The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Anxiety and depression in multiple sclerosis patients around diagnosis
Abstract
Objectives To prospectively identify anxiety and depressive symptoms, and their predictors, during the multiple sclerosis (MS) peridiagnostic period.Methods The Hospital Anxiety and Depression Scale (HADS) was administered during diagnostic workup (baseline), and one and six months after diagnosis disclosure, to SIMS-Trial participants (ISRCTN81072971).Results Of 197 screened patients, 120 (61%) were diagnosed with MS. At baseline, median HADS anxiety (HADS-A) score was 7.0 (interquartile range [IQR] 5.0-9.5), ≥8 (anxiety cut-off) in 43% (95% confidence interval [CI] 34%-52%). Median HADS depression (HADS-D) was 3.0 (IQR 1.0-5.0), ≥8 (depression cut-off) in 11% (95% CI 5%-16%). Independent predictors of anxiety were female sex (odds ratio [OR] 2.8, 95% CI 1.1-7.2) and HADS-D score (OR 20.8, 95% CI 2.5-175.5). The only predictor of depressive symptoms was HADS-A score (OR 20.0, 95% CI 2.8-260.9). Anxiety symptoms had decreased slightly but significantly (p<0.001) at six months. Depressive symptoms remained low.Conclusions Anxiety was prominent in the period surrounding MS diagnosis disclosure, particularly in women. A slight but significant reduction occurred six months after diagnosis disclosure. Depressive symptoms were less common and stable over time. In addition to sex, depressive symptoms were the only variable independently associated with anxiety.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In addition to the physical consequences, receiving an MS diagnosis and experiencing MS symptoms and progression of the disease have been associated with depression and anxiety (Giordano et al., 2011).”
From Self-concept, illness acceptance and depressive and anxiety symptoms in people with multiple sclerosis. (2021) · cites this paper as Giordano et al., 2011
In the citing paper
“Depression and anxiety have been found to be common in individuals with MS and have been reported to be at clinically high levels especially in the early stages of the illness [2–4].”
In the citing paper
“Firstly, the time around receiving a MS diagnosis has been shown to be when individuals experience significantly higher levels of depression and anxiety [2, 4, 11, 16].”
Citations
Cites
The Hospital Anxiety and Depression Scale
Zigmond, A. S., & Snaith, R. P. (1983) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1983.tb09716.x · Cited by 47,139
Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria
Polman, C. H., Reingold, S. C., Banwell, B., Clanet, M., Cohen, J. A., Filippi, M., Fujihara, K., Havrdova, E., Hutchinson, M., Kappos, L., et al. (2011) · Annals of Neurology · doi:10.1002/ana.22366 · Cited by 9,802
Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria”
Polman, C. H., Reingold, S. C., Edan, G., Filippi, M., Hartung, H., Kappos, L., Lublin, F. D., Metz, L. M., McFarland, H. F., O'Connor, P. W., et al. (2005) · Annals of Neurology · doi:10.1002/ana.20703 · Cited by 5,017
The handbook of psychological testing
Kline, P. (1993) · Choice Reviews Online · doi:10.5860/choice.31-1802 · Cited by 3,541
Cytokines sing the blues: inflammation and the pathogenesis of depression
Raison, C. L., Capuron, L., & Miller, A. H. (2006) · Trends in Immunology · doi:10.1016/j.it.2005.11.006 · Cited by 3,009
Herrmann, C. (1997) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(96)00216-4 · Cited by 2,885
The handbook of psychological testing, 2nd ed.
