Myeloid cell heterogeneity in cancer: not a single cell alike
Abstract
Tumors of various histological origins show abundant infiltration of myeloid cells from early stages of disease progression. These cells have a profound impact on antitumor immunity and influence fundamental processes that underlie malignancy, including neoangiogenesis, sustained cancer cell proliferation, metastasis and therapy resistance. For these reasons, development of therapeutic approaches to deplete or reprogram myeloid cells in cancer is an emerging field of interest. However, knowledge about the heterogeneity of myeloid cells in tumors and their variability between patients and disease stages is still limited. In this review, we summarize the most recent advances in our understanding about how the phenotype of tumor-associated macrophages, monocytes, neutrophils, myeloid-derived suppressor cells and dendritic cells is dictated by their ontogeny, activation status and localization. We also outline major open questions that will only be resolved by applying high-dimensional single-cell technologies and systems biology approaches in the analysis of the tumor microenvironment.
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Myeloid subsets include CD1C DCs, CLEC9A cells, Langerhans cells, AS DCs, plasmacytoid DCs, and migrating DCs.
“The remaining subsets were re-clustered into CD1C DCs (CD1C, CLEC10A), CLEC9A cells (CLEC9A, CADM1, XCR1), Langerhans cells (CD207, CD1A, S100B), AS DCs (AXL, IGFBP5, PPP1R14A), plasmacytoid DCs (CLEC4C, IL3RA), and migrating DCs (CCR7, CCL19) (Bronte et al., 2016, Kiss et al., 2018, Villani et al., 2017).”
From Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma (2020) · cites this paper as Kiss et al., 2018
Myeloid subsets include macrophages (CD163, CD68) and MDSCs (S100A8, S100A9, TREM1).
“clusters high in the monocyte marker CD14, which were further re-clustered into macrophages (CD163, CD68) and MDSCs (S100A8, S100A9, TREM1).”
From Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma (2020) · cites this paper as Kiss et al., 2018
Cites
The cancer genome atlas pan-cancer analysis project
The Cancer Genome Atlas Research Network, Weinstein, J. N., Collisson, E. A., Mills, G. B., Shaw, K. R. M., Ozenberger, B. A., Ellrott, K., Shmulevich, I., Sander, C., & Stuart, J. M. (2013) · Nature Genetics · doi:10.1038/ng.2764 · Cited by 9,092 · see citing works
Trapnell, C., Cacchiarelli, D., Grimsby, J., Pokharel, P., Li, S., Morse, M., Lennon, N. J., Livak, K. J., Mikkelsen, T. S., & Rinn, J. L. (2014) · Nature Biotechnology · doi:10.1038/nbt.2859 · Cited by 7,314 · see citing works
Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189 · see citing works
A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease
Keren-Shaul, H., Spinrad, A., Weiner, A., Matcovitch-Natan, O., Dvir-Szternfeld, R., Ulland, T. K., David, E., Baruch, K., Lara-Astaiso, D., Toth, B., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.018 · Cited by 5,493 · see citing works
McCarthy, D. J., Chen, Y., & Smyth, G. K. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks042 · Cited by 5,195 · see citing works
Charoentong, P., Finotello, F., Angelova, M., Mayer, C., Efremova, M., Rieder, D., Hackl, H., & Trajanoski, Z. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.019 · Cited by 5,041 · see citing works
Macrophage biology in development, homeostasis and disease
Wynn, T. A., Chawla, A., & Pollard, J. W. (2013) · Nature · doi:10.1038/nature12034 · Cited by 4,684 · see citing works
Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
Hanahan, D., & Coussens, L. M. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.022 · Cited by 4,632 · see citing works
Tumour-associated macrophages as treatment targets in oncology
Mantovani, A., Marchesi, F., Malesci, A., Laghi, L., & Allavena, P. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2016.217 · Cited by 4,065 · see citing works
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
Biswas, S. K., & Mantovani, A. (2010) · Nature Immunology · doi:10.1038/ni.1937 · Cited by 3,840 · see citing works
Visualization and analysis of gene expression in tissue sections by spatial transcriptomics
Ståhl, P. L., Salmén, F., Vickovic, S., Lundmark, A., Navarro, J. F., Magnusson, J., Giacomello, S., Asp, M., Westholm, J. O., Huss, M., et al. (2016) · Science · doi:10.1126/science.aaf2403 · Cited by 3,834 · see citing works
Coordinated regulation of myeloid cells by tumours
Gabrilovich, D. I., Ostrand-Rosenberg, S., & Bronte, V. (2012) · Nature Reviews Immunology · doi:10.1038/nri3175 · Cited by 3,544 · see citing works
Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN
Fridlender, Z. G., Sun, J., Kim, S., Kapoor, V., Cheng, G., Ling, L. E., Worthen, G. S., & Albelda, S. Μ. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.06.017 · Cited by 3,382 · see citing works
The prognostic landscape of genes and infiltrating immune cells across human cancers
Gentles, A. J., Newman, A. M., Liu, C. L., Bratman, S. V., Feng, W., Kim, D., Nair, V. S., Xu, Y., Khuong, A., Hoang, C. D., et al. (2015) · Nature Medicine · doi:10.1038/nm.3909 · Cited by 3,097 · see citing works
Functional Polarization of Tumour-Associated Macrophages by Tumour-Derived Lactic Acid
Colegio, O. R., Chu, N.-Q., Szabo, A. L., Chu, T., Rhebergen, A. M., Jairam, V., Cyrus, N., Brokowski, C. E., Eisenbarth, S. C., Phillips, G. M., et al. (2014) · Nature · doi:10.1038/nature13490 · Cited by 3,046 · see citing works
Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards
Bronte, V., Brandau, S., Chen, S.-H., Colombo, M. P., Frey, A. B., Greten, T. F., Mandruzzato, S., Murray, P. J., Ochoa, A., Ostrand-Rosenberg, S., et al. (2016) · Nature Communications · doi:10.1038/ncomms12150 · Cited by 2,751 · see citing works
Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors
Villani, A.-C., Satija, R., Reynolds, G., Sarkizova, S., Shekhar, K., Fletcher, J., Griesbeck, M., Butler, A., Zheng, S., Lazo, S., et al. (2017) · Science · doi:10.1126/science.aah4573 · Cited by 2,413 · see citing works
Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential
Sharma, P., & Allison, J. P. (2015) · Cell · doi:10.1016/j.cell.2015.03.030 · Cited by 2,345 · see citing works
Merad, M., Sathe, P., Helft, J., Miller, J., & Mortha, A. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074950 · Cited by 2,309 · see citing works
Data-Driven Phenotypic Dissection of AML Reveals Progenitor-like Cells that Correlate with Prognosis
Levine, J. H., Simonds, E. F., Bendall, S. C., Davis, K. L., Amir, E.-A. D., Tadmor, M. D., Litvin, O., Fienberg, H. G., Jager, A., Zunder, E. R., et al. (2015) · Cell · doi:10.1016/j.cell.2015.05.047 · Cited by 2,303 · see citing works
Mills, E. L., Kelly, B., Logan, A., Costa, A. S. H., Varma, M., Bryant, C. E., Tourlomousis, P., Däbritz, J. H. M., Gottlieb, E., Latorre, I., et al. (2016) · Cell · doi:10.1016/j.cell.2016.08.064 · Cited by 2,291 · see citing works
Bendall, S. C., Simonds, E. F., Qiu, P., Amir, E.-A. D., Krutzik, P. O., Finck, R., Bruggner, R. V., Melamed, R., Trejo, A., Ornatsky, O. I., et al. (2011) · Science · doi:10.1126/science.1198704 · Cited by 2,279 · see citing works
Taking dendritic cells into medicine
Steinman, R., & Banchereau, J. (2007) · Nature · doi:10.1038/nature06175 · Cited by 2,243 · see citing works
Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation
Xue, J., Schmidt, S. V., Sander, J., Draffehn, A., Krebs, W., Quester, I., De Nardo, D., Gohel, T. D., Emde, M., Schmidleithner, L., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.01.006 · Cited by 2,210 · see citing works
Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment
Lavin, Y., Winter, D., Blecher-Gonen, R., David, E., Keren-Shaul, H., Merad, M., Jung, S., & Amit, I. (2014) · Cell · doi:10.1016/j.cell.2014.11.018 · Cited by 2,167 · see citing works
Monitoring of Blood Vessels and Tissues by a Population of Monocytes with Patrolling Behavior
Auffray, C., Fogg, D., Garfa, M., Elain, G., Join-Lambert, O., Kayal, S., Sarnacki, S., Cumano, A., Lauvau, G., & Geissmann, F. (2007) · Science · doi:10.1126/science.1142883 · Cited by 1,973 · see citing works
the Immunological Genome Consortium, Gautier, E. L., Shay, T., Miller, J., Greter, M., Jakubzick, C., Ivanov, S., Helft, J., Chow, A., Elpek, K. G., et al. (2012) · Nature Immunology · doi:10.1038/ni.2419 · Cited by 1,972 · see citing works
Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry
Giesen, C., Wang, H. A. O., Schapiro, D., Zivanovic, N., Jacobs, A., Hattendorf, B., Schüffler, P. J., Grolimund, D., Buhmann, J. M., Brandt, S., et al. (2014) · Nature Methods · doi:10.1038/nmeth.2869 · Cited by 1,951 · see citing works
