Molecular mechanisms of apoptosis in the cells of the immune system in human aging
Abstract
Aging is associated with progressive decline in immune functions and increased frequency of infections, autoimmunity, and cancer. Among immune functions, a decline in T-cell functions during aging predominates. In this review, I discuss the molecular signaling of three distinct pathways of apoptosis, namely the death receptor pathway, the mitochondrial pathway, and the most recently described endoplasmic reticulum stress pathway, and the relative sensitivity of naive, central memory, and effector memory CD8(+) T-cell subsets to apoptosis. In addition, I review apoptosis, especially via death receptor pathway, in naive and various memory subsets of CD4(+) and CD8(+) T cells (with primary emphasis on CD8(+) naive and memory subsets) in human aging and discuss the role of apoptosis in immune senescence.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Increased apoptosis is implicated in the age-related reduction of T-cell subtypes in the human immune system (T-cell lymphopenia), including both CD4+ and CD8+ T-cells.
“Increased apoptosis is implicated in the age-related reduction of T-cell subtypes in the human immune system (T-cell lymphopenia), including both CD4+ and CD8+ T-cells (Gupta, 2005).”
From Programmed cell death in aging (2015) · cites this paper as Gupta, 2005
Some cell types are characterized by increased PCD during aging.
“Some cell types are characterized by increased PCD during aging.”
From Programmed cell death in aging (2015) · cites this paper as Gupta, 2005
Cites
Hengartner, M. O. (2000) · Nature · doi:10.1038/35037710 · Cited by 7,295 · see citing works
THE NF-κB AND IκB PROTEINS: New Discoveries and Insights
Baldwin, A. S. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.649 · Cited by 5,882 · see citing works
Death Receptors: Signaling and Modulation
Ashkenazi, A., & Dixit, V. M. (1998) · Science · doi:10.1126/science.281.5381.1305 · Cited by 5,866 · see citing works
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846 · see citing works
NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses
Ghosh, S., May, M. J., & Kopp, E. B. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.225 · Cited by 5,182 · see citing works
Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis
Li, H., Zhu, H., Xu, C.-J., & Yuan, J. (1998) · Cell · doi:10.1016/s0092-8674(00)81590-1 · Cited by 4,445 · see citing works
Activators and target genes of Rel/NF-κB transcription factors
Pahl, H. L. (1999) · Oncogene · doi:10.1038/sj.onc.1203239 · Cited by 3,727 · see citing works
The TNF and TNF Receptor Superfamilies
Locksley, R. M., Killeen, N., & Lenardo, M. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00237-9 · Cited by 3,650 · see citing works
Missing Pieces in the NF-κB Puzzle
Ghosh, S., & Karin, M. (2002) · Cell · doi:10.1016/s0092-8674(02)00703-1 · Cited by 3,638 · see citing works
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β
Nakagawa, T., Zhu, H., Morishima, N., Li, E., Xu, J., Yankner, B. A., & Yuan, J. (2000) · Nature · doi:10.1038/47513 · Cited by 3,262 · see citing works
Activators and Target Genes of Rel/NF-кB Transcription Factors
Loop, T., & Pahl, H. L. (2003) · Springer eBooks · doi:10.1007/978-94-010-0163-2_1 · Cited by 3,179 · see citing works
Mitochondrial control of cell death
Kroemer, G., & Reed, J. C. (2000) · Nature Medicine · doi:10.1038/74994 · Cited by 3,103 · see citing works
Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance
Sallusto, F., Geginat, J., & Lanzavecchia, A. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104702 · Cited by 3,067 · see citing works
An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death
Beg, A. A., & Baltimore, D. (1996) · Science · doi:10.1126/science.274.5288.782 · Cited by 3,047 · see citing works
Two CD95 (APO‐1/Fas) signaling pathways
Scaffidi, C., Fulda, S., Srinivasan, A., Friesen, C., Li, F., Tomaselli, K. J., Debatin, K., Krammer, P. H., & Peter, M. E. (1998) · The EMBO Journal · doi:10.1093/emboj/17.6.1675 · Cited by 3,000 · see citing works
Regulation of cell death: the calcium–apoptosis link
Orrenius, S., Zhivotovsky, B., & Nicotera, P. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1150 · Cited by 2,990 · see citing works
NF-κB at the crossroads of life and death
Karin, M., & Lin, A. (2002) · Nature Immunology · doi:10.1038/ni0302-221 · Cited by 2,709 · see citing works
TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function
Rao, A., Luo, C. H., & Hogan, P. G. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.707 · Cited by 2,605 · see citing works
Inhibition of death receptor signals by cellular FLIP
Irmler, M., Thome, M., Hahne, M., Schneider, P., Hofmann, K., Steiner, V., Bodmer, J.-L., Schröter, M., Burns, K., Mattmann, C., et al. (1997) · Nature · doi:10.1038/40657 · Cited by 2,548 · see citing works
Ichijo, H., Nishida, E., Irie, K., ten Dijke, P., Saitoh, M., Moriguchi, T., Takagi, M., Matsumoto, K., Miyazono, K., & Gotoh, Y. (1997) · Science · doi:10.1126/science.275.5296.90 · Cited by 2,310 · see citing works
Hsu, H., Shu, H., Pan, M., & Goeddel, D. V. (1996) · Cell · doi:10.1016/s0092-8674(00)80984-8 · Cited by 1,998 · see citing works
Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue
Masopust, D., Vezys, V., Marzo, A. L., & Lefrançois, L. (2001) · Science · doi:10.1126/science.1058867 · Cited by 1,952 · see citing works
Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)
Dhein, J., Walczak, H., Bäumler, C., Debatin, K., & Krammer, P. (1995) · Nature · doi:10.1038/373438a0 · Cited by 1,814 · see citing works
Endonuclease G is an apoptotic DNase when released from mitochondria
Li, L. Y., Luo, X., & Wang, X. (2001) · Nature · doi:10.1038/35083620 · Cited by 1,787 · see citing works
IAP proteins: blocking the road to death's door
Salvesen, G. S., & Duckett, C. S. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm830 · Cited by 1,756 · see citing works
CD95's deadly mission in the immune system
Krammer, P. H. (2000) · Nature · doi:10.1038/35037728 · Cited by 1,710 · see citing works
Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation
Ju, S., Panka, D., Cui, H., Ettinger, R., EI-Khatib, M., Sherr, D., Stanger, B., & Marshak-Rothstein, A. (1995) · Nature · doi:10.1038/373444a0 · Cited by 1,709 · see citing works
