Functional correlates of the lateral and medial entorhinal cortex: objects, path integration and local-global reference frames
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The hippocampus receives its major cortical input from the medial entorhinal cortex (MEC) and the lateral entorhinal cortex (LEC). It is commonly believed that the MEC provides spatial input to the hippocampus, whereas the LEC provides non-spatial input. We review new data which suggest that this simple dichotomy between 'where' versus 'what' needs revision. We propose a refinement of this model, which is more complex than the simple spatial-non-spatial dichotomy. MEC is proposed to be involved in path integration computations based on a global frame of reference, primarily using internally generated, self-motion cues and external input about environmental boundaries and scenes; it provides the hippocampus with a coordinate system that underlies the spatial context of an experience. LEC is proposed to process information about individual items and locations based on a local frame of reference, primarily using external sensory input; it provides the hippocampus with information about the content of an experience.
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Recent behavioral and electrophysiological evidence indicates that both LEC and MEC process spatial information, with local and global spatial frameworks being represented within LEC and MEC, respectively.
“Yet, recent behavioral and electrophysiological evidence indicates that both LEC and MEC process spatial information, with local and global spatial frameworks being represented within LEC and MEC, respectively (Knierim et al., 2014; Neunuebel et al., 2013).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Knierim et al., 2014
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- Authors
- Knierim, J. J., Neunuebel, J. P., & Deshmukh, S. S.
- Affiliations
- Johns Hopkins University (US)
- Venue
- Philosophical Transactions of the Royal Society B Biological Sciences
- Publisher
- The Royal Society
- Published
- 2014-02-05
- Volume
- 369
- Issue
- 1635
- Pages
- 20130369
- ISSN
- 0962-8436 (ISSN-L)
- 1471-2970
- PMC
- PMC3866456
- OpenAlex
- W2098807436
- Cited by
- 425
- References
- 86
- Citations by year
- 2026: 28 · 2025: 35 · 2024: 41 · 2023: 31 · 2022: 39 · 2021: 44 · 2020: 32 · 2019: 30 · 2018: 35 · 2017: 46 · 2016: 30 · 2015: 22 · 2014: 11 · 2013: 1
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Philosophical Transactions of the Royal Society B Biological Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01MH094146)
- National Institute of Neurological Disorders and Stroke (T32NS007467, T32NS07467, R01NS039456)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- lateral entorhinal cortex, medial entorhinal cortex, hippocampus, path integration, spatial memory, object memory, self-motion cues, environmental boundaries, spatial context
- MeSH terms
- Animals, Hippocampus, Neural Pathways, Neurons, Spatial Behavior, Entorhinal Cortex, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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