The DOI matches its Crossref record; 252 of the 254 references it cites were found in a registry or an index.
Sleep and the Price of Plasticity: From Synaptic and Cellular Homeostasis to Memory Consolidation and Integration
Open accessAbstract
Summary Sleep is universal, tightly regulated, and its loss impairs cognition. But why does the brain need to disconnect from the environment for hours every day? The synaptic homeostasis hypothesis (SHY) proposes that sleep is the price the brain pays for plasticity. During a waking episode, learning statistical regularities about the current environment requires strengthening connections throughout the brain. This increases cellular needs for energy and supplies, decreases signal-to-noise ratios, and saturates learning. During sleep, spontaneous activity renormalizes net synaptic strength and restores cellular homeostasis. Activity-dependent down-selection of synapses can also explain the benefits of sleep on memory acquisition, consolidation, and integration. This happens through the off-line, comprehensive sampling of statistical regularities incorporated in neuronal circuits over a lifetime. This review considers the rationale and evidence for SHY and points to open issues related to sleep and plasticity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The salience model of psychosis (Kapur, 2003, Kapur et al., 2005) has been linked to sleep dysfunction via the proposed role of sleep in synaptic homeostasis (Tononi & Cirelli, 2014).”
From The role of sleep dysfunction in the occurrence of delusions and hallucinations: A systematic review (2015) · cites this paper as Tononi & Cirelli, 2014
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“On the other hand, the synaptic homeostasis hypothesis is primarily proposed as a theory of the function slow wave sleep, whereas the primary sleep architecture changes directly related to psychosis in the research literature to date involve REM sleep.”
From The role of sleep dysfunction in the occurrence of delusions and hallucinations: A systematic review (2015) · cites this paper as Tononi & Cirelli, 2014
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The beneficial effect of TMR during non-REM sleep on memory performance is well established across a variety of memory domains, 115 including visuospatial 116-119 and verbal 120,121 declarative memory as well as motor learning.”
From Sleep—A brain-state serving systems memory consolidation (2023) · cites this paper as [121]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Slow wave sleep, in this theory, mediates a downscaling of synaptic strength, allowing informational efficiency to be restored for the next day.”
From The role of sleep dysfunction in the occurrence of delusions and hallucinations: A systematic review (2015) · cites this paper as Tononi & Cirelli, 2014
The cited source says what the claim attributes to it.
In the citing paper
“According to the synaptic homeostasis hypothesis, the need for sleep (or sleep pressure) arises physiologically as a result of synaptic potentiation in wakefulness (new connections are constantly made in response to the environment while awake, but there is no corresponding downscaling or removing of associations).”
From The role of sleep dysfunction in the occurrence of delusions and hallucinations: A systematic review (2015) · cites this paper as Tononi & Cirelli, 2014
The cited source says what the claim attributes to it.
In the citing paper
“At the level of global network regulation, sleep is considered to primarily serve the downregulation, i.e., in a strict sense a down-selection of synaptic connectivity.223”
From Sleep—A brain-state serving systems memory consolidation (2023) · cites this paper as [223]
The cited source says what the claim attributes to it.
In the citing paper
“This view has been comprehensively elaborated in the ''synaptic homeostasis hypothesis'' (SHY) by Tononi and Cirelli [223][224][225] (Figure 2B).”
From Sleep—A brain-state serving systems memory consolidation (2023) · cites this paper as [223]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Plum, F. (1960) · Archives of Neurology · doi:10.1001/archneur.1960.03840090124020 · Cited by 10,388
REMEMBERING: A STUDY IN EXPERIMENTAL AND SOCIAL PSYCHOLOGY
Bartlett, F. C., & Burt, C. (1933) · British Journal of Educational Psychology · doi:10.1111/j.2044-8279.1933.tb02913.x · Cited by 7,475
Sleep Drives Metabolite Clearance from the Adult Brain
Xie, L., Kang, H., Xu, Q., Chen, M. J., Liao, Y., Thiyagarajan, M., O’Donnell, J., Christensen, D. J., Nicholson, C., Iliff, J. J., et al. (2013) · Science · doi:10.1126/science.1241224 · Cited by 5,411
McClelland, J. L., McNaughton, B. L., & O'Reilly, R. C. (1995) · Psychological Review · doi:10.1037/0033-295x.102.3.419 · Cited by 5,256
Diekelmann, S., & Born, J. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2762 · Cited by 3,760
Rasch, B., & Born, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00032.2012 · Cited by 2,783 · cited 11×
“Reactivation during NREM sleep may set the stage for the induction of synaptic potentiation during a subsequent REM sleep episode (Diekelmann and Born, 2010; Rasch and Born, 2013).”