FlowSOM: Using self‐organizing maps for visualization and interpretation of cytometry data
Gassen, S. V., Callebaut, B., van Helden, M. J. G., Lambrecht, B. N., Demeester, P. M. A., Dhaene, T., & Saeys, Y. (2015) · Cytometry Part A · doi:10.1002/cyto.a.22625 · Cited by 1,930 · see citing works
Tissue-Resident Macrophage Ontogeny and Homeostasis
Ginhoux, F., & Guilliams, M. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.024 · Cited by 1,884 · see citing works
Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny
Guilliams, M., Ginhoux, F., Jakubzick, C., Naik, S. H., Onai, N., Schraml, B. U., Segura, É., Tussiwand, R., & Yona, S. (2014) · Nature reviews. Immunology · doi:10.1038/nri3712 · Cited by 1,802 · see citing works
IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis
Coffelt, S. B., Kersten, K., Doornebal, C. W., Weiden, J., Vrijland, K., Hau, C.-S., Verstegen, N. J. M., Ciampricotti, M., Hawinkels, L. J. A. C., Jonkers, J., et al. (2015) · Nature · doi:10.1038/nature14282 · Cited by 1,703 · see citing works
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
Kang, T.-W., Yevsa, T., Woller, N., Hoenicke, L., Wuestefeld, T., Dauch, D., Hohmeyer, A., Gereke, M., Rudalska, R., Potapova, A., et al. (2011) · Nature · doi:10.1038/nature10599 · Cited by 1,621 · see citing works
Antiangiogenesis Strategies Revisited: From Starving Tumors to Alleviating Hypoxia
Jain, R. K. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.10.006 · Cited by 1,589 · see citing works
Origin and functions of tissue macrophages
Epelman, S., Lavine, K. J., & Randolph, G. J. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.013 · Cited by 1,585 · see citing works
Spranger, S., Dai, D., Horton, B., & Gajewski, T. F. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.04.003 · Cited by 1,441 · see citing works
Almand, B., Clark, J. I., Nikitina, E., van Beynen, J., English, N. R., Knight, S. C., Carbone, D. P., & Gabrilovich, D. I. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.1.678 · Cited by 1,340 · see citing works
Jensen, M. P. (2003) · Journal of Pain · doi:10.1016/s1526-5900(03)00716-8 · Cited by 1,318 · see citing works
Gosselin, D., Link, V. M., Romanoski, C. E., Fonseca, G. J., Eichenfield, D. Z., Spann, N. J., Stender, J. D., Chun, H. B., Garner, H., Geissmann, F., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.023 · Cited by 1,307 · see citing works
Bandura, D. R., Baranov, V. I., Ornatsky, O. I., Antonov, A., Kinach, R., Lou, X., Pavlov, S., Vorobiev, S., Dick, J. E., & Tanner, S. D. (2009) · Analytical Chemistry · doi:10.1021/ac901049w · Cited by 1,295 · see citing works
Rodriguez, P. C., Quiceno, D. G., Zabaleta, J., Ortiz, B., Zea, A. H., Piazuelo, M. B., Delgado, A., Correa, P., Brayer, J., Sotomayor, E. M., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0465 · Cited by 1,276 · see citing works
Movahedi, K., Guilliams, M., den Bossche, J. V., den Bergh, R. V., Gysemans, C. A., Beschin, A., BAETSELIER, P. D., & Ginderachter, J. A. V. (2008) · Blood · doi:10.1182/blood-2007-07-099226 · Cited by 1,234 · see citing works
Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses
Lavin, Y., Kobayashi, S., Leader, A., Amir, E.-A. D., Elefant, N., Bigenwald, C., Remark, R., Sweeney, R., Becker, C. D., Levine, J. H., et al. (2017) · Cell · doi:10.1016/j.cell.2017.04.014 · Cited by 1,209 · see citing works
Broz, M. L., Binnewies, M., Boldajipour, B., Nelson, A. E., Pollack, J. L., Erle, D. J., Barczak, A., Rosenblum, M. D., Daud, A., Barber, D. L., et al. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.09.007 · Cited by 1,207 · see citing works
Mass Cytometry: Single Cells, Many Features
Spitzer, M. H., & Nolan, G. P. (2016) · Cell · doi:10.1016/j.cell.2016.04.019 · Cited by 1,199 · see citing works
Salmon, H., Idoyaga, J., Rahman, A. H., Leboeuf, M., Remark, R., Jordan, S., Casanova-Acebes, M., Khudoynazarova, M. N., Agudo, J., Tung, N., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.03.012 · Cited by 1,187 · see citing works
Microglia development follows a stepwise program to regulate brain homeostasis
Matcovitch-Natan, O., Winter, D. R., Giladi, A., Vargas Aguilar, S., Spinrad, A., Sarrazin, S., Ben-Yehuda, H., David, E., Zelada González, F., Perrin, P., et al. (2016) · Science · doi:10.1126/science.aad8670 · Cited by 1,180 · see citing works
TNF/iNOS-Producing Dendritic Cells Mediate Innate Immune Defense against Bacterial Infection
Serbina, N. V., Salazar‐Mather, T. P., Biron, C. A., Kuziel, W. A., & Pamer, E. G. (2003) · Immunity · doi:10.1016/s1074-7613(03)00171-7 · Cited by 1,174 · see citing works
Corzo, C. A., Condamine, T., Lu, L., Cotter, M. J., Youn, J.-I., Cheng, P., Cho, H.-I., Celis, E., Quiceno, D. G., Padhya, T., et al. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20100587 · Cited by 1,173 · see citing works
Fantin, A., Vieira, J. M., Gestri, G., Denti, L., Schwarz, Q., Prykhozhij, S., Peri, F., Wilson, S. W., & Ruhrberg, C. (2010) · Blood · doi:10.1182/blood-2009-12-257832 · Cited by 1,153 · see citing works
Multiplexed ion beam imaging of human breast tumors
Angelo, M., Bendall, S. C., Finck, R., Hale, M. B., Hitzman, C., Borowsky, A. D., Levenson, R. M., Lowe, J. B., Liu, S. D., Zhao, S., et al. (2014) · Nature Medicine · doi:10.1038/nm.3488 · Cited by 1,108 · see citing works
Sample-Size Formula for the Proportional-Hazards Regression Model
Schoenfeld, D. (1983) · Biometrics · doi:10.2307/2531021 · Cited by 1,100 · see citing works
Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors
Paul, F., Arkin, Y., Giladi, A., Jaitin, D. A., Kenigsberg, E., Keren-Shaul, H., Winter, D., Lara-Astiaso, D., Gury, M., Weiner, A., et al. (2015) · Cell · doi:10.1016/j.cell.2015.11.013 · Cited by 1,082 · see citing works
Macrophage Regulation of Tumor Responses to Anticancer Therapies
De Palma, M., & Lewis, C. E. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.02.013 · Cited by 1,079 · see citing works
Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy
Jiang, H., Hegde, S., Knolhoff, B. L., Zhu, Y., Herndon, J. M., Meyer, M. A., Nywening, T. M., Hawkins, W. G., Shapiro, I. M., Weaver, D. T., et al. (2016) · Nature Medicine · doi:10.1038/nm.4123 · Cited by 1,060 · see citing works
Single-cell spatial reconstruction reveals global division of labour in the mammalian liver
Halpern, K. B., Shenhav, R., Matcovitch-Natan, O., Tóth, B., Lemze, D., Golan, M., Massasa, E. E., Baydatch, S., Landen, S., Moor, A. E., et al. (2017) · Nature · doi:10.1038/nature21065 · Cited by 1,059 · see citing works
Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected
Marvel, D., & Gabrilovich, D. I. (2015) · Journal of Clinical Investigation · doi:10.1172/jci80005 · Cited by 1,054 · see citing works
Zhang, Q., Liu, L., Gong, C., Shi, H., Zeng, Y., Wang, X., Zhao, Y., & Wei, Y.-Q. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050946 · Cited by 1,041 · see citing works
An Immune Atlas of Clear Cell Renal Cell Carcinoma
Chevrier, S., Levine, J., Zanotelli, V. R., Siliņa, K., Schulz, D., Bacac, M., Ries, C. H., Ailles, L., Jewett, M. A. S., Moch, H., et al. (2017) · Cell · doi:10.1016/j.cell.2017.04.016 · Cited by 1,009 · see citing works
Ruffell, B., Chang-Strachan, D., Chan, V., Rosenbusch, A., Ho, C. M. T., Pryer, N., Daniel, D., Hwang, E. S., Rugo, H. S., & Coussens, L. M. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.09.006 · Cited by 1,008 · see citing works
Kamentsky, L. D., Jones, T. R., Fraser, A. N., Bray, M., Logan, D. J., Madden, K. L., Ljosa, V., Rueden, C., Eliceiri, K. W., & Carpenter, A. E. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr095 · Cited by 1,002 · see citing works
Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq
Venteicher, A. S., Tirosh, I., Hebert, C. M., Yizhak, K., Neftel, C., Filbin, M. G., Hovestadt, V., Escalante, L. E., Shaw, M. L., Rodman, C., et al. (2017) · Science · doi:10.1126/science.aai8478 · Cited by 975 · see citing works
Highly Multiplexed Subcellular RNA Sequencing in Situ
Lee, J. H., Daugharthy, E. R., Scheiman, J., Kalhor, R., Yang, J. L., Ferrante, T. C., Terry, R., Jeanty, S. S. F., Li, C., Amamoto, R., et al. (2014) · Science · doi:10.1126/science.1250212 · Cited by 973 · see citing works
In Vivo Analysis of Dendritic Cell Development and Homeostasis
Liu, K., Victora, G. D., Schwickert, T. A., Guermonprez, P., Meredith, M. M., Yao, K.-H., Chu, F.-F., Randolph, G. J., Rudensky, A. Y., & Nussenzweig, M. C. (2009) · Science · doi:10.1126/science.1170540 · Cited by 953 · see citing works
Tumor microenvironmental physiology and its implications for radiation oncology
