Cited by 85Cell death mechanisms and regulationT-cell and B-cell ImmunologyGenetics, Aging, and Longevity in Model Organisms

Molecular mechanisms of apoptosis in the cells of the immune system in human aging

Gupta, Sudhir·2005·Immunological Reviews

Abstract

Aging is associated with progressive decline in immune functions and increased frequency of infections, autoimmunity, and cancer. Among immune functions, a decline in T-cell functions during aging predominates. In this review, I discuss the molecular signaling of three distinct pathways of apoptosis, namely the death receptor pathway, the mitochondrial pathway, and the most recently described endoplasmic reticulum stress pathway, and the relative sensitivity of naive, central memory, and effector memory CD8(+) T-cell subsets to apoptosis. In addition, I review apoptosis, especially via death receptor pathway, in naive and various memory subsets of CD4(+) and CD8(+) T cells (with primary emphasis on CD8(+) naive and memory subsets) in human aging and discuss the role of apoptosis in immune senescence.

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Crossref · 10.1111/j.0105-2896.2005.00261.x

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147 of 147 references verified0 citation errors · 0 not checkable

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  • Increased apoptosis is implicated in the age-related reduction of T-cell subtypes in the human immune system (T-cell lymphopenia), including both CD4+ and CD8+ T-cells.

    “Increased apoptosis is implicated in the age-related reduction of T-cell subtypes in the human immune system (T-cell lymphopenia), including both CD4+ and CD8+ T-cells (Gupta, 2005).”

    From Programmed cell death in aging (2015) · cites this paper as Gupta, 2005

  • Some cell types are characterized by increased PCD during aging.

    “Some cell types are characterized by increased PCD during aging.”

    From Programmed cell death in aging (2015) · cites this paper as Gupta, 2005

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Authors
Gupta, S.
Affiliations
University of California, Irvine (US)
Corresponding author
Gupta, Sudhir
Venue
Immunological Reviews
Publisher
Wiley
Published
2005-05-09
Volume
205
Issue
1
Pages
114-129
ISSN
  • 0105-2896 (ISSN-L)
  • 1600-065X
OpenAlex
W2029217347
Cited by
85
References
147
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 6 · 2018: 6 · 2017: 3 · 2016: 2 · 2015: 5 · 2014: 3 · 2013: 6 · 2012: 1
FWCI
0.70
Type
journal article
Language
en
Open access
closed
Locations
  • Immunological Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Aging (AG-18313, R01AG018313)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords
apoptosis, immunosenescence, death receptor signaling, mitochondrial pathway, endoplasmic reticulum stress, CD8+ T cells, CD4+ T cells, memory T cells, naive T cells
MeSH terms
Aging, Animals, Humans, Immunologic Memory, T-Lymphocytes, Organelles, Signal Transduction, Apoptosis

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