Electrical stimulation of the medial forebrain bundle in pre-clinical studies of psychiatric disorders
Abstract
Modulating neuronal activity by electrical stimulation has expanded from the realm of motor indications into the field of psychiatric disorders in the past 10 years. The medial forebrain bundle (MFB), with a seminal role in motor, reward orientated and affect regulation behaviors, and its afferent and efferent loci, have been targeted in several DBS trials in patients with psychiatric disorders. However, little is known about the consequences of modulating the MFB in affective disorders. The paper reviews the relevant pre-clinical literature investigating electrical stimulation of regions associated with the MFB in the context of several models of psychiatric disorders, in particular depression. The clinical data is promising but limited, and pre-clinical studies are essential for improved understanding of the anatomy, the connectivity, and the consequences of stimulation of the MFB and regions associated with the neurocircuitry of psychiatric disorders. Current data suggests that the MFB is at a "privileged" position on this circuitry and its stimulation can simultaneously modulate activity at other key sites, such as the nucleus accumbens, the ventromedial prefrontal cortex or the ventral tegmental area. Future experimental work will need to shed light on the anti-depressive mechanisms of MFB stimulation in order to optimize clinical interventions.
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MFB connects VTA with NAc via mesolimbic dopaminergic connection and VTA with PFC via mesocortical dopaminergic connection.
“This structure connects the VTA with the NAc via the mesolimbic dopaminergic connection and the VTA with the PFC via the mesocortical dopaminergic connection (Döbrössy et al., 2015).”
From Circuit Mechanisms of Reward, Anhedonia, and Depression (2019) · cites this paper as Döbrössy et al., 2015
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Circuit Mechanisms of Reward, Anhedonia, and Depression
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- Authors
- Döbrössy, M. D., Furlanetti, L. L., & Coenen, V. A.
- Affiliations
- University of Freiburg (DE)
- Corresponding author
- Döbrössy, Máté D.
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 49
- Pages
- 32-42
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2033835343
- Cited by
- 47
- References
- 137
- Citations by year
- 2025: 5 · 2024: 4 · 2023: 1 · 2022: 4 · 2021: 5 · 2020: 5 · 2019: 1 · 2018: 6 · 2017: 5 · 2016: 1 · 2015: 10
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Funders
- German Research Foundation (DFG)
- Stereotactic and Functional Neurosurgery Department, University Hospital, Freiburg, Germany
- Deutscher Akademischer Austauschdienst
- CNPq
- Topics
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- medial forebrain bundle, deep brain stimulation, depression, mental illness, preclinical models, nucleus accumbens, ventromedial prefrontal cortex, ventral tegmental area, neurocircuitry
- MeSH terms
- Animals, Mental Disorders, Disease Models, Animal, Electric Stimulation, Medial Forebrain Bundle, Deep Brain Stimulation
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