Cited by 254Seaweed-derived Bioactive CompoundsEchinoderm biology and ecologyPolysaccharides Composition and Applications

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Effects of molecular weight and hydrolysis conditions on anticancer activity of fucoidans from sporophyll of Undaria pinnatifida

Yang, Chen, Chung, Donghwa, Shin, Il-Shik, Lee, HyeonYong, Kim, JinChul, Lee, YongJin, You, SangGuan·2008·International Journal of Biological Macromolecules

DOI 10.1016/j.ijbiomac.2008.08.006

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Abstract

Hydrolyzed fucoidans, from sporophyll of Undaria pinnatifida, were used to determine the effects of molecular weight (Mw) and hydrolysis conditions on cancer cell growth. Native fucoidans showed anticancer activity of 37.6%. When hydrolyzed in boiling water with HCl for 5 min, fucoidans (Mw = 490 kDa) significantly increased anticancer activity to 75.9%. However, fucoidans hydrolyzed in a microwave oven showed little improvement of anticancer activity and even exhibited the inhibition activity below 30% when treated more than 90s. This suggests that anticancer activity of fucoidans could be significantly enhanced by lowering their Mw only when they are depolymerized by mild condition.

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Authors: Yang, C., Chung, D., Shin, I.-S., Lee, H., Kim, J., Lee, Y., & You, S.
Corresponding author: You, SangGuan
ORCID: Chung, Donghwa
Lee, YongJin
You, SangGuan
Venue: International Journal of Biological Macromolecules
Publisher: Elsevier BV
Published: 2008-12
Volume: 43
Issue: 5
Pages: 433-437
ISSN: 0141-8130 (ISSN-L)
DOI: 10.1016/j.ijbiomac.2008.08.006
OpenAlex: W2003669320
Cited by: 254
References: 24
Citations by year: 2026: 3 · 2025: 15 · 2024: 13 · 2023: 18 · 2022: 14 · 2021: 15 · 2020: 23 · 2019: 25 · 2018: 22 · 2017: 23 · 2016: 10 · 2015: 14 · 2014: 21 · 2013: 15 · 2012: 8
FWCI: 7.51
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: International Journal of Biological Macromolecules (publishedVersion)
PubMed (publishedVersion)
Funders: Ministry of Knowledge Economy
Ministry of Education and Human Resources Development
Topics: Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Echinoderm biology and ecology
Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
Keywords: fucoidan, Undaria pinnatifida, sporophylls, molecular weight, hydrolysis conditions, anticancer activity, tumor cell growth inhibition, acid hydrolysis, microwave hydrolysis, depolymerization, brown seaweed polysaccharides
MeSH terms: Antineoplastic Agents, Chromatography, Gel, Dose-Response Relationship, Drug, Humans, Hydrolysis, Lung Neoplasms, Molecular Weight, Polysaccharides, Undaria, Cell Line, Tumor

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Effects of molecular weight and hydrolysis conditions on anticancer activity of fucoidans from sporophyll of Undaria pinnatifida

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