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Sleep and the Price of Plasticity: From Synaptic and Cellular Homeostasis to Memory Consolidation and Integration
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Summary Sleep is universal, tightly regulated, and its loss impairs cognition. But why does the brain need to disconnect from the environment for hours every day? The synaptic homeostasis hypothesis (SHY) proposes that sleep is the price the brain pays for plasticity. During a waking episode, learning statistical regularities about the current environment requires strengthening connections throughout the brain. This increases cellular needs for energy and supplies, decreases signal-to-noise ratios, and saturates learning. During sleep, spontaneous activity renormalizes net synaptic strength and restores cellular homeostasis. Activity-dependent down-selection of synapses can also explain the benefits of sleep on memory acquisition, consolidation, and integration. This happens through the off-line, comprehensive sampling of statistical regularities incorporated in neuronal circuits over a lifetime. This review considers the rationale and evidence for SHY and points to open issues related to sleep and plasticity.
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“The salience model of psychosis (Kapur, 2003, Kapur et al., 2005) has been linked to sleep dysfunction via the proposed role of sleep in synaptic homeostasis (Tononi & Cirelli, 2014).”
From The role of sleep dysfunction in the occurrence of delusions and hallucinations: A systematic review (2015) · cites this paper as Tononi & Cirelli, 2014
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“On the other hand, the synaptic homeostasis hypothesis is primarily proposed as a theory of the function slow wave sleep, whereas the primary sleep architecture changes directly related to psychosis in the research literature to date involve REM sleep.”
From The role of sleep dysfunction in the occurrence of delusions and hallucinations: A systematic review (2015) · cites this paper as Tononi & Cirelli, 2014
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“The beneficial effect of TMR during non-REM sleep on memory performance is well established across a variety of memory domains, 115 including visuospatial 116-119 and verbal 120,121 declarative memory as well as motor learning.”
From Sleep—A brain-state serving systems memory consolidation (2023) · cites this paper as [121]
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“Slow wave sleep, in this theory, mediates a downscaling of synaptic strength, allowing informational efficiency to be restored for the next day.”
From The role of sleep dysfunction in the occurrence of delusions and hallucinations: A systematic review (2015) · cites this paper as Tononi & Cirelli, 2014
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“According to the synaptic homeostasis hypothesis, the need for sleep (or sleep pressure) arises physiologically as a result of synaptic potentiation in wakefulness (new connections are constantly made in response to the environment while awake, but there is no corresponding downscaling or removing of associations).”
From The role of sleep dysfunction in the occurrence of delusions and hallucinations: A systematic review (2015) · cites this paper as Tononi & Cirelli, 2014
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“At the level of global network regulation, sleep is considered to primarily serve the downregulation, i.e., in a strict sense a down-selection of synaptic connectivity.223”
From Sleep—A brain-state serving systems memory consolidation (2023) · cites this paper as [223]
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“This view has been comprehensively elaborated in the ''synaptic homeostasis hypothesis'' (SHY) by Tononi and Cirelli [223][224][225] (Figure 2B).”
From Sleep—A brain-state serving systems memory consolidation (2023) · cites this paper as [223]
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Cites
Plum, F. (1960) · Archives of Neurology · doi:10.1001/archneur.1960.03840090124020 · Cited by 10,388
REMEMBERING: A STUDY IN EXPERIMENTAL AND SOCIAL PSYCHOLOGY
Bartlett, F. C., & Burt, C. (1933) · British Journal of Educational Psychology · doi:10.1111/j.2044-8279.1933.tb02913.x · Cited by 7,475
Sleep Drives Metabolite Clearance from the Adult Brain
Xie, L., Kang, H., Xu, Q., Chen, M. J., Liao, Y., Thiyagarajan, M., O’Donnell, J., Christensen, D. J., Nicholson, C., Iliff, J. J., et al. (2013) · Science · doi:10.1126/science.1241224 · Cited by 5,411
McClelland, J. L., McNaughton, B. L., & O'Reilly, R. C. (1995) · Psychological Review · doi:10.1037/0033-295x.102.3.419 · Cited by 5,256
Diekelmann, S., & Born, J. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2762 · Cited by 3,760
Rasch, B., & Born, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00032.2012 · Cited by 2,783 · cited 11×
“Reactivation during NREM sleep may set the stage for the induction of synaptic potentiation during a subsequent REM sleep episode (Diekelmann and Born, 2010; Rasch and Born, 2013).”
