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Cited by 2,173Functional Brain Connectivity StudiesMind wandering and attentionAdvanced MRI Techniques and Applications

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A default mode of brain function: A brief history of an evolving idea

Raichle, Marcus E., Snyder, Abraham Z.·2007·NeuroImage
DOI 10.1016/j.neuroimage.2007.02.041
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Abstract

The concept of a default mode of brain function arose out of a focused need to explain the appearance of activity decreases in functional neuroimaging data when the control state was passive visual fixation or eyes closed resting. The problem was particularly compelling because these activity decreases were remarkably consistent across a wide variety of task conditions. Using PET, we determined that these activity decreases did not arise from activations in the resting state. Hence, their presence implied the existence of a default mode. While the unique constellation of brain areas provoking this analysis has come to be known as the default system, all areas of the brain have a high level of organized default functional activity. Most critically, this work has called attention to the importance of intrinsic functional activity in assessing brain behavior relationships.

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Metadata

Authors
Raichle, M. E., & Snyder, A. Z.
Affiliations
Washington University in St. Louis (US)
Corresponding author
Raichle, Marcus E.
ORCID
Venue
NeuroImage
Publisher
Elsevier BV
Published
2007-10
Volume
37
Issue
4
Pages
1083-1090
ISSN
1053-8119 (ISSN-L)
DOI
10.1016/j.neuroimage.2007.02.041
OpenAlex
W2093972428
Cited by
2,173
References
20
Citations by year
2026: 38 · 2025: 79 · 2024: 106 · 2023: 65 · 2022: 99 · 2021: 92 · 2020: 94 · 2019: 122 · 2018: 111 · 2017: 133 · 2016: 141 · 2015: 163 · 2014: 176 · 2013: 167 · 2012: 163
FWCI
6.75
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • NeuroImage (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Mind wandering and attention
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords
default mode network, resting state, intrinsic brain activity, functional neuroimaging, positron emission tomography, brain-behavior relationship
MeSH terms
Animals, Brain, Cognition, Fixation, Ocular, Humans, Magnetic Resonance Imaging, Oxygen, Reference Standards, Vision, Ocular, Positron-Emission Tomography

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