139, 3371, 10.1210/endo.139.8.6185 · DOI
  39. Schlingmann, 2011, Mutations in CYP24A1 and idiopathic infantile hypercalcemia, N Engl J Med, 365, 410, 10.1056/NEJMoa1103864 · DOI · Paper page
  40. Tebben, 2012, Hypercalcemia, hypercalciuria, and elevated calcitriol concentrations with autosomal dominant transmission due to CYP24A1 mutations: effects of ketoconazole therapy, J Clin Endocrinol Metab, 97, E423, 10.1210/jc.2011-1935 · DOI
  41. Streeten, 2011, CYP24A1 mutations in idiopathic infantile hypercalcemia, N Engl J Med, 365, 1741, 10.1056/NEJMc1110226 · DOI
  42. Dinour, 2013, Loss-of-function mutations of CYP24A1, the vitamin D 24-hydroxylase gene, cause long-standing hypercalciuric nephrolithiasis and nephrocalcinosis, J Urol, 190, 552
  43. Meyer, 2010, A downstream intergenic cluster of regulatory enhancers contributes to the induction of CYP24A1 expression by 1alpha,25-dihydroxyvitamin D3, J Biol Chem, 285, 15599, 10.1074/jbc.M110.119958 · DOI
  44. Gheldof, 2010, Cell-type-specific long-range looping interactions identify distant regulatory elements of the CFTR gene, Nucleic Acids Res, 38, 4325, 10.1093/nar/gkq175 · DOI
  45. Omdahl, 1978, Interaction of the parathyroid and 1,25-dihydroxyvitamin D3 in the control of renal 25-hydroxyvitamin D3 metabolism, J Biol Chem, 253, 8474, 10.1016/S0021-9258(17)34315-6 · DOI
  46. Martin, 2012, Regulation and function of the FGF23/klotho endocrine pathways, Physiol Rev, 92, 131, 10.1152/physrev.00002.2011 · DOI · Paper page
  47. DeLuca, 1990, The vitamin D system: 1990, Kidney Int Suppl, 29, S2
  48. Hoenderop, 2005, Calcium absorption across epithelia, Physiol Rev, 85, 373, 10.1152/physrev.00003.2004 · DOI · Paper page
  49. Amling, 1999, Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: formal histomorphometric and biomechanical analyses, Endocrinology, 140, 4982, 10.1210/endo.140.11.7110 · DOI · Paper page
  50. Masuyama, 2003, Dietary calcium and phosphorus ratio regulates bone mineralization and turnover in vitamin D receptor knockout mice by affecting intestinal calcium and phosphorus absorption, J Bone Miner Res, 18, 1217, 10.1359/jbmr.2003.18.7.1217 · DOI
  51. Hochberg, 1992, Calcium therapy for calcitriol-resistant rickets, J Pediatr, 121, 803, 10.1016/S0022-3476(05)81919-5 · DOI
  52. Benn, 2008, Active intestinal calcium transport in the absence of transient receptor potential vanilloid type 6 and calbindin-D9k, Endocrinology, 149, 3196, 10.1210/en.2007-1655 · DOI
  53. Kutuzova, 2006, Calbindin D(9k) knockout mice are indistinguishable from wild-type mice in phenotype and serum calcium level, Proc Natl Acad Sci U S A, 103, 12377, 10.1073/pnas.0605252103 · DOI
  54. Kutuzova, 2008, TRPV6 is not required for 1alpha,25-dihydroxyvitamin D3-induced intestinal calcium absorption in vivo, Proc Natl Acad Sci U S A, 105, 19655, 10.1073/pnas.0810761105 · DOI
  55. Cui, 2012, Villin promoter-mediated transgenic expression of transient receptor potential cation channel, subfamily V, member 6 (TRPV6) increases intestinal calcium absorption in wild-type and vitamin D receptor knockout mice, J Bone Miner Res, 27, 2097, 10.1002/jbmr.1662 · DOI
  56. Lee, 2015, 1,25-Dihydroxyvitamin D3 controls a cohort of vitamin D receptor target genes in the proximal intestine that is enriched for calcium-regulating components, J Biol Chem, 290, 18199, 10.1074/jbc.M115.665794 · DOI
