Maternal modifiers of the infant gut microbiota: Metabolic consequences
Open accessAbstract
Transmission of metabolic diseases from mother to child is multifactorial and includes genetic, epigenetic and environmental influences. Evidence in rodents, humans and non-human primates support the scientific premise that exposure to maternal obesity or high-fat diet during pregnancy creates a long-lasting metabolic signature on the infant innate immune system and the juvenile microbiota, which predisposes the offspring to obesity and metabolic diseases. In neonates, gastrointestinal microbes introduced through the mother are noted for their ability to serve as direct inducers/regulators of the infant immune system. Neonates have a limited capacity to initiate an immune response. Thus, disruption of microbial colonization during the early neonatal period results in disrupted postnatal immune responses that highlight the neonatal period as a critical developmental window. Although the mechanisms are poorly understood, increasing evidence suggests that maternal obesity or poor diet influences the development and modulation of the infant liver and other end organs through direct communication via the portal system, metabolite production, alterations in gut barrier integrity and the hematopoietic immune cell axis. This review will focus on how maternal obesity and dietary intake influence the composition of the infant gut microbiota and how an imbalance or maladaptation in the microbiota, including changes in early pioneering microbes, might contribute to the programming of offspring metabolism with special emphasis on mechanisms that promote chronic inflammation in the liver. Comprehension of these pathways and mechanisms will elucidate our understanding of developmental programming and may expand the avenue of opportunities for novel therapeutics.
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A healthy diet of a pregnant woman rich in dietary fiber shapes the gut microbiota of her offspring.
“Moreover, the healthy diet of a pregnant woman rich in dietary fiber shapes the gut microbiota of her offspring [100].”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [100]
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An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works
Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638 · see citing works
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245 · see citing works
Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M., Ganz, T., & Kaplan, J. (2004) · Science · doi:10.1126/science.1104742 · Cited by 4,803 · see citing works
Dominguez-Bello, M. G., Costello, E. K., Contreras, M., Magris, M., Hidalgo, G., Fierer, N., & Knight, R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002601107 · Cited by 4,774 · see citing works
Toll-like receptors and innate immunity
Medzhitov, R. (2001) · Nature Reviews Immunology · doi:10.1038/35100529 · Cited by 4,308 · see citing works
Prevalence of obesity and trends in body mass index among US children and adolescents, 1999-2010.
Ogden, C., Carroll, M., Kit, B., & Flegal, K. (2012) · Journal of the American Medical Association (JAMA) · doi:10.1001/jama.2012.40 · Cited by 4,128 · see citing works
Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice
Ridaura, V. K., Faith, J. J., Rey, F. E., Cheng, J., Duncan, A. E., Kau, A. L., Griffin, N. W., Lombard, V., Henrissat, B., Bain, J. R., et al. (2013) · Science · doi:10.1126/science.1241214 · Cited by 3,788 · see citing works
Development of the Human Infant Intestinal Microbiota
Palmer, C., Bik, E. M., DiGiulio, D. B., Relman, D. A., & Brown, P. O. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050177 · Cited by 2,877 · see citing works
Nemeth, E., Rivera, S., Gabayan, V., Keller, C., Taudorf, S., Pedersen, B. K., & Ganz, T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420945 · Cited by 2,650 · see citing works
The Placenta Harbors a Unique Microbiome
Aagaard, K., Ma, J., Antony, K. M., Ganu, R., Petrosino, J., & Versalovic, J. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008599 · Cited by 2,494 · see citing works
Factors influencing the composition of the intestinal microbiota in early infancy
Penders, J., Thijs, C., Vink, C., Stelma, F. F., Snijders, B., Kummeling, I., van den Brandt, P. A., & Stobberingh, E. E. (2006) · PEDIATRICS · doi:10.1542/peds.2005-2824 · Cited by 2,232 · see citing works
Host Remodeling of the Gut Microbiome and Metabolic Changes during Pregnancy
Koren, O., Goodrich, J. K., Cullender, T. C., Spor, A., Laitinen, K., Kling Bäckhed, H., Gonzalez, A., Werner, J. J., Angenent, L. T., Knight, R., et al. (2012) · Cell · doi:10.1016/j.cell.2012.07.008 · Cited by 2,165 · see citing works
Metabolic reprogramming in macrophages and dendritic cells in innate immunity
Kelly, B., & O'Neill, L. A. (2015) · Cell Research · doi:10.1038/cr.2015.68 · Cited by 1,876 · see citing works
Control of pathogens and pathobionts by the gut microbiota
Kamada, N., Chen, G. Y., Inohara, N., & Núñez, G. (2013) · Nature Immunology · doi:10.1038/ni.2608 · Cited by 1,625 · see citing works
Boursier, J., Mueller, O., Barret, M., Machado, M., Fizanne, L., Araujo‐Perez, F., Guy, C. D., Seed, P. C., Rawls, J. F., David, L. A., et al. (2016) · Hepatology · doi:10.1002/hep.28356 · Cited by 1,483 · see citing works
Dysmetabolic Hyperferritinemia: All Iron Overload Is Not Hemochromatosis
Makker, J. S., Hanif, A., Bajantri, B., & Chilimuri, S. S. (2015) · Case Reports in Gastroenterology · doi:10.1159/000373883 · Cited by 1,353 · see citing works
Thevaranjan, N., Puchta, A., Schulz, C., Naidoo, A., Szamosi, J. C., Verschoor, C. P., Loukov, D., Schenck, L. P., Jury, J., Foley, K. P., et al. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.03.002 · Cited by 1,322 · see citing works
Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans
Vatanen, T., Kostic, A. D., d’Hennezel, E., Siljander, H., Franzosa, E. A., Yassour, M., Kolde, R., Vlamakis, H., Arthur, T. D., Hämäläinen, A.-M., et al. (2016) · Cell · doi:10.1016/j.cell.2016.04.007 · Cited by 1,289 · see citing works
The maternal microbiota drives early postnatal innate immune development
Gomez de Agüero, M., Ganal-Vonarburg, S. C., Fuhrer, T., Rupp, S., Uchimura, Y., Li, H., Steinert, A., Heikenwalder, M., Hapfelmeier, S., Sauer, U., et al. (2016) · Science · doi:10.1126/science.aad2571 · Cited by 1,231 · see citing works
Collado, M. C., Rautava, S., Aakko, J., Isolauri, E., & Salminen, S. (2016) · Scientific Reports · doi:10.1038/srep23129 · Cited by 1,098 · see citing works
Perez-Muñoz, M. E., Arrieta, M.-C., Ramer-Tait, A. E., & Walter, J. (2017) · Microbiome · doi:10.1186/s40168-017-0268-4 · Cited by 1,096 · see citing works
Everts, B., Amiel, E., Huang, S. C.-C., Smith, A. M., Chang, C.-H., Lam, W. Y., Redmann, V., Freitas, T. C., Blagih, J., van der Windt, G. J. W., et al. (2014) · Nature Immunology · doi:10.1038/ni.2833 · Cited by 1,064 · see citing works
Jakobsson, H. E., Abrahamsson, T. R., Jenmalm, M. C., Harris, K., Quince, C., Jernberg, C., Björkstén, B., Engstrand, L., & Andersson, A. F. (2014) · Gut · doi:10.1136/gutjnl-2012-303249 · Cited by 1,011 · see citing works
Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice
Le Roy, T., Llopis, M., Lepage, P., Bruneau, A., Rabot, S., Bevilacqua, C., Martin, P., Philippe, C., Walker, F., Bado, A., et al. (2013) · Gut · doi:10.1136/gutjnl-2012-303816 · Cited by 1,001 · see citing works
Is meconium from healthy newborns actually sterile?