Double identity for proteins of the Bcl-2 family
Reed, J. C. (1997) · Nature · doi:10.1038/42867 · Cited by 1,494 · see citing works
Organelle-specific initiation of cell death pathways
Ferri, K. F., & Kroemer, G. (2001) · Nature Cell Biology · doi:10.1038/ncb1101-e255 · Cited by 1,455 · see citing works
Control of IκB-α Proteolysis by Site-Specific, Signal-Induced Phosphorylation
Brown, K., Gerstberger, S., Carlson, L., Franzoso, G., & Siebenlist, U. (1995) · Science · doi:10.1126/science.7878466 · Cited by 1,434 · see citing works
Deveraux, Q. L., Roy, N., Stennicke, H. R., Arsdale, T. V., Zhou, Q., Srinivasula, S. M., Alnemri, E. S., Salvesen, G. S., & Reed, J. C. (1998) · The EMBO Journal · doi:10.1093/emboj/17.8.2215 · Cited by 1,390 · see citing works
BAX and BAK Regulation of Endoplasmic Reticulum Ca 2+ : A Control Point for Apoptosis
Scorrano, L., Oakes, S. A., Opferman, J. T., Cheng, E. H. Y., Sorcinelli, M. D., Pozzan, T., & Korsmeyer, S. J. (2003) · Science · doi:10.1126/science.1081208 · Cited by 1,387 · see citing works
Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors
Thome, M., Schneider, P., Hofmann, K., Fickenscher, H., Meinl, E., Neipel, F., Mattmann, C., Burns, K., Bodmer, J.-L., Schröter, M., et al. (1997) · Nature · doi:10.1038/386517a0 · Cited by 1,316 · see citing works
Brunner, T., Mogil, R. J., LaFace, D., Yoo, N. J., Mahboubi, A., Echeverri, F., Martin, S. J., Force, W. R., Lynch, D. H., Ware, C. F., et al. (1995) · Nature · doi:10.1038/373441a0 · Cited by 1,314 · see citing works
Kaech, S. M., & Ahmed, R. (2001) · Nature Immunology · doi:10.1038/87720 · Cited by 1,277 · see citing works
Green, D. R., & Evan, G. I. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00024-7 · Cited by 1,254 · see citing works
Lymphocyte traffic control by chemokines
Moser, B., & Loetscher, P. (2001) · Nature Immunology · doi:10.1038/84219 · Cited by 1,235 · see citing works
Suzuki, Y., Imai, Y., Nakayama, H., Takahashi, K., Takio, K., & Takahashi, R. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00341-0 · Cited by 1,116 · see citing works
Induction of apoptosis in mature T cells by tumour necrosis factor
Zheng, L., Fisher, G. H., Miller, R. E., Peschon, J. J., Lynch, D. H., & Lenardo, M. J. (1995) · Nature · doi:10.1038/377348a0 · Cited by 1,116 · see citing works
The Death Domain Kinase RIP Mediates the TNF-Induced NF-κB Signal
Kelliher, M. A., Grimm, S., Ishida, Y., Kuo, F., Stanger, B. Z., & Leder, P. (1998) · Immunity · doi:10.1016/s1074-7613(00)80535-x · Cited by 1,102 · see citing works
The mitochondrion in apoptosis: how Pandora's box opens
Zamzami, N., & Kroemer, G. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35048073 · Cited by 1,029 · see citing works
Orchestrating the unfolded protein response in health and disease
Kaufman, R. J. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0216886 · Cited by 1,015 · see citing works
Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes
Listen, P., Roy, N., Tamai, K., Lefebvre, C. A., Baird, S. D., Cherton-Horvat, G., Farahani, R., McLean, M., lkeda, J.-E., MacKenzie, A., et al. (1996) · Nature · doi:10.1038/379349a0 · Cited by 1,005 · see citing works
Breaking the mitochondrial barrier
Martinou, J., & Green, D. R. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35048069 · Cited by 951 · see citing works
Fas ligand mediates activation-induced cell death in human T lymphocytes.
Alderson, M. R., Tough, T. W., Davis-Smyth, T., Braddy, S., Falk, B. A., Schooley, K., Goodwin, R. G., Smith, C. A., Ramsdell, F., & Lynch, D. H. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.1.71 · Cited by 933 · see citing works
Li, Z., Chu, W., Hu, Y., Delhase, M., Deerinck, T. J., Ellisman, M. H., Johnson, R. S., & Karin, M. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.11.1839 · Cited by 927 · see citing works
Cytokine control of memory T-cell development and survival
Schluns, K. S., & Lefrançois, L. (2003) · Nature reviews. Immunology · doi:10.1038/nri1052 · Cited by 879 · see citing works
Cleavage of the death domain kinase RIP by Caspase-8 prompts TNF-induced apoptosisPreprint
Lin, Y., Devin, A., Rodriguez, Y., & Liu, Z.-G. (1999) · Genes & Development · doi:10.1101/gad.13.19.2514 · Cited by 835 · see citing works
Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice
Arbonés, M. L., Ord, D. C., Ley, K. F., Ratech, H., Maynard-Curry, C., Otten, G., Capon, D. J., & Teddert, T. F. (1994) · Immunity · doi:10.1016/1074-7613(94)90076-0 · Cited by 831 · see citing works
Posnett, D. N., Sinha, R., Kabak, S., & Russo, C. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.2.609 · Cited by 761 · see citing works
The Rel/NF-κB Family Directly Activates Expression of the Apoptosis Inhibitor Bcl-x L
Chen, C., Edelstein, L. C., & Gélinas, C. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.8.2687-2695.2000 · Cited by 760 · see citing works
Hegde, R. P., Srinivasula, S. M., Zhang, Z., Wassell, R. P., Mukattash, R., Cilenti, L., DuBois, G. C., Lazebnik, Y. A., Zervos, A. S., Fernandes‐Alnemri, T., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109721200 · Cited by 745 · see citing works
Induction of gadd45β by NF-κB downregulates pro-apoptotic JNK signalling
De Smaele, E., Zazzeroni, F., Papa, S., Nguyen, D. U., Jin, R., Jones, J., Cong, R., & Franzoso, G. (2001) · Nature · doi:10.1038/35104560 · Cited by 732 · see citing works
Inhibition of JNK activation through NF-κB target genes
Tang, G., Minemoto, Y., Dibling, B., Purcell, N. H., Li, Z., Karin, M., & Lin, A. (2001) · Nature · doi:10.1038/35104568 · Cited by 721 · see citing works
Increased cytokine production in mononuclear cells of healthy elderly people
Fagiolo, U., Cossarizza, A., Scala, E., Fanales‐Belasio, E., Ortolani, C., Cozzi, E., Monti, D., Franceschi, C., & Paganelli, R. (1993) · European Journal of Immunology · doi:10.1002/eji.1830230950 · Cited by 665 · see citing works
Activation‐induced cell death in T cells
Green, D. R., Droin, N. M., & Pinkoski, M. J. (2003) · Immunological Reviews · doi:10.1034/j.1600-065x.2003.00051.x · Cited by 645 · see citing works
Expression of the functional soluble form of human fas ligand in activated lymphocytes.
