The DOI matches its Crossref record; 47 of the 48 references it cites were found in a registry or an index.
Dopamine, oxytocin, and vasopressin receptor binding in the medial prefrontal cortex of monogamous and promiscuous voles
Abstract
Comparisons between monogamous and promiscuous vole species have proven useful in examining neurobiological mechanisms underlying social attachment. Reward processing is important for social attachment, and the medial prefrontal cortex (mPFC) exerts a direct influence on reward pathways. Dopamine (DA), oxytocin (OT), and arginine vasopressin (AVP) all have been implicated in the regulation of social attachment in monogamous voles. Therefore, we used radiolabeled ligands to examine dopamine D(1)- and D(2)-like, OT, and AVP V(1a) receptor binding densities in the mPFC of monogamous and promiscuous voles. Species differences were found; monogamous voles had higher densities of D(2)-like and OT receptor binding and lower densities of D(1)-like and V(1a) receptor binding than did promiscuous voles. Sex differences also were found; females had higher densities of OT receptor binding but lower densities of V(1a) receptor binding than did males in both species. Further, the laminar distribution of receptor binding indicates the possibility of an interaction between DA and OT systems in the mPFC in the regulation of social attachment. Differences in D(1)- and D(2)-like receptor binding between species are discussed in terms of how they might modulate cortical activity and subsequent DA release in the nucleus accumbens (NAcc).
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“Furthermore, in different species of voles, a monogamous, as opposed to polygamous, pattern of behavior is associated with a higher density of dopamine D2 receptors (D2R) in the medial prefrontal cortex (mPFC) (3) and of OXT receptors (OXTR) in mPFC, NAcc, and caudate putamen (4,5).”
From Oxytocin enhances brain reward system responses in men viewing the face of their female partner (2013) · cites this paper as [3]
In the citing paper
“a sex difference for V1aR was found in the medial prefrontal cortex with higher V1aR binding in male prairie and montane voles compared to females in Smeltzer et al., (2006).”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Smeltzer et al., (2006)
In the citing paper
“Interestingly, these sex-specific effects seem to be independent of whether sex differences are found in VP and/or V1aR binding (rats; Figs. 1 and 2) or whether no sex differences are found in VP and/or V1aR binding (prairie voles: Insel et al., 1991; Smeltzer et al., 2006; humans: Loup et al., 1991).”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Smeltzer et al., 2006
In the citing paper
“other rodent studies that did not find sex differences in OTR binding analyzed only a few brain regions”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Smeltzer et al., 2006
In the citing paper
“For instance, monogamous prairie voles exhibit lower concentrations of D1-like receptors and higher concentrations of D2-like receptors within the medial prefrontal cortex compared to their more promiscuous counterparts (Smeltzer et al., 2006).”
From Oxytocin, motivation and the role of dopamine (2014) · cites this paper as Smeltzer et al., 2006
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Citations
Cites
The oxytocin receptor system: structure, function, and regulation
Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089
Swanson, L. W. (1982) · Brain Research Bulletin · doi:10.1016/0361-9230(82)90145-9 · Cited by 1,718
The neurobiology of pair bonding.
Young, L. J., & Wang, Z. (2004) · Nature Neuroscience · doi:10.1038/nn1327 · Cited by 1,523
Self-citationThe neurobiology of attachment
Insel, T. R., & Young, L. J. (2001) · Nature Reviews Neuroscience · doi:10.1038/35053579 · Cited by 1,173
A role for central vasopressin in pair bonding in monogamous prairie voles
Winslow, J. T., Hastings, N., Carter, C. S., Harbaugh, C. R., & Insel, T. R. (1993) · Nature · doi:10.1038/365545a0 · Cited by 948
Carr, D. B., & Sesack, S. R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-10-03864.2000 · Cited by 880
Oxytocin receptor distribution reflects social organization in monogamous and polygamous voles
Insel, T. R., & Shapiro, L. E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.5981 · Cited by 833
Gender Differences in Dopaminergic Function in Striatum and Nucleus Accumbens
Becker, J. B. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(99)00168-9 · Cited by 696
Lim, M. M., Wang, Z., Olazábal, D. E., Ren, X., Terwilliger, E. F., & Young, L. J. (2004) · Nature · doi:10.1038/nature02539 · Cited by 628
Self-citationPhysiological substrates of mammalian monogamy: The prairie vole model
Sue Carter, C., Courtney Devries, A., & Getz, L. L. (1995) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(94)00070-h · Cited by 615
Liu, Y., & Wang, Z. X. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00555-4 · Cited by 580
Self-citationCho, M. M., DeVries, A. C., Williams, J. R., & Carter, C. S. (1999) · Behavioral Neuroscience · doi:10.1037/0735-7044.113.5.1071 · Cited by 529
Insel, T. R., & Hulihan, T. J. (1995) · Behavioral Neuroscience · doi:10.1037/0735-7044.109.4.782 · Cited by 528
Cellular Mechanisms of Social Attachment
Young, L. J., Lim, M. M., Gingrich, B., & Insel, T. R. (2001) · Hormones and Behavior · doi:10.1006/hbeh.2001.1691 · Cited by 523
Mesencephalic dopamine neurons projecting to neocortex
Lindvall, O., Björklund, A., Moore, R. Y., & Stenevi, U. (1974) · Brain Research · doi:10.1016/0006-8993(74)90947-0 · Cited by 504
Williams, J. R., Insel, T. R., Harbaugh, C. R., & Carter, C. S. (1994) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1994.tb00579.x · Cited by 483
Insel, T., Wang, Z., & Ferris, C. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-09-05381.1994 · Cited by 454
Self-citationSmiley, J. F., Levey, A. I., Ciliax, B. J., & Goldman‐Rakic, P. S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.12.5720 · Cited by 383
A critical role for nucleus accumbens dopamine in partner-preference formation in male prairie voles
Aragona, B. J., Liu, Y., Curtis, J. T., Stephan, F. K., & Wang, Z. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03483.2003 · Cited by 351
Self-citationGingrich, B., Liu, Y., Cascio, C., Wang, Z., & Insel, T. R. (2000) · Behavioral Neuroscience · doi:10.1037/0735-7044.114.1.173 · Cited by 339
Self-citationVasopressin-dependent neural circuits underlying pair bond formation in the monogamous prairie vole
Lim, M. M., & Young, L. J. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.12.008 · Cited by 322
Taber, M. T., & Fibiger, H. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-05-03896.1995 · Cited by 318
Carter, C. S., & Getz, L. L. (1993) · Scientific American · doi:10.1038/scientificamerican0693-100 · Cited by 310
Liu, Y., Curtis, J. T., & Wang, Z. (2001) · Behavioral Neuroscience · doi:10.1037/0735-7044.115.4.910 · Cited by 282
Self-citationvan Eden, C. G., Hoorneman, E. M. D., Buijs, R. M., Matthijssen, M. A. H., Geffard, M., & Uylings, H. B. M. (1987) · Neuroscience · doi:10.1016/0306-4522(87)92964-2 · Cited by 272
Cortical Regulation of Subcortical Dopamine Release: Mediation via the Ventral Tegmental Area
Taber, M. T., Das, S., & Fibiger, H. C. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65031407.x · Cited by 257
Pirot, S., Godbout, R., Mantz, J., Tassin, J., Glowinski, J., & Thierry, A. M. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90362-6 · Cited by 237
Mesocortical Dopamine Neurons Operate in Distinct Temporal Domains Using Multimodal Signaling
Lavin, A., Nogueira, L., Lapish, C. C., Wightman, R. M., Phillips, P. E. M., & Seamans, J. K. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0557-05.2005 · Cited by 233
Cellular distribution of dopamine D1 and D2 receptors in rat medial prefrontal cortex
Vincent, S. L., Khan, Y., & Benes, F. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-06-02551.1993 · Cited by 223
Mating in the monogamous male: Behavioral consequences
Insel, T. R., Preston, S., & Winslow, J. T. (1995) · Physiology & Behavior · doi:10.1016/0031-9384(94)00362-9 · Cited by 215
McGuire, B., & Novak, M. A. (1984) · Animal Behaviour · doi:10.1016/s0003-3472(84)80229-8 · Cited by 207
Wang, Z., Yu, G., Cascio, C., Liu, Y., Gingrich, B., & Insel, T. R. (1999) · Behavioral Neuroscience · doi:10.1037/0735-7044.113.3.602 · Cited by 205
Self-citationSesack, S. R., & Bunney, B. S. (1989) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24159-3 · Cited by 200
Oliveras, D. M., & Novak, M. A. (1986) · Animal Behaviour · doi:10.1016/s0003-3472(86)80120-8 · Cited by 196
Young, L. J., Winslow, J. T., Nilsen, R., & Insel, T. R. (1997) · Behavioral Neuroscience · doi:10.1037/0735-7044.111.3.599 · Cited by 196
Carr, D. B., O’Donnell, P., Card, J. P., & Sesack, S. R. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-24-11049.1999 · Cited by 160
Séguéla, P., Watkins, K. C., & Descarries, L. (1988) · Brain Research · doi:10.1016/0006-8993(88)91427-8 · Cited by 155
Cellular colocalization of dopamine D1 and D2 receptors in rat medial prefrontal cortex
Vincent, S. L., Khan, Y., & Benes, F. M. (1995) · Synapse · doi:10.1002/syn.890190207 · Cited by 139
Neurochemical regulation of pair bonding in male prairie voles
Wang, Z., & Aragona, B. J. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.08.024 · Cited by 128
Self-citationSoman-induced seizures rapidly activate astrocytes and microglia in discrete brain regions
Zimmer, L. A., Ennis, M. J., & Shipley, M. T. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970224)378:4 · Cited by 124
Self-citationPorges, C. C., & Getz, L. (1996) · American Scientist · Cited by 122
The comparative psychology of monogamy.
Dewsbury, D. A. (1987) · PubMed · Cited by 121
Holden, A. L. (1977) · Elsevier eBooks · doi:10.1016/b978-0-433-25015-9.50035-7 · Cited by 66
Nesting Patterns of Adult Voles, Microtus montanus, in Field Populations
Jannett, F. J. (1982) · Journal of Mammalogy · doi:10.2307/1380450 · Cited by 64
Wang, Z., & Young, L. J. (1997) · Developmental Brain Research · doi:10.1016/s0165-3806(97)00138-7 · Cited by 54
Self-citationWang, Z., & Insel, T. R. (1996) · Advances in the study of behavior · doi:10.1016/s0065-3454(08)60338-1 · Cited by 41
Self-citationCurtis, J. T., Stowe, J. R., & Wang, Z. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00032-0 · Cited by 30
Self-citation
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Sorted by citations
Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3044 · Cited by 1,688
The oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999
Effects of intranasal oxytocin on emotional face processing in women
Domes, G., Lischke, A., Berger, C., Grossmann, A., Hauenstein, K., Heinrichs, M., & Herpertz, S. C. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.06.016 · Cited by 521
Dumais, K. M., & Veenema, A. H. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.04.003 · Cited by 520
“…per sex, which might explain the limited brain regions in which sex differences in V1aR binding were found (C57B6 mice: Dubois Dauphin et al., 1996; Siberian hamsters: Dubois-Dauphlin et al., 1991; golden hamsters: Delville & Ferris, 1995; voles: Bales et al., 2007a; Smeltzer et al., 2006).”
BackgroundResultInfluentialBarrett, J., & Fleming, A. S. (2011) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2010.02306.x · Cited by 433
Metadata
- Authors
- Smeltzer, M. D., Curtis, J. T., Aragona, B. J., & Wang, Z.
- Affiliations
- Florida State University (US)
- Corresponding author
- Wang, Zuoxin
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2006-02
- Volume
- 394
- Issue
- 2
- Pages
- 146-151
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2163888128
- Cited by
- 222
- References
- 48
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 14 · 2023: 7 · 2022: 9 · 2021: 12 · 2020: 8 · 2019: 14 · 2018: 25 · 2017: 24 · 2016: 10 · 2015: 16 · 2014: 13 · 2013: 16 · 2012: 11
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- John Tracy Clinic
- National Institutes of Health (DA19627, MH58616, HD40722, NS07437)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- social attachment, monogamy, promiscuity, voles, medial prefrontal cortex, dopamine D1 receptor, dopamine D2 receptor, oxytocin receptor, receptor binding density, sex differences, laminar distribution, nucleus accumbens, reward processing, species differences
- MeSH terms
- Analysis of Variance, Animals, Arginine Vasopressin, Autoradiography, Benzazepines, Arvicolinae, Dopamine, Female, Iodine Isotopes, Male, Oxytocin, Protein Binding, Sex Factors, Social Behavior, Species Specificity, Spiperone, Vasotocin, Prefrontal Cortex, Receptors, Vasopressin, Dopamine Antagonists
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