Jiménez, E., Marín, M. L., Martı́n, R., Odriozola, J. M., Olivares, M. M., Xaus, J., Fernández, L., & Rodríguez, J. M. (2008) · Research in Microbiology · doi:10.1016/j.resmic.2007.12.007 · Cited by 944 · see citing works
Ionescu, D., Buchmann, B., Heim, C., Häusler, S., de Beer, D., & Polerecký, L. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00459 · Cited by 921 · see citing works
Anderson, E. L., Howe, L. D., Jones, H. E., Higgins, J. P. T., Lawlor, D. A., & Fraser, A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140908 · Cited by 902 · see citing works
Cabrera-Rubio, R., Collado, M. C., Laitinen, K., Salminen, S., Isolauri, E., & Mira, A. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.037382 · Cited by 886 · see citing works
Santacruz, A., Collado, M. C., García-Valdés, L., Segura, M. T., Martín-Lagos, J. A., Anjos, T., Martí-Romero, M., Lopez, R. M., Florido, J., Campoy, C., et al. (2010) · British Journal of Nutrition · doi:10.1017/s0007114510000176 · Cited by 868 · see citing works
Distinct composition of gut microbiota during pregnancy in overweight and normal-weight women
Collado, M. C., Isolauri, E., Laitinen, K., & Salminen, S. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.4.894 · Cited by 863 · see citing works
Erridge, C., Attina, T., Spickett, C. M., & Webb, D. J. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1286 · Cited by 776 · see citing works
The Long-Term Public Health Benefits of Breastfeeding
Binns, C., Lee, M., & Low, W. Y. (2016) · Asia Pacific Journal of Public Health · doi:10.1177/1010539515624964 · Cited by 730 · see citing works
Biosynthesis and Export of Bacterial Lipopolysaccharides
Whitfield, C., & Trent, M. S. (2014) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060713-035600 · Cited by 716 · see citing works
Functional Redundancy-Induced Stability of Gut Microbiota Subjected to Disturbance
Moya, A., & Ferrer, M. (2016) · Trends in Microbiology · doi:10.1016/j.tim.2016.02.002 · Cited by 690 · see citing works
Hepcidin and the iron-infection axis
Drakesmith, H., & Prentice, A. M. (2012) · Science · doi:10.1126/science.1224577 · Cited by 686 · see citing works
Looking for a Signal in the Noise: Revisiting Obesity and the Microbiome
Sze, M. A., & Schloss, P. D. (2016) · mBio · doi:10.1128/mbio.01018-16 · Cited by 600 · see citing works
Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates
McCurdy, C. E., Bishop, J. M., Williams, S., Grayson, B. E., Smith, M. S., Friedman, J. E., & Grove, K. L. (2009) · Journal of Clinical Investigation · doi:10.1172/jci32661 · Cited by 599 · see citing works
Spencer, M. D., Hamp, T. J., Reid, R. W., Fischer, L. M., Zeisel, S. H., & Fodor, A. A. (2011) · Gastroenterology · doi:10.1053/j.gastro.2010.11.049 · Cited by 593 · see citing works
Evolution of gut microbiota composition from birth to 24 weeks in the INFANTMET Cohort
Hill, C. J., Lynch, D. B., Murphy, K., Ulaszewska, M., Jeffery, I. B., O’Shea, C. A., Watkins, C., Dempsey, E., Mattivi, F., Tuohy, K., et al. (2017) · Microbiome · doi:10.1186/s40168-016-0213-y · Cited by 573 · see citing works
Breastfeeding and health outcomes for the mother-infant dyad
Dieterich, C. M., Felice, J. P., O’Sullivan, E., & Rasmussen, K. M. (2013) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2012.09.010 · Cited by 563 · see citing works
Probiotic Bacteria Reduce Salmonella Typhimurium Intestinal Colonization by Competing for Iron
Deriu, E., Liu, J. Z., Pezeshki, M., Edwards, R. A., Ochoa, R. J., Contreras, H., Libby, S. J., Fang, F. C., & Raffatellu, M. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.06.007 · Cited by 550 · see citing works
Ajslev, T. A., Andersen, C. S., Gamborg, M., Sørensen, T. I. A., & Jess, T. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.27 · Cited by 534 · see citing works
Ip, S., Chung, M. C., Raman, G., Trikalinos, T. A., & Lau, J. (2009) · Breastfeeding Medicine · doi:10.1089/bfm.2009.0050 · Cited by 529 · see citing works
Inhibition of Staphylococcus aureus by the commensal bacteria of human milk
Heikkilä, M., & Saris, P. E. J. (2003) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.2003.02002.x · Cited by 501 · see citing works
Hooper, L. V., Xu, J., Falk, P. G., Midtvedt, T., & Gordon, J. I. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.17.9833 · Cited by 500 · see citing works
A Strategy for Annotating the Human Milk Glycome
Niñonuevo, M. R., Park, Y., Yin, H., Zhang, J., Ward, R. E., Clowers, B. H., German, J. B., Freeman, S. L., Killeen, K., Grimm, R., et al. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0615810 · Cited by 495 · see citing works
Diet and the development of the human intestinal microbiome
Voreades, N., Kozil, A., & Weir, T. L. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00494 · Cited by 495 · see citing works
Ghanim, H., Abuaysheh, S., Sia, C. L., Korzeniewski, K., Chaudhuri, A., Fernandez-Real, J. M., & Dandona, P. (2009) · Diabetes Care · doi:10.2337/dc09-0979 · Cited by 494 · see citing works
Rodríguez, J. M. (2014) · Advances in Nutrition · doi:10.3945/an.114.007229 · Cited by 456 · see citing works
Ma, J., Prince, A., Bader, D., Hu, M., Ganu, R., Baquero, K. C., Blundell, P., Harris, R. A., Frias, A. E., Grove, K. L., et al. (2014) · Nature Communications · doi:10.1038/ncomms4889 · Cited by 440 · see citing works
Zeng, M. Y., Cisalpino, D., Varadarajan, S., Hellman, J., Warren, H. S., Cascalho, M., Inohara, N., & Núñez, G. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.006 · Cited by 417 · see citing works
Lassenius, M., Pietiläinen, K., Kaartinen, K., Pussinen, P., Syrjänen, J., Forsblom, C., Pörsti, I., Rissanen, A., Kaprio, J., Mustonen, J., et al. (2011) · Diabetes Care · doi:10.2337/dc10-2197 · Cited by 404 · see citing works
Collado, M. C., Isolauri, E., Laitinen, K., & Salminen, S. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29877 · Cited by 381 · see citing works