Tanaka, M., Suda, T., Takahashi, T., & Nagata, S. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07096.x · Cited by 639 · see citing works
A Single BIR Domain of XIAP Sufficient for Inhibiting Caspases
Takahashi, R., Deveraux, Q. L., Tamm, I., Welsh, K., Assa‐Munt, N., Salvesen, G. S., & Reed, J. C. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.14.7787 · Cited by 608 · see citing works
Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes.
Lam, M., Dubyak, G., Chen, L., Núñez, G., Miesfeld, R. L., & Distelhorst, C. W. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.14.6569 · Cited by 602 · see citing works
Tartaglia, L. A., Pennica, D., & Goeddel, D. V. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)46661-0 · Cited by 570 · see citing works
Tamatani, M., Ho, Y., Matsuzaki, H., Ogawa, S., Okado, H., Miyake, S., Mizuno, T., & Tohyama, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.13.8531 · Cited by 549 · see citing works
The caspase-8 inhibitor FLIP promotes activation of NF-κB and Erk signaling pathways
Kataoka, T., Budd, R. C., Holler, N., Thome, M., Martinon, F., Irmler, M., Burns, K. A., Hahne, M., Kennedy, N. J., Kovacsovics, M., et al. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00512-1 · Cited by 549 · see citing works
Shortage of circulating naive CD8+ T cells provides new insights on immunodeficiency in aging
Fagnoni, F. F., Vescovini, R., Passeri, G., Bologna, G., Pedrazzoni, M., Lavagetto, G., Casti, A., Franceschi, C., Passeri, M., & Sansoni, P. (2000) · Blood · doi:10.1182/blood.v95.9.2860.009k35_2860_2868 · Cited by 519 · see citing works
Yeh, W.-C., Itie, A., Elia, A. J., Ng, M., Shu, H.-B., Wakeham, A., Mirtsos, C., Suzuki, N., Bonnard, M., Goeddel, D. V., et al. (2000) · Immunity · doi:10.1016/s1074-7613(00)80214-9 · Cited by 515 · see citing works
Migratory properties of naive, effector, and memory CD8(+) T cells
Weninger, W., Crowley, M. A., Manjunath, N., & von Andrian, U. H. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.7.953 · Cited by 515 · see citing works
Apoptosis inducing factor (AIF): a phylogenetically old, caspase-independent effector of cell death
Lorenzo, H. K., Susín, S. A., Penninger, J. M., & Kroemer, G. (1999) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400527 · Cited by 508 · see citing works
Saurwein-Teissl, M., Lung, T. L., Marx, F., Gschösser, C., Asch, E., Blasko, I., Parson, W., Böck, G., Schönitzer, D., Trannoy, E., et al. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.11.5893 · Cited by 499 · see citing works
Apoptosis driven by IP3‐linked mitochondrial calcium signals
Szalai, G., Krishnamurthy, R., & Hajnóczky, G. (1999) · The EMBO Journal · doi:10.1093/emboj/18.22.6349 · Cited by 495 · see citing works
Miyawaki, T., Uehara, T., Nibu, R., Tsuji, T., Yachie, A., Yonehara, S., & Taniguchi, N. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.11.3753 · Cited by 494 · see citing works
Activation of SAPK/JNK by TNF Receptor 1 Through a Noncytotoxic TRAF2-Dependent Pathway
Natoli, G., Costanzo, A., Ianni, A., Templeton, D. J., Woodgett, J. R., Balsano, C., & Levrero, M. (1997) · Science · doi:10.1126/science.275.5297.200 · Cited by 452 · see citing works
Zandi, E., Chen, Y., & Karin, M. (1998) · Science · doi:10.1126/science.281.5381.1360 · Cited by 446 · see citing works
Effros, R. B., Boucher, N., Porter, V., Zhu, X., Spaulding, C., Walford, R. L., Kronenberg, M., Cohen, D., & Schächter, F. (1994) · Experimental Gerontology · doi:10.1016/0531-5565(94)90073-6 · Cited by 377 · see citing works
Monteiro, J., Batliwalla, F., Ostrer, H., & Gregersen, P. K. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.10.3587 · Cited by 376 · see citing works
p28 Bap31, a Bcl-2/Bcl-XL- and Procaspase-8–associated Protein in the Endoplasmic Reticulum
Ng, F. W. H., Nguyen, M., Kwan, T., Branton, P. E., Nicholson, D. W., Cromlish, J. A., & Shore, G. C. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.139.2.327 · Cited by 330 · see citing works
Zhu, W., Cowie, A., Wasfy, G. W., Penn, L. Z., Leber, B. F., & Andrews, D. W. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00788.x · Cited by 327 · see citing works
Bax and Bak Promote Apoptosis by Modulating Endoplasmic Reticular and Mitochondrial Ca2+ Stores
Nutt, L. K., Pataer, A., Pahler, J. C., Fang, B., Roth, J. A., McConkey, D. J., & Swisher, S. G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m106817200 · Cited by 320 · see citing works
Campbell, J. J., Bowman, E. P., Murphy, K. E., Youngman, K. R., Siani, M. A., Thompson, D. A., Wu, L., Zlotnik, A., & Butcher, E. C. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.4.1053 · Cited by 316 · see citing works
Iwaï, K., Miyawaki, T., Takizawa, T., Konno, A., Ohta, K., Yachie, A., Seki, H., & Taniguchi, N. (1994) · Blood · doi:10.1182/blood.v84.4.1201.1201 · Cited by 314 · see citing works
Apoptotic crosstalk between the endoplasmic reticulum and mitochondria controlled by Bcl-2
Häcki, J., Egger, L., Monney, L., Conus, S., Rossé, T., Fellay, I., & Borner, C. (2000) · Oncogene · doi:10.1038/sj.onc.1203592 · Cited by 300 · see citing works
Grell, M., Zimmermann, G., Gottfried, E., Chen, C., Grünwald, U., Huang, D. C. S., Lee, Y. W., Dürkop, H., Engelmann, H., Scheurich, P., et al. (1999) · The EMBO Journal · doi:10.1093/emboj/18.11.3034 · Cited by 284 · see citing works
Regulated Commitment of TNF Receptor Signaling
Pimentel‐Muiños, F. X., & Seed, B. (1999) · Immunity · doi:10.1016/s1074-7613(00)80152-1 · Cited by 282 · see citing works
Molecular signaling in death receptor and mitochondrial pathways of apoptosis (Review)
Gupta, S. (2003) · International Journal of Oncology · doi:10.3892/ijo.22.1.15 · Cited by 261 · see citing works
