Reversing Neurodevelopmental Disorders in Adults

Ehninger, Dan; Li, Weidong; Fox, Kevin; Stryker, Michael P.; Silva, Alcino J.

doi:10.1016/j.neuron.2008.12.007

Cited by 196Genetics and Neurodevelopmental DisordersAutism Spectrum Disorder ResearchNeuroscience and Neuropharmacology Research

Reversing Neurodevelopmental Disorders in Adults

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Ehninger, Dan, Li, Weidong, Fox, Kevin, Stryker, Michael P., Silva, Alcino J.·2008·Neuron

DOI 10.1016/j.neuron.2008.12.007PMC PMC2710296

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Abstract

Abnormalities in brain development, thought to be irreversible in adults, have long been assumed to underlie the neurological and psychiatric symptoms associated with neurodevelopmental disorders. Surprisingly, a number of recent animal model studies of neurodevelopmental disorders demonstrate that reversing the underlying molecular deficits can result in substantial improvements in function even if treatments are started in adulthood. These findings mark a paradigmatic change in the way we understand and envision treating neurodevelopmental disorders.

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The most likely explanation for this apparent discrepancy is that the proteins involved in these disorders also play important functions in the mature brain.
“The most likely explanation for this apparent discrepancy is that the proteins involved in these disorders also play important functions in the mature brain 133,134 .”
From Developmental timing and critical windows for the treatment of psychiatric disorders (2016) · cites this paper as [133]
These conclusions seem at odds with work suggesting that behavioral deficits in mouse models of FXS and RTT can be reverted in adulthood.
“It should be noted that these conclusions seem at odd with work suggesting that behavioral deficits in mouse models FXS and RTT can be reverted in adulthood 133 .”
From Developmental timing and critical windows for the treatment of psychiatric disorders (2016) · cites this paper as [133]
Experimental interventions rescue subsets of behavioral abnormalities in mouse models of autism.
“Experimental interventions, working through diverse genetic and pharmacological mechanisms, rescue subsets of behavioral abnormalities in these mouse models (31, 43, 48–52).”
From Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism (2012) · cites this paper as [50]
Therapeutic efficacy is currently evaluated by improvement in the diagnostic behavioral symptoms.
“Therefore, therapeutic efficacy is currently evaluated by improvement in the diagnostic behavioral symptoms (11, 50, 95).”
From Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism (2012) · cites this paper as [50]

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Authors: Ehninger, D., Li, W., Fox, K., Stryker, M. P., & Silva, A. J.
Affiliations: University of California, Los Angeles (US)
Cardiff University (GB)
University of California, San Francisco (US)
Corresponding author: Silva, Alcino J.
ORCID: Ehninger, Dan
Li, Weidong
Fox, Kevin
Stryker, Michael P.
Silva, Alcino J.
Venue: Neuron
Publisher: Elsevier BV
Published: 2008-12
Volume: 60
Issue: 6
Pages: 950-960
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2008.12.007
PMC: PMC2710296
OpenAlex: W2068674192
Cited by: 196
References: 94
Citations by year: 2026: 2 · 2025: 4 · 2024: 4 · 2023: 8 · 2022: 10 · 2021: 3 · 2020: 6 · 2019: 7 · 2018: 7 · 2017: 4 · 2016: 8 · 2015: 9 · 2014: 15 · 2013: 20 · 2012: 26
FWCI: 1.97
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1689 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Mental Health (P50-MH0779720, P50MH077972)
National Institute of Neurological Disorders and Stroke (R01-NS38480, R01NS038480)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: neurodevelopmental disorders, brain development, animal models, psychiatric symptoms, neurological symptoms
MeSH terms: Animals, Brain, Brain Diseases, Disease Models, Animal, Humans, Neuronal Plasticity, Recovery of Function

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Reversing Neurodevelopmental Disorders in Adults

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