The role of the hippocampus in object recognition in rats: examination of the influence of task parameters and lesion size
Abstract
Studies examining the effects of hippocampal lesions on object recognition memory in rats have produced conflicting results. The present study investigated how methodological differences and lesion size may have contributed to these discrepancies. In Experiment 1 we compared rats with complete, partial (septal) and sham hippocampal lesions on a spontaneous object recognition task, using a protocol previously reported to result in deficits following large hippocampal lesions . Rats with complete and partial hippocampal lesions were unimpaired, suggesting the hippocampus is not required for object recognition memory. However, rats with partial lesions showed relatively poor performance raising the possibility that floor effects masked a deficit on this group. In Experiment 2, we used a second spontaneous object recognition protocol similar to that used by the two other studies that have reported deficits following hippocampal lesions . Rats with complete hippocampal lesions were significantly impaired, whereas rats with partial lesions were unimpaired. However, the complete lesion group showed less object exploration during the sample phase. Thus, the apparent recognition memory deficit in Experiment 2 may be attributable to differential encoding. Together, these findings suggest that the hippocampus is not required for intact spontaneous object recognition memory. These findings suggest that levels of object exploration during the sample phase may be a critical issue, and raise the possibility that previous reports of object recognition deficits may be due to differences in object exploration rather than deficits in object recognition per se.
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Some studies showed that rats with hippocampal lesions had impaired NOP (across delays from 10 minutes to 24 hours) memory.
“Some studies showed that rats with hippocampal lesions had impaired NOP (across delays from 10 minutes to 24 hours) memory (Ainge et al., 2006; Broadbent et al., 2010; Broadbent et al., 2004; Clark et al., 2000), whereas the majority of the studies employing hippocampal lesions in rats failed to report an influence in the NOP test (Albasser et al., 2012; Albasser et al., 2010; Barker and Warburton”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Ainge et al., 2006
The effects of severe hippocampal lesions could be confounded by less object exploration during the NOP encoding.
“Yet, the effects of severe hippocampal lesions could be confounded by less object exploration during the NOP encoding (Ainge et al., 2006).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Ainge et al., 2006
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- Authors
- Ainge, J. A., Heron-Maxwell, C., Theofilas, P., Wright, P., de Hoz, L., & Wood, E. R.
- Affiliations
- University of Edinburgh (GB)
- Corresponding author
- Wood, Emma R
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2006-02
- Volume
- 167
- Issue
- 1
- Pages
- 183-195
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W1986886791
- Cited by
- 140
- References
- 53
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 7 · 2019: 2 · 2018: 13 · 2017: 5 · 2016: 4 · 2015: 4 · 2014: 7 · 2013: 8 · 2012: 11
- FWCI
- 3.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Medical Research Council
- Biotechnology and Biological Sciences Research Council
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- hippocampus, object recognition memory, hippocampal lesions, object exploration, floor effect, differential encoding
- MeSH terms
- Analysis of Variance, Animals, Behavior, Animal, Brain Injuries, Choice Behavior, Exploratory Behavior, Hippocampus, Ibotenic Acid, Male, Neuropsychological Tests, Random Allocation, Reaction Time, Time Factors, Maze Learning, Recognition, Psychology, Rats
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