Cited by 59Dementia and Cognitive Impairment ResearchCognitive Abilities and TestingNeural and Behavioral Psychology Studies

Event-related potentials elicited during working memory are altered in mild cognitive impairment

López Zunini, Rocío A., Knoefel, Frank, Lord, Courtney, Dzuali, Fiatsogbe, Breau, Michael, Sweet, Lisa, Goubran, Rafik, Taler, Vanessa·2016·International Journal of Psychophysiology

Abstract

Persons with Mild Cognitive Impairment (MCI) can experience deficits in working memory. In the present study, we investigated working memory in persons with MCI and cognitively healthy older adults using event-related potentials (ERPs). Participants performed an n-back working memory task with baseline (0-back), low load (1-back), and high load (2-back) working memory conditions. MCI participants' performance was less accurate than that of healthy older adults in both the 1-back and 2-back conditions, and reaction times were longer in MCI than control participants in the 0-back, 1-back and 2-back conditions. ERP analyses revealed delayed P200 and N200 latencies and smaller P300 amplitudes in MCI relative to control participants in the 0-back, 1-back and 2-back conditions. Deterioration in working memory performance concomitant with marked electrophysiological alterations suggests that persons with MCI exhibit deficits in several cognitive processes that include early attention, stimulus discrimination and classification, and updating and manipulation of information held in working memory.

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Crossref · 10.1016/j.ijpsycho.2016.09.012

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Authors
López Zunini, R. A., Knoefel, F., Lord, C., Dzuali, F., Breau, M., Sweet, L., Goubran, R., & Taler, V.
Affiliations
  • University of Ottawa (CA)
  • Bruyère (CA)
Corresponding author
Taler, Vanessa
Venue
International Journal of Psychophysiology
Publisher
Elsevier BV
Published
2016-11
Volume
109
Pages
1-8
ISSN
0167-8760 (ISSN-L)
OpenAlex
W2521910969
Cited by
59
References
55
Citations by year
2026: 11 · 2025: 2 · 2024: 10 · 2023: 6 · 2022: 5 · 2021: 7 · 2020: 4 · 2019: 4 · 2018: 5 · 2017: 5
FWCI
4.15
Type
journal article
Language
en
Open access
closed
Locations
  • International Journal of Psychophysiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Natural Sciences and Engineering Research Council of Canada (386467-2012)
  • MITACS (IT03787)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
mild cognitive impairment, working memory, event-related potentials, P300, P200, N2 component, n-back task, cognitive aging, attention, stimulus discrimination, memory updating, older adults
MeSH terms
Aged, Amnesia, Evoked Potentials, Female, Humans, Male, Memory, Short-Term, Cognitive Dysfunction

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