BackgroundInfluentialSquire, L. R., Stark, C. E. L., & Clark, R. E. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144130 · Cited by 2,680
Bartlett, F. C., & Kintsch, W. (1995) · Cambridge University Press eBooks · doi:10.1017/cbo9780511759185 · Cited by 2,408
Catastrophic forgetting in connectionist networks
French, R. (1999) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(99)01294-2 · Cited by 2,311
Sleep function and synaptic homeostasis
Tononi, G., & Cirelli, C. (2006) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2005.05.002 · Cited by 2,151
Self-citation
Cited by
Sorted by citations
Items 501–600 of 1,008
Evolution and plasticity of sleep
Ungurean, G., van der Meij, J., Rattenborg, N. C., & Lesku, J. A. (2019) · Current Opinion in Physiology · doi:10.1016/j.cophys.2019.12.013 · Cited by 42
Tam, S. K. E., Brown, L. A., Wilson, T. S., Tir, S., Fisk, A. S., Pothecary, C. A., van der Vinne, V., Foster, F., Vyazovskiy, V. V., Bannerman, D. M., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2101591118 · Cited by 42
Deibel, S. H., Zelinski, E. L., Keeley, R. J., Kovalchuk, O., & McDonald, R. J. (2015) · Oncotarget · doi:10.18632/oncotarget.4036 · Cited by 40
Titiz, A. S., Mahoney, J. M., Testorf, M. E., Holmes, G. L., & Scott, R. C. (2014) · Hippocampus · doi:10.1002/hipo.22297 · Cited by 40
Circadian Regulation of Synaptic Plasticity
Frank, M. G. (2016) · Biology · doi:10.3390/biology5030031 · Cited by 44
Micro-, Meso- and Macro-Dynamics of the Brain
Buzsáki, G., Christen, Y., & Publishing, S. I. (2016) · Research and perspectives in neurosciences · doi:10.1007/978-3-319-28802-4 · Cited by 44
Memory in 3‐month‐old infants benefits from a short nap
Horváth, K., Hannon, B., Ujma, P. P., Gombos, F., & Plunkett, K. (2017) · Developmental Science · doi:10.1111/desc.12587 · Cited by 43
Volk, C., Jaramillo, V., Merki, R., Tuura, R., & Huber, R. (2018) · Human Brain Mapping · doi:10.1002/hbm.24225 · Cited by 40
Impacts of Sleep Loss versus Waking Experience on Brain Plasticity: Parallel or Orthogonal?
