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Placebo in emotional processing—induced expectations of anxiety relief activate a generalized modulatory network
Open accessAbstract
Placebo analgesia and reward processing share several features. For instance, expectations have a strong influence on the subsequent emotional experience of both. Recent imaging data indicate similarities in the underlying neuronal network. We hypothesized that placebo analgesia is a special case of reward processing and that placebo treatment could modulate emotional perception in the same way as does pain perception. The behavioral part of this study indicates that placebo treatment has an effect on how subjects perceive unpleasant pictures. Furthermore, event-related fMRI demonstrated that the same modulatory network, including the rostral anterior cingulate cortex and the lateral orbitofrontal cortex, is involved in both emotional placebo and placebo analgesia. These effects were correlated with the reported placebo effect and were predicted by the amount of treatment expectation induced on a previous day. Thus, the placebo effect may be considered to be a general process of modulation induced by the subjects' expectations.
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“Importantly, this activation remained when controlling for non-emotional attentional aspects of treatment either through interaction or correlation analyses (Petrovic et al., 2002, 2005).”
From Top-Down Dysregulation—From ADHD to Emotional Instability (2016) · cites this paper as Petrovic et al., 2005
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Empathy for Pain Involves the Affective but not Sensory Components of Pain
Singer, T., Seymour, B., O'Doherty, J., Kaube, H., Dolan, R. J., & Frith, C. D. (2004) · Science · doi:10.1126/science.1093535 · Cited by 3,929
Does Rejection Hurt? An fMRI Study of Social Exclusion
Eisenberger, N. I., Lieberman, M. D., & Williams, K. D. (2003) · Science · doi:10.1126/science.1089134 · Cited by 3,849
The somatic marker hypothesis and the possible functions of the prefrontal cortex
Damasio, A. R. (1996) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.1996.0125 · Cited by 2,847
Neurobiology of emotion perception I: the neural basis of normal emotion perception
Phillips, M. L., Drevets, W. C., Rauch, S. L., & Lane, R. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00168-9 · Cited by 2,173
Emotion, cognition, and behavior
Dolan, R. J. (2002) · Science · doi:10.1126/science.1076358 · Cited by 1,979
Primate anterior cingulate cortex: Where motor control, drive and cognition interface
Paus, T. (2001) · Nature Reviews Neuroscience · doi:10.1038/35077500 · Cited by 1,722
Encoding Predictive Reward Value in Human Amygdala and Orbitofrontal Cortex
Gottfried, J. A., O'Doherty, J., & Dolan, R. J. (2003) · Science · doi:10.1126/science.1087919 · Cited by 1,165
Neural processing of emotional faces requires attention
Pessoa, L., McKenna, M., Gutierrez, E., & Ungerleider, L. G. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172403899 · Cited by 1,155
THE MECHANISM OF PLACEBO ANALGESIA
Levine, J., Gordon, N., & Fields, H. (1978) · The Lancet · doi:10.1016/s0140-6736(78)92762-9 · Cited by 1,094
State-dependent opioid control of pain
Fields, H. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1431 · Cited by 946
Flagged first, then by citations
Research works printed but not linked: 43
- Amanzio, 1999, Neuropharmacological dissection of placebo analgesia: expectation-activated opioid systems versus conditioning-activated specific subsystems, J. Neurosci., 19, 484, 10.1523/JNEUROSCI.19-01-00484.1999 · DOI · Paper page
- Becerra, 2001, Reward circuitry activation by noxious thermal stimuli, Neuron, 32, 927, 10.1016/S0896-6273(01)00533-5 · DOI
- Bechara, 1997, Deciding advantageously before knowing the advantageous strategy, Science, 275, 1293, 10.1126/science.275.5304.1293 · DOI · Paper page
- Berridge, 2003, Parsing reward, Trends Neurosci., 26, 507, 10.1016/S0166-2236(03)00233-9 · DOI · Paper page
- Blakemore, 1998, Central cancellation of self-produced tickle sensation, Nat. Neurosci., 1, 635, 10.1038/2870 · DOI · Paper page
- Breiter, 2001, Functional imaging of neural responses to expectancy and experience of monetary gains and losses, Neuron, 30, 619, 10.1016/S0896-6273(01)00303-8 · DOI · Paper page
- Bush, 2000, Cognitive and emotional influences in anterior cingulate cortex, Trends Cogn. Sci., 4, 215, 10.1016/S1364-6613(00)01483-2 · DOI · Paper page
- Davidson, 2000, Dysfunction in the neural circuitry of emotion regulation—a possible prelude to violence, Science, 289, 591, 10.1126/science.289.5479.591 · DOI · Paper page
- de la Fuente-Fernandez, 2001, Expectation and dopamine release: mechanism of the placebo effect in Parkinson’s disease, Science, 293, 1164, 10.1126/science.1060937 · DOI
- Ernst, 2004, Choice selection and reward anticipation: an fMRI study, Neuropsychologia, 42, 1585, 10.1016/j.neuropsychologia.2004.05.011 · DOI · Paper page
- Friston, 1995, Statistical parametric maps in functional imaging: A general linear approach, Hum. Brain Mapp., 2, 189, 10.1002/hbm.460020402 · DOI · Paper page
- Geday, 2003, Emotional valence modulates activity in the posterior fusiform gyrus and inferior medial prefrontal cortex in social perception, Neuroimage, 18, 675, 10.1016/S1053-8119(02)00038-1 · DOI
- Hsieh, 1999, Anticipatory coping of pain expressed in the human anterior cingulate cortex: a positron emission tomography study, Neurosci. Lett., 262, 61, 10.1016/S0304-3940(99)00060-9 · DOI · Paper page
- Ingvar, 1985, “Memory of the future”: an essay on the temporal organization of conscious awareness, Hum. Neurobiol., 4, 127
- Kaasinen, 2004, Expectation of caffeine induces dopaminergic responses in humans, Eur. J. Neurosci., 19, 2352, 10.1111/j.1460-9568.2004.03310.x · DOI · Paper page
- Kirsch, 2003, Anticipation of reward in a nonaversive differential conditioning paradigm and the brain reward system: an event-related fMRI study, Neuroimage, 20, 1086, 10.1016/S1053-8119(03)00381-1 · DOI
- Knutson, 2001, Dissociation of reward anticipation and outcome with event-related fMRI, Neuroreport, 12, 3683, 10.1097/00001756-200112040-00016 · DOI · Paper page
- Koyama, 1998, Nociceptive neurons in the macaque anterior cingulate activate during anticipation of pain, Neuroreport, 9, 2663, 10.1097/00001756-199808030-00044 · DOI
- Kringelbach, 2003, Neural correlates of rapid reversal learning in a simple model of human social interaction, Neuroimage, 20, 1371, 10.1016/S1053-8119(03)00393-8 · DOI
- Liberzon, 2002, mu-Opioid receptors and limbic responses to aversive emotional stimuli, Proc. Natl. Acad. Sci. USA, 99, 7084, 10.1073/pnas.102174799 · DOI
- Lieberman, 2004, The neural correlates of placebo effects: a disruption account, Neuroimage, 22, 447, 10.1016/j.neuroimage.2004.01.037 · DOI
- Mellers, 2000, Choice and the relative pleasure of consequences, Psychol. Bull., 126, 910, 10.1037/0033-2909.126.6.910 · DOI
- Mesulam, 1998, From sensation to cognition, Brain, 121, 1013, 10.1093/brain/121.6.1013 · DOI · Paper page
- Montgomery, 1997, Classical conditioning and the placebo effect, Pain, 72, 107, 10.1016/S0304-3959(97)00016-X · DOI · Paper page
- Ochsner, 2002, Rethinking feelings: an FMRI study of the cognitive regulation of emotion, J. Cogn. Neurosci., 14, 1215, 10.1162/089892902760807212 · DOI · Paper page
- O’Doherty, 2001, Abstract reward and punishment representations in the human orbitofrontal cortex, Nat. Neurosci., 4, 95, 10.1038/82959 · DOI · Paper page
- O’Doherty, 2002, Neural responses during anticipation of a primary taste reward., Neuron, 33, 815, 10.1016/S0896-6273(02)00603-7 · DOI · Paper page
- Pelchat, 2002, Of human bondage: food craving, obsession, compulsion, and addiction, Physiol. Behav., 76, 347, 10.1016/S0031-9384(02)00757-6 · DOI
- Petrovic, 2002, Topical review: Imaging cognitive modulation of pain processing, Pain, 95, 1, 10.1016/S0304-3959(01)00467-5 · DOI · Paper page
- Petrovic, 2002, Placebo and opioid analgesia—Imagine a shared neuronal network, Science, 295, 1737, 10.1126/science.1067176 · DOI · Paper page
- Peyron, 2000, Functional imaging of brain responses to pain. A review and meta-analysis (2000), Neurophysiol. Clin., 30, 263, 10.1016/S0987-7053(00)00227-6 · DOI · Paper page
- Ploghaus, 1999, Dissociating pain from its anticipation in the human brain, Science, 284, 1979, 10.1126/science.284.5422.1979 · DOI · Paper page
- Price, 1999, An analysis of factors that contribute to the magnitude of placebo analgesia in an experimental paradigm, Pain, 83, 147, 10.1016/S0304-3959(99)00081-0 · DOI
- Ramnani, 2003, Instructed delay activity in the human prefrontal cortex is modulated by monetary reward expectation, Cereb. Cortex, 13, 318, 10.1093/cercor/13.3.318 · DOI
- Schoenbaum, 2001, Integrating orbitofrontal cortex into prefrontal theory: common processing themes across species and subdivisions, Learn. Mem., 8, 134, 10.1101/lm.39901 · DOI
- Schultz, 2002, Getting formal with dopamine and reward, Neuron, 36, 241, 10.1016/S0896-6273(02)00967-4 · DOI · Paper page
- Surguladze, 2003, A preferential increase in the extrastriate response to signals of danger, Neuroimage, 19, 1317, 10.1016/S1053-8119(03)00085-5 · DOI
- Tremblay, 1999, Relative reward preference in primate orbitofrontal cortex, Nature, 398, 704, 10.1038/19525 · DOI · Paper page
- Ueda, 2003, Brain activity during expectancy of emotional stimuli: an fMRI study, Neuroreport, 14, 51, 10.1097/00001756-200301200-00010 · DOI
- Wager, 2004, Placebo-induced changes in FMRI in the anticipation and experience of pain, Science, 303, 1162, 10.1126/science.1093065 · DOI · Paper page
- Voudouris, 1989, Conditioned response models of placebo phenomena: further support, Pain, 38, 109, 10.1016/0304-3959(89)90080-8 · DOI
- Vuilleumier, 2001, Effects of attention and emotion on face processing in the human brain: an event-related fMRI study, Neuron, 30, 829, 10.1016/S0896-6273(01)00328-2 · DOI · Paper page
- Zubieta, 2003, Regulation of human affective responses by anterior cingulate and limbic mu-opioid neurotransmission, Arch. Gen. Psychiatry, 60, 1145, 10.1001/archpsyc.60.11.1145 · DOI
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Items 201–300 of 393
Intentional and Incidental Self-Control in Ventrolateral Prefrontal Cortex
Cohen, J. R., Berkman, E. T., & Lieberman, M. D. (2013) · Oxford University Press eBooks · doi:10.1093/med/9780199837755.003.0030 · Cited by 30
“Several other studies have replicated these results implicating rVLPFC using various manipulations of momentary pain stimulation (Kong et al., 2006; Wager et al., 2004) and even the distress associated with viewing aversive images (Petrovic et al., 2005).”
BackgroundAn Analysis of the Basic Processes of Formation and Change of Placebo Expectations
Geers, A. L., Briñol, P., & Petty, R. E. (2018) · Review of General Psychology · doi:10.1037/gpr0000171 · Cited by 26
The influence of reward sensitivity, heart rate dynamics and EEG-delta activity on placebo analgesia
Pascalis, V. D., & Scacchia, P. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.11.014 · Cited by 29
Strategy-dependent modulation of cortical pain circuits for the attenuation of pain.
Schulz, E., Stankewitz, A., Witkovský, V., Winkler, A., & Tracey, I. (2019) · Cortex; a journal devoted to the study of the nervous system and behavior · doi:10.1016/j.cortex.2018.12.014 · Cited by 24
Neural underpinnings of open-label placebo effects in emotional distress
Schaefer, M., Kühnel, A., Schweitzer, F. M., Enge, S., & Gärtner, M. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01501-3 · Cited by 35
“001 (uncorrected) as well as ROIs of amygdala activations based on previous research [21] (small volume correction, sphere of 5 mm, at p < 0.”
BackgroundMethodInfluentialSchienle, A., Unger, I., & Schwab, D. (2022) · Scientific Reports · doi:10.1038/s41598-022-10567-4 · Cited by 23
Placebo From an Enactive Perspective
Arandia-Romero, I., & Paolo, E. A. D. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.660118 · Cited by 29
“, 2006), and reduction of anxiety (Petrovic et al., 2005).”
BackgroundDread of uncertain pain: An event-related potential study
Huang, Y.-J., Shang, Q., Dai, S., & Ma, Q.-G. (2017) · PLoS ONE · doi:10.1371/journal.pone.0182489 · Cited by 23
Borsook, D., & Becerra, L. R. (2007) · Current Pain and Headache Reports · doi:10.1007/s11916-007-0191-7 · Cited by 26
“Although there are several imaging studies of the placebo effect in healthy subjects [27, 28 ], there are none that we are currently aware of in chronic pain patients.”
BackgroundBravo, F., Cross, I. R. M., Hopkins, C., Gonzalez, N., Docampo, J., Bruno, C., & Stamatakis, E. A. (2019) · Human Brain Mapping · doi:10.1002/hbm.24786 · Cited by 28
“Our results are also in line with studies tying rostral ACC activation to fear extinction (Phelps et al., 2004) and placebo anxiety reduction (Petrovic et al., 2005), processes deemed to demand “emotional” conflict resolution mechanisms (Etkin et al., 2006).”
BackgroundResultLuan, Y., Wang, C., Jiao, Y., Tang, T., Zhang, J., Lu, C.-Q., Salvi, R., & Teng, G.-J. (2018) · Brain Imaging and Behavior · doi:10.1007/s11682-018-0004-0 · Cited by 22
“One interpretation of these results is that the rostral portion of the ACC is involved in regulating anxiety, consistent with previous reports (Petrovic et al. 2005).”
ResultHodaj, H., Payen, J., & Lefaucheur, J. (2018) · Neurophysiologie clinique · doi:10.1016/j.neucli.2018.05.039 · Cited by 22
Route of placebo administration: Robust placebo effects in laboratory and clinical settings
Liu, T. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.09.018 · Cited by 25
“…following a placebo treatment, a sound body of evidence supports the view that a placebo treatment acts by means of inducing an expectation of beneficial responses (Kirsch, 1985; Kirsch et al., 2014; Montgomery and Kirsch, 1997; Pollo et al., 2001; Price et al., 1999; Wager and Atlas, 2015).”
InfluentialThe Role of Patients’ Response Expectancies in Side Effect Development and Control
Roscoe, J. A., Jean‐Pierre, P., Shelke, A. R., Kaufman, M. E., Bole, C. W., & Morrow, G. R. (2006) · Current Problems in Cancer · doi:10.1016/j.currproblcancer.2005.12.001 · Cited by 23
Neural mechanisms of expectancy-based placebo effects in antidepressant clinical trials
Zilcha-Mano, S., Wang, Z., Peterson, B. S., Wall, M. M., Chen, Y., Wager, T. D., Brown, P. J., Roose, S. P., & Rutherford, B. R. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.05.023 · Cited by 21
Darragh, M., Yow, B., Kieser, A., Booth, R. J., Kydd, R. R., & Consedine, N. S. (2016) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867415621390 · Cited by 21
“Placebos have been shown to reduce acute stress and anxiety in lab settings (Colloca et al., 2004; Darragh et al., 2014; Petrovic et al., 2005); however, in the real-world, depressed, stressed or anxious patients are required to self-administer treatments around their daily activities and amidst…”
BackgroundPain modalities in the body and brain: Current knowledge and future perspectives
Chae, Y., Park, H., & Lee, I. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104744 · Cited by 20
Lougee, H., Johnston, R., & Thomson, O. P. (2013) · Journal of Bodywork & Movement Therapies · doi:10.1016/j.jbmt.2012.06.005 · Cited by 21
Motter, J., Devanand, D., Doraiswamy, P. M., & Sneed, J. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00249 · Cited by 20
“8:249. doi: 10.3389/fnagi.2016.00249”
BackgroundInfluentialPrior experience with a pain stimulus as a predictor of placebo analgesia
Geers, A. L., Fowler, S. L., Wellman, J. A., Helfer, S. G., Close, S., & France, C. R. (2014) · Journal of Behavioral Medicine · doi:10.1007/s10865-014-9586-1 · Cited by 25
Placebo-Suggestion Modulates Conflict Resolution in the Stroop Task
da Gama, P. A. M. D. S., Slama, H., Caspar, É. A., Gevers, W., & Axel Cleeremans, B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075701 · Cited by 25
“Research has shown that manipulating expectancies can bias different cognitive processes such as the experience of pain [18,19,20], visual awareness [21], memory [22,23], implicit learning [24,25] and emotions [26].”
BackgroundMohr, C. H., Leyendecker, S., & Helmchen, C. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06036.x · Cited by 22
“Despite some controversial data, there is increasing evidence that ACC activity also encodes perceived pain intensity (Petrovic et al., 1999; Tolle et al., 1999; Mohr et al., 2005) and our data suggest that the midcingulate ACC maintains this capacity in thermal hyperalgesia.”
BackgroundSurgeons and shamans: the placebo value of ritual.
Green, S. (2006) · Clinical Orthopaedics and Related Research · doi:10.1097/01.blo.0000224044.69592.65 · Cited by 20
Neural mechanisms of modulations of empathy and altruism by beliefs of others’ pain
Wu, T., & Han, S. (2021) · eLife · doi:10.7554/elife.66043 · Cited by 26
“, 2008) and processing of emotions (Petrovic et al., 2005) including experiences of pain (Wager et al.”
BackgroundWhy we need more research into the placebo response in psychiatry
Huneke, N. T. M., van der Wee, N. J. A., Garner, M. J., & Baldwin, D. S. (2020) · Psychological Medicine · doi:10.1017/s0033291720003633 · Cited by 26
The Functional Role of Large-scale Brain Network Coordination in Placebo-induced Anxiolysis
Meyer, B., Yuen, K. S. L., Saase, V., & Kalisch, R. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy188 · Cited by 22
Linnman, C., Catana, C., Petkov, M. P., Chonde, D. B., Becerra, L. R., Hooker, J. M., & Borsook, D. (2017) · NeuroImage Clinical · doi:10.1016/j.nicl.2017.11.011 · Cited by 23
Schienle, A., Übel, S., & Wabnegger, A. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw144 · Cited by 25
Huneke, N. T. M., Aslan, I. H., Fagan, H. A., Phillips, N., Tanna, R., Cortese, S., Garner, M. J., & Baldwin, D. S. (2022) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyac009 · Cited by 24
Distinct neural networks subserve placebo analgesia and nocebo hyperalgesia
Fu, J., Wu, S., Liu, C., Camilleri, J. A., Eickhoff, S. B., & Yu, R. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.117833 · Cited by 30
“A large number of studies have explored the neurobiological mechanism of the placebo effect(de la Fuente-Fernandez et al., 2002; de la Fuente-Fernandez et al., 2001; Jarcho et al., 2016; Martikainen et al., 2005; Petrovic et al., 2005; Petrovic et al., 2002; Wager et al., 2004), suggesting that it is related to the re…”
InfluentialPlacebo prevents rumination: An experimental study.
Rebstock, L., Schäfer, L., Kube, T., Ehmke, V., & Rief, W. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.06.010 · Cited by 18
Moon, H. C., Park, C.-A., Jeon, Y.-J., You, S.-T., Baek, H. M., Lee, Y. J., Cho, C. B., Cheong, C. J., & Park, Y. S. (2018) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2018.05.005 · Cited by 23
No evidence for an acute placebo effect on emotional processing in healthy volunteers
Huneke, N. T. M., Walsh, A. E. L., Brown, R. E., Browning, M. D., & Harmer, C. J. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117739552 · Cited by 17
“In two previous studies, placebo anxiolysis was induced in participants either through a conditioning procedure or through verbal instruction (Meyer et al., 2015; Petrovic et al., 2005).”
BackgroundMethodLearning mechanisms in pain chronification—teachings from placebo research
Ingvar, M. (2015) · Pain · doi:10.1097/j.pain.0000000000000093 · Cited by 19
Self-citationFor Placebo Effects in Medicine, Seeing Is Believing
Gollub, R. L., & Kong, J. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002120 · Cited by 18
“As one nal example, pain relief can be conceptualized as a reward, and there is increasing evidence that the neural circuitry activated by other types of rewards, such as food when hungry, is also activated by anticipation of pain relief in response to a placebo treatment (30, 31).”
BackgroundDeceptive and non-deceptive placebos to reduce sadness: A five-armed experimental study
Friehs, T., Rief, W., Glombiewski, J., Haas, J., & Kube, T. (2022) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2022.100349 · Cited by 17
Mechanismen der endogenen Schmerzmodulation am Beispiel der Placeboanalgesie
Bingel, U. (2010) · Der Schmerz · doi:10.1007/s00482-010-0901-7 · Cited by 23
Explaining the placebo effect: Aliefs, beliefs, and conditioning
Haug, M. C. (2011) · Philosophical Psychology · doi:10.1080/09515089.2011.559624 · Cited by 13
“As several imaging studies have shown (e.g., Petrovic et al., 2005; Wager et al., 2004), during the production of placebo responses both affective areas (e.g., anterior cingulate cortex and amygdala) and modulatory or representational areas (e.g., the dorsolateral prefrontal cortex and lateral…”
Ortega, Á., Salazar, J. J., Galbán, N., Rojas, M., Ariza, D. V., Chávez-Castillo, M., Nava, M., Riaño-Garzón, M., Díaz-Camargo, E. A., Medina, Ó., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084196 · Cited by 22
“Mainly, these include the amygdala, the orbitofrontal cortex, and the dorsal cingulate cortex [32,33], which have important roles in the development of emotions, memory, and fear management, among others.”
BackgroundEffects of Open-Label Placebos on State Anxiety and Glucocorticoid Stress Responses
Schaefer, M., Hellmann‐Regen, J., & Enge, S. (2021) · Brain Sciences · doi:10.3390/brainsci11040508 · Cited by 16
“employed placebos to manipulate expectations and reported an effect on the perception of emotionally unpleasant pictures and associated brain activation [11].”
BackgroundAnticipation of Uncertain Threat Modulates Subsequent Affective Responses and Covariation Bias
Qiao, Z., Geng, H., Wang, Y., & Li, X. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.02547 · Cited by 18
“(2010) found the activation of anterior cingulate cortex (ACC) during the anticipatory stage, a region referring to the anticipationdriven modulatory function and regulation of emotional response (Petrovic et al., 2005; Phan et al., 2005; Etkin et al., 2006; Sarinopoulos et al., 2006; Egner et al., 2008), and the acti…”
BackgroundEmotion-specific nocebo effects: an fMRI study
Schienle, A., Höfler, C., Übel, S., & Wabnegger, A. (2017) · Brain Imaging and Behavior · doi:10.1007/s11682-017-9675-1 · Cited by 17
Placebo Analgesia—Understanding the Mechanisms and Implications for Clinical Practice
Finniss, D. G., Nicholas, M. K., & Benedetti, F. (2009) · Reviews in Pain · doi:10.1177/204946370900300205 · Cited by 13
Hjorth, O., Frick, A., Gingnell, M., Engman, J., Björkstrand, J., Faria, V., Alaie, I., Carlbring, P., Andersson, G., Jonasson, M., et al. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02187-3 · Cited by 13
Baker, J., Gamer, M., Rauh, J., & Brassen, S. (2022) · Scientific Reports · doi:10.1038/s41598-022-09342-2 · Cited by 15
Nilsonne, G., Tamm, S., Golkar, A., Sörman, K., Howner, K., Kristiansson, M., Olsson, A., Ingvar, M., & Petrovic, P. (2017) · Royal Society Open Science · doi:10.1098/rsos.160607 · Cited by 13
Self-citationWhy Do People Believe What They Do? A Functionalist Perspective
Boden, M. T., Berenbaum, H., & Gross, J. J. (2016) · Review of General Psychology · doi:10.1037/gpr0000085 · Cited by 14
“Phenomena such as the placebo and nocebo effect may be a direct reflection of the success at which treatment-related expectations fulfill a hedonic function (Petrovic et al., 2005).”
BackgroundHow neuroimaging can help us to visualise and quantify pain?
Wartolowska, K. A. (2011) · European Journal of Pain Supplements · doi:10.1016/j.eujps.2011.08.012 · Cited by 12
“The functional connectivity between the rostral anterior cingulate cortex and the prefrontal cortex is directly associated with a magnitude of pain relief related to the placebo effect (Petrovic et al., 2005; Wager et al., 2004).”
BackgroundInfluentialEmbodiment and Our Immersion With Others: Commentary On Fonagy and Target
Emde, R. (2007) · Journal of the American Psychoanalytic Association · doi:10.1177/00030651070550020301 · Cited by 13
Colloca, L. (2020) · International review of neurobiology · doi:10.1016/bs.irn.2020.04.001 · Cited by 15
Neuroimaging Studies of Antidepressant Placebo Effects: Challenges and Opportunities
Brown, V. M., & Peciña, M. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00669 · Cited by 10
“analgesic), during the associative learning phase.(24).”
BackgroundPlacebo analgesia: Friend or foe?
Price, D. D., Fillingim, R. B., & Robinson, M. E. (2006) · Current Rheumatology Reports · doi:10.1007/s11926-006-0035-1 · Cited by 15
Burke, M. J., Sandra, D. A., Peciña, M., Olson, J. A., Mollica, A., Butler, M., Moss, J. H., Nicholson, T. R., Wager, T. D., & Kaptchuk, T. J. (2026) · The Lancet Psychiatry · doi:10.1016/s2215-0366(25)00340-2 · Cited by 12
Ozpolat, M. C., Okcay, Y., Ulusoy, K. G., & Yıldız, O. (2025) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-025-03818-6 · Cited by 15
Kassaa, I. A., & Fuad, M. (2024) · Nutrients · doi:10.3390/nu16172936 · Cited by 11
Swider, K. J., Bąbel, P., Wronka, E., van Rijn, C. M., & Oosterman, J. M. (2019) · PLoS ONE · doi:10.1371/journal.pone.0222805 · Cited by 14
“EEG studies could be more effective in capturing the differences in the magnitude of the placebo effect in both PC and UC, as previous studies showed that placebo suggestions decreased brain activity in the regions related to anxiety processing [38,39].”
ResultHoring, B., Weimer, K., Muth, E. R., & Enck, P. (2015) · Applied Psychophysiology and Biofeedback · doi:10.1007/s10484-015-9284-y · Cited by 11
Lengersdorff, L. L., Wagner, I. C., Mittmann, G., Sastre-Yagüe, D., Lüttig, A., Olsson, A., Petrovic, P., & Lamm, C. (2023) · eLife · doi:10.7554/elife.84951 · Cited by 10
“To investigate emotional reactivity to violent images, we used an affective picture paradigm ( Olofsson et al., 2008 ; Petrovic et al., 2005 ).”
MethodSelf-citationCan placebos reduce intrusive memories?
Kube, T., Kirsch, I., Glombiewski, J., & Herzog, P. (2022) · Behaviour Research and Therapy · doi:10.1016/j.brat.2022.104197 · Cited by 10
Effect of expectation on pain assessment of lower- and higher-intensity stimuli
Ružić, V., Ivanec, D., & Stanke, K. M. (2016) · Scandinavian Journal of Pain · doi:10.1016/j.sjpain.2016.09.013 · Cited by 10
Annoni, M. (2016) · ecancermedicalscience · doi:10.3332/ecancer.2013.346 · Cited by 7
“Is it possible to change the way people perceive emotional pictures by manipulating their expectations? To answer this question, Petrovic and his colleagues [14] conducted a trial on the ‘emotional placebo’ in which unpleasant images were presented to people who had to rate how much unpleasantness they experienced.”
BackgroundSomatization and stimulus entrapment.
Meares, R., Gerull, F., Korner, A., Melkonian, D., Stevenson, J., & Samir, H. (2008) · Journal of American Academy of Psychoanalysis and Dynamic Psychiatry · doi:10.1521/jaap.2008.36.1.165 · Cited by 10
“When pain is made to abate either by distraction or nonhypnotic suggestion (e.g., placebo), there is increased activity in the rostral ACC (i.e., BA 24) and the lateral orbitofrontal cortex (Bantick et al., 2002; Petrovic et al., 2005), suggesting that these are involved in inhibitory mechanisms.”
BackgroundDo hypnotic analgesic interventions contain placebo effects?
Price, D. (2006) · Pain · doi:10.1016/j.pain.2006.04.021 · Cited by 10
“If so, should we call them ‘‘placebo effects’’? Neurobiologists and psychologists have independently suggested that placebo mechanisms reflect emotional regulation, an idea roughly similar to but not identical with the older idea that placebo responses reflect anxiety reduction (Price, 1999; Vase et al., 2003, 2005; F…”
ResultBrasier, A. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4614-8603-9 · Cited by 10
Positive and Negative Emotions and Placebo Analgesia
Flaten, M., Aslaksen, P., & Lyby, P. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-397928-5.00008-8 · Cited by 9
Reclaiming ritual in palliative care: A hermeneutic narrative review
Butler, C., Michael, N. G., & Kissane, D. W. (2025) · Palliative & Supportive Care · doi:10.1017/s1478951524001767 · Cited by 11
“In modern medicine, the effectiveness of placebo and nocebo treatments show that “ritual and words” can powerfully alter neurophysiology through behavioral conditioning, directing attention, expectations, and hope (Benedetti et al. 2011; Petrovic et al. 2005; Wager et al. 2004).”
Targeting neural correlates of placebo effects
Romanella, S. M., Mencarelli, L., Burke, M. J., Rossi, S., Kaptchuk, T. J., & Santarnecchi, E. (2022) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-022-01039-3 · Cited by 11
Sezer, D., Locher, C., & Gaab, J. (2022) · Scientific Reports · doi:10.1038/s41598-022-25446-1 · Cited by 9
Placebo effects on the quantity and quality of relaxation training
Höfler, C., Osmani, F., & Schienle, A. (2020) · Journal of Health Psychology · doi:10.1177/1359105320954238 · Cited by 8
“Placebos have also been used in other areas, for example, to reduce the intensity of negative feelings such as anxiety and disgust (e.g. Petrovic et al., 2005; Schienle et al., 2014), to improve physical performance (e.g. Beedie and Foad, 2009; Pollo et al., 2011), and cognitive performance (e.g.…”
Is Self-Compassion Important for Health Care Practitioners?
Clevenger, S. F. (2019) · OBM Integrative and Complementary Medicine · doi:10.21926/obm.icm.1901007 · Cited by 9
Enhanced Instructed Fear Learning in Delusion-Proneness
Louzolo, A., Almeida, R., Guitart‐Masip, M., Björnsdotter, M., Lebedev, A. V., Ingvar, M., Olsson, A., & Petrović, P. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.786778 · Cited by 9
Self-citationThe subthalamic nucleus and the placebo effect in Parkinson's disease
Frisaldi, E., Zamfira, D. A., & Benedetti, F. (2021) · Handbook of clinical neurology · doi:10.1016/b978-0-12-820107-7.00027-6 · Cited by 8
Benedetti, F., & Schedlowski, M. (2014) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-662-44519-8 · Cited by 8
“The ventral striatum (nucleus accumbens) is also involved in placebo effects in anxiety (Petrovic et al. 2005), depression (Mayberg et al.”
BackgroundBoorman, D. C., Crawford, L., Henderson, L. A., & Keay, K. A. (2025) · Communications Biology · doi:10.1038/s42003-025-07993-1 · Cited by 7
“These were the majority of the regions identi fi ed by our analysis: the dorsolateral prefrontal cortex (dlPFC 22,23 ), the medial prefrontal cortex (mPFC 24 ), the rostral ventromedial medulla (RVM), paraventricular hypothalamus (PVH 25 ), the amygdala 26 , S1, and the thalamus 21 .”
Central correlates of placebo effects in nausea differ between men and women
Haile, A., Watts, M., Aichner, S., Stahlberg, F., Hoffmann, V. S., Tschoep, M., & Meissner, K. (2022) · Brain and Behavior · doi:10.1002/brb3.2685 · Cited by 7
“…the reduction of fear and anxiety following placebo treatment, changes in prefrontal activity andACCwere detectedduring the anticipation phase, andACCactivitywas positively related to positive expectation toward the placebo treatment and the perceived placebo effect (Petrovic et al., 2005).”
BackgroundResultSchienle, A., Gremsl, A., & Wabnegger, A. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.653359 · Cited by 7
A transferable anxiolytic placebo effect from noise to negative effect
Zhao, Y., Zhang, J., Yuan, L.-Z., Luo, J., Guo, J., & Zhang, W. (2015) · Journal of Mental Health · doi:10.3109/09638237.2015.1021900 · Cited by 7
“Petrovic et al. (2005) first studied the anxiolytic placebo effect by using a potent anxiolytic drug to reinforce placebo expectation, but this method may bring potential side effect of drugs and ethical issues relating to pharmaceutical experiments.”
BackgroundSpinal and Supraspinal Mechanisms of Placebo Analgesia
Eippert, F., & Büchel, C. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-397928-5.00007-6 · Cited by 8
Constructing the Placebo Effect in the Placebo Wars: What is the Way Ahead?
Foot, D., & Ridge, D. (2012) · Health Sociology Review · doi:10.5172/hesr.2012.21.3.355 · Cited by 7
“Petrovic et al. (2005) established a positive correlation between the reported placebo effect of analgesia and expectation of relief of pain (that was reported on the previous day).”
BackgroundEffects of oxazepam on affective perception, recognition, and event-related potentials
Olofsson, J., Gospic, K. A. M., Petrović, P., Ingvar, M., & Wiens, S. (2011) · Psychopharmacology · doi:10.1007/s00213-010-2141-z · Cited by 10
“Previous studies of benzodiazepines showed mixed results (Patrick et al. 1996; Petrovic et al. 2005).”
BackgroundResultInfluentialSelf-citationBelieving in the Effectiveness of Treatment: From Placebo to Credition and Back
Meißner, K. (2017) · New approaches to the scientific study of religion · doi:10.1007/978-3-319-50924-2_9 · Cited by 8
Central nervous system influences in asthma.
Kline, J., & Rose, R. M. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4614-8603-9_19 · Cited by 7
Schienle, A., Kogler, W., & Wabnegger, A. (2023) · Scientific Reports · doi:10.1038/s41598-023-39806-y · Cited by 9
Resistance to Extinction of Evaluative Fear Conditioning in Delusion Proneness
Louzolo, A., Lebedev, A. V., Björnsdotter, M., Acar, K., Ahrends, C., Kringelbach, M. L., Ingvar, M., Olsson, A., & Petrović, P. (2022) · Schizophrenia Bulletin Open · doi:10.1093/schizbullopen/sgac033 · Cited by 6
Self-citationNeto, E. C. (2016) · Scientific Reports · doi:10.1038/srep37154 · Cited by 6
“Because the instrumental variable Q is randomized, and hence statistically independent of any variables that are not directly or indirectly influenced by Q, it follows from equation (5) and standard properties of the covariance operator that,”
InfluentialThe Therapeutic use of placebos among Hungarian GPs: A preliminary research report
Ferentzi, E., Köteles, F., & Bárdos, G. (2011) · Clinical and Experimental Medical Journal · doi:10.1556/cemed.4.2010.2.5 · Cited by 6
Irving, G. A. (2010) · Clinical Drug Investigation · doi:10.2165/11584300-000000000-00000 · Cited by 11
Biological, clinical, and ethical advances of placebo effects
Finniss, D. G., Kaptchuk, T. J., Miller, F. G., & Benedetti, F. (2010) · The Lancet · doi:10.1016/s0140-6736(09)61706-2 · Cited by 1,309
“…Changes in activity of the anterior cingulated and orbitofrontal cortices; genetic variants of serotonin transporter and tryptophan hydroxylase 2 28, 29 Addiction Changes of metabolic activity in different brain regions 30 Autonomic responses to deep brain stimulation Change of neuronal…”
Placebo Effects Are Small on Average in the 7.5% CO2 Inhalational Model of Generalized Anxiety
Huneke, N. T. M., Cross, C., Fagan, H. A., Molteni, L., Phillips, N., Garner, M. J., & Baldwin, D. S. (2024) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyae019 · Cited by 5
“In the first of these studies, placebo effects were seen following a conditioning procedure involving active medications (midazolam and flumazenil) on day 1 and then a testing session on day 2 with saline only (Petrovic et al., 2005).”
InfluentialChoi, J. C., Park, H., Park, J. A., Kang, D. R., Choi, Y.-S., Choi, S., Lee, H. G., Choi, J.-H., Choi, I., Yoon, M., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-18181-0 · Cited by 8
Hartmann, H., Riva, F., Rütgen, M., & Lamm, C. (2021) · Cerebral Cortex Communications · doi:10.1093/texcom/tgab039 · Cited by 10
Placebo Manipulations Reverse Pain Potentiation by Unpleasant Affective Stimuli
Reicherts, P., Pauli, P., Camilla, M., & Wieser, M. J. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00663 · Cited by 7
“Separate ANOVAs for each group revealed a significant main effect of Emotion for both the nocebo F(1, 19) = 22.”
BackgroundMethodInfluentialPerspectives on Placebo: The Psychology of Neurofeedback
Thornton, K. (2018) · NeuroRegulation · doi:10.15540/nr.5.4.137 · Cited by 5
“…et al., 2009; 139 | www.neuroregulation.org Vol. 5(4):137–149 2018 doi:10.15540/nr.5.4.137 Petrovic, Kalso, Petersson, & Ingvar, 2002; Wager et al., 2004; Zubieta et al., 2005), depression (Leuchter, Cook, Witte, Morgan, & Abrams, 2002), and anxiety (Furmark et al., 2008; Petrovic et al., 2005).”
InfluentialAre There Biological Commonalities Among Different Psychiatric Disorders?
Etkin, A., & Pittenger, C. (2015) · Wiley eBooks · doi:10.1002/9781118753378.ch15 · Cited by 4
Chouchou, F., & Lavigne, G. J. (2014) · Pathologie Biologie · doi:10.1016/j.patbio.2014.07.001 · Cited by 5
Vase, L., & Petersen, G. L. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-397928-5.00020-9 · Cited by 5
Placebo Response and Placebo Effect
Benedetti, F., & Shaibani, A. I. (2025) · Neurologic Clinics · doi:10.1016/j.ncl.2025.08.001 · Cited by 5
Placebo treatment entails resource-dependent downregulation of negative inputs
Mostauli, A., Rauh, J., Gamer, M., Büchel, C., Rief, W., & Brassen, S. (2025) · Scientific Reports · doi:10.1038/s41598-025-93589-y · Cited by 4
Using Neurofeedback to Improve ADHD Symptoms in School-Aged Children
McReynolds, C. J., Villalpando, L., & Britt, C. (2018) · NeuroRegulation · doi:10.15540/nr.5.4.109 · Cited by 4
Bialosky, J. E., & Robinson, M. E. (2017) · Journal of Manual & Manipulative Therapy · doi:10.1080/10669817.2017.1298699 · Cited by 4
Metadata
- Authors
- Petrovic, P., Dietrich, T., Fransson, P., Andersson, J., Carlsson, K., & Ingvar, M.
- Affiliations
- Karolinska University Hospital (SE)
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2005-06
- Volume
- 46
- Issue
- 6
- Pages
- 957-969
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1979589689
- Cited by
- 437
- References
- 0
- Citations by year
- 2026: 6 · 2025: 15 · 2024: 8 · 2023: 9 · 2022: 19 · 2021: 19 · 2020: 18 · 2019: 15 · 2018: 19 · 2017: 16 · 2016: 24 · 2015: 25 · 2014: 28 · 2013: 34 · 2012: 25
- FWCI
- 12.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Petrus och Augusta Hedlunds Stiftelse
- Sveriges Läkarförbund
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- placebo effect, emotional processing, anxiety reduction, reward processing, placebo analgesia, treatment expectations, unpleasant pictures, rostral anterior cingulate cortex, lateral orbitofrontal cortex, pain perception
- MeSH terms
- Adult, Anxiety, Benzodiazepines, Brain Mapping, Emotions, Female, Flumazenil, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Nerve Net, Oxygen, Photic Stimulation, Placebos, Time Factors, Anti-Anxiety Agents, Placebo Effect
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