Vaupel, P. W. (2004) · Seminars in Radiation Oncology · doi:10.1016/j.semradonc.2004.04.008 · Cited by 948 · see citing works
Bayne, L. J., Beatty, G. L., Jhala, N., Clark, C. E., Rhim, A. D., Stanger, B. Z., & Vonderheide, R. H. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.04.025 · Cited by 947 · see citing works
In situ sequencing for RNA analysis in preserved tissue and cells
Ke, R., Mignardi, M., Pacureanu, A., Svedlund, J., Botling, J., Wählby, C., & Nilsson, M. (2013) · Nature Methods · doi:10.1038/nmeth.2563 · Cited by 934 · see citing works
Murdoch, C., Giannoudis, A., & Lewis, C. E. (2004) · Blood · doi:10.1182/blood-2004-03-1109 · Cited by 911 · see citing works
Monocyte differentiation and antigen-presenting functions
Jakubzick, C. V., Randolph, G. J., & Henson, P. M. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.28 · Cited by 910 · see citing works
Specification of tissue-resident macrophages during organogenesis
Mass, E., Ballesteros, I., Farlik, M., Halbritter, F., Günther, P., Crozet, L., Jacome-Galarza, C. E., Händler, K., Klughammer, J., Kobayashi, Y., et al. (2016) · Science · doi:10.1126/science.aaf4238 · Cited by 891 · see citing works
Role of Macrophage Targeting in the Antitumor Activity of Trabectedin
Germano, G., Frapolli, R., Belgiovine, C., Anselmo, A., Pesce, S., Liguori, M., Erba, E., Uboldi, S., Zucchetti, M., Pasqualini, F., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.01.008 · Cited by 863 · see citing works
Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells
Scott, C. L., Zheng, F., De Baetselier, P., Martens, L., Saeys, Y., De Prijck, S., Lippens, S., Abels, C., Schoonooghe, S., Raes, G., et al. (2016) · Nature Communications · doi:10.1038/ncomms10321 · Cited by 860 · see citing works
Differential macrophage programming in the tumor microenvironment
Ruffell, B., Affara, N. I., & Coussens, L. M. (2012) · Trends in Immunology · doi:10.1016/j.it.2011.12.001 · Cited by 855 · see citing works
Tumor-Induced Tolerance and Immune Suppression Depend on the C/EBPβ Transcription Factor
Marigo, I., Bosio, E., Solito, S., Mesa, C., Fernández, A., Dolcetti, L., Ugel, S., Sonda, N., Bicciato, S., Falisi, E., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.05.010 · Cited by 854 · see citing works
Kratz, M., Coats, B. R., Hisert, K. B., Hagman, D. K., Mutskov, V. J., Peris, E., Schoenfelt, K. Q., Kuzma, J. N., Larson, I. A., Billing, P. S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.08.010 · Cited by 828 · see citing works
Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species
Guilliams, M., Dutertre, C., Scott, C. L., McGovern, N. N., Sichien, D., Chakarov, S., Gassen, S. V., Chen, J., Poidinger, M., Prijck, S. D., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.08.015 · Cited by 824 · see citing works
Phenotypic Diversity and Plasticity in Circulating Neutrophil Subpopulations in Cancer
Sagiv, J. Y., Michaeli, J., Assi, S., Mishalian, I., Kisos, H., Levy, L., Damti, P., Lumbroso, D., Polyansky, L., Sionov, R. V., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2014.12.039 · Cited by 818 · see citing works
Zhu, Y., Herndon, J. M., Sojka, D. K., Kim, K.-W., Knolhoff, B. L., Zuo, C., Cullinan, D. R., Luo, J. R., Bearden, A. R., Lavine, K. J., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.07.014 · Cited by 799 · see citing works
Condamine, T., Dominguez, G. A., Youn, J., Kossenkov, A. V., Mony, S., Alicea-Torres, K. M., Tcyganov, E. N., Hashimoto, A., Nefedova, Y., Lin, C., et al. (2016) · Science Immunology · doi:10.1126/sciimmunol.aaf8943 · Cited by 796 · see citing works
Scaling single-cell genomics from phenomenology to mechanism
Tanay, A., & Regev, A. (2017) · Nature · doi:10.1038/nature21350 · Cited by 792 · see citing works
The role of myeloid cells in cancer therapies
Engblom, C., Pfirschke, C., & Pittet, M. J. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.54 · Cited by 788 · see citing works
Nr4a1-Dependent Ly6Clow Monocytes Monitor Endothelial Cells and Orchestrate Their Disposal
Carlin, L. M., Stamatiades, E. G., Auffray, C., Hanna, R. N., Glover, L., Vizcay‐Barrena, G., Hedrick, C. C., Cook, H. T., Diebold, S. S., & Geissmann, F. (2013) · Cell · doi:10.1016/j.cell.2013.03.010 · Cited by 764 · see citing works
Development and Function of Dendritic Cell Subsets
Mildner, A., & Jung, S. (2014) · Immunity · doi:10.1016/j.immuni.2014.04.016 · Cited by 762 · see citing works
Jakubzick, C. V., Gautier, E., Gibbings, S. L., Sojka, D. K., Schlitzer, A., Johnson, T. E., Ivanov, S., Duan, Q., Bala, S., Condon, T., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.007 · Cited by 762 · see citing works
Prostaglandin E2 Promotes Tumor Progression by Inducing Myeloid-Derived Suppressor Cells
Sinha, P., Clements, V. K., Fulton, A. M., & Ostrand‐Rosenberg, S. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4174 · Cited by 756 · see citing works
Zigmond, E., Varol, C., Farache, J., Elmaliah, E., Satpathy, A. T., Friedlander, G., Mack, M., Shpigel, N. Y., Boneca, I. G., MURPHY, K. M. M., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.08.026 · Cited by 754 · see citing works
Li, X., Yao, W., Yuan, Y., Chen, P., Li, B., Li, J., Chu, R., Song, H., Xie, D., Jiang, X., et al. (2015) · Gut · doi:10.1136/gutjnl-2015-310514 · Cited by 739 · see citing works
Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia
Pylayeva-Gupta, Y., Lee, K. E., Hajdu, C. H., Miller, G., & Bar-Sagi, D. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.04.024 · Cited by 721 · see citing works
Origins of tumor-associated macrophages and neutrophils
Cortez‐Retamozo, V., Etzrodt, M., Newton, A., Rauch, P. J., Chudnovskiy, A., Berger, C., Ryan, R. J. H., Iwamoto, Y., Marinelli, B. S., Gorbatov, R., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113744109 · Cited by 680 · see citing works
Human Inflammatory Dendritic Cells Induce Th17 Cell Differentiation
Segura, É., Touzot, M., Bohineust, A., Cappuccio, A., Chiocchia, G., Hosmalin, A., Dalod, M., Soumelis, V., & Amigorena, S. (2013) · Immunity · doi:10.1016/j.immuni.2012.10.018 · Cited by 677 · see citing works
Goc, J., Germain, C., Vo-Bourgais, T. K. D., Mansuet‐Lupo, A., Klein, C., Knockaert, S., de Chaisemartin, L., Ouakrim, H., Becht, É., Alifano, M., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-1342 · Cited by 675 · see citing works
Cellular and Molecular Identity of Tumor-Associated Macrophages in Glioblastoma
Chen, Z., Feng, X., Herting, C. J., Garcia, V. A., Nie, K., Pong, W. W., Rasmussen, R. D., Dwivedi, B., Seby, S., Wolf, S. A., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-2310 · Cited by 675 · see citing works
Diffusion maps for high-dimensional single-cell analysis of differentiation data
Haghverdi, L., Buettner, F., & Theis, F. J. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btv325 · Cited by 649 · see citing works
Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer
Eruslanov, E. B., Bhojnagarwala, P. S., Quatromoni, J. G., Stephen, T. L., Ranganathan, A., Deshpande, C. G., Akimova, T., Vachani, A., Litzky, L. A., Hancock, W. W., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci77053 · Cited by 645 · see citing works
Mazzieri, R., Pucci, F., Moi, D., Zonari, E., Ranghetti, A., Berti, A., Politi, L. S., Gentner, B., Brown, J. L., Naldini, L., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.02.005 · Cited by 639 · see citing works
Harney, A. S., Arwert, E. N., Entenberg, D. R., Wang, Y., Guo, P., Qian, B., Oktay, M. H., Pollard, J. W., Jones, J. G., & Condeelis, J. S. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0012 · Cited by 622 · see citing works
Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies
Bowman, R. L., Klemm, F., Akkari, L., Pyonteck, S. M., Sevenich, L., Quail, D. F., Dhara, S., Simpson, K., Gardner, E. E., Iacobuzio–Donahue, C. A., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.10.052 · Cited by 617 · see citing works
Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinoma
Rodrı́guez, P. C., Hernandez, C. P., Quiceno, D. G., Dubinett, S. M., Zabaleta, J., Ochoa, J. B., Gilbert, J., & Ochoa, A. C. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050715 · Cited by 609 · see citing works
Eggert, T., Wolter, K., Ji, J., Ma, C., Yevsa, T., Klotz, S., Medina-Echeverz, J., Longerich, T., Forgues, M., Reisinger, F., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.09.003 · Cited by 609 · see citing works
Casazza, A., Laoui, D., Wenes, M., Rizzolio, S., Bassani, N., Mambretti, M., Deschoemaeker, S., Ginderachter, J. V. V., Tamagnone, L., & Mazzone, M. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.11.007 · Cited by 601 · see citing works
