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Placebo in emotional processing—induced expectations of anxiety relief activate a generalized modulatory network
Open accessAbstract
Placebo analgesia and reward processing share several features. For instance, expectations have a strong influence on the subsequent emotional experience of both. Recent imaging data indicate similarities in the underlying neuronal network. We hypothesized that placebo analgesia is a special case of reward processing and that placebo treatment could modulate emotional perception in the same way as does pain perception. The behavioral part of this study indicates that placebo treatment has an effect on how subjects perceive unpleasant pictures. Furthermore, event-related fMRI demonstrated that the same modulatory network, including the rostral anterior cingulate cortex and the lateral orbitofrontal cortex, is involved in both emotional placebo and placebo analgesia. These effects were correlated with the reported placebo effect and were predicted by the amount of treatment expectation induced on a previous day. Thus, the placebo effect may be considered to be a general process of modulation induced by the subjects' expectations.
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“Importantly, this activation remained when controlling for non-emotional attentional aspects of treatment either through interaction or correlation analyses (Petrovic et al., 2002, 2005).”
From Top-Down Dysregulation—From ADHD to Emotional Instability (2016) · cites this paper as Petrovic et al., 2005
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Items 101–200 of 393
Lu, H.-C., Hsieh, J., Lu, C., Niddam, D. M., Wu, Y., Yeh, T., Cheng, C.-M., Chang, F.-Y., & Lee, S. (2009) · Pain · doi:10.1016/j.pain.2009.10.012 · Cited by 85
Garza-Villarreal, E., Jiang, Z.-G., Vuust, P., Alcauter, S., Vase, L., Pasaye, E., Cavazos-Rodriguez, R., Brattico, E., Jensen, T., & Barrios, F. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.01051 · Cited by 86
“In fact, areas that have been associated to a modulatory network in central (nonpharmacological) analgesia are: the rACC, OFC, and the dlPFC (Petrovic et al., 2005).”
BackgroundYu, R., Gollub, R. L., Vangel, M. G., Kaptchuk, T. J., Smoller, J. W., & Kong, J. (2014) · Human Brain Mapping · doi:10.1002/hbm.22496 · Cited by 80
“…of reward has been suggested as a potential mechanism to explain how positive expectancy can produce pain relief (Benedetti, 2009; de la Fuente-Fernandez et al., 2001; Flaten et al., 2011; Leknes et al., 2011; Petrovic et al., 2005; Rhudy et al., 2008; Scott et al., 2007; Seymour et al., 2005).”
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Mindsets Matter: A New Framework for Harnessing the Placebo Effect in Modern Medicine
Zion, S. R., & Crum, A. J. (2018) · International review of neurobiology · doi:10.1016/bs.irn.2018.02.002 · Cited by 96
“…diseases (de la Fuente-Fernandez & Stoessl, 2002; Goebel, Meykadeh, Kou, Schedlowski, & Hengge, 2008; Levine, Gordon, Smith, & Fields, 1981; Petrovic et al., 2005; Pollo, Vighetti, Rainero, & Benedetti, 2003; Shetty, Friedman, Kieburtz, Marshall, & Oakes, 1999; Walsh, Seidman, Sysko, &…”
Kong, J., Wang, Z., Leiser, J., Minicucci, D., Edwards, R. R., Kirsch, I., Wasan, A. D., Lang, C., Gerber, J. A., Yu, S., et al. (2018) · NeuroImage Clinical · doi:10.1016/j.nicl.2018.01.021 · Cited by 81
Resignation Syndrome: Catatonia? Culture-Bound?
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“These peculiar circumstances are difficult to explain without reference to culture and context and we therefore assert RS to be culture-bound.”
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“The medial PFC and ACC were further reported to mediate placebo induced anxiolytic effects [26] as well as the effortful regulation of affective states and subsequent behaviour [20].”
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“Consistent with other reports on expectations of various forms of aversion (Koyama et al., 2005; Nitschke et al., 2006; O'Doherty et al., 2002; Petrovic et al., 2005; Ploghaus et al., 1999; Wager et al., 2004), these areas all show greater activation during the expectancy period for both conditions…”
BackgroundResultInfluentialNetwork modulation following sham surgery in Parkinson’s disease
Ko, J. H., Feigin, A., Mattis, P. J., Tang, C. C., Ma, Y., DHAWAN, V. M., During, M. J., Kaplitt, M. G., & Eidelberg, D. (2014) · Journal of Clinical Investigation · doi:10.1172/jci75073 · Cited by 91
“Indeed, changes in these and related brain regions have been found to accompany placebo effects occurring in the context of emotional processing (10, 16).”
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“…accordance with the general literature on pain and PTSD (Moeller-Bertram et al., 2012) and is supported by the generally accepted notion that cognitive pain modulation is dependent on previous pain experiences and is associated with affective aspects (Ploghaus et al., 2003; Petrovic et al., 2005).”
BackgroundDisgust regulation via placebo: an fMRI study
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“Petrovic et al. (2005) presented their subjects with unpleasant pictures after they had been treated with an anxiolytic drug.”
BackgroundMethodResultInfluentialPlacebos without deception reduce self-report and neural measures of emotional distress
Guevarra, D. A., Moser, J. S., Wager, T. D., & Kross, E. F. (2020) · Nature Communications · doi:10.1038/s41467-020-17654-y · Cited by 79
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Toward a Biological Understanding of Mortality Salience (And Other Threat Compensation Processes)
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“Recent functional neuroimaging research has suggested that placebo pills attenuate activation of neural processes associated with negative emotional responses to aversive visual stimuli (Petrovic et al., 2005).”
BackgroundSeparating the effects of alcohol and expectancy on brain activation: An fMRI working memory study
Gundersen, H. S., Specht, K., Grüner, R., Ersland, L., & Hugdahl, K. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.05.037 · Cited by 51
“Petrovic et al. (2005) have demonstrated that the placebo effect can be thought of as a general modulation process induced by the subject's expectancies.”
Placebo-Induced Improvements: How Therapeutic Rituals Affect the Patient's Brain
Benedetti, F. (2012) · Journal of Acupuncture and Meridian Studies · doi:10.1016/j.jams.2012.03.001 · Cited by 61
“Interestingly, the areas involved in placebo analgesia, including those related to placebo acupuncture, are part of a general circuit underlying the voluntary regulation of affective responses (see [20 e 22]).”
The sweetest pill to swallow: How patient neurobiology can be harnessed to maximise placebo effects
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“The potential for treatment choice to reduce anxiety is particularly important, as both prior research and theory points to anxiety reduction as a key cause of placebo effects ( Petrovic et al., 2005; Turner et al., 1994).”
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A social affective neuroscience lens on placebo analgesia
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“To what extent are the brain mechanisms of placebo conserved across modalities? Petrovic and colleagues [42] compared brain imaging data from a study of placebo analgesia [72] with a study of placebo anxiolytics [108] in which participants viewed emotional images when they believed they had received an anxiolytic trea…”
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Experimental Placebo Analgesia Changes Resting-State Alpha Oscillations
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What if I Get Busted? Deception, Choice, and Decision-Making in Social Interaction
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Experimental designs and brain mapping approaches for studying the placebo analgesic effect
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“…present in other systems and pathological conditions, such as depression (Leuchter et al. 2002, 2004; Mayberg et al. 2002), emotionself regulation (Petrovic et al. 2005), endocrine system (Benedetti et al. 2003), immune disorders (Goebel et al. 2002; for a review see Pacheco-Lopez et al. 2006),…”
BackgroundPlacebo and other psychological interactions in headache treatment
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“The analgesic placebo-induced expectation network is a part of a wider emotion control system [31].”
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“The key role of the ventral ACC in controlling negative affects has been highlighted by paradigms testing fear extinction in both humans and animals (Delgado et al. 2006; LeDoux, 2003; Phelps et al. 2004) and in human studies of anxiety suppression (Petrovic et al. 2005).”
BackgroundFrontal-Brainstem Pathways Mediating Placebo Effects on Social Rejection
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Expectancy-Induced Placebo Analgesia in Children and the Role of Magical Thinking
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“Different psychological mechanism such as activation of reward processes (48, 49), reframing (50), decline of self-defeating thoughts (51), motivational gain (52) and anxiety reduction (53) have been considered to explain these positive health-coupled changes in the mind-brain body unit.”
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Placebo and nocebo responses in drug trials of epilepsy
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Well-Loved Music Robustly Relieves Pain: A Randomized, Controlled Trial
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“Consistent with previous findings in other types of opioid analgesia (Gospic et al, 2008; Kupers et al, 1991; Price et al, 1985), remifentanil reduced overall ratings of pain unpleasantness.”
Reward processing as a common diathesis for chronic pain and depression
Rizvi, S. J., Gandhi, W., & Salomons, T. V. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.04.033 · Cited by 50
Ly, H. G., Ceccarini, J., Weltens, N., Bormans, G., van Laere, K., Tack, J., & van Oudenhove, L. (2015) · Psychotherapy and Psychosomatics · doi:10.1159/000375454 · Cited by 44
Placebo Responses in Genetically Determined Intellectual Disability: A Meta-Analysis
Curie, A., Yang, K., Kirsch, I., Gollub, R. L., des Portes, V., Kaptchuk, T. J., & Jensen, K. B. (2015) · PLOS ONE · doi:10.1371/journal.pone.0133316 · Cited by 43
“…mechanisms associated with placebo responses have been described in studies of Parkinson disease [10, 11], pain [12 – 15], depression [16] and anxiety [17, 18] and suggest a model of prefrontal cognitive control that modulates activity and neurotransmitter function further down the neural axis.”
BackgroundAffect and emotions in placebo and nocebo effects: What do we know so far?
Geers, A. L., Faasse, K., Guevarra, D. A., Clemens, K. S., Helfer, S. G., & Colagiuri, B. (2020) · Social and Personality Psychology Compass · doi:10.1111/spc3.12575 · Cited by 48
Frisaldi, E., Carlino, E., Lanotte, M., Lopiano, L., & Benedetti, F. (2014) · Cortex; a journal devoted to the study of the nervous system and behavior · doi:10.1016/j.cortex.2013.12.003 · Cited by 42
“First, expectation of a positive outcome may reduce anxiety (Petrovic et al., 2005 and Vase et al., 2005) and second, it can activate reward mechanisms, whereby the reward is the therapeutic benefit itself (de la Fuente-Fernández et al., 2001 and Scott et al., 2007).”
BackgroundTreatment history and placebo responses to experimental and clinical pain in chronic pain patients
Müller, M., Kamping, S., Benrath, J., Skowronek, H., Schmitz, J., Klinger, R., & Flor, H. (2016) · European Journal of Pain · doi:10.1002/ejp.877 · Cited by 42
The transferable placebo effect from pain to emotion: Changes in behavior and EEG activity
Zhang, W., & Luo, J. (2009) · Psychophysiology · doi:10.1111/j.1469-8986.2009.00786.x · Cited by 42
“Recent neuroimaging studies have revealed the brain basis of placebo effects on pain and emotion regulation (Petrovic et al., 2005; Wager et al., 2004).”
BackgroundInfluentialPlacebo analgesia affects the behavioral despair tests and hormonal secretions in mice
Guo, J., Yuan, X., Sui, F., Zhang, W., Wang, J., Luo, F., & Luo, J. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2259-7 · Cited by 45
“Neuroimaging studies have also revealed the brain basis of placebo effects on pain and emotion regulation (Petrovic et al. 2005; Wager et al. 2004).”
Why Symbolic Processing of Affect Can Disrupt Negative Affect
Lieberman, M. D. (2011) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195316872.003.0013 · Cited by 39
“Multiple other studies have also observed within session placebo effects associated with increased RVLPFC activity and decreased limbic activity in the domains of physical pain (Petrovic et al., 2002; Wager et al., 2004) and anxiety (Petrovic et al., 2005).”
BackgroundNeural Mechanisms of Placebo Anxiolysis
Meyer, B., Yuen, K. S. L., Ertl, M., Polomac, N., Mulert, C., Büchel, C., & Kalisch, R. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4793-14.2015 · Cited by 50
A follow‐up fMRI study of a transferable placebo anxiolytic effect
Zhang, W., Qin, S., Guo, J., & Luo, J. (2011) · Psychophysiology · doi:10.1111/j.1469-8986.2011.01178.x · Cited by 36
“In previous studies, some reports on the placebo effect have applied retrospective rating for each block of emotional pictures (e.g., Petrovic et al., 2005), whereas others adopted the immediate rating of each stimulus (e.g., Wager et al., 2004; Kong et al., 2006, 2008).”
BackgroundMethodResultInfluentialEmotional perception modulated by an opioid and a cholecystokinin agonist
Gospic, K. A. M., Gunnarsson, T., Fransson, P., Ingvar, M., Lindefors, N., & Petrović, P. (2007) · Psychopharmacology · doi:10.1007/s00213-007-1032-4 · Cited by 44
“We have previously suggested that top-down cognitive control mechanisms may be effected by specific descending neuromodulatory systems to regulate ongoing possessing of pain (Petrovic et al. 2002) and emotions ( Petrovic et al. 2005 ).”
InfluentialSelf-citationPetrovic, P., Ekman, C. J., Klahr, J., Tigerström, L., Rydén, G., Johansson, A. G. M., Sellgren, C., Golkar, A., Olsson, A., Öhman, A., et al. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsv072 · Cited by 38
“Two key regions are especially important in top-down control of emotional processing: rostral anterior cingulate cortex (rACC) (Bush et al., 2000; Petrovic et al., 2005; Etkin et al., 2006, 2011) and lateral orbitofrontal cortex (lObfc) (Petrovic et al.”
BackgroundInfluentialSelf-citationAmygdala-frontal couplings characterizing SSRI and placebo response in social anxiety disorder
Faria, V., Åhs, F., Appel, L., Linnman, C., Bani, M., Bettica, P., Pich, E. M., Fredrikson, M., & Furmark, T. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145714000352 · Cited by 37
Resolving the Delusion Paradox
Petrović, P., & Sterzer, P. (2023) · Schizophrenia Bulletin · doi:10.1093/schbul/sbad084 · Cited by 45
“75,78,79 rACC is involved in regulation of emotion and pain.”
BackgroundSelf-citationRütgen, M., Wirth, E.-M., Riečanský, I., Hummer, A., Windischberger, C., Petrović, P., Silani, G., & Lamm, C. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa385 · Cited by 40
“Also, placebo treatments have major effects on general emotional processes such as unpleasantness induced by threatening pictures (Petrovic et al. 2005).”
Self-citationCarlino, E., Pollo, A., & Benedetti, F. (2011) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0b013e328349d0c2 · Cited by 33
A new animal model of placebo analgesia: involvement of the dopaminergic system in reward learning
Lee, I., Lee, B., Park, H., Olausson, H., Enck, P., & Chae, Y. (2015) · Scientific Reports · doi:10.1038/srep17140 · Cited by 42
Understanding and translating the knowledge about placebo effects
Geers, A. L., & Miller, F. G. (2014) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000082 · Cited by 36
Pain Mirrors: Neural Correlates of Observing Self or Others’ Facial Expressions of Pain
Benuzzi, F., Lui, F., Ardizzi, M., Ambrosecchia, M., Ballotta, D., Righi, S., Pagnoni, G., Gallese, V., & Porro, C. A. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.01825 · Cited by 38
“However, a meta-analysis including both neuropsychological and neuroimaging results revealed that the network involved is widespread and includes the left fusiform gyrus, the bilateral middle, and IFG gyri and right precuneus (Platek et al., 2008).”
BackgroundEisenlohr-Moul, T. A., Girdler, S. S., Johnson, J. L., Schmidt, P. J., & Rubinow, D. R. (2017) · Depression and Anxiety · doi:10.1002/da.22673 · Cited by 41
“…(4) placebo produces attenuated reactivity to negative salient cues and a neural signature associated with cognitive control (Meyer et al., 2015; Petrovic et al., 2005); and (5) uncertainty—the expectation of clinical benefit—increases the placebo response (Benedetti, 2012; de la…”
BackgroundSzekely, A., Silton, R. L., Heller, W., Miller, G. A., & Mohanty, A. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw137 · Cited by 40
“…attending to irrelevant emotional information (Whalen et al., 1998; Vuilleumier et al., 2001; Bishop et al., 2004; Mohanty et al., 2007), or exercise top-down control upon processing of emotional stimuli (Ochsner et al., 2004; Ochsner and Gross, 2005; Petrovic et al., 2005; Banks et al., 2007).”
BackgroundLasselin, J., Petrović, P., Olsson, M. J., Göranson, S. P., Lekander, M., Jensen, K. B., & Axelsson, J. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.09.008 · Cited by 36
Self-citationPlacebo analgesia and nocebo hyperalgesia – Two sides of the same coin?
Petrović, P. (2008) · Pain · doi:10.1016/j.pain.2008.03.004 · Cited by 34
Self-citationTreatment Choice and Placebo Expectation Effects
Geers, A. L., & Rose, J. P. (2011) · Social and Personality Psychology Compass · doi:10.1111/j.1751-9004.2011.00385.x · Cited by 28
Anders, S., Eippert, F., Wiens, S., Birbaumer, N., Lotze, M., & Wildgruber, D. (2009) · Brain : a journal of neurology · doi:10.1093/brain/awp212 · Cited by 32
“However, VLPFC activity is also observed during unintended, ‘passive’ sup- pression of affect as in placebo effects (Wager et al., 2004; Petrovic et al., 2005; Kong et al., 2006), when cognitive proces- sing is required against an affective background (Yamasaki et al., 2002; Northoff et al., 2004;…”
BackgroundSomething out of nothing: the placebo effect
Vallance, A. (2006) · Advances in Psychiatric Treatment · doi:10.1192/apt.12.4.287 · Cited by 32
The Neural Bases of Placebo Effects in Pain
Wager, T. D. (2005) · Current Directions in Psychological Science · doi:10.1111/j.0963-7214.2005.00359.x · Cited by 50
“The same approach can be used to investigate the role of the placebo response in anxiety (placebo anxiolytics paired with aversive images (Petrovic et al. 2005), motor performance in Parkinson’s disease (sham stimulation of subthalamic nucleus paired with motor performance (Benedetti et al.”
BackgroundPredictability modulates the anticipation and perception of pain in both self and others
Peng, W., Huang, X.-X., Liu, Y., & Cui, F. (2019) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsz047 · Cited by 31
“Knowing that pain will occur is thought to be associated with greater fear and hypoalgesia (Petrovic et al., 2005; Labrenz et al., 2016), which are triggered through the descending activation of pain-modulation systems including the rostral anterior cingulate cortex and periaqueductal gray…”
BackgroundKotsis, V., Benson, S., Bingel, U., Forsting, M., Schedlowski, M., Gizewski, E. R., & Elsenbruch, S. (2012) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2012.01968.x · Cited by 33
Context effects on odor processing: An event-related potential study
Laudien, J. H., Wencker, S., Ferstl, R., & Pause, B. M. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.03.046 · Cited by 33
The Influence of Expectation on Nondeceptive Placebo and Nocebo Effects
Wei, H., Zhou, L., Zhang, H., Chen, J., Lu, X., & Hu, L. (2018) · Pain Research and Management · doi:10.1155/2018/8459429 · Cited by 32
Sip, K. E., Carmel, D., Agustus, J. L., Li, J., Petrović, P., Roepstorff, A., McGregor, W. B., & Frith, C. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00016 · Cited by 31
“Specifically, our beliefs and expectations modulate our emotional and physiological states, the way we interact with others, and how we make and evaluate choices (e.g., Pollina et al., 2004; Petrovic et al., 2005; De Martino et al., 2006; Mobbs et al., 2006; Sip et al., 2010, 2012).”
BackgroundSelf-citationHow people think about being alone shapes their experience of loneliness
Rodriguez, M., Schertz, K. E., & Kross, E. F. (2025) · Nature Communications · doi:10.1038/s41467-025-56764-3 · Cited by 44
“…literature to outline specific strategies for fostering more adaptive beliefs about solitude (e.g., cognitive reappraisal, mindfulness) and discuss the potential benefits and challenges of implementing such interventions in different contexts (e.g., schools, workplaces, retirement communities).”
Morphine modulation of pain processing in medial and lateral pain pathways
Wang, J.-Y., Huang, J., Chang, J.-Y., Woodward, D. J., & Luo, F. (2009) · Molecular Pain · doi:10.1186/1744-8069-5-60 · Cited by 29
“[5-7]. Positron emission tomography (PET) studies detected the presence of endogenous opioid release and the changes of opioid receptor occupancy in cortex and thalamus during the experience of acute experimental and sustained clinical pain [8, 9 ].”
BackgroundColour vision: The wonder of hue
Neitz, J., & Neitz, M. (2008) · Current Biology · doi:10.1016/j.cub.2008.06.062 · Cited by 21
Prefrontal expectancy and reinforcement-driven antidepressant placebo effects
Peciña, M., Heffernan, J., Wilson, J., Zubieta, J.-K., & Dombrovski, A. Y. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0263-y · Cited by 29
The role of cognitive reappraisal in placebo analgesia: an fMRI study
van der Meulen, M., Kamping, S., & Anton, F. (2017) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsx033 · Cited by 27
“In support of this, Lapate et al. (2012) have demonstrated that a common regulation ability impacts the experience of both emotion and pain, and placebo has been shown to modulate emotional perception of pictures and pain perception similarly (Petrovic et al., 2005; Zhang and Luo, 2009).”
BackgroundPlacebo treatment can alter primary visual cortex activity and connectivity.
Schienle, A., Ubel, S., & Scharmüller, W. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.01.016 · Cited by 28
“Whereas modulatory placebo effects on the activity of the visual association cortex (Petrovic et al., 2005) have been reported before, this is the first study to show that a pharmacologically inactive substance coupled with a positive suggestion of symptom reduction is able to change activation of…”
BackgroundHow Positive and Negative Expectations Shape the Experience of Visceral Pain
Elsenbruch, S. (2014) · Handbook of experimental pharmacology · doi:10.1007/978-3-662-44519-8_6 · Cited by 26
“2011) based on the previously established connection between placebo analgesia and reward processing (Petrovic et al. 2005).”
BackgroundA Collaborator's Reputation Can Bias Decisions and Anxiety under Uncertainty
Qi, S., Footer, O., Camerer, C. F., & Mobbs, D. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.2337-17.2018 · Cited by 24
Morales-Quezada, L., Martínez, D., El-Hagrassy, M. M., Kaptchuk, T. J., Sterman, M. B., & Yeh, G. Y. (2019) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2019.106570 · Cited by 38
“Converging evidence substantiates the view that placebo responses are complex psychoneurobiological phenomena involving the activation of distinct brain areas, particularly those associated with reward, expectations, and anxiety regulation [49].”
BackgroundDias, M., Vellarde, G., Olej, B., Salgado, A. E. T., & Rezende, I. D. B. (2014) · Acupuncture in Medicine · doi:10.1136/acupmed-2013-010408 · Cited by 26
Harte, S. E., Spuz, C. A., & Borszcz, G. S. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.10.055 · Cited by 34
“Human neuroimaging studies demonstrated preferential activation of rACC during a variety of interventions reported to reduce the perception of pain unpleasantness, and these increases in rACC activation were accompanied by a reduction of noxious-evoked activity in cACC (Garcia-Larrea et al., 1997; Garcia-Larrea et al.…”
BackgroundShimoji, K., Takahashi, N., Nishio, Y., Koyanagi, M., & Aida, S. (2007) · Neuromodulation (Malden, Mass.) · doi:10.1111/j.1525-1403.2007.00086.x · Cited by 26
Understanding the placebo effect from an evolutionary perspective
Trimmer, P. C., Marshall, J. A. R., Fromhage, L., McNamara, J., & Houston, A. (2013) · Evolution and Human Behavior · doi:10.1016/j.evolhumbehav.2012.07.004 · Cited by 26
Månsson, K. N. T., Lasselin, J., Karshikoff, B., Axelsson, J., Engler, H., Schedlowski, M., Benson, S., Petrović, P., & Lekander, M. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.09.007 · Cited by 30
“Interestingly, it has been suggested that the lateral orbitofrontal cortex has a pivotal role in such top-down predictions within the interoceptive-emotional domain (Petrovic et al., 2005, 2002).”
BackgroundSelf-citationNeural mechanism of placebo effects and cognitive reappraisal in emotion regulation
Zhang, W., Guo, J., Zhang, J., & Luo, J. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.10.020 · Cited by 25
Metadata
- Authors
- Petrovic, P., Dietrich, T., Fransson, P., Andersson, J., Carlsson, K., & Ingvar, M.
- Affiliations
- Karolinska University Hospital (SE)
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2005-06
- Volume
- 46
- Issue
- 6
- Pages
- 957-969
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1979589689
- Cited by
- 437
- References
- 0
- Citations by year
- 2026: 6 · 2025: 15 · 2024: 8 · 2023: 9 · 2022: 19 · 2021: 19 · 2020: 18 · 2019: 15 · 2018: 19 · 2017: 16 · 2016: 24 · 2015: 25 · 2014: 28 · 2013: 34 · 2012: 25
- FWCI
- 12.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Petrus och Augusta Hedlunds Stiftelse
- Sveriges Läkarförbund
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- placebo effect, emotional processing, anxiety reduction, reward processing, placebo analgesia, treatment expectations, unpleasant pictures, rostral anterior cingulate cortex, lateral orbitofrontal cortex, pain perception
- MeSH terms
- Adult, Anxiety, Benzodiazepines, Brain Mapping, Emotions, Female, Flumazenil, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Nerve Net, Oxygen, Photic Stimulation, Placebos, Time Factors, Anti-Anxiety Agents, Placebo Effect
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