  57. Wasserman, 2004, Vitamin D and the dual processes of intestinal calcium absorption, J Nutr, 134, 3137
  58. Reyes-Fernandez, 2016, Compensatory changes in calcium metabolism accompany the loss of vitamin D receptor (VDR) from the distal intestine and kidney of mice, J Bone Miner Res, 31, 143, 10.1002/jbmr.2600 · DOI
  59. Christakos, 2013, Vitamin D biology revealed through the study of knockout and transgenic mouse models, Annu Rev Nutr, 33, 71, 10.1146/annurev-nutr-071812-161249 · DOI
  60. Xiong, 2011, Matrix-embedded cells control osteoclast formation, Nat Med, 17, 1235, 10.1038/nm.2448 · DOI · Paper page
  61. Kim, 2006, Activation of receptor activator of NF-kappaB ligand gene expression by 1,25-dihydroxyvitamin D3 is mediated through multiple long-range enhancers, Mol Cell Biol, 26, 6469, 10.1128/MCB.00353-06 · DOI
  62. Lieben, 2012, Normocalcemia is maintained in mice under conditions of calcium malabsorption by vitamin D-induced inhibition of bone mineralization, J Clin Invest, 122, 1803, 10.1172/JCI45890 · DOI · Paper page
  63. Bonewald, 2007, Osteocytes as dynamic multifunctional cells, Ann N Y Acad Sci, 1116, 281, 10.1196/annals.1402.018 · DOI · Paper page
  64. Murali, 2016, Excessive osteocytic Fgf23 secretion contributes to pyrophosphate accumulation and mineralization defect in hyp mice, PLoS Biol, 14, e1002427, 10.1371/journal.pbio.1002427 · DOI
  65. Shimada, 2001, Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia, Proc Natl Acad Sci U S A, 98, 6500, 10.1073/pnas.101545198 · DOI · Paper page
  66. Yu, 2005, Genetic dissection of phosphate- and vitamin D-mediated regulation of circulating Fgf23 concentrations, Bone, 36, 971, 10.1016/j.bone.2005.03.002 · DOI
  67. Yu, 2005, FGF23 and disorders of phosphate homeostasis, Cytokine Growth Factor Rev, 16, 221, 10.1016/j.cytogfr.2005.01.002 · DOI
  68. Zinser, 2002, Vitamin D(3) receptor ablation sensitizes skin to chemically induced tumorigenesis, Carcinogenesis, 23, 2103, 10.1093/carcin/23.12.2103 · DOI
  69. Zinser, 2004, Effect of vitamin D3 receptor ablation on murine mammary gland development and tumorigenesis, J Steroid Biochem Mol Biol, 89-90, 433, 10.1016/j.jsbmb.2004.03.012 · DOI
  70. Xiang, 2005, Cardiac hypertrophy in vitamin D receptor knockout mice: role of the systemic and cardiac renin-angiotensin systems, Am J Physiol Endocrinol Metab, 288, E125, 10.1152/ajpendo.00224.2004 · DOI · Paper page
  71. Froicu, 2003, A crucial role for the vitamin D receptor in experimental inflammatory bowel diseases, Mol Endocrinol, 17, 2386, 10.1210/me.2003-0281 · DOI · Paper page
  72. Cantorna, 2010, Mechanisms underlying the effect of vitamin D on the immune system, Proc Nutr Soc, 69, 286, 10.1017/S0029665110001722 · DOI
  73. Haussler, 1968, The association of a metabolite of vitamin D3 with intestinal mucosa chromatin in vivo, J Biol Chem, 243, 4055, 10.1016/S0021-9258(18)93278-3 · DOI
  74. Burmester, 1988, Isolation and expression of rat 1,25-dihydroxyvitamin D3 receptor cDNA, Proc Natl Acad Sci U S A, 85, 1005, 10.1073/pnas.85.4.1005 · DOI
  75. Jin, 1996, Transcriptional activation and dimerization functions in the human vitamin D receptor, Mol Endocrinol, 10, 945
  76. McDonnell, 1989, Functional domains of the human vitamin D3 receptor regulate osteocalcin gene expression, Mol Endocrinol, 3, 635, 10.1210/mend-3-4-635 · DOI
