Cited by 167Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsNeurological Disease Mechanisms and Treatments

Lipopolysaccharide-Induced Memory Impairment in Rats: a Model of Alzheimer’s Disease

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ZAKARIA, R., WAN YAACOB, W. M. H., OTHMAN, Z., LONG, I., AHMAD, A. H., AL-RAHBI, B.·2017·Physiological Research

Abstract

Alzheimer’s disease (AD) is a primary cause of dementia in the middle-aged and elderly worldwide. Animal models for AD are widely used to study the disease mechanisms as well as to test potential therapeutic agents for disease modification. Among the non-genetically manipulated neuroinflammation models for AD, lipopolysaccharide (LPS)-induced animal model is commonly used. This review paper aims to discuss the possible factors that influence rats’ response following LPS injection. Factors such as dose of LPS, route of administration, nature and duration of exposure as well as age and gender of animal used should be taken into account when designing a study using LPS-induced memory impairment as model for AD.

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Crossref · 10.33549/physiolres.933480

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  • Multiple doses of 1 mg LPS/kg (over several days), or chronic endotoxin, cause more rapid neurodegeneration and have been used as models of Parkinson's or Alzheimer's disease.

    “Multiple doses of 1 mg LPS/kg (over several days), or chronic endotoxin, cause more rapid neurodegeneration and have been used as models of Parkinson’s or Alzheimer’s disease [44, 45].”

    From The endotoxin hypothesis of neurodegeneration (2019) · cites this paper as [45]

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Authors
ZAKARIA, R., WAN YAACOB, W. M. H., OTHMAN, Z., LONG, I., AHMAD, A. H., & AL-RAHBI, B.
Affiliations
  • Universiti Sains Malaysia (MY)
  • Ministry of Health (OM)
Venue
Physiological Research
Published
2017-08-15
Volume
66
Issue
4
Pages
553-565
ISSN
  • 0862-8408 (ISSN-L)
  • 1802-9973
OpenAlex
W2735061629
Cited by
167
References
118
Citations by year
2026: 8 · 2025: 16 · 2024: 22 · 2023: 28 · 2022: 28 · 2021: 19 · 2020: 24 · 2019: 16 · 2018: 6
FWCI
1.54
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Physiological Research (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords
Alzheimer's disease, lipopolysaccharide, memory impairment, animal models of Alzheimer's disease, neuroinflammation, age and sex effects, rats
MeSH terms
Alzheimer Disease, Animals, Disease Models, Animal, Humans, Lipopolysaccharides, Memory Disorders, Inflammation Mediators, Rats

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