The early infant gut microbiome varies in association with a maternal high-fat diet
Chu, D. M., Antony, K. M., Ma, J., Prince, A., Showalter, L., Moller, M., & Aagaard, K. M. (2016) · Genome Medicine · doi:10.1186/s13073-016-0330-z · Cited by 377 · see citing works
Prevalence and Characteristics Associated With Gestational Weight Gain Adequacy
Deputy, N. P., Sharma, A. J., Kim, S. Y., & Hinkle, S. N. (2015) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000000739 · Cited by 355 · see citing works
Maternal IgG and IgA Antibodies Dampen Mucosal T Helper Cell Responses in Early Life
Koch, M. A., Reiner, G. L., Lugo, K. A., Kreuk, L. S. M., Stanbery, A. G., Ansaldo, E., Seher, T. D., Ludington, W. B., & Barton, G. M. (2016) · Cell · doi:10.1016/j.cell.2016.04.055 · Cited by 315 · see citing works
Ghanim, H., Sia, C. L., Upadhyay, M., Korzeniewski, K., Viswanathan, P., Abuaysheh, S., Mohanty, P., & Dandona, P. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28584 · Cited by 299 · see citing works
Emulsified lipids increase endotoxemia: possible role in early postprandial low-grade inflammation
Laugerette, F., Vors, C., Géloën, A., Chauvin, M., Soulage, C. O., Lambert-Porcheron, S., Peretti, N., Alligier, M., Burcelin, R., Laville, M., et al. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.11.011 · Cited by 291 · see citing works
Proteobacteria-specific IgA regulates maturation of the intestinal microbiota
Mirpuri, J., Raetz, M. M., Sturge, C. R., Wilhelm, C. L., Benson, A., Savani, R. C., Hooper, L. V., & Yarovinsky, F. (2013) · Gut Microbes · doi:10.4161/gmic.26489 · Cited by 279 · see citing works
Collado, M. C., Laitinen, K., Salminen, S., & Isolauri, E. (2012) · Pediatric Research · doi:10.1038/pr.2012.42 · Cited by 270 · see citing works
Grönlund, M., Arvilommi, H., Kero, P., Lehtonen, O.-P., & Isolauri, E. (2000) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/fn.83.3.f186 · Cited by 269 · see citing works
Guerra-Ruiz, A. R., Casafont, F., Crespo, J., Cayón, A., Mayorga, M. M., Estébanez, Á., Fernández-Escalante, J. C., & Pons‐Romero, F. (2007) · Obesity Surgery · doi:10.1007/s11695-007-9243-7 · Cited by 268 · see citing works
Cultivation-independent assessment of the bacterial diversity of breast milk among healthy women
Martı́n, R., Heilig, H. G. H. J., Zoetendal, E. G., Jiménez, E., Fernández, L., Smidt, H., & Rodríguez, J. M. (2006) · Research in Microbiology · doi:10.1016/j.resmic.2006.11.004 · Cited by 261 · see citing works
Proteobacteria explain significant functional variability in the human gut microbiome
Bradley, P. H., & Pollard, K. S. (2017) · Microbiome · doi:10.1186/s40168-017-0244-z · Cited by 246 · see citing works
Diet-induced obesity promotes myelopoiesis in hematopoietic stem cells
Singer, K., DelProposto, J. L., Morris, D. L., Zamarron, B. F., Mergian, T. A., Maley, N., Cho, K. W., Geletka, L. M., Subbaiah, P., Muir, L. A., et al. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.06.005 · Cited by 237 · see citing works
Developmental origins of NAFLD: a womb with a clue
Wesolowski, S. R., Kasmi, K. C. E., Jonscher, K. R., & Friedman, J. E. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.160 · Cited by 231 · see citing works
Liver Transplantation for Nonalcoholic Steatohepatitis
Agopian, V. G., Kaldas, F. M., Hong, J. C., Whittaker, M., Holt, C., Rana, A. A., Zarrinpar, A., Petrowsky, H., Farmer, D. G., Yersiz, H., et al. (2012) · Annals of Surgery · doi:10.1097/sla.0b013e31826b4b7e · Cited by 227 · see citing works
Alderete, T. L., Autran, C. A., Brekke, B., Knight, R. D., Bode, L., Goran, M. I., & Fields, D. A. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.115451 · Cited by 200 · see citing works
Luo, Y., Chen, G., Hannemann, N., Ipseiz, N., Krönke, G., Bäuerle, T., Munos, L., Wirtz, S. J., Schett, G. A., & Bözec, A. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.08.020 · Cited by 198 · see citing works
Leoz, M. L. A. D., Kalanetra, K. M., Bokulich, N. A., Strum, J. S., Underwood, M. A., German, J. B., Mills, D. A., & Lebrilla, C. B. (2014) · Journal of Proteome Research · doi:10.1021/pr500759e · Cited by 192 · see citing works
Granowitz, E. V., Porat, R., Mier, J. W., Orencole, S. F., Kaplanski, G., Lynch, E. A., Ye, K., Vannier, E. G., Wolff, S. M., & Dinarello, C. A. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.3.1637 · Cited by 191 · see citing works
Siderophore-mediated iron acquisition and modulation of host-bacterial interactions
Ellermann, M., & Arthur, J. C. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.10.489 · Cited by 186 · see citing works
Maternal Obesity Is Associated with Alterations in the Gut Microbiome in Toddlers
Galley, J. D., Bailey, M. T., Dush, C. M. K., Schoppe‐Sullivan, S. J., & Christian, L. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113026 · Cited by 180 · see citing works
Parental Dietary Fat Intake Alters Offspring Microbiome and Immunity
Myles, I. A., Fontecilla, N. M., Janelsins, B., Vithayathil, P. J., Segre, J. A., & Datta, S. K. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301057 · Cited by 174 · see citing works
Paul, H. A., Bomhof, M. R., Vogel, H. J., & Reimer, R. A. (2016) · Scientific Reports · doi:10.1038/srep20683 · Cited by 173 · see citing works
The role of gut microbiota in programming the immune phenotype
Weng, M., & Walker, W. A. (2013) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174412000712 · Cited by 171 · see citing works
Development of gut microbiota in infants not exposed to medical interventions
Eggesbø, M. Å., Moen, B., Peddada, S. D., Baird, D. D., Rugtveit, J., Midtvedt, T., Bushel, P. R., Sekelja, M., & Rudi, K. (2010) · Apmis · doi:10.1111/j.1600-0463.2010.02688.x · Cited by 159 · see citing works
A Review of the Source and Function of Microbiota in Breast Milk
Stuebe, A. M., Seed, P. C., & LaTuga, M. S. (2014) · Seminars in Reproductive Medicine · doi:10.1055/s-0033-1361824 · Cited by 154 · see citing works
