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The Emerging Field of Neuroepigenetics
Open accessAbstract
Over the past 25 years, the broad field of epigenetics and, over the past decade in particular, the emerging field of neuroepigenetics have begun to have tremendous impact in the areas of learned behavior, neurotoxicology, CNS development, cognition, addiction, and psychopathology. However, epigenetics is such a new field that in most of these areas the impact is more in the category of fascinating implications as opposed to established facts. In this brief commentary, I will attempt to address and delineate some of the open questions and areas of opportunity that discoveries in epigenetics are providing to the discipline of neuroscience.
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“Epigenetic regulation mediates direct epigenetic effects or gene-by-environment interactions and can lead to complex diseases.33,34”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [33]
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Metadata
- Authors
- Sweatt, J. D.
- Affiliations
- University of Alabama at Birmingham (US)
- Corresponding author
- Sweatt, J. David
- ORCID
- Sweatt, J. David
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 80
- Issue
- 3
- Pages
- 624-632
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3878295
- OpenAlex
- W2162596587
- Cited by
- 324
- References
- 73
- Citations by year
- 2026: 15 · 2025: 9 · 2024: 18 · 2023: 20 · 2022: 13 · 2021: 15 · 2020: 18 · 2019: 24 · 2018: 32 · 2017: 49 · 2016: 42 · 2015: 42 · 2014: 26 · 2013: 1
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG031722)
- National Institute of Mental Health (R01MH091122, R01MH057014)
- National Institute of Nursing Research (R01NR012686)
- National Institute of Neurological Disorders and Stroke (P30NS057098)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- neuroepigenetics, epigenetics, learned behavior, neurotoxicology, central nervous system development, cognition, addiction, psychopathology
- MeSH terms
- Animals, Humans, Neurosciences, Epigenesis, Genetic, History, 20th Century, History, 21st Century, Epigenomics
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