Disentangling the effect of dietary restriction on mitochondrial function using recombinant inbred mice
Abstract
Dietary restriction (DR) extends lifespan and healthspan in many species, but precisely how it elicits its beneficial effects is unclear. We investigated the impact of DR on mitochondrial function within liver and skeletal muscle of female ILSXISS mice that exhibit strain-specific variation in lifespan under 40% DR. Strains TejJ89 (lifespan increased under DR), TejJ48 (lifespan unaffected by DR) and TejJ114 (lifespan decreased under DR) were studied following 10 months of 40% DR (13 months of age). Oxygen consumption rates (OCR) within isolated liver mitochondria were unaffected by DR in TejJ89 and TejJ48, but decreased by DR in TejJ114. DR had no effect on hepatic protein levels of PGC-1a, TFAM, and OXPHOS complexes IV. Mitonuclear protein imbalance (nDNA:mtDNA ratio) was unaffected by DR, but HSP90 protein levels were reduced in TejJ114 under DR. Surprisingly hepatic mitochondrial hydrogen peroxide (H 2 O 2) production was elevated by DR in TejJ89, with total superoxide dismutase activity and protein carbonyls increased by DR in both TejJ89 and TejJ114. In skeletal muscle, DR had no effect on mitochondrial OCR, OXPHOS complexes or mitonuclear protein imbalance, but H 2 O 2 production was decreased in TejJ114 and nuclear PGC-1a increased in TejJ89 under DR. Our findings indicate that hepatic mitochondrial dysfunction associated with reduced lifespan of TejJ114 mice under 40% DR, but similar dysfunction was not apparent in skeletal muscle mitochondria. We highlight tissue-specific differences in the mitochondrial response in ILSXISS mice to DR, and underline the importance and challenges of exploiting genetic heterogeneity to help understand mechanisms of ageing.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In female mouse strains with increased, no change, or reduced lifespan in response to 40% CR, 10 months of CR did not alter the nDNA:MtDNA ratio or protein levels of markers of mitochondrial biogenesis in liver or skeletal muscle.
“CR for 10 months did not alter the nDNA:MtDNA ratio, protein levels of markers of mitochondrial biogenesis in liver or skeletal muscle, in any of the mouse strains that were investigated.”
From Mitochondrial (Dys)function and Insulin Resistance: From Pathophysiological Molecular Mechanisms to the Impact of Diet (2019) · cites this paper as Mulvey et al. (2017)
The Mulvey et al. (2017) study could not demonstrate a beneficial effect of CR on mitochondrial dysfunction in the long-lived strain.
“This study could not demonstrate a beneficial effect of CR on mitochondrial dysfunction in the long-lived strain.”
From Mitochondrial (Dys)function and Insulin Resistance: From Pathophysiological Molecular Mechanisms to the Impact of Diet (2019) · cites this paper as Mulvey et al. (2017)
In animals whose lifespans are shortened by CR, reduced oxygen consumption rates were observed in isolated mitochondria from hepatocytes.
“Reduced oxygen consumption rates in isolated mitochondria from hepatocytes were observed in animals whose lifespans are shortened by CR.”
From Mitochondrial (Dys)function and Insulin Resistance: From Pathophysiological Molecular Mechanisms to the Impact of Diet (2019) · cites this paper as Mulvey et al. (2017)
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Part of this paper’s reference list could not be split into single entries.