Havekes, R., & Aton, S. J. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.03.010 · Cited by 40
King, B. R., Rumpf, J., Verbaanderd, E., Heise, K.-F., Dolfen, N., Sunaert, S. G., Doyon, J., Claßen, J., Mantini, D., Puts, N. A. J., et al. (2020) · Human Brain Mapping · doi:10.1002/hbm.25041 · Cited by 40
SEMYACHKINA-GLUSHKOVSKAYA, O. V., Fedosov, I. V., Penzel, T., Li, D., Yu, T., Telnova, V., Исмаиловна, К. Э., Saranceva, E. I., Terskov, A. V., Khorovodov, A. P., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043221 · Cited by 43
Psilocin acutely alters sleep-wake architecture and cortical brain activity in laboratory mice
Thomas, C. W., Blanco‐Duque, C., Bréant, B. J. B., Goodwin, G. M., Sharp, T., Bannerman, D. M., & Vyazovskiy, V. V. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01846-9 · Cited by 49
Perversi, F., Costa, C., Labate, A., Lattanzi, S., Liguori, C., Maschio, M. C. E., Meletti, S., Nobili, L., Operto, F. F., Romigi, A., et al. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1182304 · Cited by 40
Activation of locus coeruleus noradrenergic neurons rapidly drives homeostatic sleep pressure
Silverman, D., Chen, C., Chang, S., Bui, L., Zhang, Y., Raghavan, R., Jiang, A., Le, A. N., Darmohray, D. M., Sima, J., et al. (2025) · Science Advances · doi:10.1126/sciadv.adq0651 · Cited by 41
Ahnaou, A., Raeymaekers, L., Steckler, T., & Drinkenbrug, W. H. I. M. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.01.009 · Cited by 39
Xu, J., Zhu, Y., Fu, C., Sun, J., Li, H., Yang, X., Li, W., Qin, W., Shi, D., & Tian, J. (2015) · Journal of Sleep Research · doi:10.1111/jsr.12354 · Cited by 40
Calais, J. B., Ojopi, E. P. B., Morya, E., Sameshima, K., & Ribeiro, S. T. G. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.01.002 · Cited by 40
Sleep and Motor Learning: Implications for Physical Rehabilitation After Stroke
Gudberg, C., & Johansen‐Berg, H. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00241 · Cited by 40
Gaggioni, G., Ly, J. Q. M., Muto, V., Chellappa, S. L., Jaspar, M., Meyer, C., Delfosse, T., Vanvinckenroye, A., Dumont, R., Wallant, D. C. ’., et al. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.02.004 · Cited by 44
Role of the L-PGDS-PGD2-DP1 receptor axis in sleep regulation and neurologic outcomes
Ahmad, A. S., Ottallah, H., Maciel, C. B., Strickland, M. R., & Doré, S. (2019) · SLEEP · doi:10.1093/sleep/zsz073 · Cited by 42
Capone, C., Pastorelli, E., Golosio, B., & Paolucci, P. S. (2019) · Scientific Reports · doi:10.1038/s41598-019-45525-0 · Cited by 42
Hebbian and Homeostatic Synaptic Plasticity—Do Alterations of One Reflect Enhancement of the Other?
Galanis, C., & Vlachos, A. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00050 · Cited by 43
Hartsock, M. J., & Spencer, R. L. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.07.023 · Cited by 52
Changes in sleep EEG with aging in humans and rodents
Campos-Beltrán, D., & Marshall, L. (2021) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-021-02545-y · Cited by 38
Moreira, C. G., Baumann, C. R., Scandella, M., Nemirovsky, S. I., Leach, S., Huber, R., & Noaín, D. (2021) · eLife · doi:10.7554/elife.68043 · Cited by 34
Sleep loss impairs cognitive performance and alters song output in Australian magpies
Johnsson, R. D., Connelly, F., Mussoi, J. G., Vyssotski, A. L., Cain, K. E., Roth, T. C., & Lesku, J. A. (2022) · Scientific Reports · doi:10.1038/s41598-022-10162-7 · Cited by 39
López-Muciño, L. A., García‐García, F., Cueto‐Escobedo, J., Acosta-Hernández, M. E., Venebra-Muñoz, A., & Rodríguez‐Alba, J. C. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104832 · Cited by 41
Memory corticalization triggered by REM sleep: mechanisms of cellular and systems consolidation
Almeida-Filho, D. G., Queiroz, C. M., & Ribeiro, S. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2886-9 · Cited by 38
Lv, Z., Li, Y., Wang, Y., Cong, F., Li, X., Cui, W., Han, C., Wei, Y., Hong, X., Liu, Y., et al. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03234-y · Cited by 38
Understanding neuron-glia crosstalk and biological clocks in insomnia
Carvalhas-Almeida, C., Serra, J., Moita, J. J., Cavadas, C., & Álvaro, A. R. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105100 · Cited by 41
Synaptic Dysfunction and Plasticity in Amyotrophic Lateral Sclerosis