  77. Hughes, 1988, Point mutations in the human vitamin D receptor gene associated with hypocalcemic rickets, Science, 242, 1702, 10.1126/science.2849209 · DOI · Paper page
  78. Miyamoto, 1997, Structural organization of the human vitamin D receptor chromosomal gene and its promoter, Mol Endocrinol, 11, 1165, 10.1210/mend.11.8.9951 · DOI · Paper page
  79. Hughes, 1991, Genetic defects of the 1,25-dihydroxyvitamin D3 receptor, J Recept Res, 11, 699
  80. Malloy, 1990, The molecular basis of hereditary 1,25-dihydroxyvitamin D3 resistant rickets in seven related families, J Clin Invest, 86, 2071, 10.1172/JCI114944 · DOI
  81. Ritchie, 1989, An ochre mutation in the vitamin D receptor gene causes hereditary 1,25-dihydroxyvitamin D3-resistant rickets in three families, Proc Natl Acad Sci U S A, 86, 9783, 10.1073/pnas.86.24.9783 · DOI
  82. Sone, 1989, Mutant vitamin D receptors which confer hereditary resistance to 1,25-dihydroxyvitamin D3 in humans are transcriptionally inactive in vitro, J Biol Chem, 264, 20230, 10.1016/S0021-9258(19)47051-8 · DOI
  83. Brooks, 1978, Vitamin-D-dependent rickets type II. Resistance of target organs to 1,25-dihydroxyvitamin D, N Engl J Med, 298, 996, 10.1056/NEJM197805042981804 · DOI · Paper page
  84. Eil, 1981, A cellular defect in hereditary vitamin-D-dependent rickets type II: defective nuclear uptake of 1,25-dihydroxyvitamin D in cultured skin fibroblasts, N Engl J Med, 304, 1588, 10.1056/NEJM198106253042608 · DOI
  85. Pike, 1984, Vitamin D3–resistant fibroblasts have immunoassayable 1,25-dihydroxyvitamin D3 receptors, Science, 224, 879, 10.1126/science.6326262 · DOI
  86. Sone, 1990, A unique point mutation in the human vitamin D receptor chromosomal gene confers hereditary resistance to 1,25-dihydroxyvitamin D3, Mol Endocrinol, 4, 623, 10.1210/mend-4-4-623 · DOI
  87. Lin, 1996, A novel mutation in the deoxyribonucleic acid-binding domain of the vitamin D receptor causes hereditary 1,25-dihydroxyvitamin D-resistant rickets, J Clin Endocrinol Metab, 81, 2564
  88. Malloy, 2014, Vitamin D receptor mutations in patients with hereditary 1,25-dihydroxyvitamin D-resistant rickets, Mol Genet Metab, 111, 33, 10.1016/j.ymgme.2013.10.014 · DOI
  89. Christakos, 1989, Vitamin D-dependent calcium binding proteins: chemistry, distribution, functional considerations, and molecular biology, Endocr Rev, 10, 3, 10.1210/edrv-10-1-3 · DOI · Paper page
  90. Gill, 1993, Identification of sequence elements in mouse calbindin-D28k gene that confer 1,25-dihydroxyvitamin D3- and butyrate-inducible responses, Proc Natl Acad Sci U S A, 90, 2984, 10.1073/pnas.90.7.2984 · DOI
  91. Price, 1980, 1,25-Dihydroxyvitamin D3 increases synthesis of the vitamin K-dependent bone protein by osteosarcoma cells, J Biol Chem, 255, 11660, 10.1016/S0021-9258(19)70182-3 · DOI · Paper page
  92. Lian, 1989, Osteocalcin: characterization and regulated expression of the rat gene, Connect Tissue Res, 21, 61, 10.3109/03008208909049996 · DOI
  93. Prince, 1987, 1,25-Dihydroxyvitamin D3 regulates the biosynthesis of osteopontin, a bone-derived cell attachment protein, in clonal osteoblast-like osteosarcoma cells, Coll Relat Res, 7, 305, 10.1016/S0174-173X(87)80036-5 · DOI
  94. Haussler, 1980, Physiological importance of vitamin D metabolism, Prog Biochem Pharmacol, 17, 134
  95. Kerner, 1989, Sequence elements in the human osteocalcin gene confer basal activation and inducible response to hormonal vitamin D3, Proc Natl Acad Sci U S A, 86, 4455, 10.1073/pnas.86.12.4455 · DOI · Paper page