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works
A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis
Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., & Spiegelman, B. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81410-5 · Cited by 3,864 · see citing works
Assessing mitochondrial dysfunction in cells
Brand, M. D., & Nicholls, D. G. (2011) · Biochemical Journal · doi:10.1042/bj20110162 · Cited by 2,436 · see citing works
Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
Colman, R. J., Anderson, R. M., Johnson, S. C., Kastman, E. K., Kosmatka, K. J., Beasley, T. M., Allison, D. B., Cruzen, C., Simmons, H. A., Kemnitz, J. W., et al. (2009) · Science · doi:10.1126/science.1173635 · Cited by 2,277 · see citing works
The retardation of aging and disease by dietary restriction
(1989) · Choice Reviews Online · doi:10.5860/choice.26-5101 · Cited by 1,477 · see citing works
Zhou, M., Diwu, Z. J., Panchuk-Voloshina, N., & Haugland, R. P. (1997) · Analytical Biochemistry · doi:10.1006/abio.1997.2391 · Cited by 1,400 · see citing works
Promoting Health and Longevity through Diet: From Model Organisms to Humans
Fontana, L., & Partridge, L. (2015) · Cell · doi:10.1016/j.cell.2015.02.020 · Cited by 1,245 · see citing works
Mouchiroud, L., Houtkooper, R. H., Moullan, N., Katsyuba, E., Ryu, D., Cantó, C., Mottis, A., Jo, Y.-S., Viswanathan, M., Schoonjans, K., et al. (2013) · Cell · doi:10.1016/j.cell.2013.06.016 · Cited by 1,210 · see citing works
Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study
Mattison, J. A., Roth, G. S., Beasley, T. M., Tilmont, E. M., Handy, A. M., Herbert, R. L., Longo, D. L., Allison, D. B., Young, J. E., Bryant, M., et al. (2012) · Nature · doi:10.1038/nature11432 · Cited by 1,145 · see citing works
Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS
Nisoli, E., Tonello, C., Cardile, A., Cozzi, V., Bracale, R., Tedesco, L., Falcone, S., Valerio, A., Cantoni, O., Clementi, E., et al. (2005) · Science · doi:10.1126/science.1117728 · Cited by 1,107 · see citing works
The Cell Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity
Durieux, J., Wolff, S., & Dillin, A. (2011) · Cell · doi:10.1016/j.cell.2010.12.016 · Cited by 1,059 · see citing works
Overview of caloric restriction and ageing
Masoro, E. J. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.03.012 · Cited by 1,054 · see citing works
Mitonuclear protein imbalance as a conserved longevity mechanism
Houtkooper, R. H., Mouchiroud, L., Ryu, D., Moullan, N., Katsyuba, E., Knott, G., Williams, R. W., & Auwerx, J. (2013) · Nature · doi:10.1038/nature12188 · Cited by 1,035 · see citing works
Calorie Restriction Increases Muscle Mitochondrial Biogenesis in Healthy Humans
Civitarese, A. E., Carling, S., Heilbronn, L. K., Hulver, M. H., Ukropcova, B., Deutsch, W. A., Smith, S. R., & Ravussin, E. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040076 · Cited by 790 · see citing works
Sohal, R. S., Ku, H.-H., Agarwal, S., Forster, M. J., & Lal, H. (1994) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(94)90104-x · Cited by 788 · see citing works
Extending life span by increasing oxidative stress
Ristow, M., & Schmeisser, S. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.010 · Cited by 718 · see citing works
Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys
Colman, R. J., Beasley, T. M., Kemnitz, J. W., Johnson, S. C., Weindruch, R., & Anderson, R. M. (2014) · Nature Communications · doi:10.1038/ncomms4557 · Cited by 711 · see citing works
Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency
López-Lluch, G., Hunt, N., Jones, B., Zhu, M., Jamieson, H., Hilmer, S., Cascajo, M. V., Allard, J., Ingram, D. K., Navas, P., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510452103 · Cited by 699 · see citing works
Growth Curves and Survival Characteristics of the Animals Used in the Biomarkers of Aging Program
Turturro, A., Witt, W. W., Lewis, S. M., Hass, B. S., Lipman, R. D., & Hart, R. W. (1999) · The Journals of Gerontology Series A · doi:10.1093/gerona/54.11.b492 · Cited by 668 · see citing works
Is the oxidative stress theory of aging dead?