Gulino, R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054613 · Cited by 38
Korman, M., Dagan, Y., & Karni, A. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.08.051 · Cited by 41
Mutual influence of sleep and circadian clocks on physiology and cognition
Heyde, I., Kiehn, J., & Oster, H. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.11.003 · Cited by 40
Individual slow-wave morphology is a marker of aging
Ujma, P. P., Simor, P., Steiger, A., Dresler, M., & Bódizs, R. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.04.002 · Cited by 36
Neurocognitive Effects of Sleep Disruption in Children and Adolescents
Spruyt, K. (2020) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2020.08.003 · Cited by 41
Biancardi, C., Sesso, G., Masi, G., Faraguna, U., & Sicca, F. (2021) · SLEEP · doi:10.1093/sleep/zsab006 · Cited by 39
Valomon, A., Riedner, B. A., Jones, S. G., Nakamura, K., Tononi, G., Plante, D. T., Benca, R. M., & Boly, M. (2021) · Scientific Reports · doi:10.1038/s41598-021-83980-w · Cited by 43
Self-citationMitochondria: new players in homeostatic regulation of firing rate set points
Ruggiero, A., Katsenelson, M., & Slutsky, I. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2021.03.002 · Cited by 37
Doldur-Balli, F., Imamura, T., Veatch, O. J., Gong, N. N., Lim, D. C., Hart, M. P., Abel, T. G., Kayser, M. S., Brodkin, E. S., & Pack, A. I. (2022) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2022.101595 · Cited by 46
Cortical and subcortical hemodynamic changes during sleep slow waves in human light sleep
Betta, M., Handjaras, G., Leo, A., Federici, A., Farinelli, V., Ricciardi, E., Siclari, F., Meletti, S., Ballotta, D., Benuzzi, F., et al. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.118117 · Cited by 35
Sleep homeostasis, habits and habituation
Vyazovskiy, V. V., Walton, M. E., Peirson, S. N., & Bannerman, D. M. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.05.002 · Cited by 37
Zhu, Y., Xi, Y., Fei, N., Liu, Y., Zhang, X., Liu, L., Xu, Z., Sun, J., Yang, X., Yin, H. J., et al. (2017) · Journal of Sleep Research · doi:10.1111/jsr.12582 · Cited by 39
Gallinaro, J. V., & Rotter, S. (2018) · Scientific Reports · doi:10.1038/s41598-018-22077-3 · Cited by 39
Neuromodulation via the Cerebrospinal Fluid: Insights from Recent in Vitro Studies
Björefeldt, A., Illes, S., Zetterberg, H., & Hanse, E. (2018) · Frontiers in Neural Circuits · doi:10.3389/fncir.2018.00005 · Cited by 37
Sleeping with Hippocampal Damage
Spanò, G., Weber, F. D., Pizzamiglio, G., McCormick, C., Miller, T. D., Rosenthal, C. R., Edgin, J. O., & Maguire, E. A. (2020) · Current Biology · doi:10.1016/j.cub.2019.11.072 · Cited by 40
Sleep debt induces skeletal muscle injuries in athletes: A promising hypothesis
Freitas, L. D. S. N., da Silva, F. R., Andrade, H. D. A., Guerreiro, R. D. C., Paulo, F. V., de Mello, M. T., & Silva, A. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.109836 · Cited by 44
The Effects of Daytime Psilocybin Administration on Sleep: Implications for Antidepressant Action
Dudysová, D., Janků, K., Šmotek, M., Saifutdinová, E., Kopřivová, J., Bušková, J., Mander, B. A., Brunovský, M., Zach, P., Korčák, J., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.602590 · Cited by 39
Weiss, J. T., & Donlea, J. M. (2021) · Current Biology · doi:10.1016/j.cub.2021.05.018 · Cited by 33
Non-REM and REM/paradoxical sleep dynamics across phylogeny
Jaggard, J. B., Wang, G. X., & Mourrain, P. (2021) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2021.08.004 · Cited by 41
Ensemble of coupling forms and networks among brain rhythms as function of states and cognition
Chen, B., Ciria, L. F., Hu, C., & Ivanov, P. C. (2022) · Communications Biology · doi:10.1038/s42003-022-03017-4 · Cited by 44
Central Nervous Insulin Signaling in Sleep-Associated Memory Formation and Neuroendocrine Regulation
Feld, G. B., Wilhem, I., Benedict, C., Rüdel, B., Klameth, C., Born, J., & Hallschmid, M. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.312 · Cited by 36
Sleep and Oligodendrocyte Functions
Bellesi, M. (2015) · Current Sleep Medicine Reports · doi:10.1007/s40675-014-0008-2 · Cited by 36
Implicit memory for words heard during sleep
Andrillon, T., & Kouider, S. (2016) · Neuroscience of Consciousness · doi:10.1093/nc/niw014 · Cited by 37
Does sleep benefit memory consolidation in children with focal epilepsy?