Lemas, D. J., Young, B. E., Baker, P. R., Tomczik, A., Soderborg, T. K., Hernandez, T. L., de la Houssaye, B. A., Robertson, C. E., Rudolph, M. C., Ir, D., et al. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.126375 · Cited by 150 · see citing works
Human milk oligosaccharides reduceEntamoeba histolyticaattachment and cytotoxicityin vitro
Jantscher‐Krenn, E., Lauwaet, T., Bliss, L., Reed, S. L., Gillin, F. D., & Bode, L. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114511007392 · Cited by 144 · see citing works
Mueller, N. T., Shin, H., Pizoni, A., Werlang, I. C. R., Matte, Ú. D. S., Goldani, M. Z., Goldani, H. A. S., & Domínguez-Bello, M. G. (2016) · Scientific Reports · doi:10.1038/srep23133 · Cited by 141 · see citing works
Effect of Maternal Body Mass Index on Hormones in Breast Milk: A Systematic Review
Andreas, N. J., Hyde, M. J., Gale, C., Parkinson, J. R. C., Jeffries, S., Holmes, E. C., & Modi, N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115043 · Cited by 121 · see citing works
Role for MyD88-Independent, TRIF Pathway in Lipid A/TLR4-Induced Endotoxin Tolerance
Biswas, S. K., Bist, P., Dhillon, M. K., Kajiji, T., del Fresno, C., Yamamoto, M., López‐Collazo, E., Akira, S., & Tergaonkar, V. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.6.4083 · Cited by 112 · see citing works
Low and High Birth Weights are Risk Factors for Nonalcoholic Fatty Liver Disease in Children
Newton, K., Feldman, H., Chambers, C., Wilson, L., Behling, C., Clark, J., Molleston, J., Chalasani, N., Sanyal, A., Fishbein, M., et al. (2017) · Jornal de Pediatria · doi:10.1016/j.jpeds.2017.03.007 · Cited by 112 · see citing works
Thorn, S. R., Baquero, K. C., Newsom, S., Kasmi, K. E., Bergman, B., Shulman, G., Grove, K., & Friedman, J. (2014) · Diabetes · doi:10.2337/db14-0276 · Cited by 109 · see citing works
Phylogenetic and Metabolic Tracking of Gut Microbiota during Perinatal Development
CHIERICO, F. D., Vernocchi, P., Petrucca, A., Paci, P., Fuentes, S., Praticò, G., Capuani, G., Masotti, A., Reddel, S., Russo, A., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137347 · Cited by 108 · see citing works
Burgess, S. L., Buonomo, E. L., Carey, M. A., Cowardin, C. A., Naylor, C., Noor, Z., Wills-Karp, M. A., & Petri, W. A. (2014) · mBio · doi:10.1128/mbio.01817-14 · Cited by 100 · see citing works
Distinct Lipid A Moieties Contribute to Pathogen-Induced Site-Specific Vascular Inflammation
Slocum, C., Coats, S. R., Hua, N., Kramer, C. D., Papadopoulos, G., Weinberg, E. O., Gudino, C. V., Hamilton, J. A., Darveau, R. P., & Genco, C. A. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004215 · Cited by 96 · see citing works
Differential regulation of cytokine production in lipopolysaccharide tolerance in mice
Erroi, A., Fantuzzi, G., Mengozzi, M., Sironi, M., Orencole, S. F., Clark, B. D., Dinarello, C. A., Isetta, A. M., Gnocchi, P., & Giovarelli, M. (1993) · Infection and Immunity · doi:10.1128/iai.61.10.4356-4359.1993 · Cited by 95 · see citing works
Maternal Response to Two Electric Breast Pumps
Hopkinson, J. M., & Heird, W. C. (2009) · Breastfeeding Medicine · doi:10.1089/bfm.2008.0133 · Cited by 88 · see citing works
Maternal obesity during pregnancy is negatively associated with maternal and neonatal iron status
Jones, A. D., Zhao, G., Jiang, Y.-P., Zhou, M., Xu, G., Kaciroti, N., Zhang, Z., & Lozoff, B. (2016) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2015.229 · Cited by 82 · see citing works
Tang, M., Frank, D. N., Sherlock, L. G., Ir, D., Robertson, C. E., & Krebs, N. F. (2016) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001154 · Cited by 74 · see citing works
Maternal Obesity Affects Inflammatory and Iron Indices in Umbilical Cord Blood
Dosch, N. C., Guslits, E., Weber, M. B., Murray, S. E., Ha, B., Coe, C. L., Auger, A. P., & Kling, P. J. (2016) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2016.02.023 · Cited by 69 · see citing works
Microbiota, Immune Subversion, and Chronic Inflammation
Kramer, C. D., & Genco, C. A. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00255 · Cited by 66 · see citing works
Leatham-Jensen, M. P., Frimodt-Møller, J., Adediran, J., Mokszycki, M. E., Banner, M., Caughron, J. E., Krogfelt, K. A., Conway, T., & Cohen, P. S. (2012) · Infection and Immunity · doi:10.1128/iai.06193-11 · Cited by 60 · see citing works
Preterm infant nutrition, gut bacteria, and necrotizing enterocolitis
Neu, J. (2015) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000169 · Cited by 59 · see citing works
Increased Survival of Antibiotic-Resistant Escherichia coli inside Macrophages
Miskinyte, M., & Gordo, I. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01632-12 · Cited by 53 · see citing works
Erridge, C., Spickett, C. M., & Webb, D. J. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.11.004 · Cited by 52 · see citing works
Coveney, A., Wang, W., Kelly, J., Liu, J. H., Blankson, S., Wu, Q. D., Redmond, H. P., & Wang, J. H. (2015) · Scientific Reports · doi:10.1038/srep13694 · Cited by 45 · see citing works
The Cytokine Response to Lipopolysaccharide Does Not Predict the Host Response to Infection
Fensterheim, B. A., Guo, Y., Sherwood, E. R., & Bohannon, J. K. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1602106 · Cited by 45 · see citing works
Ng, R. L. X., Scott, N. M., Strickland, D. H., Gorman, S., Grimbaldeston, M. A., Norval, M., Waithman, J. C., & Hart, P. H. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202786 · Cited by 41 · see citing works
Giusti, L., Gabriele, M., Penno, G., Garofolo, M., Longo, V. G., Prato, S. D., Lucchesi, D., & Pucci, L. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/1026268 · Cited by 39 · see citing works
Ogra, P. L. O., & Welliver, R. C. (2008) · Nestlé Nutrition Institute Workshop series · doi:10.1159/000113492 · Cited by 35 · see citing works
Optimizing weight for maternal and infant health: tenable, or too late?