Aggarwal, S., Gollapudi, S. V. S., & Gupta, S. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.4.2154 · Cited by 252 · see citing works
Kasibhatla, S., Genestier, L., & Green, D. R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.2.987 · Cited by 248 · see citing works
Molecular steps of death receptor and mitochondrial pathways of apoptosis
Gupta, S. (2001) · Life Sciences · doi:10.1016/s0024-3205(01)01404-7 · Cited by 245 · see citing works
Dominant cell death induction by extramitochondrially targeted apoptosis‐inducing factor
Loeffler, M. W., Daugas, É., Susín, S. A., Zamzami, N., Métivier, D., Nieminen, A., Brothers, G. M., Penninger, J. M., & Kroemer, G. (2001) · The FASEB Journal · doi:10.1096/fj.00-0388com · Cited by 241 · see citing works
Aggarwal, S., Gollapudi, S., & Gupta, S. (1999) · PubMed · Cited by 231 · see citing works
Cell death induction by receptors of the TNF family: towards a molecular understanding
Wallach, D., Boldin, M., Varfolomeev, E. E., Beyaert, R., Vandenabeele, P., & Fiers, W. C. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00553-x · Cited by 231 · see citing works
Aggarwal, S., & Gupta, S. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.4.1627 · Cited by 229 · see citing works
The role of cell cycle‐mediated events in Alzheimer's disease
Raina, A. K., Monteiro, M. J., McShea, A., & Smith, M. A. (1999) · International Journal of Experimental Pathology · doi:10.1046/j.1365-2613.1999.00106.x · Cited by 226 · see citing works
Differentiation of Human CD8+ T Cells from a Memory to Memory/Effector Phenotype
Tomiyama, H., Matsuda, T., & Takiguchi, M. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.11.5538 · Cited by 222 · see citing works
Differential Sensitivity of Naive and Memory CD8+ T Cells to Apoptosis in Vivo
Grayson, J. M., Harrington, L. E., Lanier, J. G., Wherry, E. J., & Ahmed, R. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.7.3760 · Cited by 211 · see citing works
Vallejo, A. N., Brandes, J. C., Weyand, C. M., & Goronzy, J. J. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.11.6572 · Cited by 209 · see citing works
Thoma, B., Grell, M., Pfizenmaier, K., & Scheurich, P. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.172.4.1019 · Cited by 206 · see citing works
Early events in TNF signaling: a story of associations and dissociations
Darnay, B. G., & Aggarwal, B. B. (1997) · Journal of Leukocyte Biology · doi:10.1002/jlb.61.5.559 · Cited by 195 · see citing works
Bellomo, G., Perotti, M., Taddei, F., Mirabelli, F., Finardi, G., Nicotera, P., & Orrenius, S. (1992) · PubMed · Cited by 190 · see citing works
A Decision Between Life and Death During TNF-α-Induced Signaling
Gupta, S. (2002) · Journal of Clinical Immunology · doi:10.1023/a:1016089607548 · Cited by 183 · see citing works
Genestier, L., Kasibhatla, S., Brunner, T., & Green, D. R. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.2.231 · Cited by 177 · see citing works
Bandrés, E., Merino, J., Vázquez, B., Inogés, S., Moreno, C., Subirá, M. L., & Sánchez-Ibarrola, A. (2000) · Clinical Immunology · doi:10.1006/clim.2000.4894 · Cited by 174 · see citing works
Both TNF receptors are required for TNF-mediated induction of apoptosis in PC60 cells.
Vandenabeele, P., Declercq, W., Vanhaesebroeck, B., Grooten, J., & Fiers, W. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.6.2904 · Cited by 169 · see citing works
Haridas, V., Darnay, B. G., Natarajan, K., Heller, R. A., & Aggarwal, B. B. (1998) · PubMed · Cited by 159 · see citing works
Nociari, M., Telford, W. G., & Russo, C. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.6.3327 · Cited by 154 · see citing works
Declercq, W., Denecker, G., Fiers, W. C., & Vandenabeele, P. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.1.390 · Cited by 145 · see citing works
Fas (CD95) participates in peripheral T cell deletion and associated apoptosis in vivo
Mogil, R. J., Radvanyi, L. G., González‐Quintial, R., Miller, R. G., Mills, G. B., Theofilopoulos, A. N., & Green, D. R. (1995) · International Immunology · doi:10.1093/intimm/7.9.1451 · Cited by 136 · see citing works
Haridas, V., Darnay, B. G., Natarajan, K., Heller, R. A., & Aggarwal, B. B. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.7.3152 · Cited by 136 · see citing works
Weiß, T., Grell, M., Siemienski, K., Mühlenbeck, F., Dürkop, H., Pfizenmaier, K., Scheurich, P., & Wajant, H. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.6.3136 · Cited by 134 · see citing works
Yoshino, T., Kondo, E., Cao, L., Takahashi, K., Hayashi, K., Nomura, S., & Akagi, T. (1994) · Blood · doi:10.1182/blood.v83.7.1856.1856 · Cited by 133 · see citing works
Renno, T., Hahne, M., Tschopp, J., & MacDonald, H. R. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.2.431 · Cited by 132 · see citing works
Inhibition of the NF-κB transcription factor increases Bax expression in cancer cell lines
Bentires‐Alj, M., Dejardin, E., Viatour, P., Lint, C. M. V., Froesch, B. A., Reed, J. C., Merville, M., & Bours, V. (2001) · Oncogene · doi:10.1038/sj.onc.1204343 · Cited by 124 · see citing works
Whisler, R. L., Beiqing, L., & Chen, M. (1996) · Cellular Immunology · doi:10.1006/cimm.1996.0109 · Cited by 121 · see citing works
T cell life and death signalling via TNF-receptor family members
Screaton, G. R., & Xu, X. (2000) · Current Opinion in Immunology · doi:10.1016/s0952-7915(00)00093-5 · Cited by 109 · see citing works
Characterization of naıve, memory and effector CD8+ T cells: effect of age
Gupta, S., Bi, R., Su, K. W., Yel, L., Chiplunkar, S., & Gollapudi, S. V. S. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2003.08.013 · Cited by 107 · see citing works
