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Mechanism of Graded Persistent Cellular Activity of Entorhinal Cortex Layer V Neurons
Open accessAbstract
Working memory is an emergent property of neuronal networks, but its cellular basis remains elusive. Recent data show that principal neurons of the entorhinal cortex display persistent firing at graded firing rates that can be shifted up or down in response to brief excitatory or inhibitory stimuli. Here, we present a model of a potential mechanism for graded firing. Our multicompartmental model provides stable plateau firing generated by a nonspecific calcium-sensitive cationic (CAN) current. Sustained firing is insensitive to small variations in Ca2+ concentration in a neutral zone. However, both high and low Ca2+ levels alter firing rates. Specifically, increases in persistent firing rate are triggered only during high levels of calcium, while decreases in rate occur in the presence of low levels of calcium. The model is consistent with detailed experimental observations and provides a mechanism for maintenance of memory-related activity in individual neurons.
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“ACh enhances persistent spiking or plateau potentials within cortical structures, as demonstrated in brain slice preparations of the entorhinal cortex (Klink and Alonso, 1997; Egorov et al., 2002; Fransen et al., 2006; Tahvildari et al., 2007), prefrontal cortex (Haj-Dahmane and Andrade, 1996, 1997, 1998), postsubiculum (Yoshida and Hasselmo, 2009) and perirhinal cortex (Leung et al., 2006).”
From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Fransen et al., 2006
In the citing paper
“Persistent spiking appears to result from muscarinic receptor activation of a calcium-sensitive non-specific cation current I(CAN) (Egorov et al., 2002; Shalinsky et al., 2002; Fransen et al., 2006).”
From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Fransen et al., 2006
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Metadata
- Authors
- Fransén, E., Tahvildari, B., Egorov, A. V., Hasselmo, M. E., & Alonso, A. A.
- Affiliations
- KTH Royal Institute of Technology (SE)
- Montreal Neurological Institute and Hospital (CA)
- Heidelberg University (DE)
- Boston University (US)
- Corresponding author
- Fransén, Erik
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2006-03
- Volume
- 49
- Issue
- 5
- Pages
- 735-746
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2156985666
- Cited by
- 279
- References
- 54
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 11 · 2023: 5 · 2022: 5 · 2021: 16 · 2020: 13 · 2019: 8 · 2018: 14 · 2017: 7 · 2016: 10 · 2015: 10 · 2014: 18 · 2013: 19 · 2012: 16
- FWCI
- 11.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- Vetenskapsrådet
- Canadian Institutes of Health Research
- National Institute of Mental Health (MH 60013, MH61492, R01MH061492)
- National Institute on Drug Abuse (DA 16454, R01DA016454)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- entorhinal cortex, layer V neurons, persistent neuronal activity, working memory, multicompartmental neuron models, calcium concentration, memory maintenance
- MeSH terms
- Action Potentials, Animals, Calcium, Dose-Response Relationship, Radiation, Electric Stimulation, Enzyme Inhibitors, Indoles, Models, Neurological, Neurons, Time Factors, Calcium Channels, Potassium Channels, Nonlinear Dynamics, Entorhinal Cortex, Thapsigargin, Calcium Signaling, Rats, In Vitro Techniques
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