Pérez, V. I., Bokov, A., Remmen, H. V., Mele, J., Ran, Q., Ikeno, Y., & Richardson, A. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.06.003 · Cited by 604 · see citing works
Aging and Survival: The Genetics of Life Span Extension by Dietary Restriction
Mair, W. B., & Dillin, A. G. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.061206.171059 · Cited by 600 · see citing works
Endogenous hydrogen sulfide production is essential for dietary restriction benefits
Hine, C., Harputlugil, E., Zhang, Y., Ruckenstuhl, C., Lee, B. C., Brace, L., Longchamp, A., Treviño-Villarreal, J. H., Mejia, P., Ozaki, C. K., et al. (2015) · Cell · doi:10.1016/j.cell.2014.11.048 · Cited by 558 · see citing works
Liao, C., Rikke, B. A., Johnson, T. E., Diaz, V., & Nelson, J. F. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2009.00533.x · Cited by 501 · see citing works
Rogers, G. W., Brand, M. D., Petrosyan, S., Ashok, D., Elorza, Á. A., Ferrick, D. A., & Murphy, A. N. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021746 · Cited by 474 · see citing works
Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice
Mitchell, S. J., Madrigal-Matute, J., Scheibye-Knudsen, M., Fang, E., Aon, M., González-Reyes, J. A., Cortassa, S., Kaushik, S., Gonzalez-Freire, M., Patel, B., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.027 · Cited by 451 · see citing works
The efficiency and plasticity of mitochondrial energy transduction.
Brand, M. D. (2005) · Biochemical Society Transactions · doi:10.1042/bst0330897 · Cited by 406 · see citing works
Gredilla, R., Sanz, A., Lopez-Torres, M., & Barja, G. (2001) · The FASEB Journal · doi:10.1096/fj.00-0764fje · Cited by 372 · see citing works
Lee, H.-Y., Choi, C. S., Birkenfeld, A. L., Alves, T. C., Jornayvaz, F. R., Jurczak, M. J., Zhang, D., Woo, D. K., Shadel, G. S., Ladiges, W., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.11.004 · Cited by 319 · see citing works
Metabolic reprogramming, caloric restriction and aging
Anderson, R. M., & Weindruch, R. H. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.11.005 · Cited by 300 · see citing works
Anderson, R. M., Barger, J. L., Edwards, M. G., Braun, K. H., O’Connor, C. E., Prolla, T. A., & Weindruch, R. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2007.00357.x · Cited by 283 · see citing works
Influence of diet on survival of mice.
Fernandes, G., Yunis, E. J., & Good, R. A. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.4.1279 · Cited by 264 · see citing works
Speakman, J. R., & Selman, C. (2011) · BioEssays · doi:10.1002/bies.201000132 · Cited by 259 · see citing works
Self-citationMitochondrial dysfunction and longevity in animals: Untangling the knot
Wang, Y., & Hekimi, S. (2015) · Science · doi:10.1126/science.aac4357 · Cited by 248 · see citing works
Genotype and age influence the effect of caloric intake on mortality in mice
Forster, M. J., Morris, P., & Sohal, R. S. (2003) · The FASEB Journal · doi:10.1096/fj.02-0533fje · Cited by 236 · see citing works
Swindell, W. R. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2011.12.006 · Cited by 230 · see citing works
Lanza, I. R., Zabielski, P., Klaus, K. A., Morse, D. M., Heppelmann, C. J., Bergen, H. R., Dasari, S., Walrand, S., Short, K. R., Johnson, M. L., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.11.003 · Cited by 227 · see citing works
The coordination of nuclear and mitochondrial communication during aging and calorie restriction
Finley, L. W. S., & Haigis, M. C. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.03.003 · Cited by 207 · see citing works
The Effect of Retardation of Growth Upon the Breeding Period and Duration of Life of Rats
Osborne, T. B., Mendel, L. B., & Ferry, E. L. (1917) · Science · doi:10.1126/science.45.1160.294 · Cited by 206 · see citing works
The effects of dietary restriction on oxidative stress in rodents
Walsh, M. E., Shi, Y., & Van Remmen, H. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.05.037 · Cited by 181 · see citing works
Fontana, L., Klein, S., & Holloszy, J. O. (2009) · AGE · doi:10.1007/s11357-009-9118-z · Cited by 178 · see citing works
Review: The HSP90 molecular chaperone—an enigmatic ATPase
Pearl, L. H. (2016) · Biopolymers · doi:10.1002/bip.22835 · Cited by 172 · see citing works
Bevilacqua, L., Ramsey, J. J., Hagopian, K., Weindruch, R. H., & Harper, M. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00367.2003 · Cited by 168 · see citing works
Molecular mechanisms underlying genotype‐dependent responses to dietary restriction