Lam, M., Dubyak, G., & Distelhorst, C. (1993) · Molecular Endocrinology · doi:10.1210/mend.7.5.8316252 · Cited by 103 · see citing works
Decreased Proteasome-Mediated Degradation in T Cells from the Elderly: A Role in Immune Senescence
Ponnappan, U., Zhong, M., & Trebilcock, G. U. (1999) · Cellular Immunology · doi:10.1006/cimm.1998.1418 · Cited by 102 · see citing works
Fernandez, A., Kiefer, J., Fosdick, L., & McConkey, D. J. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.11.5133 · Cited by 99 · see citing works
Increased apoptosis of CD45RO− T cells with aging
Herndon, F. J., Hsu, H., & Mountz, J. D. (1997) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(97)01882-4 · Cited by 92 · see citing works
Molecular Steps of Tumor Necrosis Factor Receptor-Mediated Apoptosis
Gupta, S. (2001) · Current Molecular Medicine · doi:10.2174/1566524013363780 · Cited by 89 · see citing works
Gupta, S. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00195-4 · Cited by 87 · see citing works
Phelouzat, M.-A., Laforge, T., Arbogast, A., Quadri, R. A., Boutet, S. C., & Proust, J. J. (1997) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(97)01883-6 · Cited by 83 · see citing works
Gupta, S., Bi, R.-H., Kim, C., Chiplunkar, S., Yel, L., & Gollapudi, S. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401557 · Cited by 83 · see citing works
Trebilcock, G. U., & Ponnappan, U. (2009) · Gerontology · doi:10.1159/000213785 · Cited by 79 · see citing works
Excessive apoptosis of mature T lymphocytes is a characteristic feature of human immune senescence
Phelouzat, M.-A., Arbogast, A., Laforge, T., Quadri, R. A., & Proust, J. J. (1996) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(96)01714-9 · Cited by 77 · see citing works
Introduction: The molecular regulation of lymphocyte apoptosis
Lenardo, M. J. (1997) · Seminars in Immunology · doi:10.1006/smim.1996.0050 · Cited by 75 · see citing works
Potestio, M., Caruso, C., Gervasi, F., Scialabba, G., D’Anna, C., Lorenzo, G. D., Balistreri, C. R., Candore, G., & Romano, G. C. (1998) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(98)00020-7 · Cited by 72 · see citing works
Proliferation and apoptosis of human CD8+CD28+ and CD8+CD28− lymphocytes during aging
Brzezińska, A., Magalska, A., Szybińska, A., & Sikora, E. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2003.09.026 · Cited by 69 · see citing works
Molecular Steps of Cell Suicide: An Insight into Immune Senescence
Gupta, S. (2000) · Journal of Clinical Immunology · doi:10.1023/a:1006653917314 · Cited by 66 · see citing works
Lee, S. T., Hoeflich, K. P., Wasfy, G. W., Woodgett, J. R., Leber, B. F., Andrews, D. W., Hedley, D. W., & Penn, L. Z. (1999) · Oncogene · doi:10.1038/sj.onc.1202716 · Cited by 65 · see citing works
Aggarwal, S., & Gupta, S. (1999) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1999.00957.x · Cited by 62 · see citing works
Molecular mechanisms of TNF-α-induced apoptosis in aging human T cell subsets
Gupta, S., & Gollapudi, S. V. S. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.08.013 · Cited by 57 · see citing works
Molecular and biochemical pathways of apoptosis in lymphocytes from aged humans
Gupta, S. (2000) · Vaccine · doi:10.1016/s0264-410x(99)00492-2 · Cited by 55 · see citing works
Dennett, N. S., Bárcia, R. N., & McLeod, J. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00193-0 · Cited by 55 · see citing works
Shinohara, S., Sawada, T., Nishioka, Y., Tohma, S., Kisaki, T., Inoue, T., ANDO, K., Ikeda, M., Fujii, H., & Ito, K. (1995) · Cellular Immunology · doi:10.1006/cimm.1995.1130 · Cited by 50 · see citing works
Lechner, H., Amort, M., Steger, M., Maczek, C., & Grubeck‐Loebenstein, B. (2009) · International Archives of Allergy and Immunology · doi:10.1159/000237293 · Cited by 43 · see citing works
Molecular mechanisms of TNF-α-induced apoptosis in naïve and memory T cell subsets
Gupta, S., & Gollapudi, S. V. S. (2005) · Autoimmunity Reviews · doi:10.1016/j.autrev.2005.09.007 · Cited by 41 · see citing works
Effect of glucocorticosteroid treatment on intracellular calcium homeostasis in mouse lymphoma cells
Lam, M. (1993) · Molecular Endocrinology · doi:10.1210/me.7.5.686 · Cited by 39 · see citing works
Effect of age on molecular signaling of TNF-α-induced apoptosis in human lymphocytes
Gupta, S., Chiplunkar, S., Kim, C., Yel, L., & Gollapudi, S. V. S. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(03)00028-9 · Cited by 36 · see citing works
Delayed Kinetics of T Lymphocyte Anergy and Deletion in Lpr Mice
Mixter, P. F., Rusell, J. Q., & Budd, R. C. (1994) · Journal of Autoimmunity · doi:10.1006/jaut.1994.1055 · Cited by 36 · see citing works
Somma, M. M. D., Somma, F., Montani, M. S. G., Mangiacasale, R., Cundari, E., & Piccolella, E. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.7.3851 · Cited by 33 · see citing works
Aggarwal, S., Gollapudi, S., Yel, L., Gupta, A., & Gupta, S. (2000) · Genes and Immunity · doi:10.1038/sj.gene.6363674 · Cited by 29 · see citing works
Kong, S. K., Fung, K., Choy, Y. M., & Lee, C. Y. (2009) · Oncology · doi:10.1159/000227662 · Cited by 29 · see citing works
A Role of Fas-Associated Death Domain (FADD) in Increased Apoptosis in Aged Humans
Gupta, S., Kim, C., Yel, L., & Gollapudi, S. V. S. (2004) · Journal of Clinical Immunology · doi:10.1023/b:joci.0000018059.56924.99 · Cited by 27 · see citing works
Salvioli, S., Capri, M., Scarcella, E., Mangherini, S., Faranca, I., Volterra, V., Ronchi, D. D., Marini, M., Bonafè, M., Franceschi, C., et al. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(03)00016-2 · Cited by 24 · see citing works
Increased spontaneous apoptosis in T lymphocytes in DiGeorge anomaly