Nicklas, J. M., & Barbour, L. A. (2014) · Expert Review of Endocrinology & Metabolism · doi:10.1586/17446651.2014.991102 · Cited by 32 · see citing works
Intestinal Microbiota Studies in Preterm Infants
Neu, J. (2015) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001068 · Cited by 4 · see citing works
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Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing
Gantenbein, K. V., & Kanaka-Gantenbein, C. (2021) · Nutrients · doi:10.3390/nu13061951 · Cited by 288 · see citing works
The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD
Soderborg, T. K., Clark, S. E., Mulligan, C. E., Janssen, R. C., Babcock, L. R., Ir, D., Young, B. E., Krebs, N. F., Lemas, D. J., Johnson, L. K., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06929-0 · Cited by 291 · see citing works
Xie, R., Sun, Y., Wu, J., Huang, S., Jin, G., Guo, Z., Zhang, Y., Liu, T., Liu, X., Cao, X., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02608 · Cited by 126 · see citing works
Development and Function of the Intestinal Microbiome and Potential Implications for Pig Production
Nowland, T. L., Plush, K. J., BARTON, M. D., & Kirkwood, R. N. (2019) · Animals · doi:10.3390/ani9030076 · Cited by 126 · see citing works
Hsu, C., & Tain, Y. (2019) · Nutrients · doi:10.3390/nu11040894 · Cited by 106 · see citing works
Jian, C., Carpén, N., Helve, O., de Vos, W. M., Korpela, K., & Salonen, A. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103475 · Cited by 105 · see citing works
Maternal Microbiome and Metabolic Health Program Microbiome Development and Health of the Offspring
Calatayud, M., Koren, O., & Collado, M. C. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.07.021 · Cited by 97 · see citing works
Nutrition therapy within and beyond gestational diabetes
Hernandez, T. L., Mande, A., & Barbour, L. A. (2018) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2018.04.004 · Cited by 86 · see citing works
Dai, X., Guo, Z., Chen, D., Li, L., Song, X., Liu, T., Jin, G., Li, Y., Liu, Y., Ajiguli, A., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1738187 · Cited by 87 · see citing works
The microbiota composition of the offspring of patients with gestational diabetes mellitus (GDM)
Ponzo, V., Ferrocino, I., Zarovska, A., Amenta, M. B., Leone, F., Monzeglio, C., Rosato, R., Pellegrini, M., Gambino, R., Cassader, M., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0226545 · Cited by 86 · see citing works
Gestational Diabetes Is Uniquely Associated With Altered Early Seeding of the Infant Gut Microbiota
Soderborg, T. K., Carpenter, C. M., Janssen, R. C., Weir, T. L., Robertson, C. E., Ir, D., Young, B. E., Krebs, N. F., Hernandez, T. L., Barbour, L. A., et al. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.603021 · Cited by 82 · see citing works
Epigenetics and neurodegeneration: role of early-life nutrition
Gabbianelli, R., & Damiani, E. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.01.014 · Cited by 81 · see citing works
Air Pollution, Early Life Microbiome, and Development
Vallès, Y., & Francino, M. P. (2018) · Current Environmental Health Reports · doi:10.1007/s40572-018-0215-y · Cited by 65 · see citing works
Paul, H., Collins, K., Nicolucci, A. C., Urbanski, S., Hart, D. A., Vogel, H. J., & Reimer, R. A. (2019) · The FASEB Journal · doi:10.1096/fj.201801551r · Cited by 49 · see citing works
Abbasi, A., Aghebati‐Maleki, A., Yousefi, M., & Maleki, L. A. (2020) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2020.103244 · Cited by 57 · see citing works
Pre-Eclampsia: Microbiota possibly playing a role
Ahmadian, E., Saadat, Y. R., Khatibi, S. M. H., Nariman‐Saleh‐Fam, Z., Bastami, M., Vahed, F. Z., Ardalan, M., & Vahed, S. Z. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104692 · Cited by 53 · see citing works
Wang, X., Chen, D., Li, Y., Zhao, S., Chen, C., & Ning, D. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.11.022 · Cited by 52 · see citing works
Hsu, C., Hou, C., Lee, C., Chan, J. Y. H., & Tain, Y. (2019) · Nutrients · doi:10.3390/nu11091982 · Cited by 49 · see citing works
Microbiome‐immune‐metabolic axis in the epidemic of childhood obesity: Evidence and opportunities
Kincaid, H. J., Nagpal, R., & Yadav, H. (2019) · Obesity Reviews · doi:10.1111/obr.12963 · Cited by 47 · see citing works
Wang, M., Xie, Z., Li, L., Chen, Y., Yuan, L., Wang, Y., Lu, B., Zhang, S., Ma, F., Ma, C., et al. (2019) · Food & Function · doi:10.1039/c8fo02565g · Cited by 45 · see citing works
Alves, J. L. D. B., de Oliveira, Y., Carvalho, N., Cavalcante, R. G. S., Lira, M. M. P., do Nascimento, L. C. P., Magnani, M., Vidal, H., Braga, V. A., & de Souza, E. L. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104252 · Cited by 42 · see citing works
Aloisio, I., Prodam, F., Giglione, E., Cionci, N. B., Solito, A., Bellone, S., Baffoni, L., Mogna, L., Pane, M., Bona, G., et al. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00039 · Cited by 38 · see citing works
Microbiome Profiles of Ligature-Induced Periodontitis in Nonhuman Primates across the Life Span
Kirakodu, S. S., Chen, J., González‐Martínez, J., González, O. A., & Ebersole, J. L. (2019) · Infection and Immunity · doi:10.1128/iai.00067-19 · Cited by 36 · see citing works
Alsharairi, N. A. (2020) · Microorganisms · doi:10.3390/microorganisms8081119 · Cited by 34 · see citing works
Alabduljabbar, S., Zaidan, S. A., Lakshmanan, A. P., & Terranegra, A. (2021) · Life · doi:10.3390/life11060467 · Cited by 34 · see citing works
Host Factors of Favorable Intestinal Microbial Colonization
