Origin and molecular specification of globus pallidus neurons
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The mechanisms controlling the assembly of brain nuclei are poorly understood. In the forebrain, it is typically assumed that the formation of nuclei follows a similar sequence of events that in the cortex. In this structure, projection neurons are generated sequentially from common progenitor cells and migrate radially to reach their final destination, whereas interneurons are generated remotely and arrive to the cortex through tangential migration. Using the globus pallidus as a model to study the formation of forebrain nuclei, we found that the development of this basal ganglia structure involves the generation of several distinct classes of projection neurons from relatively distant progenitor pools, which then assemble together through tangential migration. Our results thus suggest that tangential migration in the forebrain is not limited to interneurons, as previously thought, but also involves projection neurons and reveal that the assembly of forebrain nuclei is more complex than previously anticipated.
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Generation of cortical interneurons is largely limited to the dorsal and intermediate MGE domains, while the ventrocaudal domain specializes in producing PV+ projection neurons for the globus pallidus.
“the generation of cortical interneurons is largely limited to the dorsal and intermediate domains of the MGE, whereas the ventrocaudal domain specializes in the production of PV+ projection neurons for the globus pallidus”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Nóbrega-Pereira et al., 2010
Lhx8-Cre fate mapping suggested that these neurons account for the majority, if not all, of cholinergic projection and interneuron populations in the nucleus basalis, medial septum, and striatum, and the majority of Pvalb-positive projection neurons in the globus pallidus.
“Genetic ‘fate-mapping’ using Lhx8-Cre suggested that these neurons account for the majority, if not all of the cholinergic projection and interneuron populations within the nucleus basalis, medial septum, and striatum, respectively, as well as the majority of Pvalb-positive projection neurons in the globus pallidus5,6”
From Developmental diversification of cortical inhibitory interneurons (2018) · cites this paper as [5]
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“Interestingly, the generation of cortical interneurons is largely limited to the dorsal and intermediate domains of the MGE, whereas the ventrocaudal domain specializes in the production of PV+ projection neurons for the globus pallidus (Flandin et al., 2010; Nóbrega-Pereira et al., 2010).”
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- Authors
- Nóbrega-Pereira, S., Gelman, D., Bartolini, G., Pla, R., Pierani, A., & Marín, O.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- Centre National de la Recherche Scientifique (FR)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-02-24
- Volume
- 30
- Issue
- 8
- Pages
- 2824-2834
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6633933
- OpenAlex
- W2093983408
- Cited by
- 142
- References
- 63
- Citations by year
- 2026: 1 · 2025: 10 · 2024: 7 · 2023: 9 · 2022: 10 · 2021: 13 · 2020: 10 · 2019: 8 · 2018: 11 · 2017: 8 · 2016: 10 · 2015: 10 · 2014: 9 · 2013: 12 · 2012: 3
- FWCI
- 2.63
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Funders
- McKnight Foundation
- European Commission (005139)
- Centre National de la Recherche Scientifique
- Ministerio de Ciencia e Innovación (CSD2007-00023)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- globus pallidus, neuronal specification, tangential migration, projection neurons, interneurons, basal ganglia development, neuronal migration
- MeSH terms
- Thyroid Nuclear Factor 1, Acetylcholine, Animals, Cell Differentiation, Cell Movement, Choline O-Acetyltransferase, DNA-Binding Proteins, gamma-Aminobutyric Acid, Globus Pallidus, Mice, Transgenic, Nerve Tissue Proteins, Neural Pathways, Neurons, Nuclear Proteins, Parvalbumins, Stem Cells, Transcription Factors, Biomarkers, Prosencephalon, Mice, Knockout, Gene Expression Regulation, Developmental, Mice, Basic Helix-Loop-Helix Proteins, Neurogenesis
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