Schleit, J., Johnson, S. C., Bennett, C. F., Simko, M., Trongtham, N., Castanza, A., Hsieh, E. J., Moller, R. M., Wasko, B. M., Delaney, J. R., et al. (2013) · Aging Cell · doi:10.1111/acel.12130 · Cited by 159 · see citing works
Dietary restriction.; mitochondrial function and aging: From yeast to humans
Ruetenik, A., & Barrientos, A. (2015) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2015.05.005 · Cited by 139 · see citing works
Miller, B. F., Robinson, M. M., Bruss, M. D., Hellerstein, M. K., & Hamilton, K. L. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00769.x · Cited by 137 · see citing works
Mitochondrial respiratory capacity and coupling control decline with age in human skeletal muscle
Porter, C., Hurren, N. M., Cotter, M. V., Bhattarai, N., Reidy, P. T., Dillon, E. L., Durham, W. J., Tuvdendorj, D., Sheffield-Moore, M., Volpi, E., et al. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00125.2015 · Cited by 134 · see citing works
Genetic differences in effects of food restriction on aging in mice
Harrison, D. E., & Archer, J. R. (1987) · The Journal of Nutrition · doi:10.1093/jn/117.2.376 · Cited by 133 · see citing works
Does calorie restriction induce mitochondrial biogenesis? A reevaluation
Hancock, C. R., Han, D., Higashida, K., Kim, S. H., & Holloszy, J. O. (2011) · The FASEB Journal · doi:10.1096/fj.10-170415 · Cited by 131 · see citing works
Mitochondrial stress signaling in longevity: A new role for mitochondrial function in aging
Hill, S., & Remmen, H. V. (2014) · Redox Biology · doi:10.1016/j.redox.2014.07.005 · Cited by 129 · see citing works
Individuals with higher metabolic rates have lower levels of reactive oxygen species in vivo
Salin, K., Auer, S. K., Rudolf, A. M., Anderson, G. J., Cairns, A. G., Mullen, W., Hartley, R. C., Selman, C., & Metcalfe, N. B. (2015) · Biology Letters · doi:10.1098/rsbl.2015.0538 · Cited by 114 · see citing works
Self-citationLife history response of Mediterranean fruit flies to dietary restriction
Carey, J. R., Liedo, P., Harshman, L. G., Zhang, Y., Müller, H., Partridge, L., & Wang, J. (2002) · Aging Cell · doi:10.1046/j.1474-9728.2002.00019.x · Cited by 113 · see citing works
UPRmt-mediated cytoprotection and organismal aging
Schulz, A. M., & Haynes, C. M. (2015) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2015.03.008 · Cited by 110 · see citing works
Modification of mitochondrial respiration by aging and dietary restriction
Weindruch, R. H., Cheung, M. K., Verity, M. A., & Walford, R. L. (1980) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(80)90070-6 · Cited by 108 · see citing works
Complex IV-deficient Surf1−/− mice initiate mitochondrial stress responses
Pulliam, D. A., Deepa, S. S., Liu, Y., Hill, S., Lin, A., Bhattacharya, A., Shi, Y., Sloane, L. B., Viscomi, C. F., Zeviani, M., et al. (2014) · Biochemical Journal · doi:10.1042/bj20140291 · Cited by 108 · see citing works
Corton, J. C., & Brown-Borg, H. M. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.12.1494 · Cited by 106 · see citing works
Finley, L. W. S., Lee, J., Souza, A., Desquiret-Dumas, V., Bullock, K., Rowe, G. C., Procaccio, V., Clish, C. B., Arany, Z., & Haigis, M. C. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1115813109 · Cited by 102 · see citing works
Williams, R. W., Bennett, B., Lu, L., Gu, J., DeFries, J. C., Carosone‐Link, P., Rikke, B. A., Belknap, J. K., & Johnson, T. E. (2004) · Mammalian Genome · doi:10.1007/s00335-004-2380-6 · Cited by 100 · see citing works
Murphy, J. C., McDaniel, J. L., Mora, K., Villareal, D. T., Fontana, L., & Weiss, E. P. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00355.2011 · Cited by 91 · see citing works
The effect of aging and caloric restriction on mitochondrial protein density and oxygen consumption
Lambert, A. J., Wang, B., Yardley, J., Edwards, J., & Merry, B. J. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2003.12.009 · Cited by 91 · see citing works
Rikke, B. A., Liao, C.-Y., McQueen, M. B., Nelson, J. F., & Johnson, T. E. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.04.008 · Cited by 84 · see citing works
Price, J. C., Khambatta, C. F., Li, K. W., Bruss, M. D., Shankaran, M., Dalidd, M., Floreani, N. A., Roberts, L. S., Turner, S., Holmes, W. E., et al. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m112.021204 · Cited by 84 · see citing works
Lambert, A. J., Portero‐Otín, M., Pamplona, R., & Merry, B. J. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.06.002 · Cited by 69 · see citing works
The impact of acute caloric restriction on the metabolic phenotype in male C57BL/6 and DBA/2 mice.
