Cholinergic suppression of visual responses in primate V1 is mediated by GABAergic inhibition
Open accessAbstract
Acetylcholine (ACh) has been implicated in selective attention. To understand the local circuit action of ACh, we iontophoresed cholinergic agonists into the primate primary visual cortex (V1) while presenting optimal visual stimuli. Consistent with our previous anatomical studies showing that GABAergic neurons in V1 express ACh receptors to a greater extent than do excitatory neurons, we observed suppressed visual responses in 36% of recorded neurons outside V1's primary thalamorecipient layer (4c). This suppression is blocked by the GABA A receptor antagonist gabazine. Within layer 4c, ACh release produces a response gain enhancement (Disney AA, Aoki C, Hawken MJ. Neuron 56: 701–713, 2007); elsewhere, ACh suppresses response gain by strengthening inhibition. Our finding contrasts with the observation that the dominant mechanism of suppression in the neocortex of rats is reduced glutamate release. We propose that in primates, distinct cholinergic receptor subtypes are recruited on specific cell types and in specific lamina to yield opposing modulatory effects that together increase neurons' responsiveness to optimal stimuli without changing tuning width.
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Stimulation of nicotinic ACh receptors with nicotine in macaque V1 causes increases in firing rates and gain modulation of sensory-evoked activity in thalamo-recipient cortical layers and has various effects in other layers.
“Stimulation of nicotinic ACh receptors (nAChRs) with nicotine in macaque V1 causes increases in firing rates and gain modulation of sensory-evoked activity in the thalamo-recipient cortical layers and has various effects in other layers165,170,171”
From Mechanisms underlying gain modulation in the cortex (2020) · cites this paper as [170]
A key portion of the impact of neuromodulation on neural response gain may occur via actions on inhibitory interneurons.
“A key portion of the impact of neuromodulation on neural response gain may occur via actions on inhibitory interneurons170.”
From Mechanisms underlying gain modulation in the cortex (2020) · cites this paper as [170]
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Self-citationMuscarinic and Nicotinic Contribution to Contrast Sensitivity of Macaque Area V1 Neurons
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- Authors
- Disney, A. A., Aoki, C., & Hawken, M. J.
- Affiliations
- New York University (US)
- Corresponding author
- Disney, Anita A.
- Venue
- Journal of Neurophysiology
- Publisher
- American Physiological Society
- Published
- 2012-10-01
- Volume
- 108
- Issue
- 7
- Pages
- 1907-1923
- ISSN
- 0022-3077 (ISSN-L)
- 1522-1598
- PMC
- PMC3545006
- OpenAlex
- W2104849082
- Cited by
- 57
- References
- 91
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2022: 1 · 2021: 6 · 2020: 7 · 2019: 3 · 2018: 7 · 2017: 5 · 2016: 6 · 2015: 1 · 2014: 7 · 2013: 8
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Neurophysiology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Eye Institute (EY8300, P30 EY-13079, R03EY015549, R01EY008300, R01EY013145, 1 R01 EY13145, EY15549, P30EY013079)
- National Institute of Neurological Disorders and Stroke (NS41091, R01NS041091, R25NS080686)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- acetylcholine, cholinergic modulation, primary visual cortex, GABAergic inhibition, GABAA receptor, gabazine, selective attention, iontophoresis, primate visual cortex
- MeSH terms
- Acetylcholine, Animals, Evoked Potentials, Visual, Macaca fascicularis, Male, Pyridazines, Visual Cortex, Cholinergic Agonists, Glutamic Acid, GABA Antagonists, GABAergic Neurons
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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