Pirr, S. M., & Viemann, D. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.584288 · Cited by 29 · see citing works
Chleilat, F., Schick, A., Deleemans, J. M., Ma, K., Alukic, E., Wong, J., Tuplin, E. W. N., Nettleton, J. E., & Reimer, R. A. (2021) · The FASEB Journal · doi:10.1096/fj.202100198rr · Cited by 31 · see citing works
Nazzari, S., Grumi, S., Mambretti, F., Villa, M., Giorda, R., Provenzi, L., MOM-COPE Study Group, Borgatti, R., Biasucci, G., Decembrino, L., et al. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02160-0 · Cited by 31 · see citing works
Khine, W. W. T., Rahayu, E. S., See, T. Y., Kuah, S., Salminen, S., Nakayama, J., & Lee, Y. K. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1761240 · Cited by 30 · see citing works
Gaukroger, C. H., Edwards, S. A., Walshaw, J., Nelson, A., Adams, I. P., Stewart, C. J., & Kyriazakis, I. (2020) · animal · doi:10.1016/j.animal.2020.100135 · Cited by 30 · see citing works
Carter, S., Lin, J. C., Chow, T., Yu, X., Rahman, M. M., Martinez, M. P., Feldman, K., Eckel, S. P., Chen, J., Chen, Z., et al. (2022) · Autism · doi:10.1177/13623613221118430 · Cited by 28 · see citing works
Preconception helminth infection alters offspring microbiota and immune subsets in a mouse model
Nyangahu, D. D., Darby, M., Havyarimana, E., Brown, B. P., Horsnell, W. G. C., & Jaspan, H. B. (2020) · Parasite Immunology · doi:10.1111/pim.12721 · Cited by 27 · see citing works
Role of Maternal Microbiota and Nutrition in Early-Life Neurodevelopmental Disorders
Daliry, A., & Pereira, E. N. G. D. S. (2021) · Nutrients · doi:10.3390/nu13103533 · Cited by 28 · see citing works
Zhang, H., Wang, Y., Zhang, X., Zhang, L. R., Zhao, X., Xu, Y., Wang, P., Liang, X., Xue, M., & Liang, H. (2023) · Nutrients · doi:10.3390/nu15224726 · Cited by 28 · see citing works
Nutrition, Gut Microbiota, and Allergy Development in Infants
Rey-Mariño, A., & Francino, M. P. (2022) · Nutrients · doi:10.3390/nu14204316 · Cited by 27 · see citing works
Conta, G., CHIERICO, F. D., Reddel, S., Marini, F., Sciubba, F., Capuani, G., Tomassini, A., Cocco, M. E. D., Laforgia, N., Baldassarre, M. E., et al. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.688440 · Cited by 25 · see citing works
Ecoevolutionary processes structure milk microbiomes across the mammalian tree of life
Keady, M., Jiménez, R. R., Bragg, M., Wagner, J. C. P., Bornbusch, S. L., Power, M. L., & Muletz‐Wolz, C. R. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2218900120 · Cited by 25 · see citing works
Radford‐Smith, D. E., & Anthony, D. C. (2023) · Metabolites · doi:10.3390/metabo13030455 · Cited by 22 · see citing works
Carson, K. E., Alvarez, J., Mackley, J., Travagli, R. A., & Browning, K. N. (2023) · The Journal of Physiology · doi:10.1113/jp284726 · Cited by 23 · see citing works
Dai, X., Wang, C., Guo, Z., Li, Y., Liu, T., Jin, G., Wang, S., Wang, B., Jiang, K., & Cao, H. (2021) · Food & Function · doi:10.1039/d1fo02921e · Cited by 20 · see citing works
Gawlik, A., Salonen, A., Jian, C., Yanover, C., Antosz, A., Shmoish, M., Wasniewska, M. G., Bereket, A., Wudy, S. A., Hartmann, M. F., et al. (2021) · Pediatric Obesity · doi:10.1111/ijpo.12835 · Cited by 20 · see citing works
Maternal Gut Dysbiosis Alters Offspring Microbiota and Social Interactions
Zhang, Z., Xue, C., Ju, M., Guo, J., Wang, M., Yi, S., & Yi, X. (2021) · Microorganisms · doi:10.3390/microorganisms9081742 · Cited by 18 · see citing works
Free threonine in human breast milk is related to infant intestinal microbiota composition
Riederer, M., Schweighofer, N., Trajanoski, S., Stelzer, C., Zehentner, M., Fuchs‐Neuhold, B., Kashofer, K., Mayr, J. A., Hörmann-Wallner, M., Holasek, S. J., et al. (2021) · Amino Acids · doi:10.1007/s00726-021-03057-w · Cited by 19 · see citing works
Consequences of colonialism: A microbial perspective to contemporary Indigenous health
Skelly, E., Kapellas, K., Cooper, A., & Weyrich, L. S. (2018) · American Journal of Physical Anthropology · doi:10.1002/ajpa.23637 · Cited by 18 · see citing works
Rodriguez‐Caro, H., & Williams, S. A. (2018) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174418000569 · Cited by 17 · see citing works
The role of gut micorbiome in obesity and diabetes
Górowska‐Kowolik, K., & Chobot, A. P. (2019) · World Journal of Pediatrics · doi:10.1007/s12519-019-00267-x · Cited by 17 · see citing works
Snow, S. J., Broniowska, K. A., Karoly, E. D., Henriquez, A. R., Phillips, P. M., Ledbetter, A. D., Schladweiler, M. C. J., Miller, C. N., Gordon, C. J., & Kodavanti, U. P. (2020) · Scientific Reports · doi:10.1038/s41598-020-73361-0 · Cited by 16 · see citing works
Cömert, T. K., Akpınar, F., Erkaya, S., Durmaz, B., & Durmaz, R. (2022) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2022.2148098 · Cited by 16 · see citing works
The influence of maternal diet on offspring’s gut microbiota in early life
Peng, L., Tan, Y., & Bajinka, O. (2023) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-023-07305-0 · Cited by 15 · see citing works
Li, J.-M., Wan, Y., Zheng, Z., Zhang, H.-Q., Li, Y., Guo, X.-F., Li, K.-L., & Li, D. (2021) · Food & Function · doi:10.1039/d1fo00906k · Cited by 12 · see citing works
Bianco, I., Ferrara, C., Romano, F., Loperfido, F., Sottotetti, F., Masri, D. E., Vincenti, A., Cena, H., & Giuseppe, R. D. (2024) · Biomedicines · doi:10.3390/biomedicines12112423 · Cited by 15 · see citing works
Tang, M. H., Ligthart, I., Varga, S., Lebeer, S., van Overveld, F. J., & Rijkers, G. T. (2025) · Biology · doi:10.3390/biology14030299 · Cited by 14 · see citing works
