Cutaneous biocompatible rutin-loaded gelatin-based nanoparticles increase the SPF of the association of UVA and UVB filters
Abstract
The encapsulation of natural ingredients, such as rutin, can offer improvements in sun protection effectiveness. This strategy can provide enhanced flavonoid content and produces an improved bioactive compound with new physical and functional characteristics. As an alternative to common synthetic-based sunscreens, rutin-entrapped gelatin nanoparticles (GNPs) were designed and associated with ethylhexyl dimethyl PABA (EHDP), ethylhexyl methoxycinnamate (EHMC) and methoxydibenzoylmethane (BMDBM) in sunscreen formulations. The purpose of this study was to develop rutin-loaded gelatin nanoparticles and characterize their physicochemical, thermal, functional and safety properties. Rutin-loaded gelatin nanoparticles increased antioxidant activity by 74% relative to free-rutin (FR) solution. Also, this new ingredient upgraded the Sun Protection Factor (SPF) by 48%, indicating its potential as a raw material for bioactive sunscreens. The safety profile indicated that GNPs and glutaraldehyde (GTA) decreased HaCaT cell viability in a concentration/time-dependent manner. However, both blank nanoparticles (B-NC) and rutin-loaded nanoparticles (R-NC) had good performance on skin compatibility tests. These results functionally characterized rutin-loaded nanoparticles as a safe SPF enhancer in sunscreens, especially in association with UV filters.
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Gelatine micro- and nano-spheres improve skin compatibility, safety, and efficacy.
“Additionally, gelatine micro- and nano-spheres improved skin compatibility, safety, and efficacy [41,42,43] and alginate microparticles influenced photostability, through the reduction of the EHMC’s (21) photoisomerisation [34].”
From UV Filters: Challenges and Prospects (2022) · cites this paper as [43]
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Self-citation
- Authors
- Oliveira, C. A. D., Peres, D. D., Graziola, F., Chacra, N. A. B., Araújo, G. L. B. D., Flórido, A. C., Mota, J., Rosado, C., Velasco, M. V. R., Rodrigues, L. M., Fernandes, A. S., & Baby, A. R.
- Affiliations
- Universidade de São Paulo (BR)
- Universidade Lusófona (PT)
- Corresponding author
- Oliveira, Camila Areias de
- ORCID
- Venue
- European Journal of Pharmaceutical Sciences
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 81
- Pages
- 1-9
- ISSN
- 0928-0987 (ISSN-L)
- OpenAlex
- W1823242841
- Cited by
- 118
- References
- 46
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 5 · 2023: 15 · 2022: 8 · 2021: 12 · 2020: 14 · 2019: 11 · 2018: 13 · 2017: 17 · 2016: 8 · 2015: 1
- FWCI
- 14.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmaceutical Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo (14/05906-0, 12/19972-0, 12/04435-9)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Agricultural and Biological Sciences › Food Science › Microencapsulation and Drying Processes
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Keywords
- rutin, gelatin nanoparticles, sunscreen, sun protection factor, UV filters, UVA and UVB protection, antioxidant activity, flavonoids, skin compatibility, HaCaT keratinocytes, glutaraldehyde crosslinking, biocompatible nanoparticles, natural sunscreen ingredients
- MeSH terms
- Administration, Cutaneous, Alkanes, Cell Line, Cell Survival, Cinnamates, Drug Stability, Female, Gelatin, Glutaral, Humans, Male, Patch Tests, Propiophenones, Rutin, Sunscreening Agents, Ultraviolet Rays, Chalcones, Nanoparticles, para-Aminobenzoates
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