Kline, P. (1993) · Cited by 1,248
Depression in multiple sclerosis: a review
Siegert, R. J. (2005) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2004.054635 · Cited by 718
Chwastiak, L., Ehde, D. M., Gibbons, L. E., Sullivan, M., Bowen, J. D., & Kraft, G. H. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.11.1862 · Cited by 555
Costantini, M., Musso, M., Viterbori, P., Bonci, F., Mastro, L. D., Garrone, O., Venturini, M., & Morasso, G. (1999) · Supportive Care in Cancer · doi:10.1007/s005200050241 · Cited by 542
Depression and multiple sclerosis
Sadovnick, A. D., Remick, R. A., Allen, J. B., Swartz, E. S., Yee, I. M. L., Eisen, K., Farquhar, R., Hashimoto, S. A., Hooge, J. P., Kastrukoff, L. F., et al. (1996) · Neurology · doi:10.1212/wnl.46.3.628 · Cited by 536
Validation of the Hospital anxiety and depression scale for use with multiple sclerosis patients
Honarmand, K., & Feinstein, A. (2009) · Multiple Sclerosis Journal · doi:10.1177/1352458509347150 · Cited by 436 · cited 2×
“These characteristics together with brevity and ease of administration explain the wide use of HADS in MS, giving rise to the advantage that anxiety and depressive symptoms can be compared in diverse MS populations and settings [7,10,12,13,18,20,28].”
BackgroundAnxiety disorders and their clinical correlates in multiple sclerosis patients
Korostil, M., & Feinstein, A. (2007) · Multiple Sclerosis Journal · doi:10.1177/1352458506071161 · Cited by 424 · cited 4×
“These characteristics together with brevity and ease of administration explain the wide use of HADS in MS, giving rise to the advantage that anxiety and depressive symptoms can be compared in diverse MS populations and settings [7,10,12,13,18,20,28].”
BackgroundResultInfluentialMS quality of life, depression, and fatigue improve after mindfulness training: A randomized trial
Grossman, P., Kappos, L., Gensicke, H., D'Souza, M., Mohr, D. C., Penner, I. K., & Steiner, C. (2010) · Neurology · doi:10.1212/wnl.0b013e3181f4d80d · Cited by 419 · cited 1×
“Only 10% of our patients started psychopharmaceuticals and another two patients started psychotherapy after MS diagnosis communication in line with other studies indicating that little attention is paid tomood symptoms in peoplewithMS [9,27,39].”
ResultThe Goldman Consensus statement on depression in multiple sclerosis
Goldman Consensus Group (2005) · Multiple Sclerosis Journal · doi:10.1191/1352458505ms1162oa · Cited by 329
Janssens, A. C. J. W., van Doorn, P. A., de Boer, J. B., van der Meché, F. G. A., Passchier, J., & Hintzen, R. Q. (2003) · Acta Neurologica Scandinavica · doi:10.1034/j.1600-0404.2003.00166.x · Cited by 294
Structural brain abnormalities in multiple sclerosis patients with major depression
Feinstein, A., Roy, P., Lobaugh, N., Feinstein, K., O’Connor, P., & Black, S. (2004) · Neurology · doi:10.1212/01.wnl.0000110316.12086.0c · Cited by 294 · cited 1×
“Its pathogenesis is thought to involve at least three mechanisms: psychological reaction to the disease [6,32] because of loss of social status/role [33] or inadequate coping [34,35]; lesion burden to the central nervous system [36]; and functional changes due to inflammatory cytokines [37].”
BackgroundPsychological interventions for multiple sclerosis.
Thomas, P. W., Thomas, S., Hillier, C., Galvin, K., & Baker, R. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004431.pub2 · Cited by 271
Adjustment to multiple sclerosis: Application of a stress and coping model.
Pakenham, K. I. (1999) · Health Psychology · doi:10.1037//0278-6133.18.4.383 · Cited by 265
Depression and anxiety amongst multiple sclerosis patients
Beiske, A. G., Svensson, E., Sandanger, I., Czujko, B., Pedersen, E. D., Aarseth, J. H., & Myhr, K. M. (2008) · European Journal of Neurology · doi:10.1111/j.1468-1331.2007.02041.x · Cited by 257
Adjustment to multiple sclerosis: Application of a stress and coping model.
Pakenham, K. I. (1999) · Health Psychology · doi:10.1037/0278-6133.18.4.383 · Cited by 208
Longitudinal assessment of anxiety, depression, and fatigue in people with multiple sclerosis.