Chan, S., Pressler, R., Boyd, S. G., Baldeweg, T., & Cross, J. H. (2017) · Epilepsia · doi:10.1111/epi.13668 · Cited by 35
Heritability of Sleep EEG Topography in Adolescence: Results from a Longitudinal Twin Study
Markovic, A., Achermann, P., Rusterholz, T., & Tarokh, L. (2018) · Scientific Reports · doi:10.1038/s41598-018-25590-7 · Cited by 37
Spiess, M., Bernardi, G., Kurth, S., Ringli, M., Wehrle, F. M., Jenni, O. G., Huber, R., & Siclari, F. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.05.024 · Cited by 37
Latifi, B., Adamantidis, A., Bassetti, C. L., & Schmidt, M. H. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00790 · Cited by 35
Cousins, J. N., van Rijn, E., Ong, J. L., & Chee, M. W. L. (2019) · SLEEP · doi:10.1093/sleep/zsz018 · Cited by 36
Tabassum, S., Misrani, A. A., Tang, B., Chen, J., Yang, L., & Long, C. (2019) · Scientific Reports · doi:10.1038/s41598-019-41114-3 · Cited by 36
Rezaie, M., Nasehi, M., Vaseghi, S., Alimohammadzadeh, K., Vaghar, M. I., Mohammadi-Mahdiabadi-Hasani, M.-H., & Zarrindast, M. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112901 · Cited by 35
Lin, Y.-S., Weibel, J., Landolt, H., Santini, F., Meyer, M., Brunmair, J., Meier, S. M., Gerner, C., Borgwardt, S., Cajochen, C., et al. (2021) · Cerebral Cortex · doi:10.1093/cercor/bhab005 · Cited by 35
The impact of stress on the hippocampal spatial code
Tomar, A., & McHugh, T. J. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2021.11.005 · Cited by 37
Mak-McCully, R. A., Rosen, B. Q., Rolland, M., Régis, J. M., Bartoloméi, F., Rey, M. F., Chauvel, P., Cash, S. S., & Halgren, E. (2015) · eNeuro · doi:10.1523/eneuro.0028-15.2015 · Cited by 34
Friedman, J., & Korman, M. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00623 · Cited by 37
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Nazari, M., Abadchi, J. K., Naghizadeh, M., Bermudez-Contreras, E. J., McNaughton, B. L., Tatsuno, M., & Mohajerani, M. H. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112450 · Cited by 36
Konduru, S. S., Wallace, E. P., Pfammatter, J. A., Rodrigues, P. V., Jones, M. V., & Maganti, R. K. (2021) · Epilepsia Open · doi:10.1002/epi4.12462 · Cited by 33
Across-night dynamics in traveling sleep slow waves throughout childhood
Schoch, S. F., Riedner, B. A., Deoni, S. C., Huber, R., LeBourgeois, M. K., & Kurth, S. (2018) · Sleep · doi:10.1093/sleep/zsy165 · Cited by 31
Jaramillo, V., Schoch, S. F., Markovic, A., Kohler, M., Huber, R., Lustenberger, C., & Kurth, S. (2023) · NeuroImage · doi:10.1016/j.neuroimage.2023.119924 · Cited by 34
Sleep need–dependent plasticity of a thalamic circuit promotes homeostatic recovery sleep
Lee, S., Liu, Q., Cheng, A., Kim, D. W., Boudreau, D. M., Mehta, A., Keleş, M. F., Fejfer, R., Palmer, I., Park, K. H., et al. (2025) · Science · doi:10.1126/science.adm8203 · Cited by 34
Gosselin, N., Beaumont, L. D., Gagnon, K., Baril, A., Mongrain, V., Blais, H., Montplaisir, J. Y., Gagnon, J., Pelleïeux, S., Poirier, J., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.4432-15.2016 · Cited by 34
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Proserpio, P., Arnaldi, D., Nobili, F. M., & Nobili, L. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180041 · Cited by 34