Bioinformatics and machine learning in gastrointestinal microbiome research and clinical application
Hopson, L. M., Singleton, S. S., David, J. A., Basuchoudhary, A., Prast‐Nielsen, S., Klein, P., Sen, S., & Mazumder, R. (2020) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2020.08.011 · Cited by 15 · see citing works
Gut Injury and the Microbiome in Neonates
Pammi, M., Hollister, E. B., & Neu, J. (2020) · Clinics in Perinatology · doi:10.1016/j.clp.2020.02.010 · Cited by 13 · see citing works
Melo, G. M., Capucho, A. M., Sacramento, J. F., Ponce-de-Leão, J., Fernandes, M. V., Almeida, I. F., Martins, F. O., & Conde, S. V. (2023) · Nutrients · doi:10.3390/nu16010067 · Cited by 12 · see citing works
Jiang, L., Du, L.-D., Zeng, J., Chu, H., Peng, Z., & Fan, J. (2025) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2025.0718 · Cited by 12 · see citing works
Zhang, Q., Dong, Y., & Fan, J. (2023) · Hepatobiliary & pancreatic diseases international · doi:10.1016/j.hbpd.2023.12.007 · Cited by 10 · see citing works
Barnett, J. A., Josephson, J. K., Yuzbashian, E., Haskey, N., Hart, M. M., Soma, K. K., Verdugo, A., McComb, C. J., Bandy, M. L., Ghosh, S., et al. (2025) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2025.180437 · Cited by 10 · see citing works
Mouse Chow Composition Influences Immune Responses and Food Allergy Development in a Mouse Model
Weidmann, E., Samadi, N., Klems, M., Heiden, D., Seppova, K., Ret, D., & Untersmayr, E. (2018) · Nutrients · doi:10.3390/nu10111775 · Cited by 10 · see citing works
Breast feeding, obesity, and asthma association: clinical and molecular views
Kian, N., Bagheri, A., Salmanpour, F., Soltani, A., Mohajer, Z., Samieefar, N., Barekatain, B., & Kelishadi, R. (2023) · Clinical and Molecular Allergy · doi:10.1186/s12948-023-00189-0 · Cited by 10 · see citing works
Developmental Contributions to Obesity
Wu, A. J., & Oken, E. (2023) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2023.02.001 · Cited by 9 · see citing works
Kebbe, M., Shankar, K., Redman, L. M., & Andres, A. (2024) · Journal of Nutrition · doi:10.1016/j.tjnut.2024.02.029 · Cited by 9 · see citing works
Mukherjee, A. M. (2025) · Infection and Immunity · doi:10.1128/iai.00502-25 · Cited by 10 · see citing works
The benefits of probiotic interventions in maternal-fetal health: An appraise review
Dhillon, P., Singh, K., & Kaur, K. (2020) · PharmaNutrition · doi:10.1016/j.phanu.2020.100211 · Cited by 9 · see citing works
The neonatal microbiome in utero and beyond: perinatal influences and long-term impacts
Hill, L., Sharma, R., Hart, L., Popov, J., Moshkovich, M., & Pai, N. (2021) · Journal of Laboratory Medicine · doi:10.1515/labmed-2021-0131 · Cited by 9 · see citing works
Novel Perspective on the Regulation of Offspring Food Allergy by Maternal Diet and Nutrients
Bai, T., Wang, Z., Shao, H., Zhang, X., Lorenz, A., Meng, X., Wu, Y., Chen, H., & Li, X. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c09108 · Cited by 11 · see citing works
Gut ecosystem during infancy: The role of “biotics”
Toca, M. D. C., Burgos, F., Fernández, A., Giglio, N., Orsi, M., Sosa, P., Tabacco, O., Ursino, F., Ussher, F., & Vinderola, G. (2020) · Archivos Argentinos de Pediatria · doi:10.5546/aap.2020.eng.278 · Cited by 8 · see citing works
Activation of Proneuronal Transcription Factor Ascl1 in Maternal Liver Ensures a Healthy Pregnancy
Lee, J., Garcia, V., Nambiar, S. M., Jiang, H., & Dai, G. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.08.009 · Cited by 8 · see citing works
Djekkoun, N., Dépeint, F., Guibourdenche, M., Sabbouri, H. E. K. E., Corona, A., Rhazi, L., Gay‐Queheillard, J., Rouabah, L., Biendo, M., Al‐Salameh, A., et al. (2022) · European Journal of Nutrition · doi:10.1007/s00394-022-03063-y · Cited by 8 · see citing works
Hypertension and renal disease programming: focus on the early postnatal period
Borghese, M. F. A., Oronel, L. H., Ortiz, M. D. C., & Majowicz, M. P. (2022) · Clinical Science · doi:10.1042/cs20220293 · Cited by 6 · see citing works
Metabolic Programming and Nutrition
Brasiel, P. G. D. A., & Luquetti, S. C. P. D. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.92201 · Cited by 6 · see citing works
Gut Microbiome of a Multiethnic Community Possessed No Predominant Microbiota
Khine, W. W. T., Teo, A. H. T., Loong, L. W. W., Tan, J. J. H., Ang, C. G. H., Ng, W., Lee, C. N., Zhu, C., Lau, Q. C., & Lee, Y. K. (2021) · Microorganisms · doi:10.3390/microorganisms9040702 · Cited by 5 · see citing works
Gut microbiota and the ways to correct it in chronic kidney disease
Стуров, Н. В., Popov, S. V., & Belikov, I. (2023) · Indian Journal of Nephrology · doi:10.4103/ijn.ijn_469_21 · Cited by 5 · see citing works
Cecchini, L., Barmaz, C., Coloma, M. J., Baeschlin, H., Etter, J., Netzer, S., Bregy, L., Marchukov, D., Trigo, N. F., Meier, R., et al. (2023) · BMC Pediatrics · doi:10.1186/s12887-023-04198-5 · Cited by 3 · see citing works
Relationship of maternal high-fat diet to intestinal barrier integrity and disease in offspring
Zhang, C., Zhong, W., Miao, L., Lin, Z., Sun, S., Jiang, M., Jin, C., & Shi, L. (2025) · Nutrition Research · doi:10.1016/j.nutres.2025.06.003 · Cited by 4 · see citing works
Nutrient metabolism and requirements in lactation
Francis, J., & Egdorf, R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818460-8.00004-6 · Cited by 4 · see citing works
Bayaga, C. L. T., Tanguilig, K. M. N., Aba, R. P. M., Pico, M. B., & Gabriel, A. A. (2020) · Journal of Applied Microbiology · doi:10.1111/jam.14974 · Cited by 4 · see citing works
Nutrigenomics as a Strategy for Neuronal Health