BackgroundInfluentialSquire, L. R., Stark, C. E. L., & Clark, R. E. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144130 · Cited by 2,680
Bartlett, F. C., & Kintsch, W. (1995) · Cambridge University Press eBooks · doi:10.1017/cbo9780511759185 · Cited by 2,408
Catastrophic forgetting in connectionist networks
French, R. (1999) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(99)01294-2 · Cited by 2,311
Sleep function and synaptic homeostasis
Tononi, G., & Cirelli, C. (2006) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2005.05.002 · Cited by 2,151
Self-citation
Flagged first, then by citations
2 of the 254 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Hippocampal sharp wave-ripple: A cognitive biomarker for episodic memory and planning
Buzsáki, G. (2015) · Hippocampus · doi:10.1002/hipo.22488 · Cited by 1,759
The two‐process model of sleep regulation: a reappraisal
Borbély, A. A., Daan, S., Wirz‐Justice, A., & Deboer, T. (2016) · Journal of Sleep Research · doi:10.1111/jsr.12371 · Cited by 1,577
Health consequences of shift work and insufficient sleep
Kecklund, G., & Axelsson, J. (2016) · BMJ · doi:10.1136/bmj.i5210 · Cited by 1,195
Mechanisms of systems memory consolidation during sleep
Klinzing, J. G., Niethard, N., & Born, J. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0467-3 · Cited by 1,176
Glymphatic failure as a final common pathway to dementia
Nedergaard, M., & Goldman, S. A. (2020) · Science · doi:10.1126/science.abb8739 · Cited by 1,145
Neural Circuitry of Wakefulness and Sleep
Scammell, T. E., Arrigoni, E., & Lipton, J. O. (2017) · Neuron · doi:10.1016/j.neuron.2017.01.014 · Cited by 966
Panel, C. C., Watson, N. F., Badr, M. S., Belenky, G., Bliwise, D. L., Buxton, O. M., Buysse, D., Dinges, D. F., Gangwisch, J., Grandner, M. A., et al. (2015) · Sleep · doi:10.5665/sleep.4886 · Cited by 906
Mechanisms linking circadian clocks, sleep, and neurodegeneration
Musiek, E. S., & Holtzman, D. M. (2016) · Science · doi:10.1126/science.aah4968 · Cited by 878
Sleep, insomnia, and depression
Riemann, D. W., Krone, L. B., Wulff, K., & Nissen, C. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0411-y · Cited by 901
What Learning Systems do Intelligent Agents Need? Complementary Learning Systems Theory Updated
Kumaran, D., Hassabis, D., & McClelland, J. L. (2016) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2016.05.004 · Cited by 759
Squire, L. R., Genzel, L., Wixted, J. T., & Morris, R. G. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021766 · Cited by 700
The Brain’s Glymphatic System: Current Controversies
Mestre, H., Mori, Y., & Nedergaard, M. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.04.003 · Cited by 609
The neurobiology, investigation, and treatment of chronic insomnia
Riemann, D. W., Nissen, C., Palagini, L., Otte, A., Perlis, M. L., & Spiegelhalder, K. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00021-6 · Cited by 657
Ultrastructural evidence for synaptic scaling across the wake/sleep cycle
de Vivo, L., Bellesi, M., Marshall, W., Bushong, E. A., Ellisman, M. H., Tononi, G., & Cirelli, C. (2017) · Science · doi:10.1126/science.aah5982 · Cited by 574
Self-citationSleep Loss Can Cause Death through Accumulation of Reactive Oxygen Species in the Gut
Vaccaro, A., Kaplan Dor, Y., Nambara, K., Pollina, E. A., Lin, C., Greenberg, M. E., & Rogulja, D. (2020) · Cell · doi:10.1016/j.cell.2020.04.049 · Cited by 541
Watson, N. F., Badr, M. S., Belenky, G., Bliwise, D. L., Buxton, O. M., Buysse, D., Dinges, D. F., Gangwisch, J., Grandner, M. A., Kushida, C., et al. (2015) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.4950 · Cited by 568
