Input to the lateral habenula from the basal ganglia is excitatory, aversive, and suppressed by serotonin

Millisecond-timescale, genetically targeted optical control of neural activity

Boyden, E. S., Zhang, F., Bamberg, E., Nagel, G., & Deisseroth, K. A. (2005) · Nature Neuroscience · doi:10.1038/nn1525 · Cited by 4,831 · see citing works

Reinforcement learning

Barto, A. (1998) · IFAC Proceedings Volumes · doi:10.1016/s1474-6670(17)38315-5 · Cited by 2,172 · see citing works

10. Reinforcement learning

Zhang, B., Li, C., & Lin, N. (2020) · De Gruyter eBooks · doi:10.1515/9783110595567-011 · Cited by 1,939 · see citing works

Two types of dopamine neuron distinctly convey positive and negative motivational signals

Matsumoto, M., & Hikosaka, O. (2009) · Nature · doi:10.1038/nature08028 · Cited by 1,378 · see citing works

Lateral habenula as a source of negative reward signals in dopamine neurons

Matsumoto, M., & Hikosaka, O. (2007) · Nature · doi:10.1038/nature05860 · Cited by 1,292 · see citing works

The habenula: from stress evasion to value-based decision-making

Hikosaka, O. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2866 · Cited by 955 · see citing works

Afferent connections of the habenular nuclei in the rat. A horseradish peroxidase study, with a note on the fiber‐of‐passage problem

Herkenham, M. A., & Nauta, W. J. H. (1977) · The Journal of Comparative Neurology · doi:10.1002/cne.901730107 · Cited by 798 · see citing works

Dopamine neurons and their role in reward mechanisms

Schultz, W. (1997) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(97)80007-4 · Cited by 769 · see citing works

Synaptic potentiation onto habenula neurons in the learned helplessness model of depression

Li, B., Piriz, J., Mirrione, M., Chung, C., Proulx, C. D., Schulz, D., Henn, F., & Malinow, R. (2011) · Nature · doi:10.1038/nature09742 · Cited by 634 · cited 2× · see citing works

Projections of the globus pallidus and adjacent structures: An autoradiographic study in the monkey

Kim, R., Nakano, K., Jayaraman, A., & Carpenter, M. B. (1976) · The Journal of Comparative Neurology · doi:10.1002/cne.901690302 · Cited by 411 · see citing works

Lateral Habenula Stimulation Inhibits Rat Midbrain Dopamine Neurons through a GABAA Receptor-Mediated Mechanism

Ji, H., & Shepard, P. D. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0958-07.2007 · Cited by 388 · see citing works

The globus pallidus sends reward-related signals to the lateral habenula

Hong, S., & Hikosaka, O. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.035 · Cited by 346 · see citing works

GABA as the pallidothalamic neurotransmitter: implications for basal ganglia function

Penney, J. B., & Young, A. B. (1981) · Brain Research · doi:10.1016/0006-8993(81)90693-4 · Cited by 257 · see citing works

Two types of projection neurons in the internal pallidum of primates: Single‐axon tracing and three‐dimensional reconstruction

Parent, M., Lévesque, M., & Parent, A. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1340 · Cited by 205 · see citing works

Lateral Habenular Influence on Dorsal Raphe Neurons

Ferraro, G., Montalbano, M. E., Sardo, P., & Grutta, V. L. (1996) · Brain Research Bulletin · doi:10.1016/0361-9230(96)00170-0 · Cited by 100 · see citing works

Pallidofugal projections to thalamus and midbrain: A quantitative antidromic activation study in monkeys and cats

Harnois, C., & Filion, M. (1982) · Experimental Brain Research · doi:10.1007/bf00239387 · Cited by 90 · see citing works

A comparison of projections of entopeduncular neurons to the thalamus, the Midbrain and the habenula in the cat

Filion, M., & Harnois, C. (1978) · The Journal of Comparative Neurology · doi:10.1002/cne.901810406 · Cited by 89 · see citing works

Retrograde HRP tracing combined with a pharmacohistochemical method for GABA transaminase for the identification of presumptive GABAergic projections to the habenula

Araki, M., McGeer, P. L., & McGeer, E. G. (1984) · Brain Research · doi:10.1016/0006-8993(84)90330-5 · Cited by 72 · see citing works

Immunocytochemical demonstration of the GABA-ergic neurons in rat globus pallidus and nucleus entopeduncularis and their GABA-ergic innervation.