Borragán, G., Gilson, M., Atas, A., Slama, H., Lysandropoulos, A. P., Schepper, M. D., & Peigneux, P. (2018) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2018.00378 · Cited by 35
Alteration of Brain Gray Matter Density After 24 h of Sleep Deprivation in Healthy Adults
Sun, J., Zhao, R., Yang, X., Deng, H., Zhu, Y., Chen, Y., Yuan, K., Xi, Y., Yin, H. J., & Qin, W. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00754 · Cited by 34
Delorme, J. E., Wang, L., Kodoth, V., Wang, Y., Ma, J., Jiang, S., & Aton, S. J. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2108534118 · Cited by 31
Narwade, S., Mallick, B. N., & Deobagkar, D. D. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00067 · Cited by 34
Sleep duration and area-level deprivation in twins
Watson, N. F., Horn, E., Duncan, G. E., Buchwald, D., Vitiello, M. V., & Turkheimer, E. (2016) · SLEEP · doi:10.5665/sleep.5320 · Cited by 33
Cecchini, M. G., Iannoni, M. E., Aceto, P., Baroni, E., Vito, C. D., & Lai, C. (2017) · Infant Behavior and Development · doi:10.1016/j.infbeh.2017.06.004 · Cited by 34
Dikeos, D. G., Wichniak, A., Ktonas, P. Y., Mikoteit, T., Crönlein, T., Eckert, A., Kopřivová, J., Ntafouli, M., Spiegelhalder, K., Hatzinger, M., et al. (2023) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2023.2171479 · Cited by 35
Ontogeny of Sleep and Its Functions in Infancy, Childhood, and Adolescence
Grigg-Damberger, M. M. (2016) · Springer eBooks · doi:10.1007/978-3-319-28640-2_1 · Cited by 34
Tactile stimulation during sleep alters slow oscillation and spindle densities but not motor skill
Pereira, S. I. R., Beijamini, F., Weber, F. D., Vincenzi, R. A., da Silva, F. A. C., & Louzada, F. M. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.11.024 · Cited by 33
Sleep reduces the testing effect—But not after corrective feedback and prolonged retention interval.
Abel, M., Haller, V., Köck, H., Pötschke, S., Heib, D. P. J., Schabus, M., & Bäuml, K. T. (2018) · Journal of Experimental Psychology Learning Memory and Cognition · doi:10.1037/xlm0000576 · Cited by 34
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Metadata
- Authors
- Tononi, G., & Cirelli, C.
- Affiliations
- University of Wisconsin System (US)
- University of Wisconsin–Madison (US)
- Corresponding author
- Tononi, Giulio
- Cirelli, Chiara
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 81
- Issue
- 1
- Pages
- 12-34
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3921176
- OpenAlex
- W1977647750
- Semantic Scholar
- 61972f1694fafd898abf59be6068327214e9f48a
- Cited by
- 2,356
- References
- 254
- Citations by year
- 2026: 211 · 2025: 247 · 2024: 194 · 2023: 265 · 2022: 196 · 2021: 185 · 2020: 225 · 2019: 228 · 2018: 149 · 2017: 142 · 2016: 127 · 2015: 126 · 2014: 57
- FWCI
- 14.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH099231, R01MH091326)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- sleep, synaptic homeostasis hypothesis, synaptic plasticity, cellular homeostasis, memory consolidation, memory integration, signal-to-noise ratio, learning, spontaneous neuronal activity
- MeSH terms
- Animals, Brain, Homeostasis, Humans, Learning, Neuronal Plasticity, Sleep, Synapses
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