A unique population of ventral tegmental area neurons inhibits the lateral habenula to promote reward
Open accessAbstract
Lateral habenula (LHb) neurons convey aversive and negative reward conditions through potent indirect inhibition of ventral tegmental area (VTA) dopaminergic neurons. Although VTA dopaminergic neurons reciprocally project to the LHb, the electrophysiological properties and the behavioral consequences associated with selective manipulations of this circuit are unknown. Here, we identify an inhibitory input to the LHb arising from a unique population of VTA neurons expressing dopaminergic markers. Optogenetic activation of this circuit resulted in no detectable dopamine release in LHb brain slices. Instead, stimulation produced GABA-mediated inhibitory synaptic transmission, which suppressed the firing of postsynaptic LHb neurons in brain slices and increased the spontaneous firing rate of VTA dopaminergic neurons in vivo. Furthermore, in vivo activation of this pathway produced reward-related phenotypes that were dependent on intra-LHb GABAA receptor signaling. These results suggest that noncanonical inhibitory signaling by these hybrid dopaminergic-GABAergic neurons act to suppress LHb output under rewarding conditions.
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VTA projections do not appear to release DA in the LHb.
“VTA projections do not appear to release DA in the LHb, 129,130”
From Synaptic and circuit functions of multitransmitter neurons in the mammalian brain (2023) · cites this paper as [130]
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- Authors
- Stamatakis, A. M., Jennings, J. H., Ung, R. L., Blair, G. A., Weinberg, R. J., Neve, R. L., Boyce, F., Mattis, J., Ramakrishnan, C., Deisseroth, K., & Stuber, G. D.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Massachusetts Institute of Technology (US)
- Massachusetts General Hospital (US)
- Stanford University (US)
- Corresponding author
- Stuber, Garret D.
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 80
- Issue
- 4
- Pages
- 1039-1053
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3873746
- OpenAlex
- W2091680313
- Cited by
- 364
- References
- 60
- Citations by year
- 2026: 15 · 2025: 17 · 2024: 28 · 2023: 29 · 2022: 19 · 2021: 36 · 2020: 22 · 2019: 26 · 2018: 27 · 2017: 34 · 2016: 36 · 2015: 37 · 2014: 36
- FWCI
- 17.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- Foundation for the National Institutes of Health
- Whitehall Foundation
- National Alliance for Research on Schizophrenia and Depression
- Foundation of Hope for Research and Treatment of Mental Illness
- National Institutes of Health (NS045892, DA032750)
- National Institute on Drug Abuse (F31DA034472, R01DA032750, DA034472, DA032750, R37DA032750)
- National Institute of Neurological Disorders and Stroke (R01NS039444, NS039444, P30NS045892)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- ventral tegmental area, lateral habenula, dopaminergic neurons, GABAergic neurons, reward, synaptic inhibition, dopamine release, optogenetic stimulation, spontaneous firing rate
- MeSH terms
- Animals, Axons, Behavior, Animal, Female, gamma-Aminobutyric Acid, Male, Mesencephalon, Mice, Inbred C57BL, Synaptic Transmission, Receptors, GABA-A, Reward, Synapses, Tyrosine 3-Monooxygenase, Radiosurgery, Ventral Tegmental Area, Neurotransmitter Agents, Patch-Clamp Techniques, Habenula, Mice, Electrophysiological Phenomena, Dopaminergic Neurons, Real-Time Polymerase Chain Reaction, Optogenetics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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