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Yolk Sac Macrophages, Fetal Liver, and Adult Monocytes Can Colonize an Empty Niche and Develop into Functional Tissue-Resident Macrophages
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“Tissue macrophages, such as Kupffer cells (KC) and alveolar macrophages (AM), have been reported to be faithfully replaced by BM-derived cells in irradiation chimeras and other small animal models involving deficiencies of the resident compartment6–9.”
From Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge (2018) · cites this paper as [9]
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BackgroundFate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis
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“…many speculations, ranging from the concept that the ability to generate self-maintaining macrophages is restricted to embryonic progenitors (Gomez Perdiguero et al., 2015) to the idea that the gradual switch from a predominantly embryonic to a predominantly adult origin of cardiac macrophages…”
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Metadata
- Authors
- van de Laar, L., Saelens, W., De Prijck, S., Martens, L., Scott, C. L., Van Isterdael, G., Hoffmann, E., Beyaert, R., Saeys, Y., Lambrecht, B. N., & Guilliams, M.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 44
- Issue
- 4
- Pages
- 755-768
- ISSN
- 1074-7613
- Cited by
- 648
- References
- 37
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 383 d)
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