Gupta, S., Aggarwal, S., & Nguyen, T. (1998) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1998.00629.x · Cited by 23 · see citing works
Pahlavani, M. A., & Harris, M. D. (1996) · AGE · doi:10.1007/bf02434070 · Cited by 22 · see citing works
Draper, D. W., Harris, V. G., Culver, C. A., & Laster, S. M. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.4.2416 · Cited by 18 · see citing works
A role of inhibitor of apoptosis (IAP) proteins in increased lymphocyte apoptosis in aged humans
Gupta, S. (2003) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2003.11.001 · Cited by 11 · see citing works
A road to ruins: an insight into immunosenescence
(2002) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(02)13010-0 · Cited by 6 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Apoptosis and caspases regulate death and inflammation in sepsis
Hotchkiss, R. S., & Nicholson, D. W. (2006) · Nature reviews. Immunology · doi:10.1038/nri1943 · Cited by 796 · see citing works
Programmed cell death in aging
Tower, J. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.04.002 · Cited by 426 · see citing works
The Biology of Aging and Frailty
Fedarko, N. S. (2010) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2010.08.006 · Cited by 344 · see citing works
Leukocyte function in the aging immune system
Desai, A., Grolleau‐Julius, A., & Yung, R. L. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.0809542 · Cited by 141 · see citing works
Xu, Z., Feng, W., Shen, Q., Yu, N., Yu, K., Wang, S., Chen, Z., Shioda, S., & Guo, Y. (2017) · Aging and Disease · doi:10.14336/ad.2016.0620 · Cited by 143 · see citing works
Differential role of lipid rafts in the functions of CD4+ and CD8+ human T lymphocytes with aging
Larbi, A., Dupuis, G., Khalil, A., Douziech, N., Fortin, C., & Fülöp, T. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2005.08.016 · Cited by 126 · see citing works
Bektas, A., Schurman, S. H., Gonzalez-Freire, M., Dunn, C. A., Singh, A. K., Macian, F., Cuervo, A. M., Sen, R., & Ferrucci, L. (2019) · Aging · doi:10.18632/aging.102438 · Cited by 116 · see citing works
Selective IgM Deficiency—An Underestimated Primary Immunodeficiency
Gupta, S., & Gupta, A. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01056 · Cited by 108 · see citing works
Chan, Q. K. Y., Ngan, H., Ip, P. P. C., Liu, V. W. S., Xue, W., & Cheung, A. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn215 · Cited by 104 · see citing works
Role of dendritic cells in innate and adaptive immune response in human aging
Gupta, S. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2013.12.009 · Cited by 80 · see citing works
A paradox of immunodeficiency and inflammation in human aging: lessons learned from apoptosis
Gupta, S., Agrawal, A., Agrawal, S., Su, H., & Gollapudi, S. (2006) · Immunity & Ageing · doi:10.1186/1742-4933-3-5 · Cited by 77 · see citing works
The ER and ageing II: Calcium homeostasis
Puzianowska-Kuznicka, M., & Kuznicki, J. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.05.002 · Cited by 73 · see citing works
Age‐related alterations of gene expression patterns in human CD8<sup>+</sup> T cells
Cao, J., Gollapudi, S., Sharman, E. H., Jia, Z., & Gupta, S. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2009.00534.x · Cited by 71 · see citing works
Self-citationSerum markers of apoptosis decrease with age and cancer stage
Kavathia, N. H., Jain, A., Walston, J. D., Beamer, B. A., & Fedarko, N. S. (2009) · Aging · doi:10.18632/aging.100069 · Cited by 64 · see citing works
Immunosenescence and organ transplantation
Heinbokel, T., Elkhal, A., Liu, G., Edtinger, K., & Tullius, S. G. (2013) · Transplantation Reviews · doi:10.1016/j.trre.2013.03.001 · Cited by 63 · see citing works
Life and death of lymphocytes: a role in immunesenescence
Gupta, S., Su, H., Bi, R., Agrawal, S., & Gollapudi, S. V. S. (2005) · Immunity & Ageing · doi:10.1186/1742-4933-2-12 · Cited by 58 · see citing works
Kajstura, J., Bolli, R., Sonnenblick, E. H., Anversa, P., & Leri, A. (2006) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2005.12.013 · Cited by 48 · see citing works
Yin, W., Deng, X., Yin, F., Zhang, X., & Cai, B. (2007) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.03.004 · Cited by 48 · see citing works
Gupta, S., & Gollapudi, S. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2007.12.006 · Cited by 57 · see citing works
Vasto, S., Malavolta, M., & Pawelec, G. (2006) · Immunity & Ageing · doi:10.1186/1742-4933-3-2 · Cited by 45 · see citing works
The Role of TCR Engagement and Activation-Induced Cell Death in Sepsis-Induced T Cell Apoptosis
Unsinger, J., Herndon, J. M., Davis, C. G., Muenzer, J. T., Hotchkiss, R. S., & Ferguson, T. A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.11.7968 · Cited by 44 · see citing works
TNF-α-induced apoptosis in human naïve and memory CD8+ T cells in aged humans
GUPTA, S., & Gollapudi, S. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.10.001 · Cited by 37 · see citing works
Massanella, M., Gómez‐Mora, E., Carrillo, J., Curriu, M., Ouchi, D., Puig, J., Negredo, E., Cabrera, C., Clotet, B., & Blanco, J. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0601-2 · Cited by 34 · see citing works
The relationship between apoptosis and aging
Lü, B., Chen, H., & Hong-Guang, H.-G. (2012) · Advances in Bioscience and Biotechnology · doi:10.4236/abb.2012.326091 · Cited by 32 · see citing works
YE, S.-W., Wang, Y., Valmori, D., Ayyoub, M., HAN, Y., Xu, X., Zhao, A., Qu, L., Gnjatic, S., Ritter, G., et al. (2006) · Journal of Clinical Immunology · doi:10.1007/s10875-006-9040-4 · Cited by 32 · see citing works
T and B Cell Deficiency Associated with Yellow Nail Syndrome
