Host-microbiota interactions and adaptive immunity
Abstract
All mucosal surfaces are colonized with a vast number of microbes, which are essential for stimulating and regulating the immune system. While intrinsic and innate mechanisms exist to promote a strong barrier between the microbiota and the host to ensure compartmentalization, the microbiota is also able to induce robust adaptive immunity. In this review, we discuss the interplay between the microbiota and the adaptive immune system, with a focus on the induction of mucosal and systemic antibody responses and newly defined roles of maternal antibodies. We also highlight recent studies that aim to decipher microbial antigen-specificity of the T-cell compartment.
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The microbiota orchestrates the local immune system in the intestine and shapes immune and non-immune cells located at distal sites and acting systemically.
“Notably, the microbiota orchestrates the local immune system in the intestine (67), and shapes immune and non-immune cells located in distal sites and acting systemically (68, 69).”
From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [69]
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- Authors
- McCoy, K. D., Ronchi, F., & Geuking, M. B.
- Affiliations
- University of Calgary (CA)
- University Hospital of Bern (CH)
- Corresponding author
- McCoy, Kathy D.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2017-08-30
- Volume
- 279
- Issue
- 1
- Pages
- 63-69
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W2753384065
- Cited by
- 77
- References
- 53
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 6 · 2023: 12 · 2022: 9 · 2021: 10 · 2020: 10 · 2019: 11 · 2018: 8 · 2017: 2
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Immunological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Bern Open Repository and Information System (University of Bern) (submittedVersion)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (SNSF310030_134902)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- host-microbiota interactions, adaptive immunity, mucosal immunity, systemic antibody response, mucosal antibody response, maternal antibodies, T cell antigen specificity, innate immunity, mucosal colonization, immune regulation
- MeSH terms
- Animals, Antibodies, Antigens, Bacterial, Humans, Immunity, Maternally-Acquired, Mucous Membrane, T-Lymphocytes, T-Cell Antigen Receptor Specificity, Adaptive Immunity, Immunity, Humoral
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