Brown, R. F., Valpiani, E. M., Tennant, C. C., Dunn, S. M., Sharrock, M., Hodgkinson, S., & Pollard, J. D. (2009) · Psychology and Psychotherapy: Theory, Research and Practice · doi:10.1348/147608308x345614 · Cited by 150
The effects of anxiety on psychiatric morbidity in patients with multiple sclerosis
Feinstein, A., O'Connor, P., Gray, T., & Feinstein, K. (1999) · Multiple Sclerosis Journal · doi:10.1177/135245859900500504 · Cited by 147
Depression, coping and level of neurological impairment in multiple sclerosis
Mohr, D. C., Goodkin, D. E., Gatto, N. M., & Wende, J. V. D. (1997) · Multiple Sclerosis Journal · doi:10.1177/135245859700300408 · Cited by 130
Dahl, O. P., Stordal, E., Lydersen, S., & Midgard, R. (2009) · Multiple Sclerosis Journal · doi:10.1177/1352458509351542 · Cited by 123
Bojar, M. (2009) · Cited by 120
Longitudinal course of depression symptoms in multiple sclerosis
Arnett, P. A. (2006) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2004.047712 · Cited by 107
Janssens, A. C., Buljevac, D., van Doorn, P. A., van der Meché, F. G., Polman, C. H., Passchier, J., & Hintzen, R. Q. (2006) · Multiple Sclerosis Journal · doi:10.1177/1352458506070935 · Cited by 107
Unrecognised symptoms of depression in a community–based population with multiple sclerosis
McGuigan, C., & Hutchinson, M. (2006) · Journal of Neurology · doi:10.1007/s00415-005-0963-0 · Cited by 102
Correlates of quality of life among persons with multiple sclerosis.
Gulick, E. (1997) · Nursing Research · doi:10.1097/00006199-199711000-00002 · Cited by 94
Depression during exacerbations in multiple sclerosis: the importance of uncertainty
Kroencke, D. C., Denney, D. R., & Lynch, S. G. (2001) · Multiple Sclerosis Journal · doi:10.1177/135245850100700405 · Cited by 92
Communicating the diagnosis of multiple sclerosis - a qualitative study
Solari, A., Acquarone, N., Pucci, E., Martinelli, V., Marrosu, M. G., Trojano, M., Borreani, C., & Uccelli, M. M. (2007) · Multiple Sclerosis Journal · doi:10.1177/1352458506074689 · Cited by 90
Self-citationThe Value of Diagnostic Information to Patients With Suspected Multiple Sclerosis
Mushlin, A. I., Mooney, C., Grow, V., Phelps, C. E., & Affiliated With the Rochester-Toronto MRI Study Group (1994) · Archives of Neurology · doi:10.1001/archneur.1994.00540130093017 · Cited by 88
The role of affect on the perception of disability in multiple sclerosis
Smith, S. J., & Young, C. A. (2000) · Clinical Rehabilitation · doi:10.1191/026921500676724210 · Cited by 72
Physical activity, disability, and mood in the early stage of multiple sclerosis.