Lane, R. D., Ryan, L., Nadel, L., & Greenberg, L. S. (2014) · Behavioral and Brain Sciences · doi:10.1017/s0140525x14000041 · Cited by 611
The neurocognitive consequences of sleep restriction: A meta-analytic review
Lowe, C. J., Safati, A., & Hall, P. A. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.07.010 · Cited by 520
Homer1a drives homeostatic scaling-down of excitatory synapses during sleep
Diering, G. H., Nirujogi, R. S., Roth, R. H., Worley, P. F., Pandey, A., & Huganir, R. L. (2017) · Science · doi:10.1126/science.aai8355 · Cited by 516
Lower synaptic density is associated with depression severity and network alterations
Holmes, S. E., Scheinost, D., Finnema, S. J., Naganawa, M., Davis, M. T., DellaGioia, N., Nabulsi, N., Matuskey, D., Angarita, G. A., Pietrzak, R. H., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09562-7 · Cited by 484
The hippocampus in aging and disease: From plasticity to vulnerability
Bartsch, T., & Wulff, P. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.07.084 · Cited by 499
Sleep function: Toward elucidating an enigma
Krueger, J. M., Frank, M. G., Wisor, J. P., & Roy, S. (2016) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2015.08.005 · Cited by 440
A contextual binding theory of episodic memory: systems consolidation reconsidered
Yonelinas, A. P., Ranganath, C., Ekstrom, A. D., & Wiltgen, B. J. (2019) · Nature reviews. Neuroscience · doi:10.1038/s41583-019-0150-4 · Cited by 492
Blake, M. J., Trinder, J. A., & Allen, N. B. (2018) · Clinical Psychology Review · doi:10.1016/j.cpr.2018.05.006 · Cited by 477
Circadian Rhythms and Sleep in Drosophila melanogaster
Dubowy, C., & Sehgal, A. (2017) · Genetics · doi:10.1534/genetics.115.185157 · Cited by 432
Changes in the composition of brain interstitial ions control the sleep-wake cycle
Ding, F., O’Donnell, J., Xu, Q., Kang, N., Goldman, N., & Nedergaard, M. (2016) · Science · doi:10.1126/science.aad4821 · Cited by 393
Circuit-based interrogation of sleep control
Weber, F., & Dan, Y. (2016) · Nature · doi:10.1038/nature19773 · Cited by 383
The Regulation of Transcription in Memory Consolidation
Alberini, C. M., & Kandel, E. R. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021741 · Cited by 362
Buzsáki, G. (2019) · doi:10.1093/oso/9780190905385.001.0001 · Cited by 383
Sleep—A brain-state serving systems memory consolidation
Brodt, S., Inostroza, M., Niethard, N., & Born, J. (2023) · Neuron · doi:10.1016/j.neuron.2023.03.005 · Cited by 343
Network Homeostasis and State Dynamics of Neocortical Sleep
Watson, B. O., Levenstein, D., Greene, J. P., Gelinas, J. N., & Buzsáki, G. (2016) · Neuron · doi:10.1016/j.neuron.2016.03.036 · Cited by 375
Sleep, insomnia and mental health
Palagini, L., Hertenstein, E., Riemann, D. W., & Nissen, C. (2022) · Journal of Sleep Research · doi:10.1111/jsr.13628 · Cited by 360
Neuromodulation of brain state and behavior
McCormick, D. A., Nestvogel, D. B., & He, B. J. (2020) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-100219-105424 · Cited by 303
The role of AMPA receptors in postsynaptic mechanisms of synaptic plasticity
Chater, T. E., & Goda, Y. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00401 · Cited by 377
Functions and Mechanisms of Sleep
Zielinski, M. R., McKenna, J. T., & McCarley, R. W. (2016) · AIMS neuroscience · doi:10.3934/neuroscience.2016.1.67 · Cited by 392
Raven, F., Van der Zee, E. A., Meerlo, P., & Havekes, R. (2018) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2017.05.002 · Cited by 331
