Cited by 130Gut microbiota and healthInflammatory Bowel DiseaseGastrointestinal motility and disorders

Host-Microbiota Interactions Shape Local and Systemic Inflammatory Diseases

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Grigg, John B, Sonnenberg, Gregory F·2017·The Journal of Immunology

Abstract

Recent advances in understanding how the mammalian immune system and intestinal microbiota functionally interact have yielded novel insights for human health and disease. Modern technologies to quantitatively measure specific members and functional characteristics of the microbiota in the gastrointestinal tract, along with fundamental and emerging concepts in the field of immunology, have revealed numerous ways in which host-microbiota interactions proceed beneficially, neutrally, or detrimentally for mammalian hosts. It is clear that the gut microbiota has a strong influence on the shape and quality of the immune system; correspondingly, the immune system guides the composition and localization of the microbiota. In the following review, we examine the evidence that these interactions encompass homeostasis and inflammation in the intestine and, in certain cases, extraintestinal tissues. Lastly, we discuss translational therapies stemming from research on host-microbiota interactions that could be used for the treatment of chronic inflammatory diseases.

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  • The microbiota orchestrates the local immune system in the intestine and shapes immune and non-immune cells located at distal sites and acting systemically.

    “Notably, the microbiota orchestrates the local immune system in the intestine (67), and shapes immune and non-immune cells located in distal sites and acting systemically (68, 69).”

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Authors
Grigg, J. B., & Sonnenberg, G. F.
Affiliations
Weill Cornell Medicine (US)
Corresponding author
Sonnenberg, Gregory F
Venue
The Journal of Immunology
Published
2017-01
Volume
198
Issue
2
Pages
564-571
ISSN
  • 0022-1767 (ISSN-L)
  • 1550-6606
OpenAlex
W2577439289
Cited by
130
References
124
Citations by year
2026: 2 · 2025: 6 · 2024: 19 · 2023: 21 · 2022: 14 · 2021: 17 · 2020: 21 · 2019: 9 · 2018: 9 · 2017: 11
FWCI
1.27
Type
journal article
Language
en
Open access
Locations
  • The Journal of Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Crohn's and Colitis Foundation of America
  • American Asthma Foundation
  • Crohn's and Colitis Foundation
  • Searle Scholars Program
  • National Institutes of Health (DP5OD012116)
  • National Institute of Allergy and Infectious Diseases (U01AI095608, R01AI123368)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R21DK110262)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
host-microbiota interactions, gut microbiota, intestinal inflammation, systemic inflammation, immune system, microbiota composition, immune homeostasis, chronic inflammatory diseases, microbiota-based therapy
MeSH terms
Gastrointestinal Microbiome, Animals, Homeostasis, Humans, Immune System, Inflammation

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