Gupta, S., Samra, D., Yel, L., & Agrawal, S. (2011) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2011.02653.x · Cited by 31 · see citing works
Gupta, S., Young, T., Yel, L., Su, H., & Gollapudi, S. (2007) · Genes and Immunity · doi:10.1038/sj.gene.6364416 · Cited by 29 · see citing works
Single-cell transcriptomics of peripheral blood in the aging mouse
Teo, Y. V., Hinthorn, S. J., Webb, A. E., & Neretti, N. (2023) · Aging · doi:10.18632/aging.204471 · Cited by 28 · see citing works
Louis, A. G., Agrawal, S., & Gupta, S. (2016) · PubMed Central · Cited by 27 · see citing works
Young, T., Jerome, D. C., & Gupta, S. (2007) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)60887-3 · Cited by 24 · see citing works
Immunological characteristics of the elderly allograft recipient
Klinger, M., & Banasik, M. (2015) · Transplantation Reviews · doi:10.1016/j.trre.2015.07.002 · Cited by 24 · see citing works
Hodkinson, C., O’Connor, J. M., Alexander, H. D., Bradbury, I., Bonham, M. P., HANNIGAN, B. M., Gilmore, W. S., Strain, J. J., & Wallace, J. M. W. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.9.907 · Cited by 22 · see citing works
Mishra, S., Mishra, J., & Kumar, A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m608307200 · Cited by 21 · see citing works
RetractedČulić, S., Labar, B., Marušić, A., & Salamunić, I. (2006) · Pediatric Blood & Cancer · doi:10.1002/pbc.20999 · Cited by 21 · see citing works
Gupta, S., Agrawal, S., & Gollapudi, S. V. S. (2009) · Journal of Virology · doi:10.1128/jvi.00106-09 · Cited by 20 · see citing works
Wang, J., Chen, Y.-C., Chen, W.-L., & Lin, C. (2017) · European Journal of Applied Physiology · doi:10.1007/s00421-017-3731-9 · Cited by 19 · see citing works
Underexpression and overexpression of Fas and Fas ligand: a double-edged sword
Randhawa, S., Chahine, B. G., Lowery‐Nordberg, M., Cotelingam, J. D., & Casillas, A. M. (2010) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2010.01.021 · Cited by 17 · see citing works
Gupta, S., Su, H., Agrawal, S., & Gollapudi, S. V. S. (2018) · Immunity & Ageing · doi:10.1186/s12979-017-0109-0 · Cited by 16 · see citing works
Inflammation & autoimmunity in human ageing: dendritic cells take a center stage.
Gupta, S., & Agrawal, A. (2013) · Europe PMC (PubMed Central) · Cited by 14 · see citing works
Ageing and its influence on wound healing
Minimas, D. A. (2007) · Cited by 14 · see citing works
Good syndrome presenting with CD8+ T-Cell large granular lymphocyte leukemia
Caperton, C. V., Agrawal, S., & Gupta, S. (2015) · Oncotarget · doi:10.18632/oncotarget.5369 · Cited by 14 · see citing works
Gharib, A., Louis, A. G., Agrawal, S., & Gupta, S. (2015) · Europe PMC (PubMed Central) · Cited by 12 · see citing works
Orai, STIM, and PMCA contribute to reduced calcium signal generation in CD8+ T cells of elderly mice
Angenendt, A., Steiner, R., Knörck, A., Schwär, G., Konrad, M., Krause, E., & Lis, A. (2020) · Aging · doi:10.18632/aging.102809 · Cited by 12 · see citing works
Age-associated decrease of CD1d protein production in normal human skin
Adly, M. A., Assaf, H. A. R., Hussein, M. R., & Neuber, K. (2006) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2006.07277.x · Cited by 12 · see citing works
Lang, C.-L., Wang, M., Hung, K., Chiang, C., & Lu, K. (2013) · The EPMA Journal · doi:10.1186/1878-5085-4-17 · Cited by 11 · see citing works
A Review of Chronic Kidney Disease and the Immune System: A Special Form of Immunosenescence
Lang, C.-L. (2014) · Journal of Gerontology & Geriatric Research · doi:10.4172/2167-7182.1000144 · Cited by 10 · see citing works
Feng, B., Guo, Y., Huang, C., Li, L., & Jiao, B. (2010) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2010.10.005 · Cited by 10 · see citing works
Collagenous Gastritis in Primary Selective IgM Deficiency: Transition to EBV+ Gastric Adenocarcinoma
Narsai, T., Su, H., Braxton, D. R., & Gupta, S. (2021) · Case Reports in Immunology · doi:10.1155/2021/5574944 · Cited by 7 · see citing works
Agrawal, S., Khokhar, A., & Gupta, S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00399 · Cited by 7 · see citing works
Increase in double-stranded DNA break-related foci in early-stage thymocytes of aged mice
Hesse, J. E., Faulkner, M. F., & Durdik, J. M. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.06.009 · Cited by 6 · see citing works
Widayati, E., & Nasihun, T. (2018) · Bangladesh Journal of Medical Science · doi:10.3329/bjms.v17i1.35292 · Cited by 6 · see citing works
Immunogenomics: Molecular hide and seek
Miretti, M. M., & Beck, S. (2006) · Human Genomics · doi:10.1186/1479-7364-2-4-244 · Cited by 6 · see citing works
Factors Predisposing to Infection
Norman, D. C. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-534-7_2 · Cited by 6 · see citing works
Death of memory T-cell subsets in humans: changes during aging
Gupta, S., & Gupta, A. (2007) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.3.4.637 · Cited by 6 · see citing works
Impact of Hepatitis C Virus Infection of Peripheral Blood Mononuclear Cells on the Immune System
Alhetheel, A. (2022) · Frontiers in Virology · doi:10.3389/fviro.2021.810231 · Cited by 5 · see citing works
In Situ Observation of Germinal Center Cell Apoptosis During a Secondary Immune Response
Saitoh, H., Maeda, K., & Yamakawa, M. (2006) · Journal of the Japan Society of the Reticuloendothelial System · doi:10.3960/jslrt.46.73 · Cited by 4 · see citing works
Sourlingas, T. G., Kypreou, K. P., Topakas, G., Karchilaki, I., Stavropoulos‐Giokas, C., & Sekeri‐Pataryas, K. E. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1404.014 · Cited by 4 · see citing works
[Age related changes of soluble Fas, Fas ligand and Bcl-2 in autoimmune thyroid diseases].
