The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Altered cerebellar feedback projections in Asperger syndrome
Abstract
It has been proposed that the biological basis of autism spectrum disorder includes cerebellar 'disconnection'. However, direct in vivo evidence in support of this is lacking. Here, the microstructural integrity of cerebellar white matter in adults with Asperger syndrome was studied using diffusion tensor magnetic resonance tractography. Fifteen adults with Asperger syndrome and 16 age-IQ-gender-matched healthy controls underwent diffusion tensor magnetic resonance imaging. For each subject, tract-specific measurements of mean diffusivity and fractional anisotropy were made within the inferior, middle, superior cerebellar peduncles and short intracerebellar fibres. No group differences were observed in mean diffusivity. However, people with Asperger syndrome had significantly lower fractional anisotropy in the short intracerebellar fibres (p<0.001) and right superior cerebellar (output) peduncle (p<0.001) compared to controls; but no difference in the input tracts. Severity of social impairment, as measured by the Autistic Diagnostic Interview, was negatively correlated with diffusion anisotropy in the fibres of the left superior cerebellar peduncle. These findings suggest a vulnerability of specific cerebellar neural pathways in people with Asperger syndrome. The localised abnormalities in the main cerebellar outflow pathway may prevent the cerebral cortex from receiving those cerebellar feedback inputs necessary for a successful adaptive social behaviour.
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“and in adults, lower fractional anisotropy in the superior cerebellar peduncles was associated with worse parent report of social behaviors in autism [271].”
From Consensus Paper: Pathological Role of the Cerebellum in Autism (2012) · cites this paper as [271]
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Metadata
- Authors
- Catani, M., Jones, D. K., Daly, E., Embiricos, N., Deeley, Q., Pugliese, L., Curran, S., Robertson, D., & Murphy, D. G. M.
- Affiliations
- King's College London (GB)
- Cardiff University (GB)
- Corresponding author
- Catani, Marco
- ORCID
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 41
- Issue
- 4
- Pages
- 1184-1191
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2030059540
- Cited by
- 244
- References
- 78
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 8 · 2022: 11 · 2021: 14 · 2020: 9 · 2019: 12 · 2018: 12 · 2017: 15 · 2016: 14 · 2015: 20 · 2014: 15 · 2013: 25 · 2012: 18
- FWCI
- 11.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- National Institute for Health and Care Research (RP-PG-0606-1045)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- Asperger syndrome, autism spectrum disorder, superior cerebellar peduncle, inferior cerebellar peduncle, middle cerebellar peduncle, fractional anisotropy, mean diffusivity, social dysfunction, social behavior
- MeSH terms
- Adolescent, Adult, Behavior, Cerebellum, Cognition, Feedback, Humans, Intelligence Tests, Male, Middle Aged, Neuropsychological Tests, Psychiatric Status Rating Scales, Anisotropy, Asperger Syndrome, Diffusion Magnetic Resonance Imaging
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