Xu, W., Tan, C., Zou, J., Cao, X., & Tan, L. (2019) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2019-321896 · Cited by 349
The epidemiology of sleep and obesity
Ogilvie, R. P., & Patel, S. R. (2017) · Sleep Health · doi:10.1016/j.sleh.2017.07.013 · Cited by 356
Sleep Disturbance, Cognitive Decline, and Dementia: A Review
Wu, M. N., Rosenberg, P. B., Spira, A. P., & Wennberg, A. M. V. (2017) · Seminars in Neurology · doi:10.1055/s-0037-1604351 · Cited by 325
Neuronal Firing Rate Homeostasis Is Inhibited by Sleep and Promoted by Wake
Hengen, K. B., Pacheco, A. T., McGregor, J. N., Hooser, S. D. V., & Turrigiano, G. G. (2016) · Cell · doi:10.1016/j.cell.2016.01.046 · Cited by 302
Sleep deprivation and stress: a reciprocal relationship
Nollet, M., Wisden, W., & Franks, N. P. (2020) · Interface Focus · doi:10.1098/rsfs.2019.0092 · Cited by 324
Oscillating circuitries in the sleeping brain
Adamantidis, A. R., Gutierrez Herrera, C., & Gent, T. C. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0223-4 · Cited by 281
Havekes, R., Park, A. J., Tudor, J. C., Luczak, V. G., Hansen, R. T., Ferri, S. L., Bruinenberg, V. M., Poplawski, S. G., Day, J. P., Aton, S. J., et al. (2016) · eLife · doi:10.7554/elife.13424 · Cited by 292
Schmidt, M. H. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.08.001 · Cited by 291
Light and Cognition: Roles for Circadian Rhythms, Sleep, and Arousal
Fisk, A. S., Tam, S. K. E., Brown, L. A., Vyazovskiy, V. V., Bannerman, D. M., & Peirson, S. N. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00056 · Cited by 295
Cortical circuit activity underlying sleep slow oscillations and spindles
Niethard, N., Ngo, H.-V. V., Ehrlich, I., & Born, J. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1805517115 · Cited by 245
Sex differences in the circadian regulation of sleep and waking cognition in humans
Santhi, N., Lázár, A. S., McCabe, P. J., Lo, J. C.-Y., Groeger, J. A., & Dijk, D. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521637113 · Cited by 290
Sleep and human cognitive development
Mason, G. M., Lokhandwala, S., Riggins, T., & Spencer, R. M. C. (2021) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2021.101472 · Cited by 311
Sleep apnoea and the brain: a complex relationship
Rosenzweig, I., Glasser, M., Polšek, D., Leschziner, G. D., Williams, S., & Morrell, M. J. (2015) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(15)00090-9 · Cited by 278
Competing Roles of Slow Oscillations and Delta Waves in Memory Consolidation versus Forgetting
Kim, J., Gulati, T., & Ganguly, K. (2019) · Cell · doi:10.1016/j.cell.2019.08.040 · Cited by 254
The role of sleep dysfunction in the occurrence of delusions and hallucinations: A systematic review
Reeve, S., Sheaves, B., & Freeman, D. (2015) · Clinical Psychology Review · doi:10.1016/j.cpr.2015.09.001 · Cited by 273
“The salience model of psychosis (Kapur, 2003; Kapur, Mizrahi, & Li, 2005) has been linked to sleep dysfunction via the proposed role of sleep in synaptic homeostasis (Tononi & Cirelli, 2014).”
BackgroundThe Slow Oscillation in Cortical and Thalamic Networks: Mechanisms and Functions
Neske, G. T. (2016) · Frontiers in Neural Circuits · doi:10.3389/fncir.2015.00088 · Cited by 296
Sleep-wake cycles drive daily dynamics of synaptic phosphorylation
Brüning, F., Noya, S. B., Bange, T., Koutsouli, S., Rudolph, J. D., Tyagarajan, S. K., Cox, J., Mann, M., Brown, S. A., & Robles, M. S. (2019) · Science · doi:10.1126/science.aav3617 · Cited by 266
Neuronal regulation of immunity: why, how and where?
