Cited by 709Immune Response and InflammationInflammasome and immune disordersNF-κB Signaling Pathways

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Stress, Inflammation, and Defense of Homeostasis

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Chovatiya, Raj, Medzhitov, Ruslan·2014·Molecular Cell

DOI 10.1016/j.molcel.2014.03.030PMC PMC4048989

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Abstract

Inflammation is traditionally considered a defense response induced by infection or injury. However, inflammation can also be induced by tissue stress and malfunction in the absence of infection or overt tissue damage. Here we discuss the relationship between homeostasis, stress responses, and inflammation. Stress responses have cell-autonomous and cell-extrinsic components, the latter contributing to tissue level adaptation to stress conditions. Inflammation can be thought of as the extreme end of a spectrum that ranges from homeostasis to stress response to bona fide inflammatory response. Inflammation can be triggered by two types of stimuli: extreme deviations of homeostasis or challenges that cause a disruption of homeostasis. This perspective may help to explain qualitative differences and functional outcomes of diverse inflammatory responses.

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Authors: Chovatiya, R., & Medzhitov, R.
Affiliations: Howard Hughes Medical Institute (US)
Corresponding author: Medzhitov, Ruslan
ORCID: Chovatiya, Raj
Medzhitov, Ruslan
Venue: Molecular Cell
Publisher: Elsevier BV
Published: 2014-04
Volume: 54
Issue: 2
Pages: 281-288
ISSN: 1097-2765 (ISSN-L)
DOI: 10.1016/j.molcel.2014.03.030
PMC: PMC4048989
OpenAlex: W1975024842
Cited by: 704
References: 54
Citations by year: 2026: 42 · 2025: 66 · 2024: 60 · 2023: 57 · 2022: 80 · 2021: 72 · 2020: 63 · 2019: 64 · 2018: 54 · 2017: 54 · 2016: 51 · 2015: 31 · 2014: 8
FWCI: 4.69
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 388 d)
Locations: Molecular Cell (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Howard Hughes Medical Institute
Blavatnik Family Foundation
National Institutes of Health (AI046688)
National Institute of General Medical Sciences (T32GM007205)
National Institute of Allergy and Infectious Diseases (R37AI046688, AI046688)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords: inflammation, homeostasis, tissue stress, stress response, tissue adaptation
MeSH terms: Gene Expression Regulation, HeLa Cells, Homeostasis, Humans, Inflammation, Models, Biological, Stress, Physiological

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Stress, Inflammation, and Defense of Homeostasis

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