Wh, O., Nitsch, C., & Mugnaini, E. (1984) · PubMed · Cited by 60 · see citing works

Expression of GAD65 and GAD67 immunoreactivity in MPTP-treated monkeys with or without l-DOPA administration

Stephenson, D. T., Li, Q., Simmons, C. A., et al. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.03.016 · Cited by 32 · see citing works

A histochemical study of GABA-transaminase in the efferents of the pallidum

Vincent, S. R., Kimura, H., & McGeer, E. G. (1982) · Brain Research · doi:10.1016/0006-8993(82)91239-2 · Cited by 31 · see citing works

Glutamatergic pallidothalamic projections and their implications in the pathophysiology of Parkinson’s disease

Barroso‐Chinea, P., Rico, A. J., Pérez‐Manso, M., Roda, E., López, I. P., Luis-Ravelo, D., & Lanciego, J. L. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.05.019 · Cited by 26 · see citing works

Reinforcement Learning

Saxena, A., & Bhardwaj, F. (2024) · Advances in computational intelligence and robotics book series · doi:10.4018/979-8-3693-1062-5.ch001 · Cited by 10 · see citing works

Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

Yang, Y., Cui, Y., Sang, K., Dong, Y., Ni, Z., Ma, S., & Hu, H. (2018) · Nature · doi:10.1038/nature25509 · Cited by 1,036 · see citing works

Astroglial Kir4.1 in the lateral habenula drives neuronal bursts in depression

Cui, Y., Yang, Y., Ni, Z., Dong, Y., Cai, G., Foncelle, A., Ma, S., Sang, K., Tang, S., Li, Y., et al. (2018) · Nature · doi:10.1038/nature25752 · Cited by 597 · see citing works

Activation of lateral habenula inputs to the ventral midbrain promotes behavioral avoidance

Stamatakis, A. M., & Stuber, G. D. (2012) · Nature Neuroscience · doi:10.1038/nn.3145 · Cited by 564 · see citing works

Reward processing by the lateral habenula in normal and depressive behaviors

Proulx, C. D., Hikosaka, O., & Malinow, R. (2014) · Nature Neuroscience · doi:10.1038/nn.3779 · Cited by 461 · see citing works

βCaMKII in Lateral Habenula Mediates Core Symptoms of Depression

Li, K., Zhou, T., Liao, L., Yang, Z., Wong, C., Henn, F., Malinow, R., Yates, J. R., & Hu, H. (2013) · Science · doi:10.1126/science.1240729 · Cited by 411 · see citing works

GABA/glutamate co-release controls habenula output and is modified by antidepressant treatment

Shabel, S. J., Proulx, C. D., Piriz, J., & Malinow, R. (2014) · Science · doi:10.1126/science.1250469 · Cited by 369 · see citing works

A unique population of ventral tegmental area neurons inhibits the lateral habenula to promote reward

Stamatakis, A. M., Jennings, J. H., Ung, R. L., Blair, G. A., Weinberg, R. J., Neve, R. L., Boyce, F., Mattis, J., Ramakrishnan, C., Deisseroth, K., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.08.023 · Cited by 364 · see citing works

Single rodent mesohabenular axons release glutamate and GABA

Root, D. H., Mejias-Aponte, C. A., Zhang, S., Wang, H.-L., Hoffman, A. F., Lupica, C. R., & Morales, M. (2014) · Nature Neuroscience · doi:10.1038/nn.3823 · Cited by 349 · see citing works