Schiller, M., Ben-Shaanan, T. L., & Rolls, A. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-020-0387-1 · Cited by 284
Hippocampal ripples down-regulate synapses
Norimoto, H., Makino, K., Gao, M., Shikano, Y., Okamoto, K., Ishikawa, T., Sasaki, T., Hioki, H., Fujisawa, S., & Ikegaya, Y. (2018) · Science · doi:10.1126/science.aao0702 · Cited by 262
Enhancement of sleep slow waves: underlying mechanisms and practical consequences
Bellesi, M., Riedner, B. A., Garcia-Molina, G. N., Cirelli, C., & Tononi, G. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00208 · Cited by 239
Self-citationAlleviating catastrophic forgetting using context-dependent gating and synaptic stabilization
Masse, N. Y., Grant, G. D., & Freedman, D. J. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1803839115 · Cited by 278
A step-by-step tutorial on active inference and its application to empirical data
Smith, R., Friston, K. J., & Whyte, C. J. (2022) · Journal of Mathematical Psychology · doi:10.1016/j.jmp.2021.102632 · Cited by 246
Exploring phylogeny to find the function of sleep
Anafi, R. C., Kayser, M. S., & Raizen, D. M. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0098-9 · Cited by 259
Slow-wave sleep: From the cell to the clinic
Léger, D., Debellemanière, E., Rabat, A., Bayon, V., Benchenane, K., & Chennaoui, M. (2018) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2018.01.008 · Cited by 284
Quantitative phosphoproteomic analysis of the molecular substrates of sleep need
Wang, Z., Ma, J., Miyoshi, C., Li, Y., Sato, M., Ogawa, Y., Lou, T., Ma, C., Gao, X., Lee, C.-Y., et al. (2018) · Nature · doi:10.1038/s41586-018-0218-8 · Cited by 251
Sleep deprivation, oxidative stress and inflammation
Atrooz, F., & Salim, S. (2019) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2019.03.001 · Cited by 265
The forebrain synaptic transcriptome is organized by clocks but its proteome is driven by sleep
Noya, S. B., Colameo, D., Brüning, F., Spinnler, A., Mircsof, D., Opitz, L., Mann, M., Tyagarajan, S. K., Robles, M. S., & Brown, S. A. (2019) · Science · doi:10.1126/science.aav2642 · Cited by 258
Alzheimer’s pathogenic mechanisms and underlying sex difference
Zhu, D., Montagne, A., & Zhao, Z. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03830-w · Cited by 275
The dialectic of Hebb and homeostasis
Turrigiano, G. G. (2017) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0258 · Cited by 251
Sleep Facilitates Memory by Blocking Dopamine Neuron-Mediated Forgetting
Berry, J. A., Cervantes-Sandoval, I., Chakraborty, M., & Davis, R. L. (2015) · Cell · doi:10.1016/j.cell.2015.05.027 · Cited by 247
Alzheimer’s Disease: From Firing Instability to Homeostasis Network Collapse
Frère, S. G. A., & Slutsky, I. (2018) · Neuron · doi:10.1016/j.neuron.2017.11.028 · Cited by 242
Circadian regulation of human cortical excitability
Ly, J. Q. M., Gaggioni, G., Chellappa, S. L., Papachilleos, S., Brzozowski, A., Borsu, C., Rosanova, M., Sarasso, S., Middleton, B., Luxen, A., et al. (2016) · Nature Communications · doi:10.1038/ncomms11828 · Cited by 226
Unraveling the evolutionary determinants of sleep
Joiner, W. J. (2016) · Current Biology · doi:10.1016/j.cub.2016.08.068 · Cited by 232
The claustrum coordinates cortical slow-wave activity
Narikiyo, K., Mizuguchi, R., Ajima, A., Mitsui, S., Shiozaki, M., Hamanaka, H., Johansen, J. P., Mori, K., & Yoshihara, Y. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0625-7 · Cited by 237
Bistability breaks-off deterministic responses to intracortical stimulation during non-REM sleep
