Effects of sleep deprivation on cortical activation during directed attention in the absence and presence of visual stimuli
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Sleep deprivation (SD) can give rise to faltering attention but the mechanics underlying this remain uncertain. Using a covert attention task that required attention to a peripheral target location, we compared the effects of attention and SD on baseline activity prior to visual stimulation as well as on stimulus-evoked activity. Volunteers were studied after a night of normal sleep (RW) and a night of SD. Baseline signal elevations evoked by preparatory attention in the absence of visual stimulation were attenuated within rFEF, rIPS (sparing SEF) and all retinotopically mapped visual areas during SD, indicative of impaired endogenous attention. In response to visual stimuli, attention modulated activation in higher cortical areas and extrastriate cortex (hV4, ventral occipital areas) after RW. SD attenuated rFEF, rIPS, V3a and VO stimulus-evoked activation regardless of whether stimuli were attended. Notably, the modulation of stimulus-evoked activation by attention was not affected by SD unlike for the preparatory period, suggesting a reduced number, but still functional circuits during SD. Deficits in endogenous attention in SD dominate in the preparatory period, whereas changes in stimulus-related activation arise from an interaction between compromised fronto-parietal top-down control of attention and reduced sensitivity of extrastriate visual cortex to top-down or bottom-up inputs.
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Sleep deprivation in adults impacts brain function related to reward processing, risk-taking, and cognition.
“Although neuroimaging research in adults has shown that sleep deprivation impacts brain function related to reward processing, risk-taking, and cognition (Chee et al., 2011; Gujar et al., 2011; Libedinsky et al., 2011; Venkatraman et al., 2011), only a few developmental studies have examined how sleep influences reward-related brain function in adolescents (Hasler et al., 2012; Holm et al., 2009)”
From The effects of poor quality sleep on brain function and risk taking in adolescence (2013) · cites this paper as Chee et al., 2011
Sleep deprivation results in deficits in the top-down allocation of attentional resources, which results in impairment in orienting to a location where a target is expected to appear, the capacity for sustained attention, and for selective attention.
“Sleep deprivation results in deficits in the top-down allocation of attentional resources, 55 which results in impairment in orienting to a location, where a target is expected to appear, 56 , 57 the capacity for sustained attention, 58 and for selective attention. 57”
From Towards an Integrative Account of Potential Mechanisms Mediating the Path From Sleep Dysfunction to Hallucinations (2025) · cites this paper as [56]
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- Authors
- Chee, M. W. L., Goh, C. S. F., Namburi, P., Parimal, S., Seidl, K. N., & Kastner, S.
- Affiliations
- National University of Singapore (SG)
- Princeton University (US)
- Corresponding author
- Chee, Michael W.L.
- ORCID
- Chee, Michael W.L.
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2011-09
- Volume
- 58
- Issue
- 2
- Pages
- 595-604
- ISSN
- 1053-8119 (ISSN-L)
- PMC
- PMC3159770
- OpenAlex
- W2102637359
- Cited by
- 81
- References
- 58
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 6 · 2023: 4 · 2022: 8 · 2021: 8 · 2020: 7 · 2019: 6 · 2018: 5 · 2017: 4 · 2015: 6 · 2014: 3 · 2013: 12 · 2012: 3
- FWCI
- 7.83
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- National University of Singapore (submittedVersion)
- Funders
- Defense Science and Technology Agency Singapore (POD0713897)
- National Research Foundation Singapore
- U.S. National Institute of Health (RO1 MH64043, RO1 EY017699, R21 EY021078)
- National Science Foundation (BCS-1025149)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- sleep deprivation, directed attention, top-down attention, preparatory attention, retinotopic visual cortex, frontal eye field, intraparietal sulcus, extrastriate cortex, top-down control, bottom-up processing, covert attention
- MeSH terms
- Adult, Attention, Cerebral Cortex, Cues, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Photic Stimulation, Retina, Sleep Deprivation, Visual Cortex, Wakefulness, Linear Models, Young Adult
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