L-arginine metabolism in myeloid cells controls T-lymphocyte functions
Bronte, V., Serafini, P., Mazzoni, A., Segal, D. M., & Zanovello, P. (2003) · Trends in Immunology · doi:10.1016/s1471-4906(03)00132-7 · Cited by 588 · see citing works
van de Laar, L., Saelens, W., Prijck, S. D., Martens, L., Scott, C. L., Isterdael, G. V., Hoffmann, E., Beyaert, R., Saeys, Y., Lambrecht, B., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.017 · Cited by 576 · see citing works
Mapping the human DC lineage through the integration of high-dimensional techniques
See, P., Dutertre, C., Chen, J., Günther, P. S., McGovern, N. N., Irac, S. E., Gunawan, M., Beyer, M., Händler, K., Duan, K., et al. (2017) · Science · doi:10.1126/science.aag3009 · Cited by 573 · see citing works
Schlitzer, A., Vijayakumar, S., Chen, J., Sumatoh, H., Schreuder, J., Lum, J., Malleret, B., Zhang, S., Larbi, A., Zolezzi, F., et al. (2015) · Nature Immunology · doi:10.1038/ni.3200 · Cited by 564 · see citing works
Ugel, S., Sanctis, F. D., Mandruzzato, S., & Bronte, V. (2015) · Journal of Clinical Investigation · doi:10.1172/jci80006 · Cited by 563 · see citing works
Meyer, C., Cagnon, L., Costa-Nunes, C. M., Baumgaertner, P., Montandon, N., Leyvraz, L., Michielin, O., Romano, E., & Speiser, D. E. (2014) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-013-1508-5 · Cited by 560 · see citing works
Tsujikawa, T., Kumar, S., Borkar, R. N., Azimi, V., Thibault, G., Chang, Y. H., Balter, A. I., Kawashima, R., Choe, G. H., Sauer, D., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.03.037 · Cited by 555 · see citing works
Tumor-associated macrophages: Functional diversity, clinical significance, and open questions
Biswas, S. K., Allavena, P., & Mantovani, A. (2013) · Seminars in Immunopathology · doi:10.1007/s00281-013-0367-7 · Cited by 551 · see citing works
Martens, A., Wistuba-Hamprecht, K., Foppen, M. G., Yuan, J., Postow, M. A., Wong, P., Romano, E., Khammari, A., Dreno, B., Capone, M., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-2412 · Cited by 541 · see citing works
Krutzik, P. O., & Nolan, G. P. (2006) · Nature Methods · doi:10.1038/nmeth872 · Cited by 525 · see citing works
Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy
Hughes, R., Qian, B., Rowan, C., Muthana, M., Keklikoglou, I., Olson, O. C., Tazzyman, S. J., Danson, S. J., Addison, C., Clemons, M. J., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-3587 · Cited by 516 · see citing works
Web‐Based Analysis and Publication of Flow Cytometry Experiments
Kotecha, N., Krutzik, P. O., & Irish, J. M. (2010) · Current Protocols in Cytometry · doi:10.1002/0471142956.cy1017s53 · Cited by 513 · see citing works
Macrophage Metabolism Controls Tumor Blood Vessel Morphogenesis and Metastasis
Wenes, M., Shang, M., Di Matteo, M., Goveia, J., Martín-Pérez, R., Serneels, J., Prenen, H., Ghesquière, B., Carmeliet, P., & Mazzone, M. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.09.008 · Cited by 496 · see citing works
l -Arginine Consumption by Macrophages Modulates the Expression of CD3ζ Chain in T Lymphocytes
Rodrı́guez, P. C., Zea, A. H., DeSalvo, J., Culotta, K. S., Zabaleta, J., Quiceno, D. G., Ochoa, J. B., & Ochoa, A. C. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.3.1232 · Cited by 494 · see citing works
Sánchez-Paulete, A. R., Cueto, F. J., Martínez‐López, M., Labiano, S., Morales‐Kastresana, A., Rodriguez-Ruiz, M. E., Jure‐Kunkel, M., Azpilikueta, A., Aznar, M. A., Quetglas, J. I., et al. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0510 · Cited by 488 · see citing works
Singhal, S. K., Bhojnagarwala, P. S., O’Brien, S., Moon, E. K., Garfall, A. L., Rao, A. S., Quatromoni, J. G., Stephen, T. L., Litzky, L. A., Deshpande, C. G., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.06.001 · Cited by 478 · see citing works
Patrolling monocytes control tumor metastasis to the lung
Hanna, R. N., Cekic, C., Sağ, D., Tacke, R., Thomas, G. D., Nowyhed, H. N., Herrley, E., Rasquinha, N., McArdle, S., Wu, R., et al. (2015) · Science · doi:10.1126/science.aac9407 · Cited by 476 · see citing works
Casbon, A.-J., Reynaud, D., Park, C., Khuc, E., Gan, D. D., Schepers, K., Passegue, E. A., & Werb, Z. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1424927112 · Cited by 475 · see citing works
Computational flow cytometry: helping to make sense of high-dimensional immunology data
Saeys, Y., Gassen, S. V., & Lambrecht, B. N. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.56 · Cited by 471 · see citing works
Hypoxia Regulates Macrophage Functions in Inflammation
Murdoch, C., Muthana, M., & Lewis, C. E. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.10.6257 · Cited by 455 · see citing works
Visualization of immediate immune responses to pioneer metastatic cells in the lung
Headley, M. B., Bins, A. D., Nip, A., Roberts, E. W., Looney, M. R., Gérard, A., & Krummel, M. F. (2016) · Nature · doi:10.1038/nature16985 · Cited by 442 · see citing works
Genard, G. C., Lucas, S., & Michiels, C. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00828 · Cited by 420 · see citing works
Neutrophils dominate the immune cell composition in non-small cell lung cancer
Kargl, J., Busch, S., Yang, G. H. Y., Kim, K.-H., Hanke, M. L., Metz, H. E., Hubbard, J. J., Lee, S. M., Madtes, D. K., McIntosh, M. W., et al. (2017) · Nature Communications · doi:10.1038/ncomms14381 · Cited by 412 · see citing works
Laoui, D., Overmeire, E. V., Conza, G. D., Aldeni, C., Keirsse, J., Morias, Y., Movahedi, K., Houbracken, I., Schouppe, E., Elkrim, Y., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-1196 · Cited by 410 · see citing works
Does niche competition determine the origin of tissue-resident macrophages?
Guilliams, M., & Scott, C. L. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.42 · Cited by 409 · see citing works
Myeloid‐derived suppressor cell heterogeneity in human cancers
Solito, S., Marigo, I., Pinton, L., Damuzzo, V., Mandruzzato, S., & Bronte, V. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12469 · Cited by 383 · see citing works
TNF signaling drives myeloid-derived suppressor cell accumulation
Zhao, X., Rong, L., Zhao, X., Li, X., Liu, X., Deng, J., Wu, H., Xu, X., Erben, U., Wu, P., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci64115 · Cited by 380 · see citing works
Chou, J., Lin, J., Brenot, A., Kim, J., Provot, S., & Werb, Z. (2013) · Nature Cell Biology · doi:10.1038/ncb2672 · Cited by 374 · see citing works
Kumar, V., Cheng, P., Condamine, T., Mony, S., Languino, L. R., McCaffrey, J. C., Hockstein, N., Guarino, M., Masters, G., Penman, E., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.01.014 · Cited by 371 · see citing works
Transcriptional regulation of myeloid-derived suppressor cells
Condamine, T., Mastio, J., & Gabrilovich, D. I. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.4ri0515-204r · Cited by 368 · see citing works
Sceneay, J., Chow, M. T., Chen, A., Halse, H. M., Wong, C. S. F., Andrews, D. M., Sloan, E. K., Parker, B. S., Bowtell, D. D. L., Smyth, M. J., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3873 · Cited by 365 · see citing works
Tumor-associated neutrophils (TAN) develop pro-tumorigenic properties during tumor progression
Mishalian, I., Bayuh, R., Levy, L., Zolotarov, L., Michaeli, J., & Fridlender, Z. G. (2013) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-013-1476-9 · Cited by 356 · see citing works
Shen, M., Hu, P., Donskov, F. N., Wang, G., Liu, Q., & Du, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098259 · Cited by 348 · see citing works
Integrating next-generation dendritic cell vaccines into the current cancer immunotherapy landscape
Garg, A. D., Coulie, P. G., Van den Eynde, B. J., & Agostinis, P. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.05.006 · Cited by 340 · see citing works
Clinical recovery from surgery correlates with single-cell immune signatures
Gaudilliere, B. L., Fragiadakis, G. K., Bruggner, R. V., Nicolau, M. M., Finck, R., Tingle, M. S., Silva, J., Ganio, E. A., Yeh, C. G., Maloney, W. J., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009701 · Cited by 333 · see citing works
Engelhardt, J., Boldajipour, B. A., Beemiller, P., Pandurangi, P., Sorensen, C. M., Werb, Z., Egeblad, M., & Krummel, M. F. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.01.008 · Cited by 330 · see citing works
Nizzoli, G., Krietsch, J., Weick, A., Steinfelder, S., Facciotti, F., Gruarin, P., Bianco, A., Steckel, B., Moro, M., Crosti, M., et al. (2013) · Blood · doi:10.1182/blood-2013-04-495424 · Cited by 328 · see citing works
Metabolic origins of spatial organization in the tumor microenvironment