Pigorini, A., Sarasso, S., Proserpio, P., Szymanski, C., Arnulfo, G., Casarotto, S., Fecchio, M., Rosanova, M., Mariotti, M., Lo Russo, G., et al. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.02.056 · Cited by 200
Karabanov, A. N., Ziemann, U., Hamada, M., George, M. S., Quartarone, A., Claßen, J., Massimini, M., Rothwell, J. C., & Siebner, H. R. (2015) · Brain stimulation · doi:10.1016/j.brs.2015.01.404 · Cited by 236
Napping: a public health issue. From epidemiological to laboratory studies
Faraut, B., Andrillon, T., Vecchierini, M.-F., & Leger, D. (2017) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2016.09.002 · Cited by 217
Sleep and synaptic down-selection
Tononi, G., & Cirelli, C. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14335 · Cited by 217
Self-citationEffects of sleep and wake on astrocytes: clues from molecular and ultrastructural studies
Bellesi, M., de Vivo, L., Tononi, G., & Cirelli, C. (2015) · BMC Biology · doi:10.1186/s12915-015-0176-7 · Cited by 218
Self-citationMicroglia Gone Rogue: Impacts on Psychiatric Disorders across the Lifespan
Tay, T. L., Béchade, C., D’Andrea, I., St‐Pierre, M., Henry, M. S., Roumier, A., & Tremblay, M. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00421 · Cited by 217
Predicting lapses of attention with sleep-like slow waves
Andrillon, T., Burns, A. C., Mackay, T., Windt, J., & Tsuchiya, N. (2021) · Nature Communications · doi:10.1038/s41467-021-23890-7 · Cited by 236
Sleep for cognitive enhancement
Diekelmann, S. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00046 · Cited by 226
Rescue of long-range circuit dysfunction in Alzheimer's disease models
Busche, M. A., Kekuš, M., Adelsberger, H., Noda, T., Förstl, H., Nelken, I., & Konnerth, A. (2015) · Nature Neuroscience · doi:10.1038/nn.4137 · Cited by 221
Driving Sleep Slow Oscillations by Auditory Closed-Loop Stimulation—A Self-Limiting Process
Ngo, H.-V. V., Miedema, A., Faude, I., Martinetz, T., Mölle, M., & Jan Born, A. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3133-14.2015 · Cited by 228
The hippocampus is crucial for forming non-hippocampal long-term memory during sleep
Sawangjit, A., Oyanedel, C. N., Niethard, N., Salazar, C., Born, J., & Inostroza, M. (2018) · Nature · doi:10.1038/s41586-018-0716-8 · Cited by 208
Local aspects of sleep and wakefulness
Siclari, F., & Tononi, G. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.05.008 · Cited by 220
Self-citationSleeping on the motor engram: The multifaceted nature of sleep-related motor memory consolidation
King, B. R., Hoedlmoser, K., Hirschauer, F., Dolfen, N., & Albouy, G. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.04.026 · Cited by 216
Varga, A. W., Wohlleber, M. E., Giménez, S., Romero, S., Alonso, J. F., Ducca, E. L., Kam, K., Lewis, C., Tanzi, E. B., Tweardy, S., et al. (2016) · SLEEP · doi:10.5665/sleep.6240 · Cited by 203
Richards, A. L., Kanady, J. C., & Neylan, T. C. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0486-5 · Cited by 217
The Epidemiology of Sleep and Diabetes
Ogilvie, R. P., & Patel, S. R. (2018) · Current Diabetes Reports · doi:10.1007/s11892-018-1055-8 · Cited by 211
Local Slow Waves in Superficial Layers of Primary Cortical Areas during REM Sleep
Funk, C. M., Honjoh, S., Rodriguez, A. V., Cirelli, C., & Tononi, G. (2016) · Current Biology · doi:10.1016/j.cub.2015.11.062 · Cited by 178
Self-citationSleep duration, brain structure, and psychiatric and cognitive problems in children
Cheng, W., Rolls, E., Gong, W., Du, J., Zhang, J., Zhang, X.-Y., Li, F., & Feng, J. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-0663-2 · Cited by 196