Hempenstall, S., Picchio, L., Mitchell, S., Speakman, J., & Selman, C. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.12.008 · Cited by 68 · see citing works
Self-citationLife Span Extension in Mice by Food Restriction Depends on an Energy Imbalance
Sohal, R. S., Ferguson, M., Sohal, B. H., & Forster, M. J. (2009) · Journal of Nutrition · doi:10.3945/jn.108.100313 · Cited by 62 · see citing works
Ferguson, M., Sohal, B. H., Forster, M. J., & Sohal, R. S. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.07.005 · Cited by 60 · see citing works
Bioenergetics of aging and calorie restriction
Hunt, N. D., Hyun, D., Allard, J. S., Minor, R. K., Mattson, M. P., Ingram, D. K., & de Cabo, R. (2006) · Ageing Research Reviews · doi:10.1016/j.arr.2006.03.006 · Cited by 55 · see citing works
Nitration of Hsp90 on Tyrosine 33 Regulates Mitochondrial Metabolism
Franco, M. C., Ricart, K. C., González, A. S., Dennys, C. N., Nelson, P. A., Janes, M. S., Mehl, R. A., Landar, A. L., & Estévez, Á. G. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.663278 · Cited by 49 · see citing works
Maynard, S., Hejl, A., Dinh, T.-S. T., Keijzers, G., Hansen, Å. M., Desler, C., Moreno‐Villanueva, M., Bürkle, A., Rasmussen, L. J., Waldemar, G., et al. (2015) · Aging · doi:10.18632/aging.100810 · Cited by 49 · see citing works
Mitochondrial Isolation from Skeletal Muscle
Garcı́a-Cazarı́n, M. L., Snider, N. N., & Andrade, F. H. (2011) · Journal of Visualized Experiments · doi:10.3791/2452 · Cited by 47 · see citing works
Hempenstall, S., Page, M. M., Wallen, K. R., & Selman, C. (2012) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2011.12.002 · Cited by 47 · see citing works
Self-citationImpaired dynamics and function of mitochondria caused by mtDNA toxicity leads to heart failure
Lauritzen, K. H., Kleppa, L., Aronsen, J. M., Eide, L., Carlsen, H., Haugen, Ø. P., Sjaastad, I., Klungland, A., Rasmussen, L. J., Attramadal, H., et al. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00253.2014 · Cited by 47 · see citing works
Dietary restriction and the pursuit of effective mimetics
Selman, C. (2014) · Proceedings of The Nutrition Society · doi:10.1017/s0029665113003832 · Cited by 43 · see citing works
Self-citationFacts and controversies in our understanding of how caloric restriction impacts the mitochondrion
Gouspillou, G., & Hepple, R. T. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.03.004 · Cited by 42 · see citing works
Lifespan Modulation in Mice and the Confounding Effects of Genetic Background
Mulvey, L., Sinclair, A., & Selman, C. (2014) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2014.06.002 · Cited by 40 · see citing works
Self-citationMitochondrial chaperone TRAP1 activates the mitochondrial UPR and extends healthspan in Drosophila
Baqri, R. M., Pietron, A. V., Gokhale, R. H., Turner, B. A., Kaguni, L. S., Shingleton, A. W., Kunes, S. M., & Miller, K. E. (2014) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2014.09.002 · Cited by 39 · see citing works
Rebrin, I., Forster, M. J., & Sohal, R. S. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.006 · Cited by 30 · see citing works
Dietary restriction and aging in rodents: a current view on its molecular mechanisms.