  96. Ozono, 1990, The vitamin D-responsive element in the human osteocalcin gene. Association with a nuclear proto-oncogene enhancer, J Biol Chem, 265, 21881, 10.1016/S0021-9258(18)45821-8 · DOI · Paper page
  97. Noda, 1990, Identification of a DNA sequence responsible for binding of the 1,25-dihydroxyvitamin D3 receptor and 1,25-dihydroxyvitamin D3 enhancement of mouse secreted phosphoprotein 1 (SPP-1 or osteopontin) gene expression, Proc Natl Acad Sci U S A, 87, 9995, 10.1073/pnas.87.24.9995 · DOI · Paper page
  98. Ohyama, 1994, Identification of a vitamin D-responsive element in the 5'-flanking region of the rat 25-hydroxyvitamin D3 24-hydroxylase gene, J Biol Chem, 269, 10545, 10.1016/S0021-9258(17)34094-2 · DOI
  99. Ohyama, 1996, Functional assessment of two vitamin D-responsive elements in the rat 25-hydroxyvitamin D3 24-hydroxylase gene, J Biol Chem, 271, 30381, 10.1074/jbc.271.48.30381 · DOI
  100. Zierold, 1994, Identification of a vitamin D-response element in the rat calcidiol (25-hydroxyvitamin D3) 24-hydroxylase gene, Proc Natl Acad Sci U S A, 91, 900, 10.1073/pnas.91.3.900 · DOI
  101. Zierold, 1995, Two vitamin D response elements function in the rat 1,25-dihydroxyvitamin D 24-hydroxylase promoter, J Biol Chem, 270, 1675, 10.1074/jbc.270.4.1675 · DOI
  102. Carlberg, 2003, Molecular basis of the selective activity of vitamin D analogues, J Cell Biochem, 88, 274, 10.1002/jcb.10337 · DOI
  103. Joshi, 2011, 1,25-dihydroxyvitamin D(3) ameliorates Th17 autoimmunity via transcriptional modulation of interleukin-17A, Mol Cell Biol, 31, 3653, 10.1128/MCB.05020-11 · DOI · Paper page
  104. Demay, 1992, Sequences in the human parathyroid hormone gene that bind the 1,25-dihydroxyvitamin D3 receptor and mediate transcriptional repression in response to 1,25-dihydroxyvitamin D3, Proc Natl Acad Sci U S A, 89, 8097, 10.1073/pnas.89.17.8097 · DOI · Paper page
  105. Liao, 1990, Vitamin D receptor interaction with specific DNA requires a nuclear protein and 1,25-dihydroxyvitamin D3, Proc Natl Acad Sci U S A, 87, 9751, 10.1073/pnas.87.24.9751 · DOI
  106. Sone, 1991, A 55-kilodalton accessory factor facilitates vitamin D receptor DNA binding, Mol Endocrinol, 5, 1578, 10.1210/mend-5-11-1578 · DOI
  107. Sone, 1991, Vitamin D receptor interaction with specific DNA. Association as a 1,25-dihydroxyvitamin D3-modulated heterodimer, J Biol Chem, 266, 23296, 10.1016/S0021-9258(18)54496-3 · DOI
  108. Mangelsdorf, 1995, The RXR heterodimers and orphan receptors, Cell, 83, 841, 10.1016/0092-8674(95)90200-7 · DOI · Paper page
  109. Kliewer, 1992, Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling, Nature, 355, 446, 10.1038/355446a0 · DOI · Paper page
  110. Thompson, 2001, Distinct retinoid X receptor activation function-2 residues mediate transactivation in homodimeric and vitamin D receptor heterodimeric contexts, J Mol Endocrinol, 27, 211, 10.1677/jme.0.0270211 · DOI
  111. Pathrose, 2002, Inhibition of 1,25-dihydroxyvitamin D3-dependent transcription by synthetic LXXLL peptide antagonists that target the activation domains of the vitamin D and retinoid X receptors, J Bone Miner Res, 17, 2196, 10.1359/jbmr.2002.17.12.2196 · DOI
  112. Orlov, 2012, Structure of the full human RXR/VDR nuclear receptor heterodimer complex with its DR3 target DNA, EMBO J, 31, 291, 10.1038/emboj.2011.445 · DOI
