The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Direct Reactivation of a Coherent Neocortical Memory of Context
Open accessAbstract
Summary Declarative memories are thought to be stored within anatomically distributed neuronal networks requiring the hippocampus; however, it is unclear how neocortical areas participate in memory at the time of encoding. Here, we use a c-fos-based genetic tagging system to selectively express the channelrhodopsin variant, ChEF, and optogenetically reactivate a specific neural ensemble in retrosplenial cortex (RSC) engaged by context fear conditioning. Artificial stimulation of RSC was sufficient to produce both context-specific behavior and downstream cellular activity commensurate with natural experience. Moreover, optogenetically, but not contextually-elicited responses were insensitive to hippocampal inactivation, suggesting that although the hippocampus is needed to coordinate activation by sensory cues, a higher-order cortical framework can independently subserve learned behavior, even shortly after learning.
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Cites
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Memory engrams: Recalling the past and imagining the future
Josselyn, S. A., & Tonegawa, S. (2020) · Science · doi:10.1126/science.aaw4325 · Cited by 1,087
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A cortical-hippocampal-cortical loop of information processing during memory consolidation
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The neurobiological foundation of memory retrieval
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Prediction and memory: A predictive coding account
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Fast track to the neocortex: A memory engram in the posterior parietal cortex
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Cooperative subnetworks of molecularly similar interneurons in mouse neocortex
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de Sousa, A. F., Cowansage, K. K., Zutshi, I., Cardozo, L. M., Yoo, E. J., Leutgeb, S., & Mayford, M. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1818432116 · Cited by 138
Self-citationMemory corticalization triggered by REM sleep: mechanisms of cellular and systems consolidation
Almeida-Filho, D. G., Queiroz, C. M., & Ribeiro, S. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2886-9 · Cited by 38
Role of the hippocampus in systems consolidation of remote fear memory
Park, H., & Kaang, B.-K. (2026) · Experimental & Molecular Medicine · doi:10.1038/s12276-026-01680-9 · Cited by 1
Metadata
- Authors
- Cowansage, K. K., Shuman, T., Dillingham, B. C., Chang, A., Golshani, P., & Mayford, M.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2014-10
- Volume
- 84
- Issue
- 2
- Pages
- 432-441
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2104742248
- Cited by
- 366
- References
- 10
- FWCI
- 14.81
- Type
- journal article
- Language
- en
- Open access
- bronze
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