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Reactive Gliosis and the Multicellular Response to CNS Damage and Disease
Open accessAbstract
The central nervous system (CNS) is prone to heterogeneous insults of diverse etiologies that elicit multifaceted responses. Acute and focal injuries trigger wound repair with tissue replacement. Diffuse and chronic diseases provoke gradually escalating tissue changes. The responses to CNS insults involve complex interactions among cells of numerous lineages and functions, including CNS intrinsic neural cells, CNS intrinsic non-neural cells, and CNS extrinsic cells that enter from the circulation. The contributions of diverse non-neuronal cell types to outcome after acute injury, or to the progression of chronic disease, are of increasing interest as the push towards understanding and ameliorating CNS afflictions accelerates. In some cases considerable information is available, in others, comparatively little, as examined and reviewed here.
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Self-citation
Metadata
- Authors
- Burda, J. E., & Sofroniew, M. V.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 81
- Issue
- 2
- Pages
- 229-248
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2047585900
- Cited by
- 1,438
- References
- 46
- FWCI
- 45.36
- Type
- journal article
- Language
- en
- Open access
- bronze
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