Myśliwiec, J., Okłota, M., Nikołajuk, A., & Górska, M. (2007) · PubMed · Cited by 4 · see citing works
Expression of CD1d Protein in Human Testis Showing Normal and Abnormal Spermatogenesis
Adly, M. A., & Hussein, M.-R. A. (2011) · Ultrastructural Pathology · doi:10.3109/01913123.2010.546944 · Cited by 4 · see citing works
Gupta, S., & Agrawal, S. (2019) · PubMed Central · Cited by 4 · see citing works
Lymphocyte Apoptosis and FAS Expression in Patients with 22q11.2 Deletion Syndrome
Aresvik, D. M., Øverland, T., Lima, K., Pettersen, R. D., & Abrahamsen, T. G. (2018) · Journal of Clinical Immunology · doi:10.1007/s10875-018-0579-7 · Cited by 3 · see citing works
Adaptive Cellular Responses following SARS-CoV-2 Vaccination in Primary Antibody Deficiency Patients
Gupta, S., Su, H., Agrawal, S., Demirdağ, Y. Y., Tran, M., & Gollapudi, S. V. S. (2024) · Pathogens · doi:10.3390/pathogens13060514 · Cited by 3 · see citing works
Apoptosis and Activation-Induced Cell Death
S., J. H. P., & Vilória, M. I. V. (2013) · InTech eBooks · doi:10.5772/52805 · Cited by 3 · see citing works
Mishra, S., Mishra, J., & Kumar, A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.a111.608307 · Cited by 2 · see citing works
Cano-Suárez, M. T., Reinoso, R., Martín, M. C., Calonge, M., Vallelado, A. I., Fernández, I., & Corell, A. (2021) · PubMed · doi:10.14670/hh-18-385 · Cited by 2 · see citing works
Li, Z., Wang, H., Zhou, Q., Li, Q., Liu, N., Jiang, S., & Deng, Y. (2025) · Journal of Pineal Research · doi:10.1111/jpi.70071 · Cited by 2 · see citing works
Balancing senescence and apoptosis: therapeutic insights into aging and cancer
Jan, N., Sofi, S., Mir, A. A., Masoodi, G., & Mir, M. A. (2025) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-025-05355-3 · Cited by 1 · see citing works
Basyreva, L. Y. (2014) · Immunome Research · doi:10.4172/1745-7580.1000068 · Cited by 1 · see citing works
Signal Transduction Changes in T-cells with Aging
Fülöp, T., Dupuis, G., Fortin, C. F., & Larbi, A. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9063-9_35 · Cited by 1 · see citing works
Activation-Induced Cell Death of T Cells in Human Aging
Sikora, E., & Brzezińska, A. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_15 · Cited by 1 · see citing works
Signal Transduction Changes in T Cells with Aging
Fülöp, T., Page, A. Y. L., Dupuis, G., Fortin, C. F., Witkowski, J. M., & Larbi, A. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_35 · Cited by 1 · see citing works
Gupta, S. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.02.018 · Cited by 1 · see citing works
Gozzelino, R. (2007) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Role of Dendritic Cells in Autoimmunity in Aged Humans
Gupta, S. (2014) · Immunome Research · doi:10.4172/1745-7580.1000067
Bcl-xL/xS phosphorylation regulates the sensitivity of PC12 cells to apoptosis
Qi, J. (2009) · University Library - University of Saskatchewan (University of Saskatchewan)
Activation-Induced Cell Death of T-Cells in Elderly
Sikora, E., & Brzezińska, A. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9063-9_15
Yakovleva, A., Алексеевна, М. О., & Supryadkina, T. V. (2013) · CARDIOVASCULAR THERAPY AND PREVENTION · doi:10.15829/1728-8800-2013-3-18-23
Molecular Mechanisms of Apoptosis in Naive and Memory Human T-Cell Subsets
Gupta, S., & Gupta, A. (2018) · Springer eBooks · doi:10.1007/978-3-319-64597-1_36-1
Signal Transduction Changes in T-Cells with Aging
Fülöp, T., Page, A. Y. L., Dupuis, G., Fortin, C. F., Witkowski, J. M., & Larbi, A. (2018) · Springer eBooks · doi:10.1007/978-3-319-64597-1_35-1
Activation-Induced Cell Death of T Cells in Human Aging
Sikora, E., & Brzezińska, A. (2018) · Springer eBooks · doi:10.1007/978-3-319-64597-1_15-1
Molecular Mechanisms of Apoptosis in Naive and Memory Human T Cell Subsets
Gupta, S., & Gupta, A. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_36
Delayed Wound Healing in Aged Mice is Associated with Traumatic Stress, not with EGFR Block
Fuentes, D. (2023) · Journal on Surgery · doi:10.52768/2691-7785/1084
Role of Apoptosis in Aging: Therapeutic Targets and Strategies
Manna, A., Majumder, C., Halder, S., & Jana, K. (2024) · Springer eBooks · doi:10.1007/978-981-97-7905-5_17
Functional remodeling of IgM+ B cells in Streptococcus agalactiae-resistant Nile tilapia
Zheng, Y., Wang, D., Yang, J., Xiao, J., Chen, L., & Wei, X. (2026) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2026.111578
- Authors
- Gupta, S.
- Affiliations
- University of California, Irvine (US)
- Corresponding author
- Gupta, Sudhir
- ORCID
- Gupta, Sudhir
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2005-05-09
- Volume
- 205
- Issue
- 1
- Pages
- 114-129
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W2029217347
- Cited by
- 85
- References
- 147
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 6 · 2018: 6 · 2017: 3 · 2016: 2 · 2015: 5 · 2014: 3 · 2013: 6 · 2012: 1
- FWCI
- 0.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Immunological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG-18313, R01AG018313)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- apoptosis, immunosenescence, death receptor signaling, mitochondrial pathway, endoplasmic reticulum stress, CD8+ T cells, CD4+ T cells, memory T cells, naive T cells
- MeSH terms
- Aging, Animals, Humans, Immunologic Memory, T-Lymphocytes, Organelles, Signal Transduction, Apoptosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review