Plaque-associated myeloid cells derive from resident microglia in an Alzheimer's disease model
Open accessAbstract
Alzheimer’s disease (AD) is accompanied by a robust inflammatory response mediated by plaque-associated myeloid cells of the brain. These cells exhibit altered gene expression profiles and serve as a barrier, preventing neuritic dystrophy. The origin of these cells has been controversial and is of therapeutic importance. Here, we genetically labeled different myeloid populations and unequivocally demonstrated that plaque-associated myeloid cells in the AD brain are derived exclusively from resident microglia, with no contribution from circulating peripheral monocytes.
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Plaques were evident in multiple brain regions by 4 months in male and female 5xFAD mice, concomitant with activation and gliosis of plaque-associated and non-plaque-associated microglia.
“Plaques were evident in multiple brain regions by 4mo in male and female 5xFAD mice, concomitant with the stereotypical activation and gliosis of plaque- and non-plaque-associated microglia (PAM and NPAM, respectively; Fig. 1A-C) [52, 53].”
From Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brain (2020) · cites this paper as [53]
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- Authors
- Reed-Geaghan, E. G., Croxford, A. L., Becher, B., & Landreth, G. E.
- Affiliations
- Case Western Reserve University (US)
- University of Zurich (CH)
- Indiana University Indianapolis (US)
- Corresponding author
- Reed-Geaghan, Erin G.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2020-01-22
- Volume
- 217
- Issue
- 4
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC7144522
- OpenAlex
- W3001503481
- Cited by
- 72
- References
- 34
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 11 · 2023: 9 · 2022: 11 · 2021: 19 · 2020: 9
- FWCI
- 4.64
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- The Journal of Experimental Medicine (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, cc-by-nc-sa)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, cc-by-nc-sa)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Alzheimer’s Association (BFG-15-364590)
- National Institute on Aging (AG050597, AG051495)
- Northeast Ohio Medical University
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- Alzheimer's disease, microglia, peripheral blood monocytes, neuroinflammation, amyloid plaques, lineage tracing
- MeSH terms
- Alzheimer Disease, Animals, Brain, Disease Models, Animal, Female, Genetic Markers, Male, Mice, Transgenic, Yolk Sac, Microglia, Myeloid Cells, Mice, Plaque, Amyloid
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