Suh, Y., Motl, R., & Mohr, D. (2010) · Disability and Health Journal · doi:10.1016/j.dhjo.2009.09.002 · Cited by 69
Solari, A., Martinelli, V, Trojano, M., Lugaresi, A., Granella, F., Giordano, A., Messmer Uccelli, M., D'Alessandro, R., Pucci, E., Confalonieri, P., et al. (2010) · Multiple Sclerosis Journal · doi:10.1177/1352458510380417 · Cited by 68
Self-citationKern, S., Schrempf, W., Schneider, H., Schultheiß, T., Reichmann, H., & Ziemssen, T. (2009) · Multiple Sclerosis Journal · doi:10.1177/1352458509103300 · Cited by 65
Legge, S. D., Piattella, M. C., Pozzilli, C., Pantano, P., Caramia, F., Pestalozza, I. F., Paolillo, A., & Lenzi, G. L. (2003) · Multiple Sclerosis Journal · doi:10.1191/1352458503ms921oa · Cited by 61
Aridon, P., Solari, A., Motta, A., Mendozzi, L., Bergamaschi, R., Ghezzi, A., Mancardi, G., Milanese, C., Montanari, E., & Pucci, E. (2004) · Neurological Sciences · doi:10.1007/s10072-003-0192-1 · Cited by 55
Self-citationSolari, A., Ferrari, G., & Radice, D. (2005) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2005.11.005 · Cited by 54
Self-citationForman, A., & Lincoln, N. (2010) · Clinical Rehabilitation · doi:10.1177/0269215509343492 · Cited by 54
Effect of Diagnostic Testing for Multiple Sclerosis on Patient Health Perceptions
O'Connor, P. W., Detsky, A. S., Tansey, C. M., Kucharczyk, W., & Rochester-Toronto MRI Study Group (1994) · Archives of Neurology · doi:10.1001/archneur.1994.00540130072013 · Cited by 30
Cited by
Sorted by citations
The link between multiple sclerosis and depression
Feinstein, A., Magalhaes, S., Richard, J., Audet, B., & Moore, C. S. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.139 · Cited by 550
Prevalence and concurrence of anxiety, depression and fatigue over time in multiple sclerosis
Wood, B., van der Mei, I., Ponsonby, A.-L., Pittas, F., Quinn, S., Dwyer, T., Lucas, R., & Taylor, B. (2013) · Multiple Sclerosis Journal · doi:10.1177/1352458512450351 · Cited by 294
Jones, K. H., Ford, D. V., Jones, P. A., John, A., Middleton, R. M., Lockhart-Jones, H., Osborne, L. A., & Noble, J. G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041910 · Cited by 190
A systematic review of anxiety amongst people with Multiple Sclerosis
Butler, E., Matcham, F., & Chalder, T. (2016) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2016.10.003 · Cited by 111
Psychological consequences of COVID-19 pandemic in Italian MS patients: Signs of resilience?
Capuano, R., Altieri, M., Bisecco, A., d’Ambrosio, A., Docimo, R., Buonanno, D., Matrone, F., Giuliano, F., Tedeschi, G., Santangelo, G., et al. (2021) · Journal of Neurology · doi:10.1007/s00415-020-10099-9 · Cited by 88
Metadata
- Authors
- Giordano, A., Granella, F., Lugaresi, A., Martinelli, V., Trojano, M., Confalonieri, P., Radice, D., & Solari, A.
- Affiliations
- Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
- University of Parma (IT)
- University of Chieti-Pescara (IT)
- IRCCS Ospedale San Raffaele (IT)
- European Institute of Oncology (IT)
- Corresponding author
- Solari, Alessandra
- Venue
- Journal of the Neurological Sciences
- Publisher
- Elsevier BV
- Published
- 2011-08
- Volume
- 307
- Issue
- 1-2
- Pages
- 86-91
- ISSN
- 0022-510X (ISSN-L)
- OpenAlex
- W1998970209
- Cited by
- 123
- References
- 41
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 7 · 2023: 8 · 2022: 11 · 2021: 15 · 2020: 12 · 2019: 13 · 2018: 6 · 2017: 4 · 2016: 8 · 2015: 12 · 2014: 8 · 2013: 10 · 2012: 3
- FWCI
- 4.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the Neurological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
- CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
- Funders
- Fondazione Italiana Sclerosi Multipla (2007/R/19)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Keywords
- multiple sclerosis, anxiety, depressive symptoms, diagnosis disclosure, sex differences, predictors of anxiety, Hospital Anxiety and Depression Scale
- MeSH terms
- Adult, Anxiety, Anxiety Disorders, Depression, Depressive Disorder, Diagnostic Techniques, Neurological, Female, Humans, Male, Middle Aged, Multiple Sclerosis, Prospective Studies, Comorbidity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