Damiani, E., & Gabbianelli, R. (2019) · Healthy ageing and longevity · doi:10.1007/978-3-030-24958-8_9 · Cited by 4 · see citing works
Alterations in Gut Microbiota of Infants Born to Mothers with Obesity
Meiirmanova, Z., Mukhanbetzhanov, N., Jarmukhanov, Z., Vinogradova, E. B., Kozhakhmetova, S., Morenko, M., Duisebayeva, A., Poddighe, D., Kushugulova, A. R., & Kozhakhmetov, S. (2025) · Biomedicines · doi:10.3390/biomedicines13040838 · Cited by 3 · see citing works
Exploring the Vital Role of Microbiota Metabolites in Early-Life Health
Zhang, B., Lin, Y., Song, S., & Guo, H. (2025) · Journal of Nutrition · doi:10.1016/j.tjnut.2025.04.025 · Cited by 3 · see citing works
Zhao, M., Li, X., Li, Y., Ma, L., Liu, Y., Wang, S., Tian, J., Liang, Y., Shen, C., Ma, X., et al. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s534551 · Cited by 3 · see citing works
Xixi, N. A., Karamanolis, G. P., Vlachogianni, E.-E., Voulgaris, T. A., Sokou, R., Volaki, P., Paliatsiou, S., Iliodromiti, Z., Iacovidou, N. M., & Boutsikou, Τ. (2026) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2026.1751708 · Cited by 2 · see citing works
Lipski, E. A. (2020) · Springer eBooks · doi:10.1007/978-3-030-30730-1_23 · Cited by 2 · see citing works
Wang, Q., Lu, X., Hu, W., Zhang, C., Liu, K., Tong, K., Chen, K., & Wang, H. (2024) · Food Science and Human Wellness · doi:10.26599/fshw.2023.9250035 · Cited by 2 · see citing works
“Molecular aspects of dietary polyphenols in pregnancy”
Santangelo, C., & Masella, R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813862-5.00010-4 · Cited by 2 · see citing works
Early Life Events and Development of Gut Microbiota in Infancy
Jeong, S. (2021) · Korean Journal of Gastroenterology · doi:10.4166/kjg.2021.408 · Cited by 2 · see citing works
Ecosistema intestinal en la infancia: rol de los “bióticos”
(2020) · Archivos Argentinos de Pediatria · doi:10.5546/aap.2020.278 · Cited by 3 · see citing works
Heinecke, F., Fornes, D. D., Capobianco, E., Quiroga, J. P. F., Labiano, M., Faletti, A. G., Jawerbaum, A., & White, V. (2024) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2024.112201 · Cited by 1 · see citing works
Experience-dependent development of vagal circuitry in rodents and humans
Panvini, S., Kamitakahara, A. K., Rinaman, L., & Levitt, P. R. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106728 · Cited by 2 · see citing works
Microbiota intestinal en pediatría
Camacho, J. H., Pinilla, L. R., Peña, D. S., Dueñas, S. S., Carvajal, D. R., Castillo, N. B., Peña, R. R., Saenz, I. P., Quesada, S. M., Salazar, A. G., et al. (2020) · Revista Repertorio de Medicina y Cirugía · doi:10.31260/repertmedcir.01217372.1100 · Cited by 1 · see citing works
Comment on G. N. Vallianatou et al.
Hu, Q., Lv, Z., & Niu, H. (2025) · Pediatric Allergy and Immunology · doi:10.1111/pai.70023 · Cited by 1 · see citing works
Hart, D. A., Herzog, W., Rios, J. L., Reimer, R. A., & Collins, K. H. (2020) · Springer eBooks · doi:10.1007/978-3-030-35358-2_7 · Cited by 1 · see citing works
Sleep Apnoea and Early Antecedents of Adult Disease
Gozal, D. (2018) · Barcelona Respiratory Network · doi:10.23866/brnrev:2017-0030
Molecular Regulation of Maternal Hepatic Adaptations to Pregnancy
Lee, J. (2020) · Purdue e-Pubs (Purdue University System) · doi:10.25394/pgs.12221951.v1
Profil Mikrobiota Saluran Cerna Pada Anak, Dewasa, Berbagai Suku dan Ras
Kurniawan, D., Makmun, A., Zulfahmidah, Z., & Aisyah, . N. (2020) · Indonesian Journal of Health · doi:10.33368/inajoh.v0i0.6
Lavine, J. E. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734302582.793574474
Dietary Fiber Intake and Chronic Diseases Outcome During Pregnancy
Guo, C., Luo, X., Xiao, M., & Zhao, Y. (2022) · Highlights in Science Engineering and Technology · doi:10.54097/hset.v2i.553
Microbiome Applications for Sustainable Food Systems
Trif, M., Alexandru Vasile, R. U. S. U., Francino, M. P., Delgado, G., & Rufián‐Henares, J. Á. (2022) · Springer eBooks · doi:10.1007/978-3-031-07434-9_8
Enaud, R. (2023) · Perfectionnement en Pédiatrie · doi:10.1016/s2588-932x(23)00149-3
Maternal thyroid-gut dynamics during pregnancy and cognitive trajectories in children
Yadav, A., Wankhede, N. L., Sangamwar, S., Taksande, B. G., Aglawe, M. M., Rahangdale, S. R., Umekar, M., & Kale, M. (2026) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2026.101254
- Authors
- Mulligan, C. M., & Friedman, J. E.
- Affiliations
- University of Colorado Anschutz (US)
- Corresponding author
- Friedman, Jacob E
- ORCID
- Friedman, Jacob E
- Venue
- Journal of Endocrinology
- Publisher
- Bioscientifica
- Published
- 2017-10-01
- Volume
- 235
- Issue
- 1
- Pages
- R1-R12
- ISSN
- 0022-0795 (ISSN-L)
- 1479-6805
- PMC
- PMC5568816
- OpenAlex
- W2739563526
- Cited by
- 101
- References
- 106
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 5 · 2023: 12 · 2022: 8 · 2021: 15 · 2020: 25 · 2019: 12 · 2018: 11
- FWCI
- 1.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (NIH-R01, DK048520)
- Nutrition Obesity Research Center, University of North Carolina
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK078590, P30DK048520)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- maternal obesity, maternal high-fat diet, infant gut microbiota, developmental programming, metabolic disorders, neonatal innate immunity, intestinal barrier integrity, offspring obesity risk
- MeSH terms
- Gastrointestinal Microbiome, Animals, Female, Humans, Infant, Metabolic Diseases, Pregnancy, Prenatal Exposure Delayed Effects
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