Cooperative subnetworks of molecularly similar interneurons in mouse neocortex

Karnani, Mahesh M.; Jackson, Jesse; Ayzenshtat, Inbal; Tucciarone, Jason; Manoocheri, Kasra; Snider, William G.; Yuste, Rafael

doi:10.1016/j.neuron.2016.02.037

Cited by 196Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionMemory and Neural Mechanisms

Cooperative subnetworks of molecularly similar interneurons in mouse neocortex

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Karnani, Mahesh M., Jackson, Jesse, Ayzenshtat, Inbal, Tucciarone, Jason, Manoocheri, Kasra, Snider, William G., Yuste, Rafael·2016·Neuron

DOI 10.1016/j.neuron.2016.02.037PMC PMC4961215

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Abstract

Simultaneous co-activation of neocortical neurons is likely critical for brain computations ranging from perception and motor control to memory and cognition. While co-activation of excitatory principal cells (PCs) during ongoing activity has been extensively studied, that of inhibitory interneurons (INs) has received little attention. Here, we show in vivo and in vitro that members of two non-overlapping neocortical IN populations, expressing somatostatin (SOM) or vasoactive intestinal peptide (VIP), are active as populations rather than individually. We demonstrate a variety of synergistic mechanisms, involving population-specific local excitation, GABAergic disinhibition and excitation through electrical coupling, which likely underlie IN population co-activity. Firing of a few SOM or VIP INs recruits additional members within the cell type via GABAergic and cholinergic mechanisms, thereby amplifying the output of the population as a whole. Our data suggest that IN populations work as cooperative units, thus generating an amplifying nonlinearity in their circuit output.

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GABA and Ach coreleased in cortex may act in parallel on different targets to achieve a common function, such as placing cortex in a more excitable and pro-plasticity state.
“GABA and Ach coreleased in the cortex may act in parallel on different targets to achieve a single common function, such as placing the cortex in a more excitable and pro-plasticity state by simultaneously inhibiting Sst+ interneurons with GABA while using Ach release to excite disinhibitory interneurons and activate muscarinic receptors on pyramidal cells.90,97,98,140,141”
From Synaptic and circuit functions of multitransmitter neurons in the mammalian brain (2023) · cites this paper as [140]

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Authors: Karnani, M. M., Jackson, J., Ayzenshtat, I., Tucciarone, J., Manoocheri, K., Snider, W. G., & Yuste, R.
Affiliations: Columbia University (US)
Cold Spring Harbor Laboratory (US)
Corresponding author: Karnani, Mahesh M.
ORCID: Karnani, Mahesh M.
Jackson, Jesse
Ayzenshtat, Inbal
Tucciarone, Jason
Manoocheri, Kasra
Yuste, Rafael
Venue: Neuron
Publisher: Elsevier BV
Published: 2016-04
Volume: 90
Issue: 1
Pages: 86-100
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2016.02.037
PMC: PMC4961215
OpenAlex: W2304994747
Cited by: 196
References: 50
Citations by year: 2026: 12 · 2025: 21 · 2024: 15 · 2023: 15 · 2022: 21 · 2021: 18 · 2020: 21 · 2019: 14 · 2018: 17 · 2017: 25 · 2016: 17
FWCI: 13.69
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 370 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
Funders: National Institute of Mental Health (R01 MH100561, R01MH101218)
National Eye Institute (DP1EY024503, R01EY011787)
Army Research Office (W911NF-12-1-0594 MURI)
Defense Advanced Research Projects Agency (SIMPLEX N66001-15-C-4032)
Canadian Institutes of Health Research
Human Frontier Science Program
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: inhibitory interneurons, neocortex, somatostatin interneurons, vasoactive intestinal peptide interneurons, GABAergic disinhibition, electrical coupling, cholinergic modulation, localized excitations, nonlinear amplification, mice
MeSH terms: Acetylcholine, Animals, gamma-Aminobutyric Acid, Interneurons, Neural Inhibition, Neurons, Somatostatin, Vasoactive Intestinal Peptide, Pyramidal Cells, Patch-Clamp Techniques, Neocortex, Mice, In Vitro Techniques

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Cooperative subnetworks of molecularly similar interneurons in mouse neocortex

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