TRIM46 Controls Neuronal Polarity and Axon Specification by Driving the Formation of Parallel Microtubule Arrays

RING Domain E3 Ubiquitin Ligases

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Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity

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Impaired disassembly of the axon initial segment restricts mitochondrial entry into damaged axons

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Functional differences of short and long isoforms of spastin harboring missense mutation

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Trafficking mechanisms underlying Nav channel subcellular localization in neurons

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A mitochondria cluster at the proximal axon initial segment controls axodendritic TAU trafficking in rodent primary and human iPSC-derived neurons

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Microtubule polarity is instructive for many aspects of neuronal polarity

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Multilayered regulations of alternative splicing, NMD, and protein stability control temporal induction and tissue-specific expression of TRIM46 during axon formation

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Phosphoregulation of Kinesins Involved in Long-Range Intracellular Transport

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The core PCP protein Prickle2 regulates axon number and AIS maturation by binding to AnkG and modulating microtubule bundling

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Many Faces of TRIM Proteins on the Road from Pluripotency to Neurogenesis

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WDR47 protects neuronal microtubule minus ends from katanin-mediated severing

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The function of the axon initial segment in neuronal polarity

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Principles of microtubule polarity in linear cells

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PTRN-1 (CAMSAP) and NOCA-2 (NINEIN) are required for microtubule polarity in Caenorhabditis elegans dendrites

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Efficient axonal transport of endolysosomes relies on the balanced ratio of microtubule tyrosination and detyrosination

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Extracellular Tau Oligomers Damage the Axon Initial Segment

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Tau here, tau there, tau almost everywhere: Clarifying the distribution of tau in the adult CNS

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Neuronal Polarity: MAP2 Shifts Secretory Vesicles into High Gear for Long-Haul Transport down the Axon

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Microtubule-associated proteins (MAPs) in microtubule cytoskeletal dynamics and spermatogenesis.

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Trim9 and Klp61F promote polymerization of new dendritic microtubules along parallel microtubules

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Complexes of tubulin oligomers and tau form a viscoelastic intervening network cross-bridging microtubules into bundles

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An evolutionarily conserved AnkyrinG-dependent motif clusters axonal K2P K+ channels

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Axon Initial Segments Are Required for Efficient Motor Neuron Axon Regeneration and Functional Recovery of Synapses

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Polarity sorting of axonal microtubules: a computational study

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It’s a TRIM-endous view from the top: the varied roles of TRIpartite Motif proteins in brain development and disease

Dudley-Fraser, J., & Rittinger, K. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1287257 · Cited by 15

Multiple layers of spatial regulation coordinate axonal cargo transport

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Precise localizations of voltage‐gated sodium and potassium channels in neurons

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Unrestrained growth of correctly oriented microtubules instructs axonal microtubule orientation

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Actin polymerization and longitudinal actin fibers in axon initial segment plasticity

Micinski, D., & Hotulainen, P. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1376997 · Cited by 12

Microtubule Organization in the Axon: TRIM46 Determines the Orientation

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Kinetochore protein Spindly controls microtubule polarity in Drosophila axons

del Castillo, U., Müller, H. ‐. J., & Gelfand, V. I. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2005394117 · Cited by 12

Trim46 contributes to the midbrain development via Sonic Hedgehog signaling pathway in zebrafish embryos

Jung, J., Kim, J., Huh, T., & Rhee, M. (2021) · Animal Cells and Systems · doi:10.1080/19768354.2021.1889661 · Cited by 12

Cultivation, Differentiation, and Lentiviral Transduction of Human-Induced Pluripotent Stem Cell (hiPSC)-Derived Glutamatergic Neurons for Studying Human Tau

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Unraveling sex differences in Alzheimer's disease and related endophenotypes with brain proteomes

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The TRIM69-MST2 signaling axis regulates centrosome dynamics and chromosome segregation

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Role of Cytoskeletal Elements in Regulation of Synaptic Functions: Implications Toward Alzheimer’s Disease and Phytochemicals-Based Interventions

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Potassium channel clustering: mechanisms shaping axonal excitability

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Endogenously expressed Ranbp2 is not at the axon initial segment

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RNA-seq transcriptome analysis in flounder cells to compare innate immune responses to low- and high-virulence viral hemorrhagic septicemia virus

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Mind the Gap: Molecular Architecture of the Axon Initial Segment – From Fold Prediction to a Mechanistic Model of Function?

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A simple human cell model for TAU trafficking and tauopathy-related TAU pathology

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Polarity reversal of stable microtubules during neuronal development

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Unveiling the cell biology of hippocampal neurons with dendritic axon origin

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Dynamics of microtubules and their associated proteins

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Microtubule polarity flaws as a treatable driver of neurodegeneration

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tubg1 Somatic Mutants Show Tubulinopathy-Associated Neurodevelopmental Phenotypes in a Zebrafish Model

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TRIM Proteins and Antiviral Microtubule Reorganization: A Novel Component in Innate Immune Responses?

