Conceptualizing the neurobiology of non-suicidal self-injury from the perspective of the Research Domain Criteria Project
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Non-suicidal self-injury (NSSI) commonly starts in adolescence and is associated with an array of negative outcomes. Neurobiological research investigating NSSI is in its early stages and most studies have examined this behavior within the context of specific diagnoses. However, the Research Domain Criteria (RDoC) initiative encourages researchers to examine brain-behavior relationships across diagnoses. This review on the neurobiology associated with NSSI is organized using the domains proposed by RDoC: Negative Valence, Positive Valence, Cognitive, Social Processes, and Arousal/Regulatory Systems. Evidence of neurobiological anomalies is found in each of these domains. We also propose future research directions, especially in regard to human development. Future NSSI studies should address this behavior independent of diagnosis, examine relevant constructs across multiple units of analysis, and assess how systems change across development and course of illness. These advances will be essential for guiding neurobiologically informed intervention and prevention strategies to target NSSI. In doing so, we may prevent the associated negative outcomes across the lifespan.
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Prior reviews have identified brain regions implicated in suicidal and non-suicidal behaviors.
“Several prior reviews have highlighted brain regions implicated in suicidal (32, 45–49) and non-suicidal behaviors (39, 50).”
From Neural correlates associated with suicide and nonsuicidal self-injury in youth (2021) · cites this paper as [50]
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- Authors
- Westlund Schreiner, M., Klimes-Dougan, B., Begnel, E. D., & Cullen, K. R.
- Affiliations
- University of Minnesota (US)
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2015-10
- Volume
- 57
- Pages
- 381-391
- ISSN
- 0149-7634 (ISSN-L)
- PMC
- PMC5549671
- OpenAlex
- W2178519976
- Cited by
- 90
- References
- 94
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 8 · 2023: 17 · 2022: 7 · 2021: 14 · 2020: 11 · 2019: 7 · 2018: 2 · 2017: 4 · 2016: 2
- FWCI
- 0.38
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- ScholarsArchive (Brigham Young University) (submittedVersion)
- Funders
- National Institute of Mental Health (K23-MH090421)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- non-suicidal self-injury, neurobiology, Research Domain Criteria, brain-behavior relationship, negative valence systems, positive valence systems, cognitive systems, social processes, adolescence, human development, prevention, intervention
- MeSH terms
- Humans, Human Development, Self-Injurious Behavior
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