Neurobiology of Decision Making in Depressed Adolescents: A Functional Magnetic Resonance Imaging Study
Open accessAbstract
Objective Despite evidence that impaired reward- and risk-related behavior during adolescence can have potentially serious short- and long-term consequences, few studies have investigated the impact of depression on reward-related selection in adolescents. This study examined the relationship between reward-related behavior and prefrontal activations in depressed and healthy adolescents during a decision-making task.Method A total of 22 adolescents with no personal or family history of psychiatric illness and 22 adolescents with major depressive disorder were administered a monetary, two-option decision-making task, the Wheel of Fortune, using a functional magnetic resonance imaging protocol. The analysis was focused on the selection phase, i.e., the first phase of the decision-making process, which typically includes two more phases, the anticipation of outcome and the feedback.Results Similar prefrontal regions were activated in healthy and depressed adolescents during reward-related selection. However, in a contrast involving the selection of high-risk (low-probability/high-magnitude reward) versus equal-risk (50% chance of reward) options, healthy adolescents showed greater activation than patients in the right lateral orbitofrontal cortex (OFC), whereas participants with depression showed greater activation than healthy subjects in the left dorsal OFC and right caudal anterior cingulate cortex. In addition, healthy adolescents, but not participants with depression, showed a negative correlation between high-risk behavior and neuronal activation in prespecified prefrontal regions.Conclusions These results suggest subtle changes in the neural responses to reward selection in depressed adolescents. These findings should be replicated in larger samples, and the association of these neuronal changes with treatment response and prognosis should be examined.
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In a sample tested with the same paradigm, adolescents with MDD had higher left OFC and dACC activation but lower right lateral OFC during high-risk trials relative to controls.
“In a sample tested with the same paradigm, adolescents with MDD had higher left OFC and dACC activation but lower right lateral OFC during high-risk trials (trials with only 25% chance of winning a higher amount) relative to controls [133].”
From Prefrontal cortex and depression (2022) · cites this paper as [133]
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- Authors
- Shad, M. U., Bidesi, A. P., Chen, L.-A., Ernst, M., & Rao, U.
- Affiliations
- The University of Texas Health Science Center at Houston (US)
- Meharry Medical College (US)
- Venue
- Journal of the American Academy of Child & Adolescent Psychiatry
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 50
- Issue
- 6
- Pages
- 612-621.e2
- ISSN
- 0890-8567 (ISSN-L)
- PMC
- PMC3105351
- OpenAlex
- W2016947175
- Cited by
- 37
- References
- 47
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 4 · 2018: 1 · 2016: 3 · 2015: 3 · 2014: 5 · 2013: 4 · 2012: 2
- FWCI
- 1.79
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH062464, R01MH068391, MH62464, MH 68391)
- National Institute on Drug Abuse (DA14037, DA17805, DA 15131, DA17804, R01DA015131, R01DA017804, R01DA014037, R01DA017805)
- National Center for Research Resources (G12RR003032, U54RR026140)
- National Institute on Minority Health and Health Disparities (U54MD007593)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- adolescent depression, major depressive disorder, decision-making, reward-related behavior, risk-taking, orbitofrontal cortex, anterior cingulate cortex, prefrontal cortex activation, neural correlates of depression
- MeSH terms
- Adolescent, Brain Mapping, Choice Behavior, Depressive Disorder, Major, Major Depressive Disorder, Dominance, Cerebral, Female, Frontal Lobe, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Oxygen Consumption, Probability Learning, Reference Values, Reward, Risk-Taking, Prefrontal Cortex
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