Neural Circuitry in the Regulation of Adrenal Corticosterone Rhythmicity

Engeland, William C.; Arnhold, Michelle M.

doi:10.1385/endo:28:3:325

Cited by 178Stress Responses and CortisolAdrenal Hormones and DisordersCircadian rhythm and melatonin

Neural Circuitry in the Regulation of Adrenal Corticosterone Rhythmicity

Engeland, William C., Arnhold, Michelle M.·2005·Endocrine

DOI 10.1385/endo:28:3:325

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Abstract

Adrenal cortical secretion of glucocorticoids is an essential adaptive response of an organism to stress. Although the hypothalamic-pituitary-adrenal axis regulates the adrenal cortex via release of ACTH, there is strong evidence supporting a role for sympathetic innervation in modulating adrenal glucocorticoid secretion. The dissociation between changes in ACTH and glucocorticoids under non-stress and stress conditions has reinforced the concept that neural control of the adrenal cortex acts to modulate steroidogenic responses to circulating ACTH. A dual control of the adrenal cortex has been implicated in the prominent circadian rhythm in glucocorticoids. However, the central neural substrate for circadian changes in glucocorticoids that are mediated by peripheral neural innervation of the adrenal cortex has not been conclusively delineated. The hypothesis to be addressed is that neurons in the paraventricular nucleus of the hypothalamus receive input from the suprachiasmatic nucleus and project to sympathetic preganglionic neurons in the spinal cord to provide inhibitory and excitatory input to the adrenal cortex that drives the circadian rhythm. This review examines anatomical and physiological evidence that forms the basis for this putative neural circuit.

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From Impact of Sleep and Its Disturbances on Hypothalamo-Pituitary-Adrenal Axis Activity (2010) · cites this paper as [18]

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Effects of Adrenal Sensitivity, Stress- and Cue-Induced Craving, and Anxiety on Subsequent Alcohol Relapse and Treatment Outcomes
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Authors: Engeland, W. C., & Arnhold, M. M.
Affiliations: University of Minnesota (US)
Corresponding author: Engeland, William C.
ORCID: Engeland, William C.
Venue: Endocrine
Publisher: Springer Science and Business Media LLC
Published: 2005
Volume: 28
Issue: 3
Pages: 325-332
ISSN: 0969-711X (ISSN-L)
DOI: 10.1385/endo:28:3:325
OpenAlex: W1991558113
Cited by: 178
References: 103
Citations by year: 2026: 5 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 11 · 2020: 6 · 2019: 8 · 2018: 10 · 2017: 6 · 2016: 6 · 2015: 7 · 2014: 18 · 2013: 14 · 2012: 17
FWCI: 3.78
Type: journal article
Language: en
Open access: closed
Locations: Endocrine (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation
National Institute on Drug Abuse (T32-DA-07097, T32DA007097)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords: circadian rhythm, glucocorticoid secretion, hypothalamic-pituitary-adrenal axis, ACTH, paraventricular nucleus, suprachiasmatic nucleus, neural circuits, stress response, steroidogenesis
MeSH terms: Adrenal Cortex, Animals, Autonomic Fibers, Preganglionic, Circadian Rhythm, Corticosterone, Humans, Paraventricular Hypothalamic Nucleus, Periodicity, Suprachiasmatic Nucleus, Sympathetic Nervous System

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Neural Circuitry in the Regulation of Adrenal Corticosterone Rhythmicity

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