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TRIM46 Is Required for Microtubule Fasciculation In Vivo But Not Axon Specification or Axon Initial Segment Formation

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Axon outgrowth and neuronal differentiation defects after a-SMN and FL-SMN silencing in primary hippocampal cultures

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Microtubules are not required to generate a nascent axon in embryonic spinal neurons in vivo

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TRIMming the tangles

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Trim46 knockout impaired neuronal architecture and caused hypoactive behavior in rats

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A Farnesyltransferase Acts to Inhibit Ectopic Neurite Formation in C. elegans

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Identification of a Specific Inhibitor of Human Scp1 Phosphatase Using the Phosphorylation Mimic Phage Display Method

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Inhibitory synapse dysfunction and epileptic susceptibility associated with KIF2A deletion in cortical interneurons

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Regulation of Axonal Microtubule Polarity Orientation in Different Kinds of Neurons

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Evolution and expression of the duck TRIM gene repertoire

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Benchmarking In-Cell Proteomics for Profiling Neuroblastoma Cell Differentiation and the Ubiquitin-Proteasome System

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Recombinant lectin Gg for brain imaging of glycan structure and formation in the CNS node of Ranvier

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TIAM-1 differentially regulates dendritic and axonal microtubule organization in patterning neuronal development through its multiple domains

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KLP-7/Kinesin-13 orchestrates axon-dendrite checkpoints for polarized trafficking in neurons

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Ankyrin-G and Its Binding Partners in Neurons: Orchestrating the Molecular Structure of the Axon Initial Segment

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Studying Microtubule Dynamics in Human Neurons: Two-Dimensional Microtubule Tracing and Kymographs in iPSC- and SH-SY5Y-Derived Neurons for Tau Research

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Axodendritic targeting of TAU and MAP2 and microtubule polarization in iPSC-derived versus SH-SY5Y-derived human neurons

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Consciousness, Microtubules, and the Axon Initial Segment

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Matrix elasticity gradients guide neuronal polarity by controlling microtubule network mobilityPreprint

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Neurons | Establishing and Maintaining Neuron Morphology

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MeCP2 binding and genome–lamina reorganization precede long gene activation during mouse corticogenesisPreprint

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Evaluating TRIM46's Role in Axon Initial Segment Formation

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Modeling human retinal ganglion cell axonal outgrowth, development, and pathology using pluripotent stem cell–based microfluidic platforms

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Tau Axonal Sorting and Interaction With Synaptic Plasticity Modulators Is Domain‐ and Isoform‐Dependent in Human iPSC ‐Derived Neurons

Bell‐Simons, M., Breuer, H., Wunderlich, L., Chmes, H., Adam, D., Klimek, J., Buchholz, S., & Zempel, H. (2025) · Aging Cell · doi:10.1111/acel.70215 · Cited by 2

Axon Initial Segment: Structure, Biological Functions, Diseases, and Therapeutic Targets

Song, D., Yuan, L., Yang, W., Li, W., & Li, J. (2026) · MedComm · doi:10.1002/mco2.70689 · Cited by 2

Comprehensive analysis of ferroptosis-related genes indicates that TRIM46 is a novel biomarker and promotes the progression of ovarian cancer via modulating ferroptosis and Wnt signaling pathway

Liu, S. (2024) · American Journal of Cancer Research · doi:10.62347/onuy8904 · Cited by 2

Deciphering the alteration of MAP2 interactome caused by a schizophrenia-associated phosphorylation

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Autoimmune cerebellar ataxia: An overlooked, but treatable, neuroimmune condition

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Methods for Identification of Substrates/Inhibitors of FCP/SCP Type Protein Ser/Thr Phosphatases

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Loss of the E3 ubiquitin ligase TRIM67 alters the post-synaptic density proteome

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Tropomyosin Tpm3.1 is required to maintain the structure and function of the axon initial segmentPreprint

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Axonal Tau sorting depends on the PRR2 domain and 0N4R-specific interactions hint at distinct roles of Tau isoforms in synaptic plasticityPreprint

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Paraneoplastic neurological syndromes

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Strikingly different neurotransmitter release strategies in dopaminergic subclassesPreprint

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SHANK3–CAMSAP2 interaction links synapses to dendritic microtubule organisation in PV neuronsPreprint

Hacker, D., Lee, S., Hecht-Bucher, M., Lee, S., Lamborelle, C. S., Doil, A. N., Fanutza, T., Brueckner, A. M., Yoo, T., Ramírez‐Ríos, S., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.10.705051 · Cited by 2

The Axon Initial Segment Plays a Dynamic Role in Peripheral Motor Neuron Synapse Regeneration following Injury

Adler, J. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.2326-22.2023 · Cited by 1

Microtubule remodeling by the innate immune factor Trim69 compromises dynein-dependent migration of HIV virion cores toward the nucleus

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TRIM46 promotes chemoresistance of ovarian cancer via activating PHLPP2/PI3K/AKT pathway

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Worm orthologues of cytokinesis-associated proteins CIT and ASPM regulate neuronal microtubule dynamics and polarity in C. elegans

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