Lipopolysaccharide-Induced Memory Impairment in Rats: a Model of Alzheimer’s Disease
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Alzheimer’s disease (AD) is a primary cause of dementia in the middle-aged and elderly worldwide. Animal models for AD are widely used to study the disease mechanisms as well as to test potential therapeutic agents for disease modification. Among the non-genetically manipulated neuroinflammation models for AD, lipopolysaccharide (LPS)-induced animal model is commonly used. This review paper aims to discuss the possible factors that influence rats’ response following LPS injection. Factors such as dose of LPS, route of administration, nature and duration of exposure as well as age and gender of animal used should be taken into account when designing a study using LPS-induced memory impairment as model for AD.
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Multiple doses of 1 mg LPS/kg (over several days), or chronic endotoxin, cause more rapid neurodegeneration and have been used as models of Parkinson's or Alzheimer's disease.
“Multiple doses of 1 mg LPS/kg (over several days), or chronic endotoxin, cause more rapid neurodegeneration and have been used as models of Parkinson’s or Alzheimer’s disease [44, 45].”
From The endotoxin hypothesis of neurodegeneration (2019) · cites this paper as [45]
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Inducing Agents for Alzheimer’s Disease in Animal Models
Khan, K., Emad, N. A., & Sultana, Y. (2024) · Journal of Exploratory Research in Pharmacology · doi:10.14218/jerp.2023.00028 · Cited by 11 · see citing works
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Rat models of major neurodegenerative disorders
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Self-citation
- Authors
- ZAKARIA, R., WAN YAACOB, W. M. H., OTHMAN, Z., LONG, I., AHMAD, A. H., & AL-RAHBI, B.
- Affiliations
- Universiti Sains Malaysia (MY)
- Ministry of Health (OM)
- Venue
- Physiological Research
- Published
- 2017-08-15
- Volume
- 66
- Issue
- 4
- Pages
- 553-565
- ISSN
- 0862-8408 (ISSN-L)
- 1802-9973
- OpenAlex
- W2735061629
- Cited by
- 167
- References
- 118
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 22 · 2023: 28 · 2022: 28 · 2021: 19 · 2020: 24 · 2019: 16 · 2018: 6
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Physiological Research (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- Alzheimer's disease, lipopolysaccharide, memory impairment, animal models of Alzheimer's disease, neuroinflammation, age and sex effects, rats
- MeSH terms
- Alzheimer Disease, Animals, Disease Models, Animal, Humans, Lipopolysaccharides, Memory Disorders, Inflammation Mediators, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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