Shimokawa, I., & Trindade, L. S. (2010) · Europe PMC (PubMed Central) · Cited by 26 · see citing works
Fragile lifespan expansion by dietary mitohormesis in C. elegans
Tauffenberger, A., Vaccaro, A., & Parker, J. A. (2016) · Aging · doi:10.18632/aging.100863 · Cited by 22 · see citing works
Lipman, R. D. (2002) · The Journals of Gerontology Series A · doi:10.1093/gerona/57.4.b153 · Cited by 18 · see citing works
Partridge, L. (2012) · New England Journal of Medicine · doi:10.1056/nejmcibr1210447 · Cited by 16 · see citing works
HSP90 cleavage associates with oxidized proteins accumulation after oxidative stress
Castro, J. P., Reeg, S., Botelho, V., et al. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.10.743 · Cited by 7 · see citing works
Flagged first, then by citations
Research works printed but not linked: 10
- [7]7. 666 [28] C. Lopez-Otin, M. A. Blasco, L. Partridge, M. Serrano, and G. Kroemer, 'XThe 667 hallmarks of aging,' Cell , vol. 153, no. 6, 2013.
- [16]16. 708 stress response,' Aging Cell , vol. 7, no. 1, pp. 101-111, 2008.
- [19]19. 711 induces mitochondrial biogenesis and bioenergetic efficiency.,' Proc. Natl.
- [20]20. 712 Acad. Sci. U. S. A. , vol. 103, no. 6, pp. 1768-73, 2006.
- [24]24. 716 changes during calorie restriction.,' Proc. Natl. Acad. Sci. U. S. A. , vol. 109,
- [25]25. 717 no. 8, pp. 2931-6, 2012.
- [28]28. 720 J. , vol. 25, pp. 785-791, 2011.
- [31]31. 723 proliferation with age and caloric restriction,' Aging Cell , vol. 11, no. 1, pp.
- [8]8. 774 measurements using minimal quantities of isolated mitochondria,' PLoS One , 775 vol. 6, no. 7, 2011.
- [9]9. 776 [58] M. L. Garcia-Cazarin, N. N. Snider, and F. H. Andrade, 'Mitochondrial Isolation from Skeletal Muscle,' J. Vis. Exp. JoVE. , vol. 49, no. 2452, p.
Cited by
Sorted by citations
Sergi, D., Naumovski, N., Heilbronn, L. K., Abeywardena, M., O’Callaghan, N., Lionetti, L., & Luscombe-Marsh, N. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00532 · Cited by 347 · see citing works
“…for the phosphorylation of insulin receptor substrate (IRS) at tyrosine residues (Sun and Rothenberg, 1991), which in turn promote the interaction between IRS and proteins containing SRC homology 2 (SH2) domains (Koch et al., 1991) including phosphoinositide 3-kinase (PI3K; Myers et al., 1992).”
Background
- Authors
- Mulvey, L., Sands, W. A., Salin, K., Carr, A. E., & Selman, C.
- Affiliations
- University of Glasgow (GB)
- Corresponding author
- Selman, Colin
- Venue
- Molecular and Cellular Endocrinology
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 455
- Pages
- 41-53
- ISSN
- 0303-7207 (ISSN-L)
- OpenAlex
- W2511506932
- Cited by
- 16
- References
- 81
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 1 · 2017: 2
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular and Cellular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion)
- Funders
- University of Glasgow
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- dietary restriction, mitochondrial function, lifespan extension, recombinant inbred mouse strains, liver mitochondria, skeletal muscle mitochondria, oxygen consumption rate, PGC-1α, OXPHOS complexes, HSP90, hydrogen peroxide production, superoxide dismutase, protein carbonylation, aging, genetic heterogeneity
- MeSH terms
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Animals, DNA-Binding Proteins, DNA, Mitochondrial, Female, Gene Expression Regulation, High Mobility Group Proteins, Hydrogen Peroxide, Liver, Longevity, Mice, Transgenic, Mitochondria, Liver, Mitochondria, Muscle, Organ Specificity, Oxidation-Reduction, Oxygen Consumption, Species Specificity, Superoxide Dismutase, Muscle, Skeletal, Genetic Heterogeneity, HSP90 Heat-Shock Proteins, Caloric Restriction, Electron Transport Chain Complex Proteins, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