Brain Oscillations in Sport: Toward EEG Biomarkers of Performance
Cheron, G. A., Petit, G., Chéron, J., Leroy, A., Cebolla, A. M., Cevallos, C., Petieau, M., Hoellinger, T., Zarka, D., Clarinval, A.-M., et al. (2016) · Frontiers in Psychology · doi:10.3389/fpsyg.2016.00246 · Cited by 215
Rattenborg, N. C., de la Iglesia, H. O., Kempenaers, B., Lesku, J. A., Meerlo, P., & Scriba, M. F. (2017) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0251 · Cited by 197
Cortical dendritic activity correlates with spindle-rich oscillations during sleep in rodents
Seibt, J., Richard, C. J., Sigl-Glöckner, J., Takahashi, N., Kaplan, D. I., Doron, G., de Limoges, D., Bocklisch, C., & Larkum, M. E. (2017) · Nature Communications · doi:10.1038/s41467-017-00735-w · Cited by 165
Sleep-Wake Disturbances After Traumatic Brain Injury: Synthesis of Human and Animal Studies
Sandsmark, D. K., Elliott, J. E., & Lim, M. M. (2017) · Sleep · doi:10.1093/sleep/zsx044 · Cited by 183
The role of sleep in recovery following ischemic stroke: A review of human and animal data
Duss, S. B., Seiler, A., Schmidt, M. H., Pace, M., Adamantidis, A., Müri, R. M., & Bassetti, C. L. (2016) · Neurobiology of Sleep and Circadian Rhythms · doi:10.1016/j.nbscr.2016.11.003 · Cited by 189
Sleep and memory in mammals, birds and invertebrates
Vorster, A. P., & Born, J. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.09.020 · Cited by 169
Ruivo, L. M. T.-G., Baker, K. L., Conway, M. W., Kinsley, P. J., Gilmour, G., Phillips, K. G., Isaac, J. T. R., Lowry, J. P., & Mellor, J. R. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.085 · Cited by 181
Sculpting memory during sleep: concurrent consolidation and forgetting
Feld, G. B., & Jan Born, A. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.02.012 · Cited by 185
Reynaud, È., Vecchierini, M., Heude, B., Charles, M.-A. A., & Plancoulaine, S. (2017) · Journal of Sleep Research · doi:10.1111/jsr.12636 · Cited by 193
Shaping the Default Activity Pattern of the Cortical Network
Sanchez-Vives, M. V., Massimini, M., & Mattia, M. (2017) · Neuron · doi:10.1016/j.neuron.2017.05.015 · Cited by 176
Mechanisms of homeostatic plasticity in the excitatory synapse
Fernandes, D., & Carvalho, A. L. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13687 · Cited by 179
The consequences of sleep deprivation on cognitive performance
Khan, M., & Al-Jahdali, H. H. (2023) · Neurosciences · doi:10.17712/nsj.2023.2.20220108 · Cited by 218
Metadata
- Authors
- Tononi, G., & Cirelli, C.
- Affiliations
- University of Wisconsin System (US)
- University of Wisconsin–Madison (US)
- Corresponding author
- Tononi, Giulio
- Cirelli, Chiara
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 81
- Issue
- 1
- Pages
- 12-34
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3921176
- OpenAlex
- W1977647750
- Semantic Scholar
- 61972f1694fafd898abf59be6068327214e9f48a
- Cited by
- 2,356
- References
- 254
- Citations by year
- 2026: 211 · 2025: 247 · 2024: 194 · 2023: 265 · 2022: 196 · 2021: 185 · 2020: 225 · 2019: 228 · 2018: 149 · 2017: 142 · 2016: 127 · 2015: 126 · 2014: 57
- FWCI
- 14.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH099231, R01MH091326)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- sleep, synaptic homeostasis hypothesis, synaptic plasticity, cellular homeostasis, memory consolidation, memory integration, signal-to-noise ratio, learning, spontaneous neuronal activity
- MeSH terms
- Animals, Brain, Homeostasis, Humans, Learning, Neuronal Plasticity, Sleep, Synapses
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