  113. Carlson, 1994, The SNF/SWI family of global transcriptional activators, Curr Opin Cell Biol, 6, 396, 10.1016/0955-0674(94)90032-9 · DOI · Paper page
  114. Smith, 2004, Coregulator function: a key to understanding tissue specificity of selective receptor modulators, Endocr Rev, 25, 45, 10.1210/er.2003-0023 · DOI · Paper page
  115. Rachez, 2000, Mechanisms of gene regulation by vitamin D(3) receptor: a network of coactivator interactions, Gene, 246, 9, 10.1016/S0378-1119(00)00052-4 · DOI · Paper page
  116. Lewis, 2003, The mediator coactivator complex: functional and physical roles in transcriptional regulation, J Cell Sci, 116, 3667, 10.1242/jcs.00734 · DOI
  117. Xie, 2013, Epigenomic analysis of multilineage differentiation of human embryonic stem cells, Cell, 153, 1134, 10.1016/j.cell.2013.04.022 · DOI · Paper page
  118. McInerney, 1998, Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation, Genes Dev, 12, 3357, 10.1101/gad.12.21.3357 · DOI · Paper page
  119. Perissi, 1999, Molecular determinants of nuclear receptor-corepressor interaction, Genes Dev, 13, 3198, 10.1101/gad.13.24.3198 · DOI · Paper page
  120. Westin, 1998, Interactions controlling the assembly of nuclear-receptor heterodimers and co-activators, Nature, 395, 199, 10.1038/26040 · DOI · Paper page
  121. Zella, 2010, Multifunctional enhancers regulate mouse and human vitamin D receptor gene transcription, Mol Endocrinol, 24, 128, 10.1210/me.2009-0140 · DOI
  122. Meyer, 2007, Characterizing early events associated with the activation of target genes by 1,25-dihydroxyvitamin D3 in mouse kidney and intestine in vivo, J Biol Chem, 282, 22344, 10.1074/jbc.M703475200 · DOI
  123. Martowicz, 2011, The mouse RANKL gene locus is defined by a broad pattern of histone H4 acetylation and regulated through distinct distal enhancers, J Cell Biochem, 112, 2030, 10.1002/jcb.23123 · DOI
  124. Hoffman, 2013, Integrative annotation of chromatin elements from ENCODE data, Nucleic Acids Res, 41, 827, 10.1093/nar/gks1284 · DOI · Paper page
  125. Ernst, 2010, Discovery and characterization of chromatin states for systematic annotation of the human genome, Nat Biotechnol, 28, 817, 10.1038/nbt.1662 · DOI · Paper page
  126. Kellis, 2014, Defining functional DNA elements in the human genome, Proc Natl Acad Sci U S A, 111, 6131, 10.1073/pnas.1318948111 · DOI · Paper page
  127. Stamatoyannopoulos, 2012, What does our genome encode?, Genome Res, 22, 1602, 10.1101/gr.146506.112 · DOI
  128. Maurano, 2015, Role of DNA methylation in modulating transcription factor occupancy, Cell Rep, 12, 1184, 10.1016/j.celrep.2015.07.024 · DOI · Paper page
  129. Hille, 2016, CRISPR-Cas: biology, mechanisms and relevance, Philos Trans R Soc Lond B Biol Sci, 371, 10.1098/rstb.2015.0496 · DOI · Paper page
  130. Singh, 2016, CRISPR/Cas9: a historical and chemical biology perspective of targeted genome engineering, Chem Soc Rev, 45, 6666, 10.1039/C6CS00197A · DOI
  131. Kim, 2005, 1,25-Dihydroxyvitamin D3 stimulates cyclic vitamin D receptor/retinoid X receptor DNA-binding, co-activator recruitment, and histone acetylation in intact osteoblasts, J Bone Miner Res, 20, 305, 10.1359/JBMR.041112 · DOI
  132. Meyer, 2010, Genome-wide analysis of the VDR/RXR cistrome in osteoblast cells provides new mechanistic insight into the actions of the vitamin D hormone, J Steroid Biochem Mol Biol, 121, 136, 10.1016/j.jsbmb.2010.02.011 · DOI
  133. Meyer, 2014, Genomic determinants of gene regulation by 1,25-dihydroxyvitamin D3 during osteoblast-lineage cell differentiation, J Biol Chem, 289, 19539, 10.1074/jbc.M114.578104 · DOI
  134. Meyer, 2016, Epigenetic plasticity drives adipogenic and osteogenic differentiation of marrow-derived mesenchymal stem cells, J Biol Chem, 291, 17829, 10.1074/jbc.M116.736538 · DOI
  135. Ramagopalan, 2010, A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution, Genome Res, 20, 1352, 10.1101/gr.107920.110 · DOI · Paper page
  136. Heikkinen, 2011, Nuclear hormone 1α,25-dihydroxyvitamin D3 elicits a genome-wide shift in the locations of VDR chromatin occupancy, Nucleic Acids Res, 39, 9181, 10.1093/nar/gkr654 · DOI
  137. Meyer, 2012, VDR/RXR and TCF4/β-catenin cistromes in colonic cells of colorectal tumor origin: impact on c-FOS and c-MYC gene expression, Mol Endocrinol, 26, 37, 10.1210/me.2011-1109 · DOI
  138. Lee, 2015, Mechanisms of enhancer-mediated hormonal control of vitamin D receptor gene expression in target cells, J Biol Chem, 290, 30573, 10.1074/jbc.M115.693614 · DOI
  139. Meyer, 2006, The human transient receptor potential vanilloid type 6 distal promoter contains multiple vitamin D receptor binding sites that mediate activation by 1,25-dihydroxyvitamin D3 in intestinal cells, Mol Endocrinol, 20, 1447, 10.1210/me.2006-0031 · DOI
  140. Deng, 2010, Do chromatin loops provide epigenetic gene expression states?, Curr Opin Genet Dev, 20, 548, 10.1016/j.gde.2010.06.007 · DOI
  141. Deng, 2014, Manipulating nuclear architecture, Curr Opin Genet Dev, 25, 1, 10.1016/j.gde.2013.10.014 · DOI
  142. Deng, 2017, Detecting long-range enhancer-promoter interactions by quantitative chromosome conformation capture, Methods Mol Biol, 1468, 51, 10.1007/978-1-4939-4035-6_6 · DOI
  143. Meyer, 2014, The RUNX2 cistrome in osteoblasts: characterization, down-regulation following differentiation, and relationship to gene expression, J Biol Chem, 289, 16016, 10.1074/jbc.M114.552216 · DOI
  144. Meyer, 2015, Selective distal enhancer control of the Mmp13 gene identified through clustered regularly interspaced short palindromic repeat (CRISPR) genomic deletions, J Biol Chem, 290, 11093, 10.1074/jbc.M115.648394 · DOI
  145. Meyer, 2015, Selective regulation of Mmp13 by 1,25(OH)2D3, PTH, and Osterix through distal enhancers, J Steroid Biochem Mol Biol
  146. Meyer, 2013, Corepressors (NCoR and SMRT) as well as coactivators are recruited to positively regulated 1α,25-dihydroxyvitamin D3-responsive genes, J Steroid Biochem Mol Biol, 136, 120, 10.1016/j.jsbmb.2012.08.006 · DOI
  147. Seth-Vollenweider, 2014, Novel mechanism of negative regulation of 1,25-dihydroxyvitamin D3-induced 25-hydroxyvitamin D3 24-hydroxylase (Cyp24a1) Transcription: epigenetic modification involving cross-talk between protein-arginine methyltransferase 5 and the SWI/SNF complex, J Biol Chem, 289, 33958, 10.1074/jbc.M114.583302 · DOI
  148. Meyer, 2015, Profiling histone modifications by chromatin immunoprecipitation coupled to deep sequencing in skeletal cells, Methods Mol Biol, 1226, 61, 10.1007/978-1-4939-1619-1_6 · DOI
  149. Pike, 2015, Epigenetic histone modifications and master regulators as determinants of context dependent nuclear receptor activity in bone cells, Bone, 81, 757, 10.1016/j.bone.2015.03.012 · DOI
  150. Pike, 2014, Regulation of gene expression by 1,25-dihydroxyvitamin D3 in bone cells: exploiting new approaches and defining new mechanisms, Bonekey Rep, 3, 482, 10.1038/bonekey.2013.216 · DOI
  151. Ong, 2008, Modulation of CTCF insulator function by transcription of a noncoding RNA, Dev Cell, 15, 489, 10.1016/j.devcel.2008.09.013 · DOI
  152. Denker, 2015, A long-distance chromatin affair, Cell, 162, 942, 10.1016/j.cell.2015.08.022 · DOI
  153. Denker, 2016, The second decade of 3C technologies: detailed insights into nuclear organization, Genes Dev, 30, 1357, 10.1101/gad.281964.116 · DOI · Paper page
  154. Galli, 2008, Targeted deletion of a distant transcriptional enhancer of the receptor activator of nuclear factor-kappaB ligand gene reduces bone remodeling and increases bone mass, Endocrinology, 149, 146, 10.1210/en.2007-0734 · DOI
  155. Suda, 1999, Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families, Endocr Rev, 20, 345, 10.1210/edrv.20.3.0367 · DOI · Paper page
  156. Lacey, 1998, Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation, Cell, 93, 165, 10.1016/S0092-8674(00)81569-X · DOI · Paper page
  157. Kitazawa, 2002, Vitamin D(3) augments osteoclastogenesis via vitamin D-responsive element of mouse RANKL gene promoter, Biochem Biophys Res Commun, 290, 650, 10.1006/bbrc.2001.6251 · DOI
  158. Kitazawa, 2003, Vitamin D3 supports osteoclastogenesis via functional vitamin D response element of human RANKL gene promoter, J Cell Biochem, 89, 771, 10.1002/jcb.10567 · DOI
  159. Bishop, 2011, Mouse Rankl expression is regulated in T cells by c-Fos through a cluster of distal regulatory enhancers designated the T cell control region, J Biol Chem, 286, 20880, 10.1074/jbc.M111.231548 · DOI
  160. Bishop, 2015, Transcriptional regulation of the human TNFSF11 gene in T cells via a cell type-selective set of distal enhancers, J Cell Biochem, 116, 320, 10.1002/jcb.24974 · DOI
  161. Onal, 2016, Deletion of the distal Tnfsf11 RL-D2 enhancer that contributes to PTH-mediated RANKL expression in osteoblast lineage cells results in a high bone mass phenotype in mice, J Bone Miner Res, 31, 416, 10.1002/jbmr.2698 · DOI
  162. Onal, 2016, Unique distal enhancers linked to the mouse Tnfsf11 gene direct tissue-specific and inflammation-induced expression of RANKL, Endocrinology, 157, 482, 10.1210/en.2015-1788 · DOI
  163. Selvamurugan, 2006, Overexpression of Runx2 directed by the matrix metalloproteinase-13 promoter containing the AP-1 and Runx/RD/Cbfa sites alters bone remodeling in vivo, J Cell Biochem, 99, 545, 10.1002/jcb.20878 · DOI
  164. Shimizu, 2007, Parathyroid hormone regulates histone deacetylases in osteoblasts, Ann N Y Acad Sci, 1116, 349, 10.1196/annals.1402.037 · DOI
  165. Shimizu, 2014, Parathyroid hormone regulates histone deacetylase (HDAC) 4 through protein kinase A-mediated phosphorylation and dephosphorylation in osteoblastic cells, J Biol Chem, 289, 21340, 10.1074/jbc.M114.550699 · DOI

Cited by

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Metadata

Authors
Pike, J. W., & Christakos, S.
Venue
Endocrinology and Metabolism Clinics of North America
Publisher
Elsevier BV
Published
2017-12
Volume
46
Issue
4
Pages
815-843
ISSN
0889-8529
DOI
10.1016/j.ecl.2017.07.001
Cited by
247
References
19
Language
en
Licence
  • www.elsevier.com/tdm/userlicense/1.0/ (tdm)
  • www.elsevier.com/legal/tdmrep-license (tdm)
Funders
NIH

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