Carmona‐Fontaine, C., Déforet, M., Akkari, L., Thompson, C. B., Joyce, J. A., & Xavier, J. B. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1700600114 · Cited by 322 · see citing works
Macrophage Metabolism As Therapeutic Target for Cancer, Atherosclerosis, and Obesity
Geeraerts, X., Bolli, E., Fendt, S., & Ginderachter, J. A. V. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00289 · Cited by 315 · see citing works
The pancreas anatomy conditions the origin and properties of resident macrophages
Calderon, B., Carrero, J. A., Ferris, S. T., Sojka, D. K., Moore, L., Epelman, S., Murphy, K. M., Yokoyama, W. M., Randolph, G. J., & Unanue, E. R. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20150496 · Cited by 308 · see citing works
Resolving early mesoderm diversification through single-cell expression profiling
Scialdone, A., Tanaka, Y., Jawaid, W., Moignard, V., Wilson, N. K., Macaulay, I. C., Marioni, J. C., & Göttgens, B. (2016) · Nature · doi:10.1038/nature18633 · Cited by 293 · see citing works
Menezes, S., Melandri, D., Anselmi, G., Perchet, T., Loschko, J., Dubrot, J., Patel, R., Gautier, E. L., Hugues, S., Longhi, M. P., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.12.001 · Cited by 288 · see citing works
Computational genomics tools for dissecting tumour–immune cell interactions
Hackl, H., Charoentong, P., Finotello, F., & Trajanoski, Z. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.67 · Cited by 266 · see citing works
Laoui, D., Keirsse, J., Morias, Y., van Overmeire, E., Geeraerts, X., Elkrim, Y., Kiss, M., Bolli, E., Lahmar, Q., Sichien, D., et al. (2016) · Nature Communications · doi:10.1038/ncomms13720 · Cited by 255 · see citing works
Czimmerer, Z., Dániel, B., Horváth, A., Rückerl, D., Nagy, G., Kiss, M., Peloquin, M., Budai, M. M., Cuaranta‐Monroy, I., Simándi, Z., et al. (2018) · Immunity · doi:10.1016/j.immuni.2017.12.010 · Cited by 253 · see citing works
The Multifaceted Role of Perivascular Macrophages in Tumors
Lewis, C. E., Harney, A. S., & Pollard, J. W. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.05.017 · Cited by 250 · see citing works
Parker, K. H., Sinha, P., Horn, L. A., Clements, V. K., Yang, H., Li, J., Tracey, K. J., & Ostrand‐Rosenberg, S. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-2347 · Cited by 246 · see citing works
Tumor-associated fibrosis as a regulator of tumor immunity and response to immunotherapy
Jiang, H., Hegde, S., & DeNardo, D. G. (2017) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-017-2003-1 · Cited by 244 · see citing works
Welford, A. F., Biziato, D., Coffelt, S. B., Nucera, S., Fisher, M. L., Pucci, F., Serio, C. D., Naldini, L., Palma, M. D., Tozer, G. M., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44562 · Cited by 228 · see citing works
Zhao, L., Lim, S. Y., Gordon-Weeks, A. N., Tapmeier, T. T., Im, J. H., Cao, Y., Beech, J. S., Allen, P. D., Smart, S., & Muschel, R. J. (2012) · Hepatology · doi:10.1002/hep.26094 · Cited by 226 · see citing works
Opposing macrophage polarization programs show extensive epigenomic and transcriptional cross-talk
Piccolo, V., Curina, A., Genua, M., Ghisletti, S., Simonatto, M., Sabò, A., Amati, B. B., Ostuni, R., & Natoli, G. (2017) · Nature Immunology · doi:10.1038/ni.3710 · Cited by 209 · see citing works
Circulating precursors of human CD1c+ and CD141+ dendritic cells
Breton, G., Lee, J., Zhou, Y. J., Schreiber, J. J., Keler, T., Puhr, S., Anandasabapathy, N., Schlesinger, S. J., Caskey, M. F., Liu, K., et al. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20141441 · Cited by 203 · see citing works
Sade-Feldman, M., Kanterman, J., Klieger, Y., Ish-Shalom, E., Olga, M., Saragovi, A., Shtainberg, H., Lotem, M., & Baniyash, M. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-3104 · Cited by 201 · see citing works
A Clonogenic Progenitor with Prominent Plasmacytoid Dendritic Cell Developmental Potential
Onai, N., Kurabayashi, K., Hosoi-Amaike, M., Toyama‐Sorimachi, N., Matsushima, K., Inaba, K., & Ohteki, T. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.006 · Cited by 196 · see citing works
Wang, R., Zhang, J., Chen, S., Lu, M., Luo, X., Yao, S., Liu, S., Qin, Y., & Chen, H. (2011) · Lung Cancer · doi:10.1016/j.lungcan.2011.04.009 · Cited by 188 · see citing works
In-depth tissue profiling using multiplexed immunohistochemical consecutive staining on single slide
Remark, R., Merghoub, T., Grabe, N., Litjens, G. J. S., Damotte, D., Wolchok, J. D., Mérad, M., & Gnjatic, S. (2016) · Science Immunology · doi:10.1126/sciimmunol.aaf6925 · Cited by 184 · see citing works
Overmeire, E. V., Laoui, D., Keirsse, J., Ginderachter, J. A. V., & Sarukhan, A. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00127 · Cited by 182 · see citing works
Zhu, Y., Herndon, J. M., Sojka, D. K., Kim, K.-W., Knolhoff, B. L., Zuo, C., Cullinan, D. R., Luo, J., Bearden, A. R., Lavine, K. J., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.08.018 · Cited by 180 · see citing works
Neutrophils Oppose Uterine Epithelial Carcinogenesis via Debridement of Hypoxic Tumor Cells
Blaisdell, A., Créquer-Grandhomme, A., Columbus, D., Daikoku, T., Mittal, K., Dey, S. K., & Erlebacher, A. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.11.005 · Cited by 176 · see citing works
Feng, P., Lee, K., Chang, Y.-L., Chan, Y., Kuo, L.-W., Lin, T., Chung, F., Kuo, C.-S., Yu, C.-T., Lin, S., et al. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201204-0636oc · Cited by 168 · see citing works
Haverkamp, J. M., Smith, A. M., Weinlich, R., Dillon, C. P., Qualls, J. E., Neale, G. A. M., Koss, B. S., Kim, Y., Bronte, V., Herold, M. J., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.10.020 · Cited by 167 · see citing works
Bodogai, M., Moritoh, K., Lee-Chang, C., Hollander, C. M., Sherman‐Baust, C. A., Wersto, R. P., Araki, Y., Miyoshi, I., Li, Y., Trinchieri, G., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-3077 · Cited by 167 · see citing works
Cuccarese, M. F., Dubach, J. M., Pfirschke, C., Engblom, C., Garris, C. S., Miller, M. A., Pittet, M., & Weissleder, R. (2017) · Nature Communications · doi:10.1038/ncomms14293 · Cited by 167 · see citing works
Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy
Jung, K., Heishi, T., Khan, O. F., Kowalski, P. S., Incio, J., Rahbari, N. N., Chung, E., Clark, J. W., Willett, C. G., Luster, A. D., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci93182 · Cited by 164 · see citing works
Wallace, K. L., & Linden, J. M. (2010) · Blood · doi:10.1182/blood-2010-06-290643 · Cited by 152 · see citing works
Tissue-resident versus monocyte-derived macrophages in the tumor microenvironment
Lahmar, Q., Keirsse, J., Laoui, D., Movahedi, K., Overmeire, E. V., & Ginderachter, J. A. V. (2015) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2015.06.009 · Cited by 151 · see citing works
Wimmers, F., Schreibelt, G., Sköld, A. E., Figdor, C. G., & de Vries, I. J. M. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00165 · Cited by 145 · see citing works
Myeloid-Derived Suppressor Cells
Nagaraj, S., & Gabrilovich, D. I. (2007) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-72005-0_22 · Cited by 134 · see citing works
Malek, M., Taghiyar, M. J., Chong, L. C., Finak, G., Gottardo, R., & Brinkman, R. R. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu677 · Cited by 128 · see citing works
Immune surveillance of the lung by migrating tissue monocytes
Rodero, M. P., Poupel, L., Loyher, P.-L., Hamon, P., Licata, F., Pessel, C., Hume, D. A., Combadière, C., & Boissonnas, A. (2015) · eLife · doi:10.7554/elife.07847 · Cited by 123 · see citing works
Perivascular Macrophages Limit Permeability
He, H., Mack, J. J., Güç, E., Warren, C. M., Squadrito, M. L., Kilarski, W. W., Baer, C., Freshman, R. D., McDonald, A. I., Ziyad, S., et al. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.307592 · Cited by 119 · see citing works
Papaspyridonos, M., Matei, I. R., Huang, Y., André, M. D. R., Brazier, H., Waite, J. C., Chan, A., Kalter, J., Ramos, I., Wu, Q., et al. (2015) · Nature Communications · doi:10.1038/ncomms7840 · Cited by 115 · see citing works
Bakdash, G., Buschow, S. I., Gorris, M. A. J., Halilović, A., Hato, S. V., Sköld, A. E., Schreibelt, G., Sittig, S. P., Torensma, R., Boer, T. D., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-1695 · Cited by 115 · see citing works
Exploring Metabolic Configurations of Single Cells within Complex Tissue Microenvironments
Miller, A., Nagy, C., Knapp, B., Laengle, J., Ponweiser, E., Gröger, M., Starkl, P. M., Bergmann, M. M., Wagner, O. F., & Haschemi, A. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.08.014 · Cited by 115 · see citing works
Blasio, S. D., Wortel, I. M. N., van Bladel, D. A. G., de Vries, L. E., Boer, T. D., Worah, K., de Haas, N., Buschow, S. I., de Vries, I. J. M., Figdor, C. G., et al. (2016) · OncoImmunology · doi:10.1080/2162402x.2016.1192739 · Cited by 105 · see citing works
Laoui, D., Overmeire, E. V., Movahedi, K., den Bossche, J. V., Schouppe, E., Mommer, C., Nikolaou, A., Morias, Y., BAETSELIER, P. D., & Ginderachter, J. A. V. (2011) · Immunobiology · doi:10.1016/j.imbio.2011.06.007 · Cited by 102 · see citing works
Roussel, M., Ferrell, P. B., Greenplate, A. R., Lhomme, F., Le Gallou, S., Diggins, K. E., Johnson, D. B., & Irish, J. M. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.5ma1116-457r · Cited by 93 · see citing works
Platzer, B., Elpek, K. G., Cremasco, V., Baker, K., Stout, M., Schultz, C., Dehlink, E., Shade, K.-T., Anthony, R. M., Blumberg, R. S., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.02.015 · Cited by 77 · see citing works
Aligning bona fide dendritic cell populations across species
Dutertre, C., Wang, L., & Ginhoux, F. (2014) · Cellular Immunology · doi:10.1016/j.cellimm.2014.08.006 · Cited by 69 · see citing works
Porta, C., Sica, A., & Riboldi, E. (2017) · FEBS Journal · doi:10.1111/febs.14288 · Cited by 69 · see citing works
Melanoma immunology: past, present and future
Parmiani, G., Castelli, C., Santinami, M., & Rivoltini, L. (2007) · Current Opinion in Oncology · doi:10.1097/cco.0b013e32801497d7 · Cited by 68 · see citing works
Novel insights in the regulation and function of macrophages in the tumor microenvironment
Bolli, E., Movahedi, K., Laoui, D., & Ginderachter, J. A. V. (2016) · Current Opinion in Oncology · doi:10.1097/cco.0000000000000344 · Cited by 57 · see citing works
The Ontogeny and Microenvironmental Regulation of Tumor-Associated Macrophages
Movahedi, K., & Ginderachter, J. A. V. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6704 · Cited by 53 · see citing works
Flies, D. B., Higuchi, T., Harris, J. C., Jha, V., Gimotty, P. A., & Adams, S. F. (2016) · OncoImmunology · doi:10.1080/2162402x.2016.1185583 · Cited by 44 · see citing works
Reflections on immunological nomenclature: in praise of imperfection
Mantovani, A. (2016) · Nature Immunology · doi:10.1038/ni.3354 · Cited by 40 · see citing works
Schrøder, M., Melum, G. R., Landsverk, O. J. B., Bujko, A., Yaqub, S., Gran, E., Aamodt, H., Bækkevold, E. S., Jahnsen, F. L., & Richter, L. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157387 · Cited by 34 · see citing works
Zhao, C., Pavicic, P. G., Datta, S., Sun, D., Novotny, M., & Hamilton, T. A. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1303396 · Cited by 31 · see citing works
Exploiting tumor-associated dendritic cell heterogeneity for novel cancer therapies
Keirsse, J., Damme, H. V., Ginderachter, J. A. V., & Laoui, D. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.4mr1116-466r · Cited by 31 · see citing works
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Peng, J., Sun, B.-F., Chen, C.-Y., Zhou, J.-Y., Chen, Y.-S., Chen, H., Liu, L., Huang, D., Jiang, J., Cui, G.-S., et al. (2019) · Cell Research · doi:10.1038/s41422-019-0195-y · Cited by 1,321 · see citing works
Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma
Ji, A. L., Rubin, A. J., Thrane, K., Jiang, S., Reynolds, D. L., Meyers, R. M., Guo, M. G., George, B. M., Mollbrink, A., Bergenstråhle, J., et al. (2020) · Cell · doi:10.1016/j.cell.2020.05.039 · Cited by 1,117 · see citing works
Macrophages: versatile players in renal inflammation and fibrosis
Tang, P. M.-K., Nikolic-Paterson, D. J., & Lan, H.-Y. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0110-2 · Cited by 1,033 · see citing works
Developmental and Functional Heterogeneity of Monocytes
Guilliams, M., Mildner, A., & Yona, S. (2018) · Immunity · doi:10.1016/j.immuni.2018.10.005 · Cited by 973 · see citing works
Friebel, E., Kapolou, K., Unger, S., Núñez, N. G., Utz, S. G., Rushing, E. J., Regli, L., Weller, M., Greter, M., Tugues, S., et al. (2020) · Cell · doi:10.1016/j.cell.2020.04.055 · Cited by 675 · see citing works
Lineage plasticity in cancer: a shared pathway of therapeutic resistance
Quintanal-Villalonga, À., Chan, J. M., Yu, H. A., Pe’er, D., Sawyers, C. L., Sen, T., & Rudin, C. M. (2020) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0340-z · Cited by 573 · see citing works
Current advance of nanotechnology in diagnosis and treatment for malignant tumors
Wang, B., Hu, S., Teng, Y., Chen, J., Wang, H., Xu, Y., Wang, K., Xu, J., Cheng, Y., & Gao, X. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01889-y · Cited by 604 · see citing works
Seidman, J. S., Troutman, T. D., Sakai, M., Gola, A., Spann, N. J., Bennett, H., Bruni, C. M., Ouyang, Z., Li, R. Z., Sun, X., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.04.001 · Cited by 443 · see citing works
Bernard, V., Semaan, A., Huang, J. H., Lucas, F. A. S., Mulu, F. C., Stephens, B. M., Guerrero, P. A., Huang, Y., Zhao, J., Kamyabi, N., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-1955 · Cited by 387 · see citing works
Diverse Functions of Macrophages in Different Tumor Microenvironments
Yang, M., McKay, D., Pollard, J. W., & Lewis, C. E. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-1367 · Cited by 390 · see citing works
Martin, K. E., & Garcı́a, A. J. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.03.038 · Cited by 375 · see citing works
Metal Drugs and the Anticancer Immune Response
Englinger, B., Pirker, C., Heffeter, P., Terenzi, A., Kowol, C. R., Keppler, B. K., & Berger, W. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00396 · Cited by 355 · see citing works
Rodríguez-García, A., Lynn, R. C., Poussin, M., Eiva, M. A., Shaw, L. C., O’Connor, R. S., Minutolo, N. G., Casado‐Medrano, V., López, G., Matsuyama, T., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-20893-2 · Cited by 349 · see citing works
Cancer-associated fibroblasts and their influence on tumor immunity and immunotherapy
Barrett, R. L., & Puré, E. (2020) · eLife · doi:10.7554/elife.57243 · Cited by 351 · see citing works
Rodríguez, E., Boelaars, K., Brown, K., Li, R. J. E., Kruijssen, L. J. W., Bruijns, S. C. M., van Ee, T., Schetters, S. T. T., Crommentuijn, M. H. W., van der Horst, J. C., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21550-4 · Cited by 319 · see citing works
Small molecule immunomodulation: the tumor microenvironment and overcoming immune escape
Osipov, A., Saung, M. T., Zheng, L., & Murphy, A. G. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0667-0 · Cited by 244 · see citing works
Etzerodt, A., Tsalkitzi, K., Maniecki, M. B., Damsky, W., Delfini, M., Baudoin, E., Moulin, M., Bosenberg, M., Graversen, J. H., Auphan‐Anezin, N., et al. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20182124 · Cited by 231 · see citing works
Fleur, L. L., Botling, J., He, F., Pelicano, C., Zhou, C., He, C., Palano, G., Mezheyeuski, A., Micke, P., Ravetch, J. V., et al. (2020) · Cancer Research · doi:10.1158/0008-5472.can-20-1885 · Cited by 226 · see citing works
Tumor-associated myeloid cells: diversity and therapeutic targeting
Mantovani, A., Marchesi, F., Jaillon, S., Garlanda, C., & Allavena, P. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-00613-4 · Cited by 218 · see citing works
Zhao, Q., Huang, L., Qin, G., Qiao, Y., Ren, F., Shen, C., Wang, S., Liu, S., Lian, J., Wang, D., et al. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.06.009 · Cited by 190 · see citing works
Wang-Bishop, L., Wehbe, M., Shae, D., James, J. L., Hacker, B. C., Garland, K. M., Chistov, P. P., Rafat, M., Balko, J. M., & Wilson, J. T. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2019-000282 · Cited by 173 · see citing works
Eisinger, S., Sarhan, D., Boura, V. F., Ibarlucea-Benitez, I., Tyystjärvi, S., Oliynyk, G., Arsenian‐Henriksson, M., Lane, D. P., Wickström, S. L., Kiessling, R. W., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2015343117 · Cited by 173 · see citing works
Trial watch: dendritic cell vaccination for cancer immunotherapy
Sprooten, J., Ceusters, J., Coosemans, A., Agostinis, P., Vleeschouwer, S. D., Zitvogel, L., Kroemer, G., Galluzzi, L., & Garg, A. D. (2019) · OncoImmunology · doi:10.1080/2162402x.2019.1638212 · Cited by 148 · see citing works
Relief of tumor hypoxia unleashes the tumoricidal potential of neutrophils
Mahiddine, K., Blaisdell, A., Ma, S., Créquer-Grandhomme, A., Lowell, C. A., & Erlebacher, A. (2019) · Journal of Clinical Investigation · doi:10.1172/jci130952 · Cited by 140 · see citing works
Oncometabolites lactate and succinate drive pro-angiogenic macrophage response in tumors.
Kes, M., van den Bossche, J., Griffioen, A., & Huijbers, E. (2020) · Biochimica et biophysica acta. Reviews on cancer · doi:10.1016/j.bbcan.2020.188427 · Cited by 130 · see citing works
Kumar, A., Knops, A. M., Swendseid, B. P., Martinez-Outschoom, U., Harshyne, L. A., Philp, N. J., Rodeck, U., Luginbuhl, A., Cognetti, D. M., Johnson, J. M., et al. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00656 · Cited by 134 · see citing works
Raskov, H., Orhan, A., Gaggar, S., & Gögenür, I. (2022) · Oncogenesis · doi:10.1038/s41389-022-00398-3 · Cited by 133 · see citing works
Systemic Reprogramming of Monocytes in Cancer
Kiss, M., Caro, A. A., Raes, G., & Laoui, D. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01399 · Cited by 132 · see citing works
The immune cell atlas of human neuroblastoma
Verhoeven, B. M., Mei, S., Olsen, T. K., Gustafsson, K. U., Valind, A., Lindström, A., Gisselsson, D., Fard, S. S., Hagerling, C., Kharchenko, P. V., et al. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100657 · Cited by 100 · see citing works
Immune cells as tumor drug delivery vehicles
Combes, F., Meyer, E., & Sanders, N. N. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.07.043 · Cited by 98 · see citing works
Lipid Metabolism and Cancer Immunotherapy: Immunosuppressive Myeloid Cells at the Crossroad
Bleve, A., Durante, B., Sica, A., & Consonni, F. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165845 · Cited by 99 · see citing works
Kiss, M., Walle, L. V., Saavedra, P. H. V., Lebegge, E., Damme, H. V., Murgaski, A., Qian, J., Ehling, M., Pretto, S., Bolli, E., et al. (2020) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-20-0431 · Cited by 98 · see citing works
Single-cell immunology: Past, present, and future
Ginhoux, F., Yalin, A., Dutertre, C., & Amit, I. (2022) · Immunity · doi:10.1016/j.immuni.2022.02.006 · Cited by 93 · see citing works
Albonici, L., Giganti, M. G., Modesti, A., Manzari, V., & Bei, R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20122970 · Cited by 85 · see citing works
Wang, Q., Guldner, I. H., Golomb, S. M., Sun, L., Harris, J. A., Lü, X., & Zhang, S. (2019) · Nature Communications · doi:10.1038/s41467-019-11729-1 · Cited by 87 · see citing works
Biology and therapeutic targeting of tumour‐associated macrophages
Beltraminelli, T., & Palma, M. D. (2020) · The Journal of Pathology · doi:10.1002/path.5403 · Cited by 87 · see citing works
Advances in Pancreatic Ductal Adenocarcinoma Treatment
Anderson, E. M., Thomassian, S., Gong, J., Hendifar, A. E., & Osipov, A. (2021) · Cancers · doi:10.3390/cancers13215510 · Cited by 78 · see citing works
Targeting myeloid cells for cancer immunotherapy: Siglec-7/9/10/15 and their ligands
Boelaars, K., & van Kooyk, Y. (2023) · Trends in cancer · doi:10.1016/j.trecan.2023.11.009 · Cited by 79 · see citing works
Gaggero, S., Witt, K., Carlsten, M., & Mitra, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.621225 · Cited by 75 · see citing works
Allies or Enemies—The Multifaceted Role of Myeloid Cells in the Tumor Microenvironment
Haas, L., & Obenauf, A. C. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02746 · Cited by 73 · see citing works
Polyamine Immunometabolism: Central Regulators of Inflammation, Cancer and Autoimmunity
Chia, T.-Y., Zolp, A. J., & Miska, J. M. (2022) · Cells · doi:10.3390/cells11050896 · Cited by 75 · see citing works
Boelaars, K., Rodríguez, E., Huinen, Z. R., Liu, C., Wang, D., Springer, B. O., Olesek, K., Kruijssen, L. J. W., van Ee, T., Lindijer, D., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-06087-8 · Cited by 72 · see citing works
Lu, Y.-P., Wu, H., Zhu, T., Li, X.-T., Zuo, J., Hasan, A. A., Reichetzeder, C., Delić, D., Yard, B. A., Klein, T., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113947 · Cited by 71 · see citing works
Transcriptomic Hallmarks of Tumor Plasticity and Stromal Interactions in Brain Metastasis
Wingrove, E., Liu, Z. Z., Patel, K. D., Estape, A. A., Cai, W. L., Melnick, M., Politi, K. A., Monteiro, C., Zhu, L., Valiente, M., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.03.085 · Cited by 70 · see citing works
Myeloid signature reveals immune contexture and predicts the prognosis of hepatocellular carcinoma
Wu, C., Lin, J., Weng, Y., Zeng, D.-N., Xu, J., Luo, S., Xu, L., Liu, M., Hua, Q., Liu, C., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci135048 · Cited by 69 · see citing works
Neutrophils to lymphocytes ratio as a useful prognosticator for stage II colorectal cancer patients
Dimitriou, N., Felekouras, E. S., Karavokyros, I., Alexandrou, A. P., Pikoulis, E., & Grınıatsos, J. (2018) · BMC Cancer · doi:10.1186/s12885-018-5042-x · Cited by 67 · see citing works
From immune checkpoints to vaccines: The past, present and future of cancer immunotherapy
Osipov, A., Murphy, A. G., & Zheng, L. (2019) · Advances in cancer research · doi:10.1016/bs.acr.2019.03.002 · Cited by 67 · see citing works
Zhang, W., Zhang, Q., Yang, N., Shi, Q., Su, H., Lin, T., He, Z., Wang, W., Guo, H., & Shen, P. (2022) · 癌症:英文版 · doi:10.1002/cac2.12311 · Cited by 65 · see citing works
mPGES-1 and ALOX5/-15 in tumor-associated macrophages
Weigert, A., Strack, E., Snodgrass, R. G., & Brüne, B. (2018) · Cancer and Metastasis Reviews · doi:10.1007/s10555-018-9731-3 · Cited by 62 · see citing works
Jacobson, M. E., Wang-Bishop, L., Becker, K. W., & Wilson, J. T. (2018) · Biomaterials Science · doi:10.1039/c8bm01064a · Cited by 62 · see citing works
Wang, X., Miao, J., Wang, S., Shen, R., Zhang, S., Tian, Y., Li, M., Zhu, D., Yao, A., Bao, W., et al. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01596-8 · Cited by 62 · see citing works
Role of protein phosphatases in the cancer microenvironment
Ruvolo, P. P. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2018.07.006 · Cited by 59 · see citing works
Interactions among myeloid regulatory cells in cancer
Umansky, V., Adema, G. J., Baran, J., Brandau, S., Ginderachter, J. A. V., Hu, X., Jabłońska, J., Mojsilović, S. B., Papadaki, H. Α., de Coaña, Y. P., et al. (2018) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-018-2200-6 · Cited by 59 · see citing works
Ding, L., Qian, J., Yu, X., Wu, Q., Mao, J., Liu, X., Wang, Y., Guo, D., Su, R., Xie, H., et al. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216568 · Cited by 54 · see citing works
Anti-PD-L1 F(ab) Conjugated PEG-PLGA Nanoparticle Enhances Immune Checkpoint Therapy
Lee, C. K., Atibalentja, D. F., Yao, L. E., Park, J., Kuruvilla, S. P., & Felsher, D. W. (2022) · Nanotheranostics · doi:10.7150/ntno.65544 · Cited by 53 · see citing works
Zhang, Q., Cheng, S., Wang, Y., Wang, M., Lu, Y., Wen, Z., Ge, Y., Ma, Q., Chen, Y., Zhang, Y., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-27018-9 · Cited by 50 · see citing works
Getting TANned: How the tumor microenvironment drives neutrophil recruitment
SenGupta, S., Subramanian, B. C., & Parent, C. A. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.3ri0718-282r · Cited by 48 · see citing works
Ali, A., Abouleila, Y., Shimizu, Y., Hiyama, E., Watanabe, T. M., Yanagida, T., & Germond, A. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.8b04393 · Cited by 42 · see citing works
In Situ Single‐Cell Western Blot on Adherent Cell Culture
Zhang, Y., Naguro, I., & Herr, A. E. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201906920 · Cited by 41 · see citing works
Intestinal Macrophages at the Crossroad between Diet, Inflammation, and Cancer
Caprara, G., Allavena, P., & Erreni, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144825 · Cited by 38 · see citing works
Wang, S., Kuai, Y., Lin, S., Li, L., Gu, Q., Zhang, X., Li, X., He, Y., Chen, S., Xia, X., et al. (2023) · BMC Medicine · doi:10.1186/s12916-023-02791-0 · Cited by 37 · see citing works
Diamonds in the Rough: Harnessing Tumor-Associated Myeloid Cells for Cancer Therapy
Clappaert, E. J., Murgaski, A., Damme, H. V., Kiss, M., & Laoui, D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02250 · Cited by 37 · see citing works
Enhanced tumor immune surveillance through neutrophil reprogramming due to Tollip deficiency
Zhang, Y., Lee, C., Geng, S., & Li, L. (2019) · JCI Insight · doi:10.1172/jci.insight.122939 · Cited by 37 · see citing works
Crosstalk Between Mesenchymal Stromal Cells and Tumor-Associated Macrophages in Gastric Cancer
Zheng, P., & Li, W. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.571516 · Cited by 37 · see citing works
Epigenetic mechanisms of tumor resistance to immunotherapy
Arenas-Ramirez, N., Sahin, D., & Boyman, O. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2908-7 · Cited by 36 · see citing works
Phenotypic and transcriptomic characterization of canine myeloid-derived suppressor cells
Goulart, M. R., Hlavaty, S. I., Chang, Y., Polton, G. A., Stell, A. J., Perry, J. A., Wu, Y., Sharma, E., Broxholme, J., Lee, A. C., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-40285-3 · Cited by 36 · see citing works
Targeting Myeloid Suppressive Cells Revives Cytotoxic Anti-Tumor Responses in Pancreatic Cancer
Sarhan, D., Eisinger, S., He, F., Bergsland, M., Pelicano, C., Driescher, C., Westberg, K., Ibarlucea-Benitez, I., Hamoud, R., Palano, G., et al. (2022) · iScience · doi:10.1016/j.isci.2022.105317 · Cited by 36 · see citing works
Angiogenesis Still Plays a Crucial Role in Human Melanoma Progression
Cazzato, G., Ingravallo, G., & Ribatti, D. (2024) · Cancers · doi:10.3390/cancers16101794 · Cited by 35 · see citing works
NK Cell Anti-Tumor Surveillance in a Myeloid Cell-Shaped Environment
Russo, E., Laffranchi, M., Tomaipitinca, L., Prete, A. D., Santoni, A., Sozzani, S., & Bernardini, G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.787116 · Cited by 36 · see citing works
Tracking Monocytes and Macrophages in Tumors With Live Imaging
Laviron, M., Combadière, C., & Boissonnas, A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01201 · Cited by 35 · see citing works
Rémot, A., Doz, E., & Winter, N. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00417 · Cited by 30 · see citing works
Brief review on the roles of neutrophils in cancer development
Wang, L., Chen, J., Chen, G., Lin, Z., Xie, X., & Dai, H. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.4mr0820-011r · Cited by 31 · see citing works
Metronomic Anti-Cancer Therapy: A Multimodal Therapy Governed by the Tumor Microenvironment
Muñoz, R., Girotti, A., Hileeto, D., & Arias, F. J. (2021) · Cancers · doi:10.3390/cancers13215414 · Cited by 29 · see citing works
Jiang, X., Wang, C., Ke, Z., Duo, L., Wu, T., Wang, W., Yang, Y., & Dai, Y. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.12.012 · Cited by 28 · see citing works
Innate Immune Defense Mechanisms by Myeloid Cells That Hamper Cancer Immunotherapy
Lebegge, E., Arnouk, S. M., Bardet, P. M. R., Kiss, M., Raes, G., & Ginderachter, J. A. V. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01395 · Cited by 27 · see citing works
Tumor and Peripheral Immune Status in Soft Tissue Sarcoma: Implications for Immunotherapy
Sousa, L. M., Almeida, J. S., Fortes-Andrade, T., Santos-Rosa, M., Freitas-Tavares, P., Casanova, J., & Rodrigues‐Santos, P. (2021) · Cancers · doi:10.3390/cancers13153885 · Cited by 26 · see citing works
Chemokines as Regulators of Neutrophils: Focus on Tumors, Therapeutic Targeting, and Immunotherapy
Bonecchi, R., Mantovani, A., & Jaillon, S. (2022) · Cancers · doi:10.3390/cancers14030680 · Cited by 26 · see citing works
Chen, Q., Chen, B., Wang, C., Hu, L., Wu, Q., Zhu, Y., & Zhang, Q. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1159085 · Cited by 24 · see citing works
Kerdidani, D., Magkouta, S., Chouvardas, P., Karavana, V. N., Glynos, K., Roumelioti, F., Zakynthinos, S. G., Wauters, E., Janssens, W., Lambrechts, D., et al. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1700700 · Cited by 24 · see citing works
Coosemans, A., Baert, T., Ceusters, J., Busschaert, P., Landolfo, C., Verschuere, T., Rompuy, A. V., Vanderstichele, A., Froyman, W., Neven, P., et al. (2019) · International Journal of Gynecological Cancer · doi:10.1136/ijgc-2019-000521 · Cited by 24 · see citing works
Zhou, Y., Xiao, D., & Jiang, X. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03536-y · Cited by 23 · see citing works
Myeloid checkpoints for cancer immunotherapy
Qian, Y., Yang, T., Liang, H., & Deng, M. (2022) · Chinese Journal of Cancer Research · doi:10.21147/j.issn.1000-9604.2022.05.07 · Cited by 23 · see citing works
Prat, M., Coulson, K., Blot, C., Jacquemin, G., Romano, M., Renoud, M.-L., AlaEddine, M., Naour, A. L., Authier, H., Rahabi, M. C., et al. (2023) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2023-007031 · Cited by 23 · see citing works
Wang, Y., Wang, Y., Xu, C., Liu, Y., & Huang, Z. (2020) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2020.08.029 · Cited by 23 · see citing works
Dander, E., Fallati, A., Gulić, T., Pagni, F., Gaspari, S., Silvestri, D., Cricrì, G., Bedini, G., Portale, F., Buracchi, C., et al. (2021) · British Journal of Haematology · doi:10.1111/bjh.17330 · Cited by 22 · see citing works
Single-cell RNA sequencing in melanoma: what have we learned so far?
Lim, S. Y., & Rizos, H. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.104969 · Cited by 22 · see citing works
Svensson, M. C., Svensson, M., Nodin, B., Borg, D., Hedner, C., Hjalmarsson, C., Leandersson, K., & Jirström, K. (2022) · Journal of Innate Immunity · doi:10.1159/000524434 · Cited by 19 · see citing works
Sorenson, L., Fu, Y., Hood, T., Warren, S. E., & McEachron, T. A. (2019) · OncoImmunology · doi:10.1080/2162402x.2019.1629779 · Cited by 19 · see citing works
Evolution and Targeting of Myeloid Suppressor Cells in Cancer: A Translational Perspective
Bleve, A., Consonni, F. M., Porta, C., Garlatti, V., & Sica, A. (2022) · Cancers · doi:10.3390/cancers14030510 · Cited by 17 · see citing works
Domingos‐Pereira, S., Sathiyanadan, K., Polák, L., Haefliger, J., Schmittnaegel, M., Ries, C. H., Jichlinski, P., Roth, B., Derré, L., & Nardelli‐Haefliger, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010123 · Cited by 17 · see citing works
Role of Myeloid Cells in Oncolytic Reovirus-Based Cancer Therapy
Kumar, V., Giacomantonio, M., & Gujar, S. A. (2021) · Viruses · doi:10.3390/v13040654 · Cited by 16 · see citing works
Liu, Z., Zhang, D., Liu, C., Li, G., Chen, H., Ling, H. H., Zhang, F., Huang, D., Wang, X., Liu, Y., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.659184 · Cited by 16 · see citing works
Delineating Pro-Angiogenic Myeloid Cells in Cancer Therapy
Johnson, B. W., Achyut, B. R., Fulzele, S., Mondal, A. K., Kolhe, R. B., & Arbab, A. S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092565 · Cited by 16 · see citing works
c-Rel-dependent monocytes are potent immune suppressor cells in cancer
Li, T., Bou-Dargham, M. J., Fultang, N., Li, X., Pear, W. S., Sun, H., & Chen, Y. H. (2022) · Journal of Leukocyte Biology · doi:10.1002/jlb.1ma0422-518rr · Cited by 15 · see citing works
Engineering stromal heterogeneity in cancer
Tang, L. J. W., Zaseela, A., Toh, C. C. M., Adine, C., Aydar, A. O., Iyer, N. G., & Fong, E. L. S. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.05.027 · Cited by 15 · see citing works
CRISPR Screens to Identify Regulators of Tumor Immunity
LaFleur, M. W., & Sharpe, A. H. (2021) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-070120-094725 · Cited by 15 · see citing works
Ding, J., Zheng, Y., Wang, G., Zheng, J., & Chai, D. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188763 · Cited by 14 · see citing works
Sakai, Y., Miyazawa, M., Komura, T., Yamada, T., Nasti, A., Yoshida, K., Takabatake, H., Yamato, M., Yamashita, T., Yamashita, T., et al. (2019) · Cancer Science · doi:10.1111/cas.13944 · Cited by 14 · see citing works
New Perspectives on Myeloid-Derived Suppressor Cells and Their Emerging Role in Haematology
Bizymi, N., Matthaiou, A. Μ., Matheakakis, A., Voulgari, I., Aresti, N., Zavitsanou, K., Karasachinidis, A., Mavroudi, I., Pontikoglou, C. G., & Papadaki, H. Α. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11185326 · Cited by 12 · see citing works
Milenova, I. E., González, M. L., Quixabeira, D. C. A., Santos, J. M., Cervera-Carrascón, V., Dong, W., Hemminki, A., van Beusechem, V. W., van de Ven, R., & de Gruijl, T. D. (2021) · Human Gene Therapy · doi:10.1089/hum.2020.277 · Cited by 12 · see citing works
- Authors
- Kiss, M., Van Gassen, S., Movahedi, K., Saeys, Y., & Laoui, D.
- Affiliations
- Vrije Universiteit Brussel (BE)
- Ghent University (BE)
- Corresponding author
- Laoui, Damya
- Venue
- Cellular Immunology
- Publisher
- Elsevier BV
- Published
- 2018-08
- Volume
- 330
- Pages
- 188-201
- ISSN
- 0008-8749 (ISSN-L)
- OpenAlex
- W2789612591
- Cited by
- 159
- References
- 188
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 14 · 2023: 11 · 2022: 38 · 2021: 23 · 2020: 23 · 2019: 24 · 2018: 18
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cellular Immunology (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- VUBIR (Vrije Universiteit Brussel) (submittedVersion)
- Funders
- Fonds Wetenschappelijk Onderzoek
- Agentschap voor Innovatie door Wetenschap en Technologie
- Innoviris
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Keywords
- myeloid cell heterogeneity, tumor-associated macrophages, tumor-associated monocytes, tumor-associated neutrophils, myeloid-derived suppressor cells, tumor-associated dendritic cells, tumor microenvironment, antitumor immunity, myeloid cell activation, neoangiogenesis, metastasis, treatment resistance, single-cell technologies
- MeSH terms
- Animals, Dendritic Cells, Humans, Macrophages, Monocytes, Neoplasms, Neutrophils, Myeloid Cells, Cell Proliferation, Tumor Microenvironment
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