Lapsing when sleep deprived: neural activation characteristics of resistant and vulnerable individuals
Abstract
Lapses of attention, in the form of delayed responses to salient stimuli, increase in frequency for some but not all persons after sleep deprivation (SD). To identify patterns of task-related brain activation that might explain differences in vulnerability to SD, we performed fMRI on participants during a visual, selective attention task. We analyzed the correct responses in a trial-by-trial fashion to model the effects of response time. Stimulus contrast was varied to modulate perceptual difficulty. Attentional lapses and low-contrast stimuli were independently associated with increased signal in fronto-parietal regions associated with biasing attention. Sleep-deprived vulnerable individuals showed reduced top down fronto-parietal signal across all levels of image contrast and this reduction was particularly significant during lapses. There was concurrent reduction in extrastriate cortex and thalamus activation. Non-vulnerable persons showed a trend towards higher top-down biasing of attention and preserved visual cortex activation during SD lapses. A major contributor to performance degradation in SD appears to be a reduction in top-down biasing of attention that is independent of task difficulty.
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Individuals cognitively vulnerable to sleep deprivation showed reduced frontoparietal activation, while resilient individuals showed increased parietal activation associated with lapses of attention during total sleep deprivation.
“Individuals cognitively vulnerable to sleep deprivation showed reduced frontoparietal activation, while resilient individuals showed increased parietal activation associated with lapses of attention during total sleep deprivation201”
From Circadian rhythms, sleep deprivation, and human performance (2013) · cites this paper as [201]
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- Authors
- Chee, M. W. L., & Tan, J. C.
- Affiliations
- National University of Singapore (SG)
- Corresponding author
- Chee, Michael W.L.
- ORCID
- Chee, Michael W.L.
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 51
- Issue
- 2
- Pages
- 835-843
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2122410827
- Cited by
- 168
- References
- 38
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 8 · 2023: 13 · 2022: 10 · 2021: 21 · 2020: 14 · 2019: 13 · 2018: 7 · 2017: 6 · 2016: 5 · 2015: 13 · 2014: 8 · 2013: 11 · 2012: 10
- FWCI
- 15.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion)
- Funders
- Defense Science and Technology Agency Singapore (POD0713897)
- National Research Foundation Singapore (STaR Award)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Mind wandering and attention
- Keywords
- sleep deprivation, attentional lapses, selective attention, top-down attentional control, visual contrast, stimulus contrast, reaction time (psychology), thalamus, extrastriate cortex, visual cortex, task difficulty
- MeSH terms
- Attention, Brain, Brain Mapping, Female, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Reaction Time, Sleep Deprivation, Young Adult
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