Distinct Ventral Pallidal Neural Populations Mediate Separate Symptoms of Depression

Knowland, D., Lilascharoen, V., Pacia, C. P., Shin, S., Wang, E. H.-J., & Lim, B. K. (2017) · Cell · doi:10.1016/j.cell.2017.06.015 · Cited by 273 · see citing works

Lateral habenula in the pathophysiology of depression

Yang, Y., Wang, H., Hu, J., & Hu, H. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.10.024 · Cited by 254 · see citing works

Reward and aversion

Hu, H. (2016) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-070815-014106 · Cited by 253 · see citing works

Basal ganglia circuit loops, dopamine and motivation: a review and enquiry

Ikemoto, S., Yang, C., & Tan, A. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.04.018 · Cited by 226 · see citing works

Chronic Stress Induces Activity, Synaptic, and Transcriptional Remodeling of the Lateral Habenula Associated with Deficits in Motivated Behaviors

Cerniauskas, I., Winterer, J., de Jong, J. W., Lukacsovich, D., Yang, H., Khan, F., Peck, J. R., Obayashi, S. K., Lilascharoen, V., Lim, B. K., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.09.005 · Cited by 187 · see citing works

PERIL AND PLEASURE: AN RDOC-INSPIRED EXAMINATION OF THREAT RESPONSES AND REWARD PROCESSING IN ANXIETY AND DEPRESSION: Neighborhood Characteristics and Mental Health

Dillon, D. G., Rosso, I. M., Pechtel, P., Killgore, W. D. S., Rauch, S. L., & Pizzagalli, D. A. (2014) · Depression and Anxiety · doi:10.1002/da.22202 · Cited by 209 · see citing works

Genetically distinct parallel pathways in the entopeduncular nucleus for limbic and sensorimotor output of the basal ganglia

Wallace, M. L., Saunders, A., Huang, K. W., Philson, A. C., Goldman, M., Macosko, E. Z., McCarroll, S. A., & Sabatini, B. L. (2017) · Neuron · doi:10.1016/j.neuron.2017.03.017 · Cited by 205 · see citing works

The lateral habenula in addiction and depression: an anatomical, synaptic and behavioral overview

Lecca, S., Meye, F. J., & Mameli, M. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12480 · Cited by 196 · see citing works

The evolutionary origin of the vertebrate basal ganglia and its role in action selection

Grillner, S., Robertson, B., & Stephenson‐Jones, M. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2012.246660 · Cited by 184 · see citing works

Aversive stimuli drive hypothalamus-to-habenula excitation to promote escape behavior

Lecca, S., Meye, F. J., Trusel, M., Tchenio, A., Harris, J., Schwarz, M. K., Burdakov, D., Georges, F., & Mameli, M. (2017) · eLife · doi:10.7554/elife.30697 · Cited by 166 · see citing works

Shifted pallidal co-release of GABA and glutamate in habenula drives cocaine withdrawal and relapse

Meye, F. J., Soiza-Reilly, M., Smit, T., Diana, M. A., Schwarz, M. K., & Mameli, M. (2016) · Nature Neuroscience · doi:10.1038/nn.4334 · Cited by 173 · see citing works

Transcriptional and spatial resolution of cell types in the mammalian habenula

Hashikawa, Y., Hashikawa, K., Rossi, M. A., Basiri, M. L., Liu, Y., Johnston, N. L., Ahmad, O. R., & Stuber, G. D. (2020) · Neuron · doi:10.1016/j.neuron.2020.03.011 · Cited by 167 · see citing works

Hypothalamus-habenula potentiation encodes chronic stress experience and drives depression onset

Zheng, Z., Guo, C., Li, M., Yang, L., Liu, P., Zhang, X., Liu, Y., Guo, X., Cao, S., Dong, Y., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.01.011 · Cited by 142 · see citing works

Left Habenula Mediates Light-Preference Behavior in Zebrafish via an Asymmetrical Visual Pathway

Zhang, B.-B., Yao, Y.-Y., Zhang, H.-F., Kawakami, K., & Du, J.-L. (2017) · Neuron · doi:10.1016/j.neuron.2017.01.011 · Cited by 115 · see citing works

The molecular pathophysiology of depression and the new therapeutics

Tian, H., Hu, Z., Xu, J., & Wang, C. (2022) · MedComm · doi:10.1002/mco2.156 · Cited by 122 · see citing works

Anhedonia in depression symptomatology: appetite dysregulation and defective brain reward processing

Coccurello, R. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112041 · Cited by 106 · see citing works

Sources of input to the rostromedial tegmental nucleus, ventral tegmental area, and lateral habenula compared: A study in rat

Yetnikoff, L., Cheng, A. Y., Lavezzi, H. N., Parsley, K. P., & Zahm, D. S. (2015) · Journal of Comparative Neurology · doi:10.1002/cne.23797 · Cited by 101 · see citing works

Progress in understanding mood disorders: optogenetic dissection of neural circuits

Lammel, S., Tye, K. M., & Warden, M. R. (2014) · Genes, Brain and Behavior · doi:10.1111/gbb.12049 · Cited by 98 · see citing works

Multi-transmitter neurons in the mammalian central nervous system

Granger, A. J., Wallace, M. L., & Sabatini, B. L. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.04.007 · Cited by 95 · see citing works

Target-specific modulation of the descending prefrontal cortex inputs to the dorsal raphe nucleus by cannabinoids

Geddes, S. D., Assadzada, S., Lemelin, D., Sokolovski, A., Bergeron, R., Haj-Dahmane, S., & Béïque, J.-C. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1522754113 · Cited by 90 · see citing works

Co-packaging of opposing neurotransmitters in individual synaptic vesicles in the central nervous system

Kim, S., Wallace, M. L., El-Rifai, M., Knudsen, A. R., & Sabatini, B. L. (2022) · Neuron · doi:10.1016/j.neuron.2022.01.007 · Cited by 58 · see citing works

Synaptic and circuit functions of multitransmitter neurons in the mammalian brain

Wallace, M. L., & Sabatini, B. L. (2023) · Neuron · doi:10.1016/j.neuron.2023.06.003 · Cited by 59 · see citing works

Effects of Halothane on Glutamate Receptor-mediated Excitatory Postsynaptic Currents: A Patch-Clamp Study in Adult Mouse Hippocampal Slices

Perouansky, M., Baranov, D., Salman, M., & Yaari, Y. (1995) · Anesthesiology · doi:10.1097/00000542-199507000-00014 · Cited by 104 · see citing works

Ketamine attenuates the glutamatergic neurotransmission in the ventral posteromedial nucleus slices of rats

Fu, B., Liu, C., Zhang, Y., Fu, X., Zhang, L., & Yu, T. (2017) · BMC Anesthesiology · doi:10.1186/s12871-017-0404-5 · Cited by 12 · see citing works

Quantal properties of H-type glutamatergic synaptic input to the striatal medium spiny neurons

Mori, A., Takahashi, T., Miyashita, Y., et al. (1994) · Brain Research · doi:10.1016/0006-8993(94)91587-3 · Cited by 8 · see citing works

[Dopaminergic regulation of the activity of peptidergic, GABAergic and glutamatergic neuronal systems in the striatum].

Kerkerian, L., Cupo, A., Dusticier, N., et al. (1989) · PubMed · Cited by 2 · see citing works

A glutamatergic projection from the lateral hypothalamus targets VTA-projecting neurons in the lateral habenula of the rat

Poller, W. C., Madai, V. I., Bernard, R., Laube, G., & Veh, R. W. (2013) · Brain Research · doi:10.1016/j.brainres